This paper explores methods for extracting information from radiology reports that generalize across exam modalities to reduce requirements for annotated data. We demonstrate that multi-pass T5-based text-to-text gene...
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This study presents the design and development of a light fidelity (Li-Fi) technology-based smart rover for sustainable monitoring of marine environments. A rover equipped with Li-Fi transmitters, receivers, and envir...
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The study explores knockout of c-Myc and doxorubicin toxicity influence on mouse kidney's metabolism. Cryo-imaging unveils knockout is significantly more oxidized compared to control group while this was not obser...
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In the industrial context, the transformation of any process related information to a digital format affects the entire company, from administration to production and logistics (digitization). This paper focuses on Ed...
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Shear-stiffening materials have garnered significant attention due to their inherent ability to rapidly respond to changes in strain rate. However, conventional studies on these materials exhibit limited mechanical pe...
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The increasing proliferation of third-generation semiconductor silicon carbide (SiC) products has led to the emergence of SiC powder as an industrial byproduct. To reutilize the SiC efficiently, we propose a facile me...
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Navigating a busy cityscape with a fleet of autonomous vehicles requires each to seamlessly maneuver through traffic with split-second decisions. Path planning is the backbone of such advanced machinery applications, ...
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The study explores knockout of c-Myc and doxorubicin toxicity influence on mouse kidney's metabolism. Cryo-imaging unveils knockout is significantly more oxidized compared to control group while this was not obser...
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Background: Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are impo...
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Background: Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are important for detecting and relaying sensory information from the periphery to the central nervous system to modulate feeding behavior, metabolism, and inflammation. Confounding variables complicate the process of isolating the role of the vagal afferents in mediating these physiological processes. Therefore, we developed a microfluidic model of the sensory branch of the gut-brain axis. We show that this microfluidic model successfully compartmentalizes the cell body and neurite terminals of the neurons, thereby simulates the anatomical layout of these neurons to more accurately study physiologically-relevant processes. Methods: We implemented a primary rat vagal afferent neuron culture into a microfluidic platform consisting of two concentric chambers interconnected with radial microchannels. The microfluidic platform separated cell bodies from neurite terminals of vagal afferent neurons. We then introduced physiologically-relevant gastrointestinal effector molecules at the nerve terminals and assessed their retrograde transport along the neurite or capacity to elicit an electrophysiological response using live cell calcium imaging. Results: The angle of microchannel outlets dictated the probability of neurites growing into a chamber versus tracking along chamber walls. When the neurite terminals were exposed to fluorescently-labeled cholera toxin subunit B, the proteins were taken up and retrogradely transported along the neurites over the course of 24 h. Additionally, mechanical perturbation (e.g., rinsing) of the neurite terminals significantly increased intracellular calcium concentration in the distal soma. Finally, membrane-displayed receptor for capsaicin was expressed and trafficked along newly projected neurites, as revealed by confocal microscopy
This article designs a 14-bit successive approximation register analog-to-digital converter(SAR ADC).A novel digital bubble sorting calibration method is proposed and applied to eliminate the effect of capacitor mis...
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This article designs a 14-bit successive approximation register analog-to-digital converter(SAR ADC).A novel digital bubble sorting calibration method is proposed and applied to eliminate the effect of capacitor mismatch on the linearity of the SAR ADC. To reduce the number of capacitors, a hybrid architecture of a high 8-bit binary-weighted capacitor array and a low 6-bit resistor array is adopted by the digital-to-analog(DAC). The common-mode voltage VCM-based switching scheme is chosen to reduce the switching energy and area of the DAC. The time-domain comparator is employed to obtain lower power consumption. Sampling is performed through a gate voltage bootstrapped switch to reduce the nonlinear errors introduced when sampling the input signal. Moreover, the SAR logic and the whole calibration is totally implemented on-chip through digital integrated circuit(IC) tools such as design compiler, IC compiler, etc. Finally, a prototype is designed and implemented using 0.18 μm bipolar-complementary metal oxide semiconductor(CMOS)-double-diffused MOS 1.8 V CMOS technology. The measurement results show that the SAR ADC with on-chip bubble sorting calibration method achieves the signal-to-noise-and-distortion ratio of 69.75 dB and the spurious-free dynamic range of 83.77 dB.
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