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Concurrently bioprinted scaffolds with autologous bone and allogeneic BMSCs promote bone regeneration through native BMSC recruitment

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Bio-Design and Manufacturing 2025年第1期8卷 85-99,I0042,I0043页

作者： Yu Huan Hongqing Chen Dezhi Zhou Xin He Sanzhong Li Xiuquan Wu Bo Jia Yanan Dou Xiaowei Fei Shuang Wu Zhou Fei Tao Xu Fei Fei Department of Neurosurgery Xijing HospitalAir Force Medical UniversityXi’an 710032China Department of Neurosurgery General Hospital of Northern Theater CommandShenyang 110840China Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationDepartment of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Precision Medicine and Healthcare Tsinghua Berkeley Shenzhen InstituteShenzhen 518055China Center for Bio-intelligent Manufacturing and Living Matter Bioprinting Research Institute of Tsinghua University in ShenzhenShenzhen 518057China Department of Ophthalmology Xijing HospitalAir Force Medical UniversityXi’an 710032China

Autologous bone marrow-derived mesenchymal stem cells(BMSCs)have been shown to promote osteogenesis;however,the effects of allogeneic BMSCs(allo-BMSCs)on bone regeneration remain ***,we explored the bone regeneration promotion effect of allo-BMSCs in 3D-printed autologous bone particle(ABP)***,we concurrently printed scaffolds with polycaprolactone,ABPs,and allo-BMSCs for appropriate support,providing bioactive factors and seed cells to promote *** vitro studies showed that ABP scaffolds promoted allo-BMSC osteogenic *** vivo studies revealed that the implantation of scaffolds loaded with ABPs and allo-BMSCs into canine skull defects for nine months promoted *** experiments suggested that only a small portion of implanted allo-BMSCs survived and differentiated into vascular endothelial cells,chondrocytes,and *** implanted allo-BMSCs released stromal cell-derived factor 1 through paracrine signaling to recruit native BMSCs into the defect,promoting bone *** study contributes to our understanding of allo-BMSCs,providing information relevant to their future application.

关键词： Concurrent 3D bioprinting Cranioplasty Autologous bone particles Allogeneic mesenchymal stem cells Recruitment

Microstructure, Mechanical and Soft Magnetic Properties of In-Situ Tic Reinforced Fe27.5ni27.5co45-Based Medium Entropy Composites

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SSRN 2023年

作者： Chen, Tao Jiang, Zhenfei Fu, Zhiqiang Chu, Chenliang Chen, Weiping Guangdong Key Laboratory for Advanced Metallic Materials Processing South China University of Technology Guangdong Guangzhou510641 China National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of Technology Guangzhou510641 China

The insufficient mechanical properties of conventional soft magnetic materials (SMMs) hinder their widespread applications, and unfortunately, traditional strengthening mechanisms could dramatically deteriorate their soft magnetic properties without adjusting the alloy composition. Here, we developed TiC/Fe27.5Ni27.5Co45 medium-entropy composites (MECs) possessing multi-scale microstructure consisting of ultrafine and micron-sized grains by introducing in-situ formed TiC nano particles during the spark plasma sintering (SPS) process. Compared with the precipitate-free Fe27.5Ni27.5Co45 medium-entropy alloy, TiC/Fe27.5Ni27.5Co45 MEC with ~8.7 vol% TiC (noted as Ti5-MEC) demonstrated a significant improvement in compressive yield strength (from 459 MPa to 1114 MPa), attributing to the grain-boundary strengthening and dispersive precipitation strengthening, as well as hetero-deformation induced (HDI) strengthening. Meanwhile, the Ti5-MEC exhibits a high saturation magnetization (Ms) of 153.1 emu/g and a low coercivity (Hc) of ~8.2 Oe, indicating excellent soft magnetic properties, primarily due to the multi-scale microstructure. Our work has demonstrated that engineering multi-scale microstructures in MECs is an effective strategy to achieve desirable combinations of soft magnetic and mechanical properties. © 2023, The Authors. All rights reserved.

