检索结果-内蒙古大学图书馆

Efficient Intramolecular Charge-Transfer Fluorophores Based on Substituted Triphenylphosphine Donors

Angewandte Chemie 2021年第27期133卷

作者： Zhang Liu Dr. Chao Deng Liwu Su Dr. Dan Wang Yongshi Jiang Prof. Taiju Tsuboi Prof. Qisheng Zhang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

Triphenylphosphine (TPP)-based luminescent compounds are rarely investigated because of the low photoluminescence quantum yield (PLQY). Here, we demonstrate that introducing steric hindrance groups to the TPP moiety and separating the orbitals involved in the transition can drastically suppress the non-radiative decay induced by structural distortion of TPP in the excited state. High PLQY up to 0.89 as well as thermally activated delayed fluorescence are observed from the intramolecular charge-transfer (ICT) molecules with substituted TPP donors (sTPPs) in doped films. The red organic light-emitting diodes employing these emitters achieve comparable external quantum efficiencies to the control device containing a classical phosphorescent dye, revealing the great potential of the ICT emitters based on electrochemically stable sTPPs.

关键词： intramolecular charge transfer non-radiative decay organic light emitting diodes thermally activated delayed fluorescence triphenylphosphine donor

来源：评论

学校读者我要写书评

暂无评论

Bacteria-based bioactive materials for tumor immunotherapy

Precision Medicine and Engineering

引用

Precision Medicine and Engineering 2024年第2期1卷

作者： Yongcan Li Fangfang Cao Lie Ma Lulu Jin MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 PR China Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore 119074 Singapore Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore 117597 Singapore

As one of the most abundant biological populations endowed with unique properties such as specific targeting and genetic engineering vectors, bacteria with immunogenic potential have garnered significant attention for their ability to elicit immune activation against tumors. This approach has achieved substantial breakthroughs as a modality for cancer treatment and is known as bacterial immunotherapy. However, the immunosuppressive tumor microenvironment (TME) can inhibit the immune response induced by bacteria and promote tumor growth and metastasis. To overcome this challenge, recent advancements in bacteria-based bioactive materials, which are biological substances synthesized by bacteria, have not only harnessed the inherent properties of bacteria but also specifically targeted the modulation of the TME, providing a more favorable environment for immune activation and significantly enhancing the efficacy of immunotherapy for cancer treatment. This review introduces the key mechanisms of bacteria-based biomaterials as anticancer agents and reviews the latest research progress, along with their clinical applications in cancer treatment. Finally, the potential and challenges of bacteria-based biomaterials for tumor therapy are explored, aiming to provide insights into the functions of bacteria-based bioactive materials and their role in advancing cancer immunotherapy while offering recommendations for the development of new bacteria-based biomaterials.

关键词： Tumor immunotherapy Immune cells Tumor microenvironment Bioactive materials

来源：评论

学校读者我要写书评

暂无评论

A Honeybee Stinger Inspired Self-Interlocking Microneedle Patch and its Application in Myocardial Infarction Treatment

SSRN

引用

SSRN 2022年

作者： Lu, Yuwen Ren, Tanchen Zhang, Hua Jin, Qiao Shen, Liyin Shan, Mengqi Zhao, Xinzhe Chen, Qichao Dai, Haoli Yao, Lin Xie, Jieqi Ye, Di Lin, Tengxiang Hong, Xiaoqian Deng, Kaicheng Shen, Ting Pan, Jiazhen Jia, Mengyan Ling, Jun Li, Peng Zhang, Yue Wang, Huanan Zhuang, Lenan Gao, Changyou Mao, Jifu Zhu, Yang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou310027 China Department of Cardiology Cardiovascular Key Laboratory of Zhejiang Province Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou310009 China College of Animal Sciences Zhejiang University Hangzhou310058 China Institute of Genetics and Reproduction College of Animal Sciences Zhejiang University Hangzhou China College of Textiles Donghua University Shanghai201620 China Shanghai Banyun Med Tech Co. Ltd. Shanghai201203 China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou310027 China Department of Surgery University of California San FranciscoCA United States Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of Cardiology Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou China Binjiang Institute of Zhejiang University Hangzhou310053 China

