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Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

National Science Review 2022年第7期9卷 17-31页

作者： Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman K.Thomas Kwok-Kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji State Key Laboratory of Cell Biology Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Center for Excellence in Mathematical Sciences National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemHua Loo-Keng Center for Mathematical Sciences Academy of Mathematics and Systems ScienceChinese Academy of Sciences Shenzhen Key Laboratory of Translational Medicine of Tumor Department of Cell Biology and Genetics Shenzhen University Health Sciences Center Shanghai Pulmonary Hospital Tongji University Shanghai Chest Hospital Shanghai Jiaotong University Zhongshan Hospital Fudan University Department of Pathology School of Basic Medical Sciences Fudan University School of Life Science and Technology Shanghai Tech University CAS Key Laboratory of Tissue Microenvironment and Tumor CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Nutrition and Health SciencesChinese Academy of Sciences Laura and Isaac Perlmutter Cancer Center New York University Langone Medical Center School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Department of Translational Genomics Center of Integrated Oncology Cologne-BonnMedical FacultyUniversity of Cologne Department of Pathology University Hospital Cologne

Small-cell lung cancer（SCLC） is a recalcitrant cancer characterized by high ***,the exact cell type contributing to metastasis remains *** a Rb1L/L/Trp53L/Lmouse model,we identify the NCAMhiCD44lo/-subpopulation as the SCLC metastasizing cell（SMC）,which is progressively transitioned from the non-metastasizing NCAMloCD44hicell（non-SMC）.Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brgl,significantly inhibits such phenotypic transition and ***,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and ***,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates ***-cell RNA-se quencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient *** data uncover high SCLC plasticity and identify TAZ as the key mole cular switch in orchestrating SCLC phenotypic transition and metastasis.

关键词： small cell lung cancer SWI/SNF complex TAZ phenotypic transition metastasis

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Improved Anti-Adhesive Wear Performance of Cu/Al Pair Via Interfacial Energy Modulation

SSRN

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SSRN 2023年

作者： Lu, Tian-Tian Hua, Dong-Peng An, Bai-Ling Hafeez, Muhammad Arslan Pan, Jie Lu, Jun-Yong Zhou, Qing Zhang, Cheng Liu, Lin School of Materials Science and Engineering State Key Lab for Materials Processing and Die & Mold Technology Huazhong University of Science and Technology Wuhan430074 China School of Materials Science and Engineering State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal Materials Northwestern Polytechnical University Shaanxi Xi’an710072 China National Key Laboratory of Science and Technology on Vessel Integrated Power System Naval University of Engineering Wuhan430033 China

The prevention of adhesive wear between metals is challenging due to the strong adhesion forces that arise from the interaction of asperities. Here, we propose a novel approach to enhance the anti-adhesive wear performance of Cu/Al pair through interfacial energy modulation, with potential applications in electromagnetic railgun. Our findings indicate that the interfacial energy of the Cu-Al pair can be significantly reduced by magnetron sputtering a W thin film onto the Al alloy surface. A lower coefficient of friction and a substantial alleviation in adhesion and mechanical damage of the Cu alloy are thus obtained. Molecular dynamics simulations reveal that the immiscibility and low interfacial energy of the Cu/W pair result in the formation of an amorphous interfacial layer during friction, facilitating countermotion at the contacting surfaces, thus in turn enables the low friction. This study provides a guideline for designing novel wear-resistant pairs based on interfacial energy modulation. © 2023, The Authors. All rights reserved.

关键词： Adhesives

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Physical-layer key distribution using synchronous complex dynamics of DBR semiconductor lasers

arXiv

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arXiv 2023年

作者： Wang, Anbang Du, Yicheng Li, Qingtian Wang, Longsheng Jia, Zhiwei Qin, Yuwen Wang, Yuncai Institute of Advanced Photonics Technology School of Information Engineering Guangdong University of Technology Guangzhou51006 China Key Laboratory of Photonic Technology for Integrated Sensing and Communication Ministry of Education of China Guangdong University of Technology Guangzhou51006 China Guangdong Provincial Key Laboratory of Information Photonics Technology Guangdong University of Technology Guangzhou51006 China Key Lab of Advanced Transducers and Intelligent Control System Ministry of Education Taiyuan University of Technology Taiyuan030024 China College of Optoelectronics Taiyuan University of Technology Taiyuan030024 China

