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TaxDiff: taxonomic-guided diffusion model for protein sequence generation

science China(Information sciences) 2025年第4期68卷 385-386页

作者： Zongying LIN Hao LI Liuzhenghao LV Yu WANG Bin LIN Junwu ZHANG Zijun CHEN Calvin Yu-Chian CHEN Li YUAN Yonghong TIAN School of Electronic and Computer Engineering Peking University AI for Science (AI4S)-Preferred Program Peking University Shenzhen Graduate School Peng Cheng Laboratory School of Chemical Biology and Biotechnology Peking University

Protein design aims to generate protein variants with targeted biological functions, which is significant in multiple biological areas, including enzyme reaction catalysis, vaccine design, and fluorescence intensity. Protein design contains two paradigms: sequence generation and structure generation. Recently, EvoDiff [1] proposed a universal designing paradigm, combining structure and sequence generation using the diffusion framework, which improves the protein design efficiency.

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The Effect of WebRTC Jitter Buffer on Cloud Streaming Game QoE

The Effect of WebRTC Jitter Buffer on Cloud Streaming Game Q...

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Consumer Technology (ICCT-Pacific), International Conference on

作者： Naoyasu Kaneko Toshiro Nunome Department of Engineering Computer Science Program Graduate School of Engineering Nagoya Institute of Technology Nagoya Japan

ISBN: (数字)9798331504120

ISBN: (纸本)9798331504137

This paper considers a cloud streaming game using WebRTC. Since the cloud streaming game consists of a server and a client, the network quality between them affects the game. Among the network quality degradation factors, we focus on delay jitter. We reduce the effect of the jitter by buffering. We conduct a subjective experiment of a single-player action game and evaluate application-level QoS and QoE. We investigate the impact of buffering on the video and audio quality of the user playing the game.

关键词： Degradation Games Quality of service Jitter Streaming media Cloud gaming Delays Quality of experience Servers WebRTC

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A Design Study on Integrated Complex Coefficient Filters with Peripheral Circuits for Accurate Frequency Response Measurement

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2025年第1期145卷 16-24页

作者： Shouno, Kazuhiro Sato, Lina Fukagawa, Kanta Tanimoto, Hiroshi Muto, Cosy Division of Information Engineering University of Tsukuba 1-1-1 Tennoudai Ibaraki Tsukuba305-8573 Japan Graduate School of Science and Technology Degree Programs in Systems and Information Engineering Master’s Program in Computer Science University of Tsukuba Japan Kitami Institute of Technology 165 Koen-cho Hokkaido Kitami090-8507 Japan Faculty of Education Nagasaki University 1-14 Bunkyo-machi Nagasaki852-8521 Japan

This paper proposes a measurement technique for an integrated complex filter. The proposed method is based on two measurement methods with integrated circuitry for calibration. It is accomplished by applying square waves to an FUT (Filter Under Test) instead of sinusoidal waves or by superposing transfer characteristics obtained by applying a single sinusoidal wave to an FUT. In both of the above methods, the output signal connected to the external measurement equipment via a 50 Ω coaxial cable and so on. In this case, the output signal of the FUT should be amplified by internal or external amplifiers, which degrades the response. However, it is cancelled out by the proposed calibration circuitry with some analog switches. In addition to the above, for the RC polyphase filter, the source resistance and the load capacitance degrade the measurement results and their effect is discussed. The validity of the proposal is confirmed through computer simulation for a third-order RCPF whose passband is 8–40 MHz fabricated by Phenitec 0.6 µm CMOS process. It is shown that the measurement error is −1.10 dB for the square-wave method and −1.00 dB and −0.43 degrees for the superposition method at 40 MHz. © 2025 The Institute of Electrical Engineers of Japan.