Weak tissue adhesion remains a major challenge in clinical translation of microneedle patches. Mimicking the structural features of honeybee stingers, stiff polymeric microneedles with unidirectionally backward facing barbs were fabricated and embedded into various elastomer films to produce self-interlocking microneedle patches. The spirality of the barbing pattern was adjusted to increase interlocking efficiency. In addition, the micro-bleeding caused by microneedle puncturing adhered the porous surface of the patch substrate to the target tissue via coagulation. In the demonstrative application of myocardial infarction treatment, the bioinspired microneedle patches firmly fixed on challenging beating hearts, significantly reduced cardiac wall stress and strain in the infarct, maintained left ventricular function and morphology. In addition, the microneedle patch was minimally invasively implanted onto beating porcine heart in 10 minutes, free of sutures and adhesives. Therefore, the honeybee stinger inspired microneedles could provide an adaptive and convenient means to adhere patches for various medical *** Information: This study is financially supported by the National key Research and Development Program of China (No. 2019YFE0117400), National Natural Science Foundation of China (No. 32000971, 52005097, 81941003), "Leading Goose" R&D Program of Zhejiang, Natural Science Foundation of Shanghai (No. 21ZR1401300).Conflict of Interests: Y.Z., Y.L., C.G., T.R., L.S., X.H. have patent applications (CN113907915A) related to the present study and thus may have related financial interests. All other authors declare no competing *** Approval: All animal experiments were approved by the Institutional Animal Care and Use Committee of Zhejiang University (No. ZJU20210245). © 2022, The Authors. All rights reserved.

关键词： Medical applications

来源：评论

学校读者我要写书评

暂无评论

A Mitochondrion-Targeting Two-Photon Photosensitizer with Aggregation-Induced Emission Characteristics for Hypoxia-Tolerant Photodynamic Therapy

SSRN

引用

SSRN 2022年

作者： Jiang, Yihang Zhu, Wei Xu, Zhourui Zhang, Zhijun Tang, Shuo Fan, Miaozhuang Li, Zhengzheng Zhang, Jianyu Yang, Chengbin Law, Wing-Cheung Yong, Ken-Tye Wang, Dong Xu, Gaixia Tang, Ben Zhong Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging School of Biomedical Engineering Health Science Center Shenzhen University Guangdong Shenzhen518055 China Centre for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials College of Material Science and Engineering Shenzhen University Guangdong Shenzhen518055 China Key Laboratory of Advanced Textile Materials and Manufacturing Technology Engineering Research Center for Eco-Dyeing & Finishing of Textiles Ministry of Education Zhejiang Sci-Tech University Hangzhou310018 China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study The Hong Kong University of Science and Technology Clear Water Bay Kowloon999077 Hong Kong Department of Industrial and Systems Engineering The Hong Kong Polytechnic University Hong Hum Kowloon999077 Hong Kong School of Biomedical Engineering The University of Sydney SydneyNSW2006 Australia MOE Key Laboratory of Macromolecular Synthesis and Functionalization China

In recent years, two-photon photodynamic therapy (TP-PDT) has received extensive attention in cancer treatment owing to its unique advantages of deep tissue penetration and high spatial-temporal controls. However, the high oxygen dependency of photosensitizers still remained as the major obstacle which undermined its overall therapeutic efficacy, especially in hypoxic-tolerant tumors. Exploration of new TP-PDT strategy with less-oxygen-dependency and subcellular organelle-targeting ability is an appealing yet seriously challenging task. In this work, a mitochondrion-targeting TP-PDT protocol based on type-I PSs with aggregation-induced emission (AIE) characteristics is proposed for the first time. Of the two synthesized AIE-active PSs, TPABP-Ir is demonstrated superior reactive oxygen species (ROS) production (both type I&II) owing to the doping of Ir(III). After encapsulation into bovine serum albumin (BSA) matrix, TPABP-Ir@BSA nanoparticles (Ir-NPs) are capable of realizing mitochondrion-targeting, high ROS production, and suppression of tumor growth under 880 nm femtosecond laser excitation. This study provides a novel treatment strategy which maximizes the PDT efficacy and offers a conceptual but practical paradigm for cancer treatment in translational nanomedicine. © 2022, The Authors. All rights reserved.

