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Reproducibility of evoked and induced MEG responses to proprioceptive stimulation of the ankle joint

Neuroimage: Reports 2022年第3期2卷 100110-100110页

作者： Mujunen, Toni Seipäjärvi, Santtu Nurminen, Mila Parviainen, Tiina Piitulainen, Harri Faculty of Sport and Health Sciences University of Jyväskylä P.O. BOX 35 Jyväskylä FI-40014 Finland Center for Interdisciplinary Brain Research Department of Psychology Faculty of Education and Psychology University of Jyväskylä P.O. BOX 35 Jyväskylä FI-40014 Finland Department of Neuroscience and Biomedical Engineering Aalto University School of Science AALTO P.O. BOX 12200 Espoo 00076 Finland

Cortical processing of proprioceptive afference can be investigated by examining phase locked evoked and induced responses in cortical signals to passive movement stimuli. Reproducibility of evoked and induced responses has been studied using electroencephalography (EEG), but proprioceptive domain has received little attention. It is unclear whether evoked and induced responses to proprioceptive stimulation arising from the lower limbs are reproducible using magnetoencephalography (MEG). Nineteen healthy volunteers (18 right-foot dominant, 36.1 ± 6.6 yr, 7 females) were measured in two MEG sessions separated by 9 ± 5 days in which their right ankle was rotated intermittently using a pneumatic movement actuator (160 stimuli, 3000 ± 250 ms interstimulus interval) to elicit evoked fields and induced responses. The peak evoked field amplitude used in the final analysis was calculated from the gradiometer pair yielding the peak vector sum over vertex (i.e., the primary sensorimotor cortex for the lower limb). Peak induced response amplitudes were analyzed from the peak gradiometer demonstrating the most robust beta suppression and beta rebound. The between session reproducibility was estimated using intra-class correlation coefficient (ICC). Evoked field amplitudes, beta suppression and beta rebound amplitudes all demonstrated a large inter-individual variation but excellent between session reproducibility (ICC >0.81). Kinematics of the proprioceptive stimuli were stable and did not correlate with MEG response strengths. The results indicate that evoked and induced responses to proprioceptive stimuli from the lower limbs are reproducible and provide a valid tool for longitudinal experiments investigating the processing of proprioceptive afference in e.g., different clinical populations, but caution is advised when comparing individuals using these measures. © 2022 The Authors

关键词： Beta modulation Event-related desynchronization Event-related synchronization Magnetoencephalography Reliability Temporal spectral evolution

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Design Strategies and Emerging Applications of Perovskite-Based Sensors

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SmartMat 2025年第3期6卷

作者： Yingchun Li Yarong Ding Jiachun Sun Shaozhe Tan Yufeng Li Xiaodong Wang Jun Cai Jianbin Bai Xinmeng Lv Wenhui Guo Yue Hao Yannan Liu Zhenhua Lin Jingjing Chang Advanced Interdisciplinary Research Center for Flexible Electronics Academy of Advanced Interdisciplinary Research Xidian University Xi'an China State Key Laboratory of Wide-Bandgap Semiconductor Devices and Integrated Technology Faculty of Integrated Circuit Xidian University Xi'an China Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical Engineering Northwest University Xi'an China Shaanxi Medical Device Quality Inspection Institute Xi'an China

Perovskite materials, with their outstanding optoelectronic properties, low cost, solution-processability, and scalability, have emerged as promising candidates in the field of sensors. Despite extensive exploration into the photoelectric properties and traditional applications (e.g., gas sensing) of perovskite sensors, there has been limited focus on the fabrication processes that dominate their performance and emerging application directions. The flourishing development of perovskite sensors should comprehend the challenges in fabrication processes (e.g., stability, uniformity, and scale-up production) of perovskite sensors and further improve the sensing performance in conjunction with the working principles, extending their application fields. Herein, a comprehensive overview primarily focuses on the significant challenges faced by perovskite sensors in emerging application fields, including performance enhancement and process optimization. The key performance parameters and working principles of perovskite sensor are analyzed first. Then we review the effective design strategies and solutions proposed in recent research, while providing insights into optimizing sensor design to enhance sensing performance for precise detection. Moreover, some emerging applications of perovskite sensors, such as smart biomedical diagnosis, wearable devices, and artificial intelligence, are explored. Current challenges and future trends are also addressed, emphasizing the growing potential of perovskite sensors in advancing sensor technology innovation and interdisciplinary applications.

