检索结果-内蒙古大学图书馆

Congress on Evolutionary Computation

作者： Sun Kim Soo-Jin Kim Byoung-Tak Zhang The Center for Bioinformatics Technology Graduate Program in Bioinformatics Seoul National University Seoul South Korea The School of Computer Science and Engineering Seoul National University Seoul South Korea

High-throughput microarrays inform us on different outlooks of the molecular mechanisms underlying the function of cells and organisms. While computational analysis for the microarrays show good performance, it is still difficult to infer modules of multiple co-regulated genes. Here, we present a novel classification method to identify the gene modules associated with cancers from microarray data. The proposed approach is based on 'hypernetworks', a hypergraph model consisting of vertices and weighted hyperedges. The hypernetwork model is inspired by biological networks and its learning process is suitable for identifying interacting gene modules. Applied to the analysis of microRNA (miRNA) expression profiles on multiple human cancers, the hypernetwork classifiers identified cancer-related miRNA modules. The results show that our method performs better than decision trees and naive Bayes. The biological meaning of the discovered miRNA modules has been examined by literature search.

关键词： Cancer Gene expression Biological system modeling Data analysis Support vector machines Support vector machine classification Evolutionary computation Humans Decision trees Diseases

来源：评论

学校读者我要写书评

暂无评论

The concept of molecular machinery is useful for design of stimuli-responsive gene delivery systems in the mammalian cell

引用

Journal of Inclusion Phenomena and Macrocyclic Chemistry 2007年第3-4期58卷 205-219页

作者： Nagasaki, Takeshi Shinkai, Seiji Department of Applied Chemistry and Bioengineering Graduate School of Engineering Osaka City University 3-3-138 Sugimoto Sumiyoshi-ku. Osaka 558-8585 Japan SORST Program Japan Science and Technology Corporation Kawaguchi. Saitama 332-0012 Japan Department of Chemistry and Biochemistry Graduate School of Engineering Kyushu University Fukuoka 819-0395 Japan Center for Future Chemistry Kyushu University Fukuoka 819-0395 Japan

Since the first generation of molecular machines including photoresponsive crown ethers and its analogues was reported by Shinkai et al., a huge number of molecular machines exhibiting dynamic chemical and physical functions have been designed and developed. On the other hand, non-viral vectors are desired to possess conflicting properties to associate with DNA until reaching the nucleus as their final destination and dissociate from DNA there. In other words, non-viral vectors should work as a sort of molecular machinery. To overcome this dilemma, recently, much attention is focused on the development of the intelligent vectors, also called as "stimuli responsive vectors' working as molecular machines. In this review, stimulus responsive gene delivery systems in which some structural factors and/or physiological properties are regulated in response to extracellular signals such as redox, pH, ultrasound, light, temperature, etc. are introduced as a new generation of non-viral vectors. These extracellular signals such as ultrasound, light, and temperature can be potent stimuli capable of site-, timing-, and duration-specific gene expression. © Springer Science+Business Media B.V. 2007.

关键词： Ultrasonics

来源：评论

学校读者我要写书评

暂无评论

Waters network's potential to transform environmental engineering education

Waters network's potential to transform environmental engine...

引用

114th Annual ASEE Conference and Exposition, 2007

作者： Eschenbach, Elizabeth Montgomery, Jami Johnson, James Brus, Chris Carlson, Patricia Giammar, Dan Grauer, Bette Hotaling, Liesl Oguntimein, Gbekeloluwa Safferman, Steven Wentling, Tim Humboldt State University United States Department of Environmental Resources Engineering Humboldt State University United States WATERS Network - CLEANER Project Office Network Howard University United States Department of Environmental Engineering College of Engineering Architecture and Computer Sciences Howard University United States American Academy of Environmental Engineers United States University of Iowa United States Program University of Iowa United States Rose-Hulman Institute of Technology United States Department of Rhetoric Rose-Hulman Institute of Technology United States National Research Council U. S. Air Force United States NASA's Classroom of the Future Wheeling WV United States Washington University United States Department of Energy Environmental and Chemical Engineering Washington University St. Louis United States Environmental Studies Program Center for Materials Innovation United States McPherson High School United States McPherson High School McPherson KS United States Stevens Institute of Technology United States Stevens Institute of Technology United States Morgan State University United States Michigan State University United States Biosystems and Agricultural Engineering Department Michigan State University United States University of Dayton United States Education Planning Committee National Center for Supercomputing Applications United States Department of Information Science Graduate School of Library and Information Science National Center for Supercomputing Applications University or Illinois United States Knowledge and Learning Systems Group NCSA United States

