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Dynamic changes of fatty acids and (R)-dichlorprop toxicity in Arabidopsis thaliana: correlation, mechanism, and implications

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Environmental Science and Pollution Research 2024年第43期31卷 55522-55534页

作者： Li, Jun Zhang, Qiushui Chen, Hui Xu, Dongmei Chen, Zunwei Wen, Yuezhong MOE Key Laboratory of Environmental Remediation & amp Ecosystem Health College of Environmental and Resource Sciences Zhejiang University Hangzhou310058 China College of Science and Technology Ningbo University Ningbo315211 China Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province College of Biological and Environmental Engineering Zhejiang Shuren University Hangzhou310015 China Program in Molecular and Integrative Physiological Sciences Department of Environmental Health Harvard University T.H. Chan School of Public Health BostonMA02115 United States

Plant fatty acids (FAs) are critical components of lipids and play an important role in coping with pollution-induced stress. However, the relationship between the fluctuating changes of FAs and the toxic effects of pollutants is not clear. Here, we analyzed and identified 19 FAs, namely 14 medium and long chain fatty acids (MLCFAs) and 5 very long chain fatty acids (VLCFAs). First, a positive correlation between plant biomass and LCFA content was observed. Changes in unsaturation were inversely related to cell membrane permeability, which serves as an indicator of the toxic effects. In particular, the use of herbicides led to a reduction in total FA content, but caused a significant increase in free fatty acids (FFAs), which facilitate oxidative stress. In addition, supplementation with exogenous FAs, particularly linoleic and alpha-linolenic acids, effectively alleviated the toxic inhibition. (R)-dichlorprop causes abnormal FA metabolism that can be reversed by ferrostatin-1, a ferroptosis inhibitor. Under (R)-dichlorprop exposure, the balance of FA unsaturation in plants is disrupted by inhibition of FA desaturase activity, ultimately leading to ferroptosis and disruption of cell membrane integrity. This study aims to enhance the understanding of the ecotoxic effects of herbicides by examining changes in FAs. The findings will provide a scientific basis for controlling environmental risks associated with hazardous substances. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.

关键词： Cell membranes

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Resolving p53 to Create Clinically-Relevant Mutation Models

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 1087-1090页

作者： Solares, Maria J. Jonaid, G.M. Kelly, Deborah F. Molecular Cellular Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States Department of Biomedical Engineering Pennsylvania State University University Park PA United States Center for Structural Oncology Pennsylvania State University University Park PA United States Bioinformatics and Genomics Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States

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The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine

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Nature Neuroscience 2025年第6期28卷 1146-1159页

作者： Li, Wei Morarach, Khomgrit Liu, Ziwei Banerjee, Sanghita Chen, Yanan Harb, Ashley L. Kosareff, Joel M. Hall, Charles R. López-Redondo, Fernando Jalalvand, Elham Mohamed, Suad H. Mikhailova, Anastassia Linden, David R. Marklund, Ulrika Division of Molecular Neurobiology Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Sweden Enteric Neuroscience Program (ENSP) Mayo Clinic Rochester MN United States Department of Physiology and Biomedical Engineering Mayo Clinic Rochester MN United States RIKEN Center for Integrative Medical Sciences Yokohama Japan

The enteric submucosal plexus regulates essential digestive functions, yet its neuronal composition remains incompletely understood. We identified two putative secretomotor neuron classes and a previously unrecognized submucosal intrinsic primary afferent neuron class through single-cell RNA sequencing in the mouse small intestine. Using viral-mediated labeling of each class, we uncovered their morphologies and neural projections in the submucosa–mucosa context, finding connections among all classes and an unexpected close association with enterochromaffin cells. Further transcriptome analysis at the postnatal stage and lineage tracing revealed that neuron identities in the submucosal plexus emerge through an initial binary fate split at neurogenesis, followed by phenotypic diversification, akin to the developmental process of the myenteric plexus. We propose a unified developmental framework for neuronal diversification across the gut wall. Our study offers comprehensive molecular, developmental and morphological insights into submucosal neurons, opening new avenues for exploring physiological functions, circuit dynamics and formation of the submucosal plexus. © The Author(s) 2025.