Common-signal-induced synchronization of semiconductor lasers with optical feedback inspired a promising physical key distribution with information-theoretic security and potential in high rate. A significant challenge is the requirement to shorten the synchronization recovery time for increasing key rate without sacrificing operation parameter space for security. Here, open-loop synchronization of wavelength-tunable multi-section distributed Bragg reflector (DBR) lasers is proposed as a solution for physical-layer key distribution. Experiments show that the synchronization is sensitive to two operation parameters, i.e., currents of grating section and phase section. Furthermore, fast wavelength-shift keying synchronization can be achieved by direct modulation on one of the two currents. The synchronization recovery time is shortened by one order of magnitude compared to close-loop synchronization. An experimental implementation is demonstrated with a final key rate of 5.98 Mbit/s over 160 km optical fiber distance. It is thus believed that fast-tunable multi-section semiconductor lasers opens a new avenue of high-rate physical-layer key distribution using laser synchronization. Copyright © 2023, The Authors. All rights reserved.

关键词： Synchronization

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Resistive Memory-based Neural Differential Equation Solver for Score-based Diffusion Model

arXiv

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arXiv 2024年

作者： Yang, Jichang Chen, Hegan Chen, Jia Wang, Songqi Wang, Shaocong Yu, Yifei Chen, Xi Wang, Bo Zhang, Xinyuan Cui, Binbin Li, Yi Lin, Ning Xu, Meng Li, Yi Xu, Xiaoxin Qi, Xiaojuan Wang, Zhongrui Zhang, Xumeng Shang, Dashan Wang, Han Liu, Qi Cheng, Kwang-Ting Liu, Ming Department of Electrical and Electronic Engineering the University of Hong Kong Hong Kong ACCESS – AI Chip Center for Emerging Smart Systems InnoHK Centers Hong Kong Science Park Hong Kong Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing100029 China State Key Laboratory of Integrated Chips and Systems Frontier Institute of Chip and System Fudan University Shanghai200433 China Institute of the Mind the University of Hong Kong Hong Kong University of Chinese Academy of Sciences Beijing100049 China School of Integrated Circuits Hubei Key Laboratory for Advanced Memories Huazhong University of Science and Technology Wuhan430074 China Department of Electronic and Computer Engineering the Hong Kong University of Science and Technology Hong Kong

Human brains image complicated scenes when reading a novel. Replicating this imagination is one of the ultimate goals of AI-Generated Content (AIGC). However, current AIGC methods, such as score-based diffusion, are still deficient in terms of rapidity and efficiency. This deficiency is rooted in the difference between the brain and digital computers. Digital computers have physically separated storage and processing units, resulting in frequent data transfers during iterative calculations, incurring large time and energy overheads. This issue is further intensified by the conversion of inherently continuous and analog generation dynamics, which can be formulated by neural differential equations, into discrete and digital operations. Inspired by the brain, we propose a time-continuous and analog in-memory neural differential equation solver for score-based diffusion, employing emerging resistive memory. The integration of storage and computation within resistive memory synapses surmount the von Neumann bottleneck, benefiting the generative speed and energy efficiency. The closed-loop feedback integrator is time-continuous, analog, and compact, physically implementing an infinite-depth neural network. Moreover, the software-hardware co-design is intrinsically robust to analog noise. We experimentally validate our solution with 180 nm resistive memory in-memory computing macros. Demonstrating equivalent generative quality to the software baseline, our system achieved remarkable enhancements in generative speed for both unconditional and conditional generation tasks, by factors of 64.8 and 156.5, respectively. Moreover, it accomplished reductions in energy consumption by factors of 5.2 and 4.1. Our approach heralds a new horizon for hardware solutions in edge computing for generative AI applications. © 2024, CC BY-NC-SA.

关键词： Diffusion

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Twitter Bot Detection with Multi-Head Attention and Supervised Contrastive Learning

Twitter Bot Detection with Multi-Head Attention and Supervis...

引用

International Conference on Wavelet Active Media Technology and Information Processing (ICWAMTIP)

作者： Liu Qiang Lu Jiazhong Huang Yuanyuan Zhang Weisha Lv Jun School of Cybersecurity (Xin Gu Industrial College) Chengdu University of Information Technology Chengdu China Advanced Cryptography and System Security Key Laboratory of Sichuan Province Chengdu China SUGON Industrial Control and Security Center Chengdu China School of Foreign Languages University of Electronic Science and Technology of China Chengdu China MetaX Integrated Circuits (Shanghai) Co. Ltd

ISBN: (数字)9798331519254

ISBN: (纸本)9798331519261

The task of detecting bots on Twitter is an indispensable task for combating social network disinformation, curbing rumors, and managing online public opinion. However, today's social bots often disguise themselves by mimicking various aspects of real user characteristics to escape detection, which poses an unprecedented challenge to the existing Twitter bot detection task. To address this, an innovative detection method is presented in this study that improves the accuracy of Twitter bot detection by realizing the effective fusion of multi-dimensional features through the multi-head attention mechanism and applying it to a relational graph convolutional network. It also combines supervised contrastive learning to strengthen the differentiation ability of the high-latitude features. Experiments conducted on the publicly available dataset Twibot-20, compared to the baseline, the proposed method achieves approximately 1% better results in both Accuracy and the Matthews Correlation Coefficient, proving its effectiveness.