关键词： Diseases

来源：评论

学校读者我要写书评

暂无评论

Copper Nanodrugs by Atom Transfer Radical Polymerization

引用

Angewandte Chemie 2024年第20期136卷

作者： Peng Chen Ziyan Song Xuxia Yao Weibin Wang Lisong Teng Krzysztof Matyjaszewski Weipu Zhu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China School of Materials Science and Engineering Zhejiang University Hangzhou 310027 China The First Affiliated Hospital Department of Surgical Oncology Zhejiang University School of Medicine Hangzhou 310003 China Department of Chemistry Carnegie Mellon University Pittsburgh Pennsylvania 15213 United States Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030000 China Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province Zhejiang University Hangzhou 310027 China

In this study, some copper catalysts used for atom transfer radical polymerization (ATRP) were explored as efficient anti-tumor agents. The aqueous solution of copper-containing nanoparticles with uniform spheric morphology was in situ prepared through a copper-catalyzed activator generated by electron transfer (AGET) ATRP in water. Nanoparticles were then directly injected into tumor-bearing mice for antitumor chemotherapy. The copper nanodrugs had prolonged blood circulation time and enhanced accumulation at tumor sites, thus showing potent antitumor activity. This work provides a novel strategy for precise and large-scale preparation of copper nanodrugs with high antitumor activity.

关键词： atom transfer radical polymerization miniemulsion polymerization nanodrugs copper complex anti-tumor

来源：评论

学校读者我要写书评

暂无评论

A Biomimetic Nanoplatform for Precise Reprogramming of Tumor-Associated Macrophages and NIR-II Mediated Antitumor Immune Activation

SSRN

引用

SSRN 2022年

作者： Ding, Yuan Qian, Xiaohui Lin, Fenghao Gao, Bingqiang Wang, Weili Yang, Huang Du, Yang Wang, Weilin Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang Hangzhou310009 China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Zhejiang Hangzhou310009 China Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province Zhejiang Hangzhou310009 China National Innovation Center for Fundamental Research on Cancer Medicine Zhejiang Hangzhou310009 China Cancer Center Zhejiang University Zhejiang Hangzhou310058 China ZJU-Pujian Research & Development Center of Medical Artificial Intelligence for Hepatobiliary and Pancreatic Disease Zhejiang Hangzhou310058 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Zhejiang Hangzhou310027 China Department of Hepatobiliary and Pancreatic Surgery

The therapeutic effects of photothermal therapy (PTT) are dependent on the photothermal conversion efficiency of photothermal agents (PTAs) in tumors and the subsequent activation of the antitumor immune system. However, the insufficient tumor accumulation of current PTAs and the inevitable recruitment of tumor-associated macrophages (TAMs) could further compromise the antitumor activities of PTT. To address these issues, a biomimetic photothermal nanoplatform Au@Fe-PM is developed for the targeted remodeling of TAMs, which promotes the antitumor immunity of PTT. Au nanorods with second near-infrared (NIR-II) absorptions are fabricated to serve as PTAs to induce immunogenic cell death in tumor cells. The ferric hydroxide shell coated on Au nanorods can release iron ions to repolarize M2-like TAMs into the tumoricidal M1 phenotype via P38 and STAT1-mediated signaling pathways. Moreover, the surface decoration of platelet membranes endows biomimetic nanoplatform with excellent tumor targeting ability for precise tumor ablation and TAM regulation. Consequently, Au@Fe-PM under NIR-II laser irradiation exhibits significantly higher inhibitory effects in a poor immunogenic 4T1 tumor-bearing mouse model with a 50% complete remission rate compared to conventional PTT (0%). By simultaneously reversing the immunosuppressive tumor microenvironment, this biomimetic nanoplatform offers a promising strategy for enhancing the antitumor efficacy of PTT. © 2022, The Authors. All rights reserved.