关键词： Titanium carbide

Research on thermal inkjet technology based on CFD 3rd

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Research on thermal inkjet technology based on CFD

3rd International Conference on Materials Science and Industrial Applications, MSIA 2021

作者： Wang, Yifei Shan, Zhongde Yang, Haoqin Ren, Yongxin Meng, Linghan State Key Laboratory of Advanced Forming Technology and Equipment Beijing100083 China Beijing National Innovation Institute of Lightweight Ltd Beijing100083 China College of Material science and Technology Nanjing University of Aeronautics and Astronautics Nanjing210016 China

ISBN: (纸本)9783035738056

In this paper, a thermal inkjet printing simulation model is established in the CFD simulation platform, and the influence of inkjet driver parameters and ink physical parameters on the printing process is studied by numerical simulation. The evaporation-condensation model is coupled with the VOF multiphase flow model in Fluent software to establish a thermal inkjet printing process simulation model. Based on the orthogonal test method, we investigate the influence of fluid physical parameters (ink viscosity, surface tension) and inkjet driver parameters (heater temperature value) on droplet formation by changing the physical parameters of the material and the boundary conditions of the model. Through the comparison of the results, exploring the adjustment rules of thermal inkjet technology and obtaining the optimal combination of material and process parameters for high-quality ink drop formation. © 2021 Trans Tech Publications Ltd, Switzerland.

关键词： Simulation platform

Design and Structure Simulation Analysis of Sand-mold Inkjet Printing Device 7

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Design and Structure Simulation Analysis of Sand-mold Inkjet...

2021 7th International Conference on Manufacturing technology and Applied Materials, ICAMMT 2021

作者： Wang, Yifei Shan, Zhongde Wu, Shuangfeng Guo, Zhi Dong, Shijie Hu, Shan State Key Laboratory of Advanced Forming Technology and Equipment Beijing100083 China Beijing National Innovation Institute of Lightweight Ltd Beijing100083 China College of Material Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing210016 China

Ink-jet printing technology is a digital high-efficiency forming technology that can realize the rapid manufacturing of sand mold for foundry. This paper designs a low-cost, high-reliability ink-jet printing device based on the sand-mold inkjet printing process, and uses ANSYS finite element analysis software to carry out static analysis and modal analysis for its main frame. The analysis results show that the main frame has good rigidity and high strength, there will be no large deformation and resonance in frame under the working conditions, which can meet the requirements of sand-type inkjet printing devices. © Published under licence by IOP Publishing Ltd.

关键词： Ink jet printing

Effects Of Applied Pressure And Residual Heat Quenching on the Mechanical and Thermal Properties of Al-Mg-Zn-Mn-Fe Alloys

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SSRN 2023年

作者： Chen, Jingsi Zhang, Weiwen Zhao, Yuliang Song, Dongfu Wang, Zhi Luo, Zongqiang Guangdong Key Laboratory for Processing Forming of Advanced Metallic Materials South China University of Technology Guangzhou510640 China School of Mechanical and Automotive Engineering South China University of Technology Guangzhou510640 China School of Mechanical Engineering Dongguan University of Technology Dongguan523808 China Guangdong Provincial Key Laboratory of Metal Toughening Technology and Application Institute of New Materials Guangdong Academy of Sciences Guangzhou510650 China National Engineering Research Centre of Near-net-shape Forming for Metallic Materials China

In this study, the effects of applied pressure (AP) and residual heat quenching (RQ) on the mechanical properties and thermal conductivities of Al-4.6Mg-3.6Zn-0.86Mn-0.48Fe alloys were investigated based on intensively microstructure analysis by scanning electron microscope (SEM), high resolution transmission electron microscopy (HRTEM) and synchrotron X-ray tomography (SXT). The results indicated that AP and RQ did not change the type of intermetallic;instead, they reduced the length and quantity of lath-like Al6(Fe,Mn), which was prone to crack formation during the tensile process. Moreover, η' precipitation particles were enriched at grain boundaries, which was beneficial for the yield strength of the alloy;the AP+RQ sample exhibited the best mechanical properties of the ultimate tensile strength, yield strength and elongation of 269 MPa, 164 MPa and 11.4%, respectively, which were 19%, 17%, and 83.8% higher than those of the gravity cast (GC) sample. Moreover, the thermal conductivity of the AP+RQ sample did not show significant changes, which were attributed to the reduction in solid solute caused by the increased volume fraction of η' precipitates, thus improving the thermal conductivity;however, the formation of numerous coherent interfaces between η' and the matrix led to increased lattice distortion, resulting in electron scattering. © 2023, The Authors. All rights reserved.