关键词： Training Attention mechanisms Accuracy Social networking (online) Graph convolutional networks Blogs Contrastive learning Information processing Feature extraction Fake news

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High Color Gamut Top-Emitting Organic Light-Emitting Diode Based on Metal/Transparent Conductive Oxide Composite Electrode

SSRN

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SSRN 2025年

作者： Lin, Yang Zhu, Yangyang Zhao, Ben Gu, Jialu Xu, Yachen Lan, Weixia Chen, Guo Shi, Wei Kido, Junji Wei, Bin Shanxi Datong University China School of Mechatronic Engineering and Automation Shanghai University Shanghai200072 China Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials Shanghai University Shanghai200072 China Key Laboratory of Advanced Display and System Applications Ministry of Education Shanghai University Shanghai200072 China Nanan Institute Shanghai University Nan'an Fujian Quanzhou362300 China Frontier Center for Organic Materials Yamagata University 4-3-16 Jonan Yonezawa992-8510 Japan

Top-emitting organic light-emitting diodes (TEOLEDs) based on metal/transparent conductive oxide composite anodes, which were Al/ITO and Ag/ITO, were studied. The microcavity effect was optimized by adjusting the microcavity thickness and microcavity order to achieve high color gamut RGB monochromatic light display. Through mathematical modeling and spectral simulation, TEOLEDs with different microcavity structures were designed. The results showed that the full width at half maximum and the color purity of the light of the TEOLED based on the second-order microcavity were significantly optimized compared to those of the TEOLED based on the first-order microcavity. Meanwhile, the TEOLEDs based on the Ag/ITO composite electrode exhibited better optoelectronic performance, with the significantly enhanced external quantum efficiency of up to 19.40%, narrower full width at half maximum of down to 20 nm, and improved color purity. The corresponding red, green, and blue TEOLEDs had achieved excellent color coordinates of (0.697, 0.301), (0.154, 0.769), and (0.139, 0.050), and the color gamut area of the device had reached 172.4% of the color gamut area of the bottom-emitting OLED, 125.6% of the National Television system Committee standard color gamut, and 93.8% of the ITU-R Recommendation BT.2020 standard color gamut. © 2025, The Authors. All rights reserved.

关键词： Organic light emitting diodes (OLED)

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Microstructural evolution and thermal conductivity of diamond/Al composites during thermal cycling

引用

International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1821-1827页

作者： Ping-ping Wang Guo-qin Chen Wen-jun Li Hui Li Bo-yu Ju Murid Hussain Wen-shu Yang Gao-hui Wu School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Qiqihar Xiangke New Material Co. Ltd.Qiqihar 161005China Key Laboratory of Advanced Structure-Function Integrated Materials and Green Manufacturing Technology School of Material Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Beijing Institute of Spacecraft System Engineering Beijing 100094China Department of Chemical Engineering COMSATS University IslamabadLahore CampusDefence RoadOff Raiwind RoadLahore 54000Pakistan

The microstructural evolution and performance of diamond/Al composites during thermal cycling has rarely been *** the present work,the thermal stability of diamond/Al composites during thermal cycling for up to 200 cycles was ***,the thermal conductivity(λ)of the composites was measured and scanning electron microscopy of specific areas in the same samples was carried out to achieve quasi-in situ *** interface between the(100)plane of diamond and the Al matrix was well bonded with a zigzag morphology and abundant needle-like Al4C3 *** contrast,the interface between the(111)plane of diamond and the Al matrix showed weak bonding and debonded during thermal *** debonding length increased rapidly over the first 100 thermal cycles and then increased slowly in the following 100 ***λof the diamond/Al composites decreased abruptly over the initial 20 cycles,increased afterward,and then decreased monotonously once more with increasing number of thermal *** in theλof the Al matrix and the corresponding stress concentration at the diamond/Al interface caused by thermal mismatch,rather than interfacial debonding,may be the main factors influencing the decrease inλof the diamond/Al composites,especially in the initial stages of thermal cycling.