关键词： Cell death

来源：评论

学校读者我要写书评

暂无评论

Magneto-Orientation of Magnetic Double Stacks for Patterned Anisotropic Hydrogels with Multiple Responses and Modulable Motions

引用

Angewandte Chemie 2022年第35期134卷

作者： Chen Fei Dai Olena Khoruzhenko Chengqian Zhang Qing Li Zhu Dejin Jiao Prof. Miao Du Prof. Josef Breu Prof. Peng Zhao Prof. Qiang Zheng Prof. Zi Liang Wu Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China The State Key Laboratory of Fluid Power Transmission and Control Systems Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical Engineering Zhejiang University Hangzhou 310028 China Bavarian Polymer Institute and Department of Chemistry University of Bayreuth Universitätsstrasse 30 95440 Bayreuth Germany

Reported here is a multi-response anisotropic poly( N -isopropylacrylamide) hydrogel developed by using a rotating magnetic field to align magnetic double stacks (MDSs) that are fixed by polymerization. The magneto-orientation of MDSs originates from the unique structure with γ-Fe 2 O 3 nanoparticles sandwiched by two silicate nanosheets. The resultant gels not only exhibit anisotropic optical and mechanical properties but also show anisotropic responses to temperature and light. Gels with complex ordered structures of MDSs are further devised by multi-step magnetic orientation and photolithographic polymerization. These gels show varied birefringence patterns with potentials as information materials, and can deform into specific configurations upon stimulations. Multi-gait motions are further realized in the patterned gel through dynamic deformation under spatiotemporal light and friction regulation by imposed magnetic force. The magneto-orientation assisted fabrication of hydrogels with anisotropic structures and additional functions should bring opportunities for gel materials in biomedical devices, soft actuators/robots, etc.

关键词： Anisotropic Hydrogels Ferronematic Liquid Crystals Magnetic Orientation Nanosheets Soft Robots

来源：评论

学校读者我要写书评

暂无评论

Chitosan hydrogels loaded with pH-responsive nanozymes for precision treatment of wound infection

Precision Medicine and Engineering

引用

Precision Medicine and Engineering 2024年第2期1卷

作者： Binglin Ye Xiaojiong Bao Danfeng Jian Huang Yang Lulu Jin Zongrui Tong Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou Zhejiang 310009 China Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province Hangzhou Zhejiang 310009 China National Innovation Center for Fundamental Research on Cancer Medicine Hangzhou Zhejiang 310009 China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China MOE Key Laboratory of Advanced Textile Materials and Manufacturing Technology Zhejiang Sci-Tech University Hangzhou 310018 China

Chronic wounds often exhibit protracted healing processes, predominantly attributed to the pervasive presence of bacterial pathogens. Nanozymes with reactive oxygen species (ROS) generation capabilities have become a burgeoning strategy within the realm of antibacterial intervention. However, an overabundance of toxic ROS can cause damage to healthy tissues surrounding the wound or during the tissue regeneration phase. Thus, there is a need for an accurate antibacterial dressing that can be applied directly to wounds. In this study, we fabricated chitosan hydrogels loaded with pH-responsive palladium (Pd) nanozymes (Pd@QCS/OD) for precision treatment of wound infection. The peroxidase-like activity of Pd enzymes can be triggered by the acidic microenvironment of infected wounds and then generate many poisonous hydroxyl radicals to achieve precise antibacterial behavior. Moreover, chitosan hydrogels synthesized via a Schiff base reaction are conducive to subsequent tissue regeneration. Both in vitro and in vivo experiments demonstrated that the Pd@QCS/OD hydrogels had effective antibacterial effects and accelerated wound recovery. This research offers some insight into the precise treatment of bacterial infections.