关键词： artificial intelligence design strategy fabrication method perovskite sensor wearable device

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Recent Advancements in engineering Strategies for Manipulating Neural Stem Cell Behavior

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Current tissue microenvironment reports 2020年第2期1卷 41-47页

作者： Brian J O'Grady Ethan S Lippmann Department of Chemical and Biomolecular Engineering Vanderbilt University Nashville TN USA. Department of Biomedical Engineering Vanderbilt University Nashville TN USA. Vanderbilt Brain Institute Vanderbilt University Nashville TN USA. Interdisciplinary Materials Science Program Vanderbilt University Nashville TN USA.

PURPOSE OF REVIEW:Stem cells are exquisitely sensitive to biophysical and biochemical cues within the native microenvironment. This review focuses on emerging strategies to manipulate neural cell behavior using these influences in three-dimensional (3D) culture systems. RECENT FINDINGS:Traditional systems for neural cell differentiation typically produce heterogeneous populations with limited diversity rather than the complex, organized tissue structures observed . Advancements in developing engineering tools to direct neural cell fates can enable new applications in basic research, disease modeling, and regenerative medicine. SUMMARY:This review article highlights engineering strategies that facilitate controlled presentation of biophysical and biochemical cues to guide differentiation and impart desired phenotypes on neural cell populations. Specific highlighted examples include engineered biomaterials and microfluidic platforms for spatiotemporal control over the presentation of morphogen gradients.

关键词： biomaterial morphogen gradient neural stem cell stem cell differentiation

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Cellucalst enzyme-assisted extraction of Sargassum horneri enhances the immunomodulation by regulating TLR4/MyD88/NF-kB pathway in murine splenocytes with or without Concanavalin A

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Biomedicine and Pharmacotherapy 2024年 181卷 117673-117673页

作者： Yang, Jiwon Kim, Hyo Jin Herath, Kalahe Hewage Iresha Nadeeka Madushani Jee, Youngheun Interdisciplinary Graduate Program in Advanced Convergence Technology & Science Jeju National University Jeju 63243 South Korea Department of Food Bioengineering Jeju National University Jeju 690-756 South Korea Department of Environmental Health Harvard T.H. Chan School of Public Health Harvard University Boston Massachusetts United States Department of Biosystems Engineering Faculty of Agriculture and Plantation Management Wayamba University Gonawila Makandura 60170 Sri Lanka Department of Veterinary Medicine and Veterinary Medical Research Institute Jeju National University Jeju 64243 South Korea

Sargassum horneri (S. horneri) is an edible species of large brown algae inhabiting along the coasts of northeastern Asia. The study focuses on the impact of celluclast enzyme extract of S. hoeneri (SHC) on various immune cell populations in splenocytes including granulocytes, macrophages, dendritic cells, and T lymphocytes. SHC alone increased the population of granulocytes and macrophages and the secretion of M1 macrophage-derived cytokines (TNF-α, IL-22), and M2 macrophage-derived cytokines (IL-4, IL-10). Interestingly, however, SHC suppressed the concanavalin A (Con A)-expanded populations of macrophages, dendritic cells, granulocytes, T and B cells, and Con A-promoted secretion of M1-macrophage derived cytokines (IFN-γ, IL-1β, TNF-α, IL-17, IL-22) and M2-macrophage derived cytokines (IL-4, IL-10, IL-13, TGF-β). SHC further restrained the Th1, Th2, and Th17 cell responses through attenuating the expression of respective transcription factors T-bet, Gata3, and Rorγt. The anti-inflammatory property of SHC is highlighted through its influence on cytokine production, particularly in the NF-κB pathway, and the attenuation of Toll-like receptor (TLR) signaling. The results reveal that SHC acts as both an immunostimulator and an inhibitor of hyperimmune reactions, showcasing its potential therapeutic applications in conditions involving dysregulated immune responses such as autoimmune diseases and inflammatory disorders. This positions SHC as a promising candidate for the development of functional ingredients with diverse applications encompassing the realms of food, pharmaceuticals, and cosmetics. © 2024

