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arXiv 2025年

作者： Lai, Haoran Jiang, Zihang Yao, Qingsong Wang, Rongsheng He, Zhiyang Tao, Xiaodong Wei, Wei Lv, Weifu Zhou, S. Kevin School of Biomedical Engineering Division of Life Sciences and Medicine University of Science and Technology of China Anhui Hefei230026 China Suzhou Institute for Advanced Research University of Science and Technology of China Jiangsu Suzhou215123 China Stanford University Palo AltoCA94305 United States Medical Business Department iFlytek Co.Ltd. Anhui Hefei230088 China The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Anhui Hefei230001 China Department of Radiology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Anhui Hefei230001 China Suzhou Institute for Advance Research USTC Jiangsu Suzhou215123 China State Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China Anhui Hefei230026 China Institute of Computing Technology CAS Beijing100190 China

3D medical images such as Computed tomography (CT) are widely used in clinical practice, offering a great potential for automatic diagnosis. Supervised learning-based approaches have achieved significant progress but rely heavily on extensive manual annotations, limited by the availability of training data and the diversity of abnormality types. Vision-language alignment (VLA) offers a promising alternative by enabling zero-shot learning without additional annotations. However, we empirically discover that the visual and textural embeddings after alignment endeavors from existing VLA methods form two well-separated clusters, presenting a wide gap to be bridged. To bridge this gap, we propose a Bridged Semantic Alignment (BrgSA) framework. First, we utilize a large language model to perform semantic summarization of reports, extracting high-level semantic information. Second, we design a Cross-Modal Knowledge Interaction (CMKI) module that leverages a cross-modal knowledge bank as a semantic bridge, facilitating interaction between the two modalities, narrowing the gap, and improving their alignment. To comprehensively evaluate our method, we construct a benchmark dataset that includes 15 underrepresented abnormalities as well as utilize two existing benchmark datasets. Experimental results demonstrate that BrgSA achieves state-of-the-art performances on both public benchmark datasets and our custom-labeled dataset, with significant improvements in zero-shot diagnosis of underrepresented abnormalities. © 2025, CC BY.

关键词： Zero-shot learning

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Dynamic radiomics: A new methodology to extract quantitative time-related features from tomographic images

arXiv

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arXiv 2020年

作者： Che, Fengying Shi, Ruichuan Li, Shuqin Wu, Jian Li, Haoran Chen, Weixing Zhang, Hao Qu, Hui Li, Zhi Cui, Xiaoyu College of Medicine and Biological Information Engineering Northeastern University Liaoning Shenyang China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Key Laboratory of Data Analytics and Optimization for Smart Industry Northeastern University Liaoning Shenyang China Department of Medical Oncology The First Affiliated Hospital of China Medical University Liaoning110001 China Shenzhen College of Advanced Technology University of the Chinese Academy of Sciences Beijing100049 China Department of Breast Surgery Liaoning Cancer Hospital and Institute Cancer Hospital of China Medical University Liaoning Shenyang110042 China

The feature extraction methods of radiomics are mainly based on static tomographic images at a certain moment, while the occurrence and development of disease is a dynamic process that cannot be fully reflected by only static characteristics. This study proposes a new dynamic radiomics feature extraction workflow that uses time-dependent tomographic images of the same patient, focuses on the changes in image features over time, and then quantifies them as new dynamic features for diagnostic or prognostic evaluation. We first define the mathematical paradigm of dynamic radiomics and introduce three specific methods that can describe the transformation process of features over time. Three different clinical problems are used to validate the performance of the proposed dynamic feature with conventional 2D and 3D static *** results show that compared with static features, dynamic feature extraction can achieve higher robustness and accuracy for time-dependent tomographic images. We also found that the dynamic features that influence different clinical problems are also quite different. Copyright © 2020, The Authors. All rights reserved.