The WATERS Network (WATer and Environmental Research Systems Network) will be an integrated real-time distributed observing system which will enable academic and government scientists, engineers, educators, and practitioners to advance effective management of our nation's water resources by understanding human interactions with water and the natural and built environment. WATERS will provide easily accessible real time environmental data as well as analysis tools to engineers, scientists, educators, K- graduate students and policymakers so they can better understand how water quantity, quality and related components of the hydrologic cycle are impacted by natural and human influences. The WATERS strategic plan will be completed by July 2007 and requires constituent input. This paper describes the draft Conceptual Design and the Education Plan of WATERS Network. This paper will highlight the potential impact of WATERS on undergraduate and graduate environmental engineering education in order to elicit input from the environmental engineering education community on how WATERS Network could better meet the future needs of undergraduate and graduate students and educators. More information can be found at ***. © American Society for engineering Education, 2007.

关键词： Water resources

来源：评论

学校读者我要写书评

暂无评论

Strategies for integrating service-learning into the engineering core at the university of Massachusetts Lowell and the Massachusetts institute of technology

Strategies for integrating service-learning into the enginee...

引用

113th Annual ASEE Conference and Exposition, 2006

作者： Banzaert, Amy Duffy, John Wallace, David Massachusetts Institute of Technology United States MIT's Mechanical Engineering Department University of Massachusetts Lowell United States Mechanical Engineering Department Solar Engineering Graduate Program Center for Sustainable Energy University of Massachusetts Lowell United States Department of Mechanical Engineering MIT United States MIT Computer-aided Design Laboratory

While the pedagogy of Service-Learning (S-L) has been applied beneficially in a variety of disciplines, only recently have engineering departments begun to adopt the practice of integrating academically-relevant community service projects into classes and, in doing so, it is most common to offer service-oriented projects in elective classes. However, the University of Massachusetts Lowell and the Massachusetts Institute of technology have independently begun to develop S-L programs in engineering fields that work specifically to use the pedagogy in the core curriculum of the discipline. While the two universities and educational programs are distinct, the approach to S-L has been reasonably similar, and faculty and staff from each school have used common tools and methods to assess certain aspects of the integration from student and faculty perspectives. From surveys used at both of the schools (almost 760 pre-surveys and 680 post-surveys administered in the 04-05 academic year), a key finding was that student opinion changed significantly regarding the relationship between engineering and societal problems;students developed the belief that engineers should apply their skills to solve social problems. Additionally, both institutions surveyed the engineering faculty about their attitudes toward S-L and found the majority of faculty showed considerable interest in the concept. Overall, these findings show promise for integrating S-L into core engineering curriculums. © American Society for engineering Education, 2006.

关键词： Learning systems

来源：评论

学校读者我要写书评

暂无评论

Pyrolyzed Polymer as Absorbent of Nitrogen Dioxide Sensor

Pyrolyzed Polymer as Absorbent of Nitrogen Dioxide Sensor

引用

IEEE International Conference on Micro Electro Mechanical Systems

作者： K. Naka T. Hashishin Jun Tamaki S. Konishi Graduate School of Science and Engineering Ritsumeikan University Japan Center of Promotion of the COE program Ritsumeikan University Japan Department of Applied Chemistry Ritsumeikan University Japan Department of Micro System Technology Ritsumeikan University Japan

This paper deals with a pyrolyzed polymer as a kind of carbon materials obtained by pyrolysis of polymers. Through the combination of micromachining of polymers and following pyrolysis process, we can obtain pyrolyzed polymer MEMS structures for various applications. This work focuses on pyrolyzed polymer as an absorbent of nitrogen dioxide sensor. The resistance of the developed sensor was dramatically decreased when the sensor was exposed to the NO 2 mixture gas. Through evaluations of dependence on pyrolysis temperature and operating temperature, it is found that higher pyrolysis temperature and higher operating temperature contribute to higher sensitivity against gas mixture of NO 2 .

关键词： Polymers Nitrogen Gas detectors Temperature sensors Organic materials Temperature dependence Raman scattering Electrodes Batteries Gases

来源：评论

学校读者我要写书评

暂无评论

Perpendicular Co-Zn-Gd Magnetic Film Electrodeposited by Molten Chlorozincate Electrolyte

Perpendicular Co-Zn-Gd Magnetic Film Electrodeposited by Mol...