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Diving into COVID-19: Visualizing SARS-CoV-2 Patient Proteins using Liquid-Electron Microscopy

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Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 2023年第1期29卷 662-664页

作者： Berry, Samantha DiCecco, Liza-Anastasia Gray, Jennifer Boylan, Jack Solares, Maria Kelly, Deborah F. Department of Biomedical Engineering Pennsylvania State University University Park PA United States Department of Materials Science and Engineering McMaster University Hamilton ON Canada Materials Research Institute Pennsylvania State University University Park PA United States Molecular Cellular Integrative Biosciences Graduate Program Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States Huck Institutes of the Life Sciences Pennsylvania State University University Park PA United States

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Passive elasticity properties of Octopus rubescens arm

arXiv

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arXiv 2023年

作者： Halder, Udit Gribkova, Ekaterina Gillette, Rhanor Mehta, Prashant G. Coordinated Science Laboratory United States Neuroscience Program United States Department of Molecular and Integrative Physiology Department of Mechanical Science and Engineering University of Illinois Urbana-ChampaignIL61801 United States

In this report, passive elasticity properties of Octopus rubescens arm tissue are investigated using a multidisciplinary approach encompassing biomechanical experiments, computational modeling, and analyses. Tensile tests are conducted to obtain stress-strain relationships of the arm under axial stretch. Rheological tests are also performed to probe into dynamic shear response of the arm tissue. Based on these tests, comparisons against three different viscoelasticity models are reported. © 2023, CC BY-NC-ND.

关键词： Tissue

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Imaging atomic-scale chemistry from fused multi-modal electron microscopy

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npj Computational Materials 2022年第1期8卷 164-171页

作者： Jonathan Schwartz Zichao Wendy Di Yi Jiang Alyssa J.Fielitz Don-Hyung Ha Sanjaya D.Perera Ismail El Baggari Richard D.Robinson Jeffrey A.Fessler Colin Ophus Steve Rozeveld Robert Hovden Department of Materials Science and Engineering University of MichiganAnn ArborMIUSA Mathematics and Computer Science Division Argonne National LaboratoryLemontILUSA Advanced Photon Source Facility Argonne National LaboratoryLemontILUSA Dow Chemical Co. MidlandMIUSA Department of Material Science and Engineering Cornell UniversityIthacaNew YorkUSA School of Integrative Engineering Chung-Ang UniversitySeoulRepublic of Korea Department of Physics Cornell UniversityIthacaNYUSA The Rowland Institute at Harvard CambridgeMAUSA Department of Electrical Engineering and Computer Science University of MichiganAnn ArborMIUSA National Center for Electron Microscopy Lawrence Berkeley National LaboratoryMolecular FoundryBerkeleyCAUSA Applied Physics Program University of MIchiganAnn ArborMIUnited States

Efforts to map atomic-scale chemistry at low doses with minimal noise using electron microscopes are fundamentally limited by inelastic ***,fused multi-modal electron microscopy offers high signal-to-noise ratio(SNR)recovery of material chemistry at nano-and atomic-resolution by coupling correlated information encoded within both elastic scattering(high-angle annular dark-field(HAADF))and inelastic spectroscopic signals(electron energy loss(EELS)or energy-dispersive x-ray(EDX)).By linking these simultaneously acquired signals,or modalities,the chemical distribution within nanomaterials can be imaged at significantly lower doses with existing detector *** many cases,the dose requirements can be reduced by over one order of *** high SNR recovery of chemistry is tested against simulated and experimental atomic resolution data of heterogeneous nanomaterials.

关键词： materials chemistry fused

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Hippo signaling:bridging the gap between cancer and neurodegenerative disorders

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Neural Regeneration Research 2021年第4期16卷 643-652页

作者： Neha Gogia Anuradha Venkatakrishnan Chimata Prajakta Deshpande Aditi Singh Amit Singh Department of Biology University of DaytonDaytonOHUSA Medical Candidate University of Toledo College of Medicine and Life SciencesToledoOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

During development,regulation of organ size requires a balance between cell proliferation,growth and cell *** of these fundamental processes can cause a variety of *** cell proliferation results in cancer whereas excessive cell death results in neurodegenerative *** signaling pathways known-to-date have a role in growth *** them,evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and ***,a complex process of progressive death of neuronal population,results in fatal disorders with no available cure to *** normal development,cell death is required for sculpting of an ***,aberrant cell death in neuronal cell population can result in neurodegenerative *** pathway has gathered major attention for its role in growth regulation and cancer,however,other functions like its role in neurodegeneration are also emerging *** review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo *** Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future.