关键词： Tomography

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Transfer Learning for EEG-Based Brain-Computer Interfaces: A Review of Progress Made Since 2016

arXiv

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arXiv 2020年

作者： Wu, Dongrui Xu, Yifan Lu, Bao-Liang The Ministry of Education Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan430074 China The Center for Brain-Like Computing and Machine Intelligence Department of Computer Science and Engineering Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering Brain Science and Technology Research Center Qing Yuan Research Institute Shanghai Jiao Tong University 800 Dong Chuan Road Shanghai200240 China

A brain-computer interface (BCI) enables a user to communicate with a computer directly using brain signals. The most common non-invasive BCI modality, electroencephalogram (EEG), is sensitive to noise/artifact and suffers between-subject/within-subject non-stationarity. Therefore, it is difficult to build a generic pattern recognition model in an EEG-based BCI system that is optimal for different subjects, during different sessions, for different devices and tasks. Usually, a calibration session is needed to collect some training data for a new subject, which is time-consuming and user unfriendly. Transfer learning (TL), which utilizes data or knowledge from similar or relevant subjects/sessions/devices/tasks to facilitate learning for a new subject/session/device/task, is frequently used to reduce the amount of calibration effort. This paper reviews journal publications on TL approaches in EEG-based BCIs in the last few years, i.e., since 2016. Six paradigms and applications - motor imagery, event-related potentials, steady-state visual evoked potentials, affective BCIs, regression problems, and adversarial attacks - are considered. For each paradigm/application, we group the TL approaches into cross-subject/session, cross-device, and cross-task settings and review them separately. Observations and conclusions are made at the end of the paper, which may point to future research directions. Copyright © 2020, The Authors. All rights reserved.

关键词： Brain computer interface

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Motion Classification Based on sEMG Signals Using Deep Learning 4th

Motion Classification Based on sEMG Signals Using Deep Learn...

引用

4th International Conference on Machine Learning and intelligent Communications, MLICOM 2019

作者： Shen, Shu Gu, Kang Chen, Xinrong Wang, Ruchuan School of Computer Science Nanjing University of Posts and Telecommunications Nanjing210023 China Jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks Nanjing210023 China Academy for Engineering and Technology Fudan University Shanghai200433 China Shanghai Key Laboratory of Medical Image Computing and Computer Assisted Intervention Shanghai200032 China

ISBN: (纸本)9783030323875

Nowadays, surface electromyography (sEMG) signal plays an important role in helping physically disabled people during daily life. The development of electronic information technology has also led to the emergence of low-cost, multi-channel, wearable sEMG signal acquisition devices. Therefore, this paper proposes a new motion recognition model based on deep learning to improve the accuracy of motion recognition of sEMG signals. The model uses architecture including 6 convolutional layers and 6 pooling layers which enables the Batch Normalization layer to enhance network performance and prevent overfitting. In the experiment, NinaPro DB5 data set was used for training and testing. The data set consists of sEMG signal data collected by the double Myo armbands which contains data of 52 movements for 10 subjects. The results show that the accuracy of about 90% can be achieved when using 52 sEMG signal data from every single subject or all subjects. © 2019, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

关键词： Deep learning

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Automatic Detection of ECG Abnormalities by Using an Ensemble of Deep Residual Networks with Attention 1st

Automatic Detection of ECG Abnormalities by Using an Ensembl...

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1st International Workshop on Machine Learning and medical Engineering for Cardiovasvular Healthcare, MLMECH 2019, and the 8th International Joint Workshops on computing and Visualization for Intravascular Imaging and Computer Assisted Stenting, CVII-STENT 2019, held in conjunction with 22nd International Conference on medical image computing and Computer-Assisted Intervention, MICCAI 2019

作者： Liu, Yang He, Runnan Wang, Kuanquan Li, Qince Sun, Qiang Zhao, Na Zhang, Henggui Harbin150001 China School of Physics and Astronomy The University of Manchester ManchesterM13 9PL United Kingdom SPACEnter Space Science and Technology Institute Shenzhen518117 China International Laboratory for Smart Systems and Key Laboratory of Intelligent of Computing in Medical Image Ministry of Education Northeastern University Shenyang110004 China The Department of Pharmacology Beijing Electric Power Hospital Beijing100073 China

ISBN: (纸本)9783030333263

Heart disease is one of the most common diseases causing morbidity and mortality. Electrocardiogram (ECG) has been widely used for diagnosing heart diseases for its simplicity and non-invasive property. Automatic ECG analyzing technologies are expected to reduce human working load and increase diagnostic efficacy. However, there are still some challenges to be addressed for achieving this goal. In this study, we develop an algorithm to identify multiple abnormalities from 12-lead ECG recordings. In the algorithm pipeline, several preprocessing methods are firstly applied on the ECG data for denoising, augmentation and balancing recording numbers of variant classes. In consideration of efficiency and consistency of data length, the recordings are padded or truncated into a medium length, where the padding/truncating time windows are selected randomly to suppress overfitting. Then, the ECGs are used to train deep neural network (DNN) models with a novel structure that combines a deep residual network with an attention mechanism. Finally, an ensemble model is built based on these trained models to make predictions on the test data set. Our method is evaluated based on the test set of the First China ECG intelligent Competition dataset by using the F1 metric that is regarded as the harmonic mean between the precision and recall. The resultant overall F1 score of the algorithm is 0.875, showing a promising performance and potential for practical use. © 2019, Springer Nature Switzerland AG.

