检索结果-内蒙古大学图书馆

PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation

生物化学与生物物理学报（英文版） 2023年第9期55卷 1370-1379页

作者： Gongyu Fu Shi-Ting Li Zetan Jiang Qiankun Mao Nanchi Xiong Xiang Li Yijie Hao Huafeng Zhang Anhui Key Laboratory of Hepatopancreatobiliary Surgery Department of General SurgeryAnhui Provincial Hospitalthe First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Hefei National Laboratory for Physical Sciences at Microscale the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Hefei National Laboratory for Physical Sciences at Microscale the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230027China

Tumor metabolic reprogramming and epigenetic modification work together to promote tumorigenesis and *** lysine acetylation,which affects a variety of biological functions of proteins,plays an important role under physiological and pathological ***,through immunoprecipitation and mass spectrum data,we show that phosphoglycerate mutase 5(PGAM5)deacetylation enhances malic enzyme 1(ME1)metabolic enzyme activity to promote lipid synthesis and proliferation of liver cancer ***,we demonstrate that the deacetylase SIRT2 mediates PGAM5 deacetylation to activate ME1 activity,leading to ME1 depho-sphorylation,subsequent lipid accumulation and the proliferation of liver cancer *** together,our study establishes an important role for the SIRT2-PGAM5-ME1 axis in the proliferation of liver cancer cells,suggesting a potential innovative cancer therapy.

关键词： metabolic reprograming PGAM5 protein acetylation SIRT2 ME1 liver cancer

来源：评论

学校读者我要写书评

暂无评论

Scheme Design and Challenges of DNA Sequencing Terminal Equipment Based on Solid-State Nanopore Sequencing 4th

Scheme Design and Challenges of DNA Sequencing Terminal Equi...

引用

4th International Conference on Mechanical Design and Simulation, MDS 2024

作者： Zhao, Yuanzhe Zhang, Jie Sun, Zepeng Cao, Zheqi Xu, Liqun Li, Jian Key Laboratory of DGHD MOE School of Life Science and Technology Southeast University Nanjing China Industrial Research Institute Chengdu China

ISBN: (纸本)9789819778867

Nanopore sequencing has become the primary technology for modern DNA sequencing. Solid nanopores are favored for their cost-effectiveness, stability, and scalability, particularly for portable applications. This paper presents a new design for a portable solid-state nanopore sequencing device based on the Linux platform. It employs a cutting-edge biological sequencing chip with a nanopore channel to capture through-hole data. Electrical signals from the chip are processed to create DNA sequence data files. The Linux-based Raspbian OS serves as the control terminal, facilitating seamless communication between components. Data is then transmitted to a cloud platform via a 5G unit for further analysis. This study integrates software and hardware for instrument validation. © The Author(s) 2025.

关键词： Nanopores

来源：评论

学校读者我要写书评

暂无评论

Nanozymes regulated by nitrogen element:Mechanism,design,and application

Advanced Powder Materials

引用

Advanced Powder Materials 2024年第4期3卷 9-26页

作者： Longhua Ding Longwei Wang Jian Zhang Na Ren Aizhu Wang Hong Liu Xin Yu Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaUniversity of Chinese Academy of ScienceBeijing 100190China Division of Systems and Synthetic Biology Department of Life SciencesChalmers University of Technology41296GöoteborgSweden State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOEQingdao University of Science and TechnologyQingdao 266042China

Nanozymes,a category of nanomaterials endowed with enzyme-mimicking capabilities,have exhibited considerable potential across diverse application *** comprehensive review delves into the intricacies of regulating nanozymes through N elements,elucidating the mechanisms governing N element control in the design and application of these *** initial sections introduce the foundational background and significance of *** exploration delves into the detailed discussion of N element regulation mechanisms on nanozymes,encompassing N vacancies,N doping,N coordination,and *** regulatory pathways play an instrumental role in fine-tuning the catalytic activity and specificity of *** review further scrutinizes practical applications of N element regulation on nanozymes,spanning sensing detection,infection therapy,tumor therapy,and pollutant *** conclusion,it succinctly summarizes the current research findings and proposes future directions for *** thorough investigation into the regulation of nanozymes by N elements anticipates precise control over their performance,thereby advancing the extensive utilization of nanozymes in the realms of biomedical and environmental applications.

关键词： Nnanozyme Nitrogen doping Nitrogen corrdination Infection therapy Tumor therapy

来源：评论

学校读者我要写书评

暂无评论

Comparisons of thermogenic features in four coexisting songbirds:Is the northward colonized White-browed Laughingthrush different?

引用

Avian Research 2023年第1期14卷 78-85页

作者： Pengfei Liu Rongrong Jin Miaomiao Jiang Saiyue Zhang Yuehua Sun School of Life Sciences and Technology Longdong UniversityQingyang745000China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of ScienceBeijing100101China

Thermogenic features are often invoked to illustrate animal’s colonization,distribution,and response to climate *** understand why the White-browed Laughingthrush(Pterorhinus sannio)has expanded its distribution to temperate zones in recent years,we compared its thermogenic features with three species of songbirds that cooccur in its newly colonized *** parameters of these four species were measured under different ambient temperatures,ranging from 0 to 40℃.The results showed that basal metabolic rate(BMR)was 44.5±3.9 mL O2/h in ***,which is lower than predicted value by its body *** is also lower than the BMR of both its temperate congener the Plain Laughingthrush(***)and the montane,similar species Elliot’s Laughingthrush(Trochalopteron elliotii).The thermal neutral zone(TNZ)in *** was 15-35℃,as compared to 10-27.5℃in ***,25-30℃in ***,and 7.5-32.5℃in the Green-capped Greenfinch(Chloris sinica).Thermal conductance was lowest in ***,with the minimum value lower than the predicted value based on its body *** results showed that the northward-colonizing *** exhibited different thermogenic characteristics compared with its coexisting species in the new habitat,even its congener ***,which shared similar microhabitats to *** suggest that researchers further explore the physiological mechanisms of birds’northward expansion.