关键词： animal models cell death mechanisms cell-signaling chemical inhibitors Drosophila eye Hippo pathway neurodegeneration neurological diseases therapeutic targets

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Effects of nanopores and sulfur doping on hierarchically bunched carbon fibers to protect lithium metal anode

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Carbon Energy 2021年第5期3卷 784-794页

作者： Ji In Jung Sunwoo Park Son Ha Se Youn Cho Hyoung-Joon Jin Young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheonSouth Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Carbon Composite Materials Research Center Korea Institute of Science and TechnologyWanju-gunJeollabuk-doSouth Korea Department of Polymer Science and Engineering Inha UniversityIncheonSouth Korea Department of Integrative Energy Engineering Korea UniversitySeoulSouth Korea

Studies on three-dimensional structured carbon templates have focused on how to guide homogeneous lithium metal nucleation and growth for lithium metal anodes(LMAs).However,there is still insufficient evidence for a key factor to achieve their high electrochemical ***,the effects of nanopores and sulfur doping on carbon-based nanoporous host(CNH)electrode materials for LMAs were investigated using natural polymer-derived *** pore-filling behaviors of lithium metal in the nanopores of the CNH electrode materials were first observed by ex situ scanning electron microscopy analysis,where the protective lithium metal nucleation and growth process led to significantly high Coulombic efficiency(CE)of~99.4%and stable 600 *** addition,a comparison study of CNH and sulfurdoped CNH(S-CNH)electrodes,which differ only in the presence or absence of sulfur,revealed that sulfur doping can cause lower electrochemical series resistance,higher CE value,and better cycling stability in a wide range of current densities and number of ***,S-CNH-based LMAs showed high electrochemical performance in full-cell Li-S battery tests using a sulfur copolymer cathode,where a high energy density of 1370Wh kgelectrode−1 and an excellent power density of 4120Wkgelectrode−1 were obtained.

关键词： carbon template Li-S batteries lithium metal anode lithium metal batteries nanoporous carbon sulfur doping

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Cerebral Oxygenation Dynamics in Awake Behaving Mice

Cerebral Oxygenation Dynamics in Awake Behaving Mice

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Clinical and Translational Biophotonics, Translational 2022

作者： Zhang, Qingguang Roche, Morgane Gheres, Kyle W. Chaigneau, Emmanuelle Haselden, William D. Kedarasetti, Ravi T. Charpak, Serge Drew, Patrick J. Department of Engineering Science and Mechanics The Pennsylvania State University University ParkPA United States Institut National de la Santé et de la Recherche Médicale ParisU1128 France Laboratory of Neurophysiology and New Microscopies Université Paris Descartes Paris France Graduate Program in Molecular Cellular and Integrative Biosciences The Pennsylvania State University University ParkPA United States Medical Scientist Training Program and Neuroscience Graduate Program The Pennsylvania State University University ParkPA United States Department of Neurosurgery Department of Biomedical Engineering The Pennsylvania State University University ParkPA United States

We investigated (1) how and by what mechanisms voluntary exercise impacts brain tissue oxygenation, and (2) what is the origin of the 1/f-like oxygen fluctuations, in awake behaving mice. © 2022 The Author(s).

ISBN: (纸本)9781557528209

关键词： Mammals

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Microarchitectural Design Variation of the Echinoid Skeleton: A 3D Structural and Mechanical Study of Paracentrotud lividusi

SSRN

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SSRN 2024年

作者： Perricone, Valentina Cesarano, Pasquale Deb, Mainak Lublin, Derek Mutalipassi, Mirko Pappalardo, Lucia Kisailus, David Marmo, Francesco Department of Materials Science and Engineering University of California Irvine United States Department of Structures for Engineering and Architecture University of Naples Federico II Italy Materials and Manufacturing Technology Program University of California Irvine United States Department of Integrative Marine Ecology Stazione Zoologica Anton Dohrn Villa Comunale Napoli Italy Palermo Italy Italy Wipro Technologies

Biological materials usually show remarkable mechanical properties, despite being composed of fragile and simple components (i.e., strong but brittle minerals and tough but weak proteins). These properties are conferred through a multiscale design, in which shapes, structures and composition are coherently organized leading to unique emerging strategies. Noteworthy is the case of the sea urchin skeleton, a hierarchical tasseled structure composed of multiple calcitic plates that are both lightweight and load-bearing. At the microscale, each plate shows a unique species-specific pattern consisting of a porous 3D lattice-like meshwork of trabeculae, called stereom. Interestingly, the stereom architecture is extremely complex and variable in different basic types, each one characterized by a unique topology and structural behaviors. In this context, the present study provides an in-depth analysis of the microarchitectural variability in the sea urchin Paracentrotus lividus. Accordingly, micro-CT scans, image analysis, 3D modeling, and linear elastic FE-Analysis were conducted to provide new insights about the topological and geometrical variability of the different stereom types, and their region-specific mechanical behavior calculated for tensile and shear loading. These results are of value to ameliorate the understanding of the mechanical function of the stereom variability, as well as to identify adaptive solutions useful for future biomimetic transfer applications. © 2024, The Authors. All rights reserved.

关键词： Finite element method

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