关键词： Capacitance

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Data-Driven Incentive Mechanisms for Federated Learning in Vehicular Networks

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IEEE Transactions on Vehicular Technology 2025年

作者： Fathi, Faeze Montazeri, Mina N.araabi, Babak Du, Hongyang Niyato, Dusit Kebriaei, Hamed University of Tehran School of Ece College of Engineering Tehran Iran Urban Energy Systems Laboratory Dübendorf8600 Switzerland Nanyang Technological University School of Computer Science and Engineering The Energy Research Institute @ Ntu Interdisciplinary Graduate Program Singapore Nanyang Technological University School of Computer Science and Engineering Singapore School of Computer Science Tehran Iran

Centralized machine learning algorithms in vehicular networks face privacy and resource constraints. Federated Learning (FL) addresses these by enabling collaborative model training without sharing raw data. To incentivize vehicle participation despite resource constraints, we propose a contract between Roadside Units (RSUs) and vehicles, specifying required computation resources and rewards based on local data quality. The contract is designed to maximize the utility of the RSU, subject to constraints that ensure the participation of the vehicles in the task and truthful reporting of their data quality parameter. However, designing an optimal contract with classical methods is limited to specific utility functions. To extend the design methodology of optimal contracts to a broader range of utility functions, our study proposes a deep learning-based solution. Specifically, we present a novel application of Deep Neural Networks (DNNs), marking the first instance of applying DNNs in contract theory-based incentive mechanisms to achieve nearoptimal contracts. We design the DNN's structure to inherently satisfy specific constraints of the optimization problem, enhancing its efficiency and accuracy in determining the optimal contract. We utilize an augmented Lagrangian method to approximate the optimal contract in federated learning tasks. A case study on traffic sign recognition demonstrates the applicability and effectiveness of our method. Comparing our approach with the well-known generative diffusion model shows that in the FL scenarios, the DNN results are closer to the optimal contract compared to those of the generative diffusion model. © 1967-2012 IEEE.

关键词： Traffic signs

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Testing Facility Location with Constrained Queue Time Problem: A Case Study in Florida, USA 24

Testing Facility Location with Constrained Queue Time Proble...

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Proceedings of the Winter Simulation Conference

作者： Almir Antonio Monteiro Junior Rafael Schneider Vanessa de Almeida Guimarães Pedro Henrique González System Engineering and Computer Science Program Federal University of Rio de Janeiro BRAZIL COPPEAD Graduate School of Business Federal University of Rio de Janeiro BRAZIL

ISBN: (纸本)9798331534202

This study addresses the Testing Facility Location with Constrained Queue Time Problem. This optimization problem focuses on determining the best places to deploy testing sites and their available testers for infectious diseases, while constraining the maximum time in the queue with a given probability. An integer programming model is introduced and applied to the three biggest counties, in terms of population, of Florida, United States. Moreover, the Monte Carlo method is used to evaluate the model's output, aiming to check if the queueing time constraint is being satisfied. Through the experiments, a testing facility deployment plan can be determined for each county and further validated by the simulation. The results show that the solutions returned by the model behaved successfully when submitted to the Monte Carlo method, not exceeding the time in the queue in more than the predefined probability.

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MERNet: Multimodal Emotion Recognition in Conversation Network via Cross-Modal Knowledge Distillation and Contrastive Learning

MERNet: Multimodal Emotion Recognition in Conversation Netwo...

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International Conference on Big Data and Smart Computing (BIGCOMP)

作者： Sooyeon Hwang Gahgene Gweon Eunseong Kwon Interdisciplinary Program in Artificial Intelligence Seoul National University South Korea Graduate School of Convergence Science and Technology Seoul National University South Korea Dept. of Computer Science and Engineering POSTECH South Korea

ISBN: (数字)9798331529024

ISBN: (纸本)9798331529031

Multimodal Emotion Recognition in Conversation (ERC) is a task of predicting the emotion of each utterance in a conversation by utilizing both verbal and non-verbal modalities. However, existing approaches often struggle to bridge cross-modal gaps, resulting in misaligned features and frequent misclassification of minority emotions into semantically similar majority emotions. To address these challenges, we propose MERNet, a framework that employs cross-modal knowledge distillation and contrastive learning to align multimodal features and effectively distinguish subtle emotions in conversations. Our framework consists of two stages: 1) guiding non-verbal modalities with the text modality to transfer knowledge and align their features, and 2) applying contrastive learning with emotion labels as anchors to distinguish subtle differences between similar emotions and address the class imbalance problem. Experiments conducted on two benchmark datasets, IEMOCAP and MELD, demonstrate that our MERNet outperforms existing state-of-the-art models.