关键词： Nanozyme Antibacterial application Hydrogels Precision treatment

来源：评论

学校读者我要写书评

暂无评论

Conductive Metallophthalocyanine Framework Films with High Carrier Mobility as Efficient Chemiresistors

引用

Angewandte Chemie 2021年第19期133卷

作者： Dr. Yan Yue Peiyu Cai Xiaoyi Xu Prof. Hanying Li Prof. Hongzheng Chen Prof. Hong-Cai Zhou Prof. Ning Huang MOE Key Laboratory of Macromolecular Synthesis and Functionalization State Key Laboratory of Silicon Materials Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China Department of Chemistry Texas A&M University College Station TX 77843-3255 USA

The poor electrical conductivity of two-dimensional (2D) crystalline frameworks greatly limits their utilization in optoelectronics and sensor technology. Herein, we describe a conductive metallophthalocyanine-based NiPc-CoTAA framework with cobalt(II) tetraaza[14]annulene linkages. The high conjugation across the whole network combined with densely stacked metallophthalocyanine units endows this material with high electrical conductivity, which can be greatly enhanced by doping with iodine. The NiPc-CoTAA framework was also fabricated as thin films with different thicknesses from 100 to 1000 nm by the steam-assisted conversion method. These films enabled the detection of low-concentration gases and exhibited remarkable sensitivity and stability. This study indicates the enormous potential of metallophthalocyanine-based conductive frameworks in advanced stand-off chemical sensors and provides a general strategy through tailor-make molecular design to develop sensitive and stable chemical sensors for the detection of low-concentration gases.

关键词： conducting materials conjugated polymers covalent organic frameworks metal–organic frameworks porous polymers

来源：评论

学校读者我要写书评

暂无评论

Preparation of Mn2+@PolyDOPA-b-polysarcosine micelle as MRI contrast agent with high longitudinal relaxivity

引用

Journal of macromolecular Science, Part A 2021年第3期58卷 175-181页

作者： Qingda Yan Xue Dong Rongze Xie Xiufang Xu Xiaoyan Wang Ke Zhang Jingya Xia Jun Ling Fei Zhou Jihong Sun a MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou China b Department of Radiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China c Department of Radiology Jiulongpo People’s Hospital Chongqing China d Department of Medical Imagine Hangzhou Medical College Hangzhou China b Department of Radiology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou Chinac Department of Radiology Jiulongpo People’s Hospital Chongqing Chinae Innovation Center for Minimally Invasive Techniques and Devices Zhejiang University Hangzhou China

Magnetic resonance imaging (MRI) is a promising technique widely used in clinical diagnose. Poly(α-amino acid)s are excellent carriers for MRI due to their excellent biocompatibility. PDOPA-b-PSar copolymers (defined as “DoS”) are synthesized by sequential polymerizations of 3,4-dihydroxy-L-phenylalanine N-thiocarboxyanhydride (DOPA-NTA) and sarcosine N-thiocarboxyanhydride (Sar-NTA) initiated by neopentylamine in tetramethylene sulfone. Mn2+@DoS micelles have been prepared as T1-weighted MRI contrast agents according to efficient coordination between catechol units and Mn2+cation. High longitudinal relaxivity (27.7 mM−1·s−1) of Mn2+@PDOPA12-b-PSar72was observed, and the aqueous micelle exhibits effective MRI contrast enhancementin vivoof nude mice. Mn2+@DoS shows potential clinical application in diagnostic radiology as a novel MRI contrast agent. Gd3+@DoS micelles are also investigated presenting a longitudinal relaxivity of 16.4 mM−1·s−1. Unfortunately, the Gd3+loading percentage is quite low as 19%.Preparation of Mn2+@PolyDOPA-b-polysarcosine micelle as MRI contrast agent with high longitudinal relaxivityAll authorsQingdaYan,XueDong,RongzeXie,XiufangXu,XiaoyanWang,KeZhang,JingyaXia,JunLing,FeiZhou&JihongSunhttps://***/10.1080/10601325.2020.1840918Published online:02 November 2020

关键词： Poly(α-amino acid)s polypeptides polypeptoids magnetic resonance imaging longitudinal relaxivity

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：