关键词： Celluclast Concanavalin A S. horneri Splenocytes

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Titanium dioxide/nitrogen-doped graphene-biopolymer based nanocomposite films for pollutant photodegradation and laser desorption ionization mass spectrometry of biomarkers

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Nano-Structures and Nano-Objects 2024年 38卷

作者： Siripongpreda, Tatiya Jiraborvornpongsa, Noppakhate Composto, Russell J. Rodthongkum, Naddudda Nanoscience and Technology Interdisciplinary Program Chulalongkorn University Phayathai Road Wangmai Patumwan Bangkok 10330 Thailand Metallurgy and Materials Science Research Institute Chulalongkorn University Phayathai Road Wangmai Patumwan Bangkok 10330 Thailand Photocatalysts for Clean Environment and Energy Research Unit Faculty of Science Chulalongkorn University Phayathai Road Wangmai Patumwan Bangkok 10330 Thailand Department of Materials Science and Engineering University of Pennsylvania Philadelphia 19104 PA United States Center of Excellence in Responsive Wearable Materials Chulalongkorn University Soi Chula 12 Phayathai Road Pathumwan Bangkok 10330 Thailand

Titanium dioxide (TiO2)/nitrogen-doped graphene (NG) nanocomposite is prepared via a solvent-free hydrothermal reaction. The resulting TiO2/NG materials exhibit a reduction of the band gap energy compared to pristine ... 详细信息

Titanium dioxide (TiO₂)/nitrogen-doped graphene (NG) nanocomposite is prepared via a solvent-free hydrothermal reaction. The resulting TiO₂/NG materials exhibit a reduction of the band gap energy compared to pristine TiO₂ from 3.27 eV to 2.69 eV. These materials are characterized by scanning transmission electron microscopy (STEM), energy dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). To prepare biopolymer films with photocatalytic properties, TiO₂ and NG are mixed with biodegradable chitosan and spin-coated on a silicon wafer. Film roughness and thickness are evaluated by atomic force microscopy (AFM). These films are then tested for ciprofloxacin photodegradation by irradiating with visible light. In comparison to the TiO₂/chitosan films, the addition of NG substantially enhances photodegradation efficiency by up to 34 % upon the addition of 5 % w/w of NG. Furthermore, this film is shown to be a good substrate for biomarker detection using laser desorption ionization mass spectrometry (LDI-MS). In summary, this nanocomposite-biopolymer film provides good photocatalytic activity towards ciprofloxacin degradation and enhances the ionization efficiency of peptide biomarkers in LDI-MS owing to high efficiency of laser absorption/desorption. This nanocomposite film might be useful for environmental-related and medical application. © 2024 Elsevier B.V.