关键词： Aluminum alloys

Effect of Gd Addition on Phase Formation, Microstructure and Mechanical Performance of Cocrfeni Multi-Principal Element Alloy

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SSRN 2023年

作者： Long, Yan Meng, Wenxing Vogel, Florian Zhang, Lijing Li, Guiqi Guangdong Provincial Key Laboratory for Processing and Forming of Advanced Metallic Materials Guangzhou510640 China School of Mechanical and Automotive Engineering South China University of Technology Guangzhou510640 China Jinan University Institute of Advanced Wear & Corrosion Resistant and Functional Materials Guangzhou510632 China

In the present work, two Multi-Principal Element Alloys (MPEAs): CoCrFeNi and CoCrFeNiGd0.05 were fabricated by high-energy ball milling and spark plasma sintering. The effect of Gd on the microstructure and mechanical properties of CoCrFeNi MPEA was investigated. Addition of Gd into the CoCrFeNi base alloy led to precipitation of a Gd2Ni7-type Hexagonal Structure (HS) phase and minor Gd-rich oxide phase from the FCC matrix. Compared with the CoCrFeNi base alloy, the grain size of CoCrFeNiGd0.05 was decreased, and the tensile yield strength of CoCrFeNiGd0.05 significantly increased from 546 MPa to 859 MPa, while hardly sacrificing its plasticity with the elongation slightly decreased from 20.8% to 19.4%. The enhanced strength of Gd-containing MPEA could be attributed to the precipitation strengthening brought by second phases, the grain boundary strengthening from the ultrafine-grained microstructure as well as the solid solution strengthening effect of Gd in the matrix. TEM results demonstrated that the Gd2Ni7-type intermetallic phase was coherent with the FCC matrix and had the following relationship: {111(—)}FCC//{2(—)119(—)}HS. The high plasticity of the composite-structured CoCrFeNiGd0.05 alloy was related with the homogenous distribution of the ultrafine HS phase and the coherent HS-FCC interface facilitating the dislocation slipping. © 2023, The Authors. All rights reserved.

关键词： Microstructure

Microstructure evolution during continuous cooling process in Ti microalloyed steel 2

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Microstructure evolution during continuous cooling process i...

2nd International Conference on advanced Materials and Intelligent Manufacturing, ICAMIM 2021

作者： Chen, Songjun Li, Liejun Peng, Zhengwu Huo, Xiangdong Gao, Jixiang Guangdong key Laboratory for Processing and Forming of Advanced Metallic Materials South China University of Technology Guangzhou510640 China School of Material Science and Technology Jiangsu University Zhenjiang212013 China Guangdong Polytechnic Normal University Guangzhou510640 China

： The phase transformation law and microstructure evolution of austenite in Ti microalloyed steel under different continuous cooling rates (0.1-30℃/s) after a two-stage deformation were studied based on the Gleeble-3800 Thermo-Mechanical Simulator. The continuous cooling transformation (CCT) curve was obtained by thermal expansion method combining with microstructures. The results showed that the Ac1 and Ac3 of the steel were 835℃ and 902℃ ， respectively. With the increase of cooling rate, the austenite phase transition temperature decreased, from 778.5-712.2℃ at 0.1℃/s to 633.7-488.7℃/s at 30℃/s. Accordingly, the austenite transformation structure changed from polygonal ferrite and pearlite to granular bainite. In addition, with the increase of cooling rate, the ferrite transformation was inhibited, and the transformation region of granular bainite was increased. © 2021 Institute of Physics Publishing. All rights reserved.