关键词： Electrocardiograms

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Global context aware RCNN for object detection

arXiv

引用

arXiv 2020年

作者： Zhang, Wenchao Fu, Chong Xie, Haoyu Zhu, Mai Tie, Ming Chen, Junxin School of Computer Science and Engineering Northeastern University Shenyang110819 China Engineering Research Center of Security Technology of Complex Network System Ministry of Education China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Northeastern University Shenyang110819 China Science and Technology on Space Physics Laboratory Beijing100076 China College of Medicine and Biological Information Engineering Northeastern University Shenyang110819 China

RoIPool/RoIAlign is an indispensable process for the typical two-stage object detection algorithm, it is used to rescale the object proposal cropped from the feature pyramid to generate a fixed size feature map. However, these cropped feature maps of local receptive fields will heavily lose global context information. To tackle this problem, we propose a novel end-to-end trainable framework, called Global Context Aware (GCA) RCNN, aiming at assisting the neural network in strengthening the spatial correlation between the background and the foreground by fusing global context information. The core component of our GCA framework is a context aware mechanism, in which both global feature pyramid and attention strategies are used for feature extraction and feature refinement, respectively. Specifically, we leverage the dense connection to improve the information flow of the global context at different stages in the top-down process of FPN, and further use the attention mechanism to refine the global context at each level in the feature pyramid. In the end, we also present a lightweight version of our method, which only slightly increases model complexity and computational burden. Experimental results on COCO benchmark dataset demonstrate the significant advantages of our approach. Copyright © 2020, The Authors. All rights reserved.

关键词： Object recognition

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Automatic Segmentation of Microaneurysm in Retinal Fundus images

引用

IOP Conference Series: Materials Science and Engineering 2020年第7期768卷

作者： Guodong Zhang HasinduMaduranga Suraweera AdevianFairuz Pratama Dazhe Zhao Zhaoxuan Gong Wei Guo Shenyang Aerospace University Shenyang Liaoning China Key Laboratory of Intelligent Computing in Medical Image Ministry of Education Shenyang Liaoning China

Diabetes interferes with the body's ability to use and store sugar (glucose), which it can cause damage throughout the body. Generally, Microaneurysm (MA) is the first clinically observable lesions in the Diabetic Retinopathy (DR). Since interference of biological objects in eye fundus images are similar to MA, locate Microaneurysm lesions precisely is a challenging task for researches. This research employs U-Net Convolutional Neural Network to model saliency of objects in images, global and local context are both taken into account to provide a better initialization for the process. Feature extraction techniques are applied first to assign a local saliency value to each pixel by considering its local context from fundus images such as ORB, SURF, and MSER. The extracted feature vectors are applied for training the network. The sum of the weighted salient object regions produce the final saliency map, then implements U-Net to segment MA *** experiment has carried out using the publicly available Indian Diabetic Retinopathy image Dataset (IDRiD), which has used in 'Diabetic Retinopathy: Segmentation and Grading Challenge' workshop and our proposed method has given an outstanding accuracy of 98.78 %.

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Metrics Reloaded: Recommendations for image analysis validation