关键词： metal-matrix composites diamond stability thermal mismatch stress

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Brief Review of Silver Sinter-bonding Processing for Packaging High-temperature Power Devices

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Chinese Journal of Electrical Engineering 2020年第3期6卷 25-34页

作者： Haidong Yan Peijie Liang Yunhui Mei Zhihong Feng School of Mechanical and Electrical Engineering Guilin University of Electronic TechnologyGuilin 541004China Guangxi Key Lab of Manufacturing System and Advanced Manufacturing Technology Guilin 541004China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education Guilin 541004China National Key Lab of Application Specific Integrated Circuit Hebei Semiconductor Research InstituteShijiazhuang 050051China

Silver sintering is receiving increasing attention due to its novel die-attach technique for high-temperature power *** thermal conductivity,high melting point/remelting temperature and low-temperature sintering behaviors of the silver sintered attachment meet the requirements of high-temperature applications for power devices,specifically SiC *** merits and demerits of the existing pressure-assisted sintering and pressure-less sintering techniques using nano-scale,micro-scale and micro-nano-scale hybrid silver sintered materials are separately *** emerging rapid sintering approaches,such as the electric-assisted approach,are briefly introduced and the technical outlook is *** addition,the study highlights the importance of creating a brief resource guide on using the correct sintering methods.

关键词： Pressure-less sintering pressure-assisted nanosilver paste high-temperature power module insulated gate bipolar translators(IGBT) silicon carbide(SiC)

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Parallel chaotic sources based on microcombs

Parallel chaotic sources based on microcombs

引用

Conference on Lasers and Electro-Optics (CLEO)

作者： Bitao Shen Haowen Shu Weiqiang Xie Ruixuan Chen Zhi Liu Xuguang Zhang Yimeng Wang Yunhao Zhang Buwen Cheng Shaohua Yu John E. Bowers Lin Chang Xingjun Wang State Key Laboratory of Advanced Optical Communications System and Networks School of Electronics Peking University Beijing China Department of Electrical and Computer Engineering University of California Santa Barbara CA USA State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences Beijing China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing China Peng Cheng Laboratory Shenzhen China Frontiers Science Center for Nano-Optoelectronics Peking University Beijing China

Massively parallel optical chaotic sources with large bandwidth are demonstrated based on chaotic microcombs in the AlGaAsOI platform. 30-channel parallel random bit generation with 30 Gbit/s per channel is realized b... 详细信息

ISBN: (纸本)9781957171258

关键词： Diode lasers integrated photonics Kerr effect Nonlinear effects Optical microscopy Random number generation

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Significantly Improving Mechanical Properties of Cf/Pai Composites: The Influence of Interfacial Modification Coupled with Post Heat Treatment

SSRN

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SSRN 2023年

作者： Zhang, Shouchun Zhou, Fang Zhao, Zhenbo Jing, Deqi Zhang, Xinghua Wang, Peng Su, Weiguo CAS Key Laboratory for Carbon Materials Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan030001 China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing100049 China National Key Laboratory of Science and Technology on Vessel Integrated Power System Naval University of Engineering Wuhan430033 China Research Center of Advanced Thermoplastic Composites Engineering Institute of Coal Chemistry Chinese Academy Sciences Taiyuan030001 China

Carbon fiber reinforced polyamide-imide (CF/PAI) composites is a potential candidate for high temperature applications under high stress conditions. However, the structure-property relationships of CF/PAI are not clear. This work presented an experimental investigation into the influence of interfacial modification and heat modification on the microstructures and mechanical properties of CF/PAI composites. The CF/PAI interfacial interactions was improved by the combined effect of chemical bonding between PAI-compatible sizing and CF as well as hydrogen bonding between the sizing and matrix. Meanwhile, heat modification enhanced the modulus of matrix, which was beneficial to stress transfer in the interfacial region. Therefore, the interlaminar shear strength (ILSS), flexural strength and flexural modulus of RS0.6-CF/PAI composites were remarkably improved by 81.3%, 23.7% and 39.1% compared with the control specimen. Microstructure examinations of modified and unmodified CF/PAI composites showed that both interfacial modification and heat modification played an important role in transitions of failure mode under interlaminar shear loading and flexural loading. These findings provide an effective method to tailor the microstructures of CF/PAI composites in achieving desired properties. © 2023, The Authors. All rights reserved.

关键词： Polyamideimides

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