引用

International Conference on Magnetics (INTERMAG)

作者： M. Shu T. Wu C. Yang Taiwan SPIN Research Center National Yunlin University of Science and Technology Yunlin Taiwan National Yunlin University of Science and Technology Douliou TW Graduate School of Engineering Science and Technology (Doctoral Program) National Yunlin University of Science and Technology Yunlin Taiwan Department of Environmental Resources Management Overseas Chinese Institute of Technology Taichung Taiwan

We have utilized ZnCl 2 -dimethylsulfone (DMSO 2 ) as the electrolyte with added CoCl 2 and GdCl 3 for electrodepositing a magnetic film. Moreover, the controlled potential method was utilized for film deposition. The voltammogram revealed that the reduction of Co-Zn-Gd film can be achieved by applying a potential in the range from -0.1 to -0.5 volts. From the results of AGM analyses, a high squareness value (Mr/Ms = 0.923) of the Co-Zn-Gd film at -0.3 volt was observed. In previous research, perpendicular magnetic materials have been applied to magnetic optic (MO) media, magnetic recording heads, and perpendicular magnetic tunneling junction (pMTJ). However, preparation of magnetic materials is normally carried out in high vacuum systems. Since electrodeposition methods for preparation of magnetic films have several advantages, such as simple equipment, ease of operation and relatively large area, the use of electrodeposition has great potential for preparing films.

关键词： Magnetic films Optical films Magnetic materials Magnetic analysis Perpendicular magnetic recording Optical recording Magnetic recording Magnetic heads Magnetic tunneling Vacuum systems

来源：评论

学校读者我要写书评

暂无评论

A novel gene carrier responding to intracellular signal protein kinase Cα

A novel gene carrier responding to intracellular signal prot...

引用

55th Society of Polymer Science Japan Symposium on Macromolecules

作者： Toita, Riki Kang, Jeong-Hun Jiang, Yuhua Mori, Takeshi Niidome, Takuro Ktayama, Yoshiki Graduate School of System Life Sciences Kyushu University 744 Motooka Nishi-ku Fukuoka 819-0395 Japan Department of Applied Chemistry Faculty of Engineering Kyushu University 744 Motooka Nishi-Ku Fukuoka 819-0395 Japan CREST Japan Science and Technology Corporation 4-1-8 Honcho Kawaguchi-shi Saitama 322-0012 Japan Center for Future Chemistry Kyushu University Grant-in-Aid for the 21st Century COE Program

Gene therapy has been expected as a medical approach to treat tumors, inheritable diseases and so on. For gene therapy, effective delivery of gene to the target tissue is vitally important. Previously, we have proposed a novel approach for gene therapy using a drug delivery system responding to cellular signal (D-RECS), especially to protein kinase C (PKC) α. PKCα plays an important role in the differentiation and proliferation of tumor cell. It was known that extraordinary activation of PKCα is seen in many cancers such as breast cancer, melanoma, liver cancer and so on. In this study, PKCα was used as a target protein kinase for D-RECS.

关键词： Genes

来源：评论

学校读者我要写书评

暂无评论

Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

Capturing Cellular Communication with Guided Electrode Netwo...

引用

2006 8th International Conference on Solid-State and Integrated Circuit technology

作者： Mansun Chan Chi-Kong Yeung Yijin Wang Jin He Sven Ingebrandt Andreas Offenhaeusser Dept.of Electronic and Computer Engineering Hong Kong University of Science & Technology Bioengineering Graduate Program Hong Kong University of Science & Technology Institute of Microelectronic Peking University Juelich Research Center Institute for Thin Films and Interfaces(ISG-2)Leo-Brandt Str.52425 JuelichGermany

ISBN: (纸本)1424401607

This paper describes the development of a Multi-Electrode Array(MEA)with Guided Network for Cell-to-Cell Communication Transduction using a standard integrated circuit(IC) fabrication *** conventional electronic system,bio-system requires a special handling environment that is uncommon in conventional IC *** work presented here demonstrated the interaction between electrically active cells such as neuron and cardiac cells and an IC based *** a carefully designed array,and ionic action of a cell, extracellular signals can be captured and imaged.

关键词： Capturing Cellular Communication with Guided Electrode Network on a Silicon Integrated Circuit Chip

来源：评论

学校读者我要写书评

暂无评论

Transforming K-12 education via the collaborative large-scale engineering analysis network for environmental research (CLEANER) project

Transforming K-12 education via the collaborative large-scal...