arXiv

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arXiv 2022年

作者： Maier-Hein, Lena Reinke, Annika Godau, Patrick Tizabi, Minu D. Buettner, Florian Christodoulou, Evangelia Glocker, Ben Isensee, Fabian Kleesiek, Jens Kozubek, Michal Reyes, Mauricio Riegler, Michael A. Wiesenfarth, Manuel Emre Kavur, A. Sudre, Carole H. Baumgartner, Michael Eisenmann, Matthias Heckmann-Nötzel, Doreen Rädsch, Tim Acion, Laura Antonelli, Michela Arbel, Tal Bakas, Spyridon Benis, Arriel Blaschko, Matthew B. Jorge Cardoso, M. Cheplygina, Veronika Cimini, Beth A. Collins, Gary S. Farahani, keyvan Ferrer, Luciana Galdran, Adrian Ginneken, Bram Van Haase, Robert Hashimoto, Daniel A. Hoffman, Michael M. Huisman, Merel Jannin, Pierre Kahn, Charles E. Kainmueller, Dagmar Kainz, Bernhard Karargyris, Alexandros Karthikesalingam, Alan Kenngott, Hannes Kofler, Florian Kopp-Schneider, Annette Kreshuk, Anna Kurc, Tahsin Landman, Bennett A. Litjens, Geert Madani, Amin Maier-Hein, Klaus Martel, Anne L. Mattson, Peter Meijering, Erik Menze, Bjoern Moons, Karel G.M. Müller, Henning Nichyporuk, Brennan Nickel, Felix Petersen, Jens Rajpoot, Nasir Rieke, Nicola Saez-Rodriguez, Julio Sánchez, Clara I. Shetty, Shravya Smeden, Maarten Van Summers, Ronald M. Taha, Abdel A. Tiulpin, Aleksei Tsaftaris, Sotirios A. Calster, Ben Van Varoquaux, Gaël Jäger, Paul F. Heidelberg Division of Intelligent Medical Systems and HI Helmholtz Imaging Germany Faculty of Mathematics and Computer Science and Medical Faculty Heidelberg University Heidelberg Germany NCT Heidelberg a partnership between DKFZ University Medical Center Heidelberg Germany Faculty of Mathematics and Computer Science Heidelberg University Heidelberg Germany Heidelberg Division of Intelligent Medical Systems Germany partner site Frankfurt/Mainz a partnership between DKFZ and UCT Frankfurt-Marburg Germany Heidelberg Goethe University Frankfurt Germany Department of Medicine Goethe University Frankfurt Germany Department of Informatics Frankfurt Cancer Insititute Germany Department of Computing Imperial College London London United Kingdom Heidelberg Division of Medical Image Computing and HI Applied Computer Vision Lab Germany Institute for AI in Medicine University Medicine Essen Essen Germany Centre for Biomedical Image Analysis Faculty of Informatics Masaryk University Brno Czech Republic ARTORG Center for Biomedical Engineering Research University of Bern Bern Switzerland Department of Radiation Oncology University Hospital Bern University of Bern Bern Switzerland Simula Metropolitan Center for Digital Engineering Oslo Norway UiT The Arctic University of Norway Romsø Norway Heidelberg Division of Biostatistics Germany Heidelberg Division of Intelligent Medical Systems Division of Medical Image Computing HI Applied Computer Vision Lab Germany MRC Unit for Lifelong Health and Ageing UCL Centre for Medical Image Computing Department of Computer Science University College London London United Kingdom School of Biomedical Engineering and Imaging Science King’s College London London United Kingdom Heidelberg Division of Medical Image Computing Germany Instituto de Cálculo CONICET – Universidad de Buenos Aires Buenos Aires Argentina Centre for Medical Image Computing University College London London United Kingdom McGill University Montréal

Increasing evidence shows that flaws in machine learning (ML) algorithm validation are an underestimated global problem. Particularly in automatic biomedical image analysis, chosen performance metrics often do not reflect the domain interest, thus failing to adequately measure scientific progress and hindering translation of ML techniques into practice. To overcome this, we created Metrics Reloaded, a comprehensive framework guiding researchers in the problem-aware selection of metrics. It was developed by a large international consortium in a multi-stage Delphi process and is based on the novel concept of a problem fingerprint – a structured representation of the given problem that captures all aspects that are relevant for metric selection, from the domain interest to the properties of the target structure(s), data set and algorithm output. Based on the problem fingerprint, users are guided through the process of choosing and applying appropriate validation metrics while being made aware of potential pitfalls. Metrics Reloaded targets image analysis problems that can be interpreted as a classification task at image, object or pixel level, namely image-level classification, object detection, semantic segmentation, and instance segmentation tasks. To improve the user experience, we implemented the framework in the Metrics Reloaded online tool. Following the convergence of ML methodology across application domains, Metrics Reloaded fosters the convergence of validation methodology. Its applicability is demonstrated for various biomedical use cases. © 2022, CC BY.