关键词： LDI-MS Nanocomposite film Nitrogen-doped graphene Photodegradation Titanium dioxide

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A zein coacervate biomaterial and its time-dependant behaviour

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Materials Today: Proceedings 2019年 16卷 1929-1934页

作者： Timothy Quek Wassanai Wattanutchariya Biomedical Engineering Program Faculty of Engineering Chiang Mai University Thailand Biomedical Engineering Center Chiang Mai University Thailand Advanced Manufacturing Technology Research Center Department of Industrial Engineering Faculty of Engineering Chiang Mai University Thailand

Zein is a corn-derived protein which has potential as a biomaterial for use in bone surgery. A zein coacervate, in the form of a visco-elastic solid, is proposed for use in other bone-related applications. Unlike other low-cost natural-derived materials such as chitosan and gelatin, zein is insoluble in water. This enables it to perform as a substitute for bone wax, as well as a bone filler which undergoes slow degradation. Two methods for producing the non-adhesive resinous substance are described: either directly through adding zein powder into an ethanol-water solution, or indirectly through dissolving zein into solution before coacervation upon further addition of water. Zein coacervate samples are then analysed for changes in properties with time. Loss of mass from the resinous substance is attributed to the evaporation of ethanol and water; this was measured for up for 20 minutes. Rheometeric stress sweeps performed at 0, 10, and 20 minutes after its preparation indicate that the visco-elastic material became harder with time, and more force would be required to deform the material. Finally, in vitro degradation was carried out by immersing zein samples in fluid containing lysozyme. The results suggest that the zein coacervate may be easily manipulated for up until about 10 minutes after preparation, and would degrade in vivo within a matter of weeks.

关键词： zein biomaterial rheology bone surgery bone filler haemostatic agent

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Design strategies and willingness to pay for circular economy service policies in sustainable tourism

Environmental Challenges

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Environmental Challenges 2025年 18卷

作者： Suhardono, Sapta Phan, Thi Thanh Thuy Lee, Chun-Hung Suryawan, I Wayan Koko Environmental Sciences Study Program Faculty of Mathematics and Natural Sciences Universitas Sebelas Maret Surakarta 57126 Indonesia Faculty of Natural Resources & Environment Dong Nai Campus Vietnam National University of Forestry Bien Hoa Dong Nai 810000 Viet Nam Department of Natural Resources and Environmental Studies College of Environmental Studies and Oceanography National Dong Hwa University Taiwan Hualien 97401 Taiwan Department of Environmental Engineering Faculty of Infrastructure Planning Universitas Pertamina Jalan Sinabung II Jakarta Terusan Simprug 12220 Indonesia Center for Environmental Solution (CVISION) Universitas Pertamina Jalan Sinabung II Terusan Simprug Jakarta 12220 Indonesia Center for Interdisciplinary Research on Ecology and Sustainability College of Environmental Studies and Oceanography National Dong Hwa University Taiwan Hualien 97401 Taiwan

The transition towards a circular economy within the tourism industry is increasingly seen as essential to achieving sustainable development goals. This study explores the relationships between various design strategies, tourists' willingness to pay (WTP) for sustainable practices, and their participation in circular economy activities. Using Structural Equation Modeling (SEM) to analyze data collected from 640 tourists in Bali, the research identifies the critical factors that influence tourists' engagement with sustainability. The findings reveal that design strategies focused on longevity, serviceability, reusability, and material recovery significantly enhance WTP for sustainable practices. In turn, WTP is shown to be a key driver of participation in circular economy activities, such as purchasing recycled items and green purchasing behaviors. However, barriers such as cost concerns, lack of awareness, and limited incentives pose significant challenges to widespread adoption. © 2025 The Authors

关键词： Circular economy Design strategies Structural equation modeling Sustainable tourism Willingness to pay

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Isolation and anticancer activity assay of stonefish (Synanceia horrida) bioactive stonustoxin

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AIP Conference Proceedings 2022年第1期2537卷 020002页

作者： Anondho Wijanarko Aulia Firdianna Mikael Januardi Ginting Kenny Lischer Muhamad Sahlan Heri Hermansyah Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Marine Science Postgraduate Program Faculty of Mathematics and Natural Science Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia Research Center for Biomedical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok West Java 16424 Indonesia