关键词： Knowledge engineering Bridges Emotion recognition Visualization Computational modeling Contrastive learning Benchmark testing Linguistics Big Data

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Implementation and Evaluation of 0.6 µm CMOS Complex RCPF for Accurate Frequency Response Measurement

IEEJ Transactions on Electronics, Information and Systems

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IEEJ Transactions on Electronics, Information and Systems 2025年第1期145卷 25-37页

作者： Sato, Lina Fukagawa, Kanta Shouno, Kazuhiro Tanimoto, Hiroshi Muto, Cosy Moriyama, Seijiro Takahashi, Chikau Yoshino, Michitaka Graduate School of Science and Technology Degree Programs in Systems and Information Engineering Master’s Program in Computer Science University of Tsukuba Japan Division of Information Engineering University of Tsukuba 1-1-1 Tennoudai Ibaraki Tsukuba305-8573 Japan Kitami Institute of Technology 165 Koen-cho Hokkaido Kitami090-8507 Japan Faculty of Education Nagasaki University 1-14 Bunkyo-machi Nagasaki852-8521 Japan Anagix Corporation 3-22-27 Numama Kanagawa Zushi249-0004 Japan Takamori Corporation Japan Research Center for Micro-Nano Technology Hosei University 3-11-15 Midori-cho Koganei Tokyo184-0003 Japan

This paper describes the implementation and evaluation of an RC polyphase filter (RCPF) and circuitry for measuring its frequency characteristics. The integrated circuit is fabricated on a 0.6 µm CMOS process and its supply voltage is 5 V. The integrated circuit includes a filter under test (FUT), a four-phase square wave generator, several analog switches and differential amplifiers to amplify the high-impedance signals of the RCPF. This FUT is a third-order complex RCPF whose passband is 8 − 40 MHz. This paper describes the design of these circuits in detail. This integrated circuit can select two measurement methods by means of external control signals. The first method uses a four-phase square wave. The frequency characteristics are measured by using an on-chip four-phase square wave generator driven by an external clock generator and by a spectrum analyzer tuned to the fundamental frequency. The second method uses an external network analyzer. Furthermore, this integrated circuit is equipped with a calibration circuit to measure the frequency characteristics of the circuitry except FUT by passing through the input / output signals of the FUT. As a result, the frequency characteristics of the FUT itself can be accurately measured. The effectiveness is confirmed through evaluation of the fabricated integrated circuit. © 2025 The Institute of Electrical Engineers of Japan.

关键词： Differential amplifiers

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FDAM: Filter-Dedicated Approximate Multiplier Design for Real-Time CNN Acceleration

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IEEE Transactions on computer-Aided Design of Integrated Circuits and Systems 2025年

作者： Nguyen, Kihwan Kim Xuan Truong Jeon, Dongsuk Lee, Hyuk-Jae Korea Republic of program Department of Electrical Engineering Seoul08826 Korea Republic of Inter-University Semiconductor Research Center Seoul National University Graduate School of Convergence Science and Technology Research Institute for Convergence Science Seoul08826 Korea Republic of Department of Electrical and Computer Engineering Seoul08826 Korea Republic of

Video super-resolution (VSR) is widely used in various high-definition applications, such as HDTVs and smartphones, requiring a dedicated upscaling technique for realtime full-HD generation. To reduce on-chip buffers for largesize output feature maps, a streaming VSR accelerator may employ an output stationary dataflow, leading to a large energy consumption caused by frequent filter switching. To mitigate this, we introduce a new filter-dedicated multiplier design for realtime VSR acceleration. We replace costly multipliers with adders, shifters, and multiplexers (MUXes), referred to as unified multiple constant multiplications (UMCM). The conventional UMCM, however, may incur considerable area/power overhead due to the unified topology constraint among different filter sets. To address this problem, we propose a new approximated MCM (AMCM) problem to relax the constraint and an approximate compatible graph synthesis (A-CGS) framework to efficiently solve AMCM by jointly searching for approximated filters and constructing a unified graph. Additionally, we suggest a lightweight finetuning method by freezing approximated filters and only finetuning biases, which can recover the original model’s accuracy within a few epochs. Experimental results with synthetic data demonstrate that AMCM reduces the area by up to 49.8%, 44.8%, and 40.3% when considering constant sets of 2, 4, and 8, respectively. Our designs with SR application achieve up to a 73.3% reduction in energy consumption. Experiments with the Set5 and Set14 datasets show that our model with bias correction achieves similar restoration performance compared to the eightbit models. © 1982-2012 IEEE.