关键词： Semantic Segmentation

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Re: Ana Cavillon, Damien Pouessel, Nadine Houédé, et al. Assessing Long-term Treatment Benefits Using Complementary Statistical Approaches: An In Silico Analysis of the Phase III keynote-045 and Checkmate-214 Immune Checkpoint Inhibitor Trials. Eur Urol. In press. https://***/10.1016/***.2023.02.011

引用

European urology 2023年第1期84卷 e20-e21页

作者： Binghao Zhao Ruidong Zhang Jiaming Wu DKTK Clinical Cooperation Unit for Neuroimmunology and Brain Tumor Immunology German Cancer Research Center Heidelberg Germany. Electronic address: zhaobhao@***. Division of Medical Image Computing German Cancer Research Center Heidelberg Germany. Department of Neurosurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing PR China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing PR China.

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GAMMA Challenge: Glaucoma grAding from Multi-Modality images

arXiv

引用

arXiv 2022年

作者： Wu, Junde Fang, Huihui Li, Fei Fu, Huazhu Lin, Fengbin Li, Jiongcheng Huang, Yue Yu, Qinji Song, Sifan Xu, Xinxing Xu, Yanyu Wang, Wensai Wang, Lingxiao Lu, Shuai Li, Huiqi Huang, Shihua Lu, Zhichao Ou, Chubin Wei, Xifei Liu, Bingyuan Kobbi, Riadh Tang, Xiaoying Lin, Li Zhou, Qiang Hu, Qiang Bogunović, Hrvoje Orlando, José Ignacio Zhang, Xiulan Xu, Yanwu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Intelligent Healthcare Unit Baidu Inc. Beijing China Singapore School of Informatics Xiamen University Xiamen China Shanghai Jiao Tong University Shanghai China Xi'an Jiaotong-Liverpool University Suzhou China Institute of High Performance Computing A*STAR Singapore Institute of Biomedical Engineering Chinese Academy of Medical Sciences Peking Union Medical College Tianjin China School of Medical Technology Beijing Institute of Technology Beijing China Department of Computing Hong Kong Polytechnic University Hong Kong Department of Computer Science and Engineering Southern University of Science and Technology Shenzhen China Weizhi Medical Technology Company Suzhou China École de Technologie Supérieure Montreal Montreal Canada DIAGNOS Inc. Quebec Canada Department of Electrical and Electronic Engineering Southern University of Science and Technology Shenzhen China Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong Technology Co. Ltd. Shanghai China School of Information and Electronics Beijing Institute of Technology Beijing China Christian Doppler Lab for Artificial Intelligence in Retina Department of Ophthalmology Medical University of Vienna Austria Yatiris Group PLADEMA Institute CONICET UNICEN Tandil Argentina

Glaucoma is a chronic neuro-degenerative condition that is one of the world's leading causes of irreversible but preventable blindness. The blindness is generally caused by the lack of timely detection and treatment. Early screening is thus essential for early treatment to preserve vision and maintain life quality. Color fundus photography and Optical Coherence Tomography (OCT) are the two most cost-effective tools for glaucoma screening. Both imaging modalities have prominent biomarkers to indicate glaucoma suspects, such as the vertical cup-to-disc ratio (vCDR) on fundus images and retinal nerve fiber layer (RNFL) thickness on OCT volume. In clinical practice, it is often recommended to take both of the screenings for a more accurate and reliable diagnosis. However, although numerous algorithms are proposed based on fundus images or OCT volumes for the automated glaucoma detection, there are few methods that leverage both of the modalities to achieve the target. To fulfill the research gap, we set up the Glaucoma grAding from Multi-Modality images (GAMMA) Challenge to encourage the development of fundus & OCT-based glaucoma grading. The primary task of the challenge is to grade glaucoma from both the 2D fundus images and 3D OCT scanning volumes. As part of GAMMA, we have publicly released a glaucoma annotated dataset with both 2D fundus color photography and 3D OCT volumes, which is the first multi-modality dataset for machine learning based glaucoma grading. In addition, an evaluation framework is also established to evaluate the performance of the submitted methods. During the challenge, 1272 results were submitted, and finally, ten best performing teams were selected for the final stage. We analyze their results and summarize their methods in the paper. Since all the teams submitted their source code in the challenge, we conducted a detailed ablation study to verify the effectiveness of the particular modules proposed. Finally, we identify the proposed techniqu

关键词： Grading

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