Breast cancer is a disease in which cells in the breast mutate and turn malignant, where the mutated cells spread to other parts of the body and develop into secondary cancer. In 2018, there were 58,256 new cases of breast cancer. With improper handling, breast cancer can be lethal, where there are 22,692 deaths in 2018 alone. One type of cancer with the most sufferers is estrogen, progesterone, and glucocorticoid receptors. Research on cancer treatment continues by looking for potential substances as new drugs. Toxins from animals that are cytolytic can trigger apoptosis in cancer cells. Some studies suggest that the lethal factor of the stonefish poison, Stonustoxin (SNTX), has cytolytic properties that damage cell membranes. This study discusses the stonefish (Synanceia horrida) venom as a breast anticancer agent. Stonefish poison was milked using a syringe, and the SNTX purification was carried out by the FPLC method using a 5 ml HiTrap Q H.P. substantial anion column. The percentage of inhibition of MCF-7 breast cancer cells will be measured using the MTT Assay method. As a result, MCF-7 breast cancer cells could be inhibited with IC50 values of 8.2771 µg/ml.

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Progressive graphene derivatives scaffold based for tissue engineering application: A review

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AIP Conference Proceedings 2021年第1期2344卷

作者： Muhammad Artha Jabatsudewa Maras Siti Fauziyah Rahman Gilar Wisnu Hardi Biomedical Engineering Program Department of Electrical Engineering Faculty of Engineering Universitas Indonesia Kampus UI Depok Depok West Java 16424 Indonesia

Tissue engineering is able to produce, reconstruct, restore tissue, and organ through the scaffold. Tissue engineering formations are scaffold, cells, and growth factors. Graphene derivatives have opportunities to become materials promote endurance cells growth for tissue engineering forming a scaffold with specific characteristic in proper mechanical properties, physicochemical ability, enhance adhesion, proliferation, differentiation, and signaling to cells. Graphene and its derivatives are divided into three common types are pristine graphene as pure graphene, graphene oxide, and reduced graphene. Graphene derivatives have been used for various applications in tissue engineering, particularly for the use of induced osteogenesis, chondrogenesis, and drug delivery systems. Drug delivery is a new method to a vehicle the drugs through the site and control the drug loads inside using a scaffold. This review will demonstrate the progressive developments of the graphene derivatives scaffold-based in tissue engineering. In Preferential, we critically discuss and analyze the application of graphene derivatives in bone, cartilage tissue engineering, drug delivery system, and graphene biocompatibility. We hope the summary of this review will inspire others to studies on graphene derivatives in tissue engineering application so that it can be implemented in the next future clinical treatment.

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Complete mitochondrial genome of saw-jawed monocle breamScolopsis ciliataand its phylogenetic relationship in genusScolopsis

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Mitochondrial DNA Part B 2019年第1期4卷 393-394页

作者： Sapto Andriyono Sinar Pagi Sektiana Md. Jobaidul Alam Hyun-Woo Kim Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Faculty of Fisheries and Marine Universitas Airlangga C Campus JI Surabaya Indonesia Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of Korea Interdisciplinary Program of Biomedical Mechanical and Electrical Engineering Pukyong National University Busan Republic of KoreaDepartment of Marine Biology Pukyong National University Busan Republic of Korea

The complete mitochondrial genome of the saw-jawed monocle bream,Scolopsis ciliatawas determined by the next generation sequencing (NGS) technique. The circular mitogenome ofS. ciliata(16,733 bp) encoded the canonical 37 genes including 13 proteins, 22tRNAgenes, 2 rRNAs (12S rRNA and 16S rRNA), and two non-coding regions; the origin of light strand replication (OL) and the putative control region (D-Loop). The gene arrangement of theS. ciliatamitogenome was identical to its relative,Scolopsis vosmeri. Phylogenetic analysis based on the full mitochondrial genome sequences showed thatS. ciliatais most closely related toS. vosmeriwith 83% nucleotide sequence identity. The mitogenome information ofS. ciliatawould be the useful information to understand the evolutional relationship of fishes in genus Scolopsis.

关键词： Next generation sequencing Scolopsis ciliata mitogenome monocle bream

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