关键词： Acceleration

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Effective Dimension Aware Fractional-Order Stochastic Gradient Descent for Convex Optimization Problems

arXiv

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arXiv 2025年

作者： Partohaghighi, Mohammad Marcia, Roummel Chen, YangQuan Electrical Engineering and Computer Science graduate program University of California Merced United States Department of Applied Mathematics University of California Merced MercedCA United States Lab Department of Mechanical Engineering School of Engineering University of California MercedCA95343 United States

Fractional-order stochastic gradient descent (FOSGD) leverages a fractional exponent to capture long-memory effects in optimization, yet its practical impact is often constrained by the difficulty of tuning and stabilizing this exponent. In this work, we introduce 2SED Fractional-Order Stochastic Gradient Descent (2SEDFOSGD), a novel method that synergistically combines the Two-Scale Effective Dimension (2SED) algorithm with FOSGD to automatically calibrate the fractional exponent in a data-driven manner. By continuously gauging model sensitivity and effective dimensionality, 2SED dynamically adjusts the exponent to curb erratic oscillations and enhance convergence rates. Theoretically, we demonstrate how this dimension-aware adaptation retains the benefits of fractional memory while averting the sluggish or unstable behaviors frequently observed in naive fractional SGD. Empirical evaluations across multiple benchmarks confirm that our 2SED-driven fractional exponent approach not only converges faster but also achieves more robust final performance, suggesting broad applicability for fractional-order methodologies in large-scale machine learning and related domains. © 2025, CC BY.

关键词： Convex optimization

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Biomedical data and AI

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science China Life sciences 2025年第5期68卷 1536-1540页

作者： Hao Xu Shibo Zhou Zefeng Zhu Vincenzo Vitelli Liangyi Chen Ziwei Dai Ning Yang Luhua Lai Shengyong Yang Sergey Ovchinnikov Zhuoran Qiao Sirui Liu Chen Song Jianfeng Pei Han Wen Jianfeng Feng Yaoyao Zhang Zhengwei Xie Yang-Yu Liu Zhiyuan Li Fulai Jin Hao Li Mohammad Lotfollahi Xuegong Zhang Ge Yang Shihua Zhang Ge Gao Pulin Li Qi Liu Jing-Dong Jackie Han Peking-Tsinghua Center for Life Sciences (CLS) Academy for Advanced Interdisciplinary StudiesPeking University Center for Quantitative Biology (CQB) Academy for Advanced Interdisciplinary StudiesPeking University Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program Academy for Advanced Interdisciplinary StudiesPeking University Department of Physics University of Chicago School of Life Sciences Southern University of Science and Technology Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies College of Chemistry and Molecular Engineering Peking University Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Biology Massachusetts Institute of Technology Lambic Therapeutics Inc. Changping Laboratory Al for Science Institute Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan University Department of Obstetrics and Gynecology West China Second University HospitalSichuan University Peking University International Cancer Institute and Peking University-Yunnan Baiyao International Medical Institute and State Key Laboratory of Natural and Biomimetic Drugs Department of Molecular and Cellular PharmacologySchool of Pharmaceutical SciencesPeking University Health Science CenterPeking University Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical School Center for Artificial Intelligence and Modeling the Carl R.Woese Institute for Genomic BiologyUniversity of Illinois Urbana-Champaign Department of Genetics and Genome Sciences School of Medicine and Department of Computer and Data Sciences and Department of Population and Quantitative Health SciencesCase Western Reserve University Department of Biochemistry and Biophysics University of California Sanger Institute Department of Automation Tsinghua University State Key Laboratory of Multimodal Artificial Intelligence Systems I

The development of artificial intelligence(AI) and the mining of biomedical data complement each other. From the direct use of computer vision results to analyze medical images for disease screening, to now integrating biological knowledge into models and even accelerating the development of new AI based on biological discoveries, the boundaries of both are constantly expanding, and their connections are becoming closer.

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