关键词： Austenite

Mechanical Properties of Al_(2)O_(3)/FeCo Interface under Magnetic Field:A Molecular Dynamics Study

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Chinese Journal of Chemical Physics 2025年第3期38卷 323-333,I0037-I0047,I0109页

作者： Chun Wang Haijun Su Xi Li Wei Ren Yongle Li Department of Physics International Centre for Quantum and Molecular StructuresShanghai Key Laboratory of High Temperature Superconductorsand Institute for Quantum Science and TechnologyShanghai UniversityShanghai 200444China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics International Center of Quantum and Molecular StructuresInstitute for Quantum Science and Technologyand Shanghai Key Laboratory of High Temperature SuperconductorsShanghai UniversityShanghai 200444China

Metal-ceramic composites combine the excellent properties of metals and ceramics,which have high strength,stability,and corrosion ***_(2)O_(3)/FeCo composites have been proven to be useful in ap-plications such as catalysts,mi-crowave absorption materials,and enhanced permeability *** understanding of the mechani-cal properties and dynamics at the atomic scale of the Al_(2)O_(3)/FeCo in-terface can promote the design and exploitment of metal-ceramic *** this work,we have obtained Young’s modulus and diffusion coefficient of the Al_(2)O_(3)/FeCo interface using molecular dynamics simulation,elucidated the structural characteristics of the Al_(2)O_(3)/FeCo interface at the atomic scale,and investigated the impact of atomic magnetism and the exter-nal magnetic field on the *** results show that Young’s modulus of the Al_(2)O_(3)/FeCo interface is significantly improved compared with pure Al_(2)O_(3)and FeCo alloy at room and high *** the atomic magnetism and the external magnetic field are applied,Young’s modulus of the Al_(2)O_(3)/FeCo interface further increases to 612 GPa at 300 K and 602 GPa at 500 ***,the average density,diffusion coefficient,and radial distri-bution function are found to be modified *** study will shed light on the atom-istic investigations of the metal-ceramic composites.

关键词： Molecular dynamics Al_(2)O_(3)/FeCo interface Young’s modulus Magnetism Magnetic field Diffusion coefficient

Enhanced Identification of Damage Evolution in Two-Dimensional Woven Laminated Materials Through Multimodal Information Fusion of Acousto-Optic-Force Data

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SSRN 2024年

作者： Zhang, Fangfang Xiao, Yang Duan, Yongchuan Xiao, Yuangan Wu, Honglin Zhu, Song Key Laboratory of Advanced Forming & Stamping Technology and Science Ministry of Education of China Yanshan University Hebei Qinhuangdao066004 China College of Mechanical Engineering Yanshan University Hebei Qinhuangdao066004 China Chongqing Hongjiang Machinery Co. Ltd. Chongqing402160 China

Non-destructive testing is a widely used inspection method for the safe maintenance of large composite structures. Acoustic signals and optical images, etc, are indirectly associated with damage. However, the complex damage modes of composites and the specific usage scenarios cause limitations, such as a modal signal that is stage-sensitive and selection-sensitive to the damage mode. This study proposes an advanced method to analyze the evolution of damage in composite materials using multimodal information fusion for enhanced identification while mitigating dispersion of recognition results. First, a experimental system is established with a synchronous data sampling logic. By combining mechanical, acoustic, and optical signals, we obtained a three-stage characteristic association of damage initiation, evolution, and instability of unidirectional stretching and three-point bending. Damage initiation identification was facilitated by distinguishability of the typical features, followed by combining the load and acoustic emission. The damage instability was determined by combining the optical and load signals. By combining the acoustic and load signals, the three damage modes and their corresponding peak frequency ranges were determined. Multimodal signals were combined to determine the association rules, laying a theoretical foundation for the reliable identification of multimodal and incomplete model damage in composites. © 2024, The Authors. All rights reserved.

关键词： Information fusion