引用

113th Annual ASEE Conference and Exposition, 2006

作者： Eschenbach, Elizabeth Johnson, James H. Brus, Chris Carlson, Patricia Giammar, Dan Grauer, Bette Hotaling, Liesl Oguntimein, Gbekeloluwa Safferman, Steven Wentling, Tim Humboldt State University United States Department of Environmental Resources Engineering Humboldt State University United States Howard University United States Department of Environmental Engineering College of Engineering Architecture and Computer Sciences Howard University United States Board of Scientific Counselors Executive Committee U.S. Environmental Protection Agency Office of Research and Development United States EPA's Science Advisory Board Department of Energy-sponsored HBCU/MI Environmental Technology Consortium Board Environmental Studies and Toxicology and the Engineering Council of the American Society for Engineering Education United States University of Iowa United States Program University of Iowa United States Rose-Hulman Institute of Technology United States Department of Rhetoric Rose-Hulman Institute ot Technology U.S. Air Forcer United States Army's Aberdeen Proving Ground NASA's Classroom of the Future Wheeling WV United States Washington University United States Department of Civil Engineering Washington University St. Louis United States Environmental Engineering Science Program Center for Materials Innovation United States McPherson High School United States McPherson High School McPherson KS United States Stevens Institute of Technology United States Stevens Institute of Technology United States Morgan State University United States Michigan State University United States Biosystems and Agricultural Engineering Department Michigan State University United States University of Dayton United States U.S. EPA Office of Research and Development United States National Center for Supercomputing Applications United States Department of Information Science Graduate School of Library and Information Science National Center for Supercomputing Applications University of Illinois United States

The Collaborative Large-scale engineering Analysis Network for Environmental Research (CLEANER) Project Office has been established with funding from the National Science Foundation (NSF) to the University of Illinois Urbana-Champaign (UIUC) and a coalition of 11 other institutions. The project office is coordinating the creation of a strategic plan consisting of research, cyberinfrastructure, and education plans that set forth a roadmap for the collaborative engineering analysis network for the study of environmental problems. This report will be completed by July 2007 and requires input from K-12 educators, administrators and other stakeholders in K-12 education. This paper describes the CLEANER project, provides an example of the CLEANER Education Committee's vision for the K-12 area and lists contacts for further information. The intention of this paper is to elicit input from the K-12 engineering education community, including K-12 educators, on how the CLEANER Education Plan could better meet the future needs of K-12 students and educators © American Society for engineering Education, 2006.

关键词： engineering education

来源：评论

学校读者我要写书评

暂无评论

Real-time organ motion tracking and fast image registration system for MRI-guided surgery

引用

Systems and Computers in Japan 2006年第1期37卷 83-92页

作者： Tokuda, Junichi Hirano, Masaya Tsukamoto, Tetsuji Dohi, Takeyoshi Hata, Nobuhiko Graduate School of Information Science and Technology University of Tokyo Tokyo 113-8656 Japan GE Yokogawa Medical Systems Ltd. Hino 191-8503 Japan International Society for Computer-Aided Surgery Japan Society for Computer-Aided Surgery Japan Society for Magnetic Resonance in Medicine GE Yokogawa Medical Systems Ltd. Imaging Application Tech. Center MR Group R and D Laboratory Technology Center GE Yokogawa Medical Systems Ltd. Society for Magnetic Resonance in Medicine Graduate School of Information Science and Technology Society for Life Support Technology Japan Society for Organ Preservation Biology and Medicine Society for Precision Engineering Society for Medical Image Computing and Computer Assisted Intervention International Union for Physics and Engineering Sciences in Medicine JSMEBE Japan Society for Life Assistance Technology Brigham and Women's Hospital Harvard Medical School MR Therapy Program

The advantage of magnetic resonance imaging (MRI)-guided surgery, in which MR images taken during surgery are used to guide the surgery, has been recognized recently. However, there is a problem, due to long imaging time of MRI, that it is difficult to capture the respiratory organ motion. It is often a constraint that the patient must hold his or her breath, especially in the treatment of the abdominal region. Consequently, this paper proposes a method of eliminating this constraint in MRI-guided surgery by real-time monitoring of the movement of the organ involved in the surgery by means of the signal derived from MRI. Specifically, the navigator echo is extracted in imaging during surgery. The movement of the organ involved in surgery is detected on the basis of the change in the calculated projection profile, and the results are presented to the surgeon. In this study, the procedure is built into a 1.5-T clinical MRI system. The feasibility of the proposed system was examined under clinical conditions by evaluating its accuracy and delay in a phantom experiment, and also in an in vivo experiment on the liver of a volunteer. The results are reported in this paper. © 2005 Wiley Periodicals, Inc.

关键词： Motion estimation

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：