关键词： Colonization Evaporative water los Thermal physiology Thermal neutral zone Temperature

来源：评论

学校读者我要写书评

暂无评论

Dynamic transcriptome profiles and novel markers in bovine spermatogenesis revealed by single-cell sequencing

引用

Journal of Integrative Agriculture 2024年第7期23卷 2362-2378页

作者： Yuan Gao Fuxia Bai Qi Zhang Xiaoya An Zhaofei Wang Chuzhao Lei Ruihua Dang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China College of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China

Testicular development is an important biological process in male and requires interaction between the male germ cells and somatic ***,the mechanisms of testicular development in livestock,particularly in cattle,are poorly ***,cellular heterogeneity hinders the profiling of different cell types at different developmental *** this study,we first performed a single-cell transcriptomic study of the bovine testis development during puberty by using 10×genomics single-cell RNA sequencing(scRNA-seq).By collecting the scRNA-seq data from 11,083 cells from prepubertal and pubertal bovine testes,a high-resolution scRNA-seq atlas was described,identifying 9 somatic and 13 spermatogenic *** also distinguished several stage-specific marker genes for bovine germ cells and somatic cells,such as GRAF2 and MORC1 for SSC(spermatogonial stem cells),HJURP and TCF19 for differentiating spermatogonia,ARSE for immature Sertoli,CLEC12B for mature Sertoli,LOC112441470 for *** conclusion,we have examined the transcription levels and constructed the single-cell developmental maps of germ cells and somatic cells during testicular development in Angus *** datasets provided new insights into spermatogenesis and testicular somatic cell development in cattle.

关键词： scRNA-seq cattle spermatogenesis testis development

来源：评论

学校读者我要写书评

暂无评论

Advances in nanocarriers for targeted drug delivery and controlled drug release

引用

Chinese Journal of Natural Medicines 2025年第5期 513-528页

作者： Yuqian Wang Renqi Huang Shufan Feng Ran Mo State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseasesCenter of Advanced Pharmaceuticals and BiomaterialsSchool of Life Science and TechnologyChina Pharmaceutical University

Nanocarrier-based drug delivery systems(nDDSs) present significant opportunities for improving disease treatment, offering advantages in drug encapsulation, solubilization, stability enhancement, and optimized pharmacokinetics and biodistribution. n DDSs, comprising lipid,polymeric, protein, and inorganic nanovehicles, can be guided by or respond to biological cues for precise disease treatment and management. Equipping nanocarriers with tissue/celltargeted ligands enables effective navigation in complex environments, while functionalization with stimuli-responsive moieties facilitates site-specific controlled release. These strategies enhance drug delivery efficiency, augment therapeutic efficacy, and reduce side effects. This article reviews recent strategies and ongoing advancements in n DDSs for targeted drug delivery and controlled release, examining lesion-targeted nanomedicines through surface modification with small molecules, peptides, antibodies, carbohydrates, or cell membranes, and controlled-release nanocarriers responding to endogenous signals such as pH,redox conditions, enzymes, or external triggers like light, temperature, and magnetism. The article also discusses perspectives on future developments.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Ribosome profiling reveals the translational landscape and allele-specific translational efficiency in rice

引用

Plant Communications 2023年第2期4卷 119-135页

作者： Xi-Tong Zhu Run Zhou Jian Che Yu-Yu Zheng Muhammad Tahir ul Qamar Jia-Wu Feng Jianwei Zhang Junxiang Gao Ling-Ling Chen National Key Laboratory of Crop Genetic Improvement College of InformaticsHuazhong Agricultural UniversityWuhan 430070China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Translational regulation is a critical step in the process of gene expression and governs the synthesis of proteins from *** studies have revealed translational regulation in plants in response to various environmental ***,there have been no studies documenting the comprehensive landscape of translational regulation and allele-specific translational efficiency in multiple plant tissues,especially those of rice,a main staple crop that feeds nearly half of the world’s *** we used RNA sequencing and ribosome profiling data to analyze the transcriptome and translatome of an elite hybrid rice,Shanyou 63(SY63),and its parental varieties Zhenshan 97 and Minghui *** results revealed that gene expression patterns varied more among tissues than among varieties at the transcriptional and translational *** identified 3392 upstream open reading frames(uORFs),and the uORF-containing genes were enriched in transcription *** 668 of 13492 long non-coding RNAs could be translated into ***,we discovered numerous genes with allele-specific translational efficiency in SY63 and demonstrated that some cis-regulatory elements may contribute to allelic divergence in translational ***,these findings may improve our understanding of translational regulation in rice and provide information for molecular breeding research.

关键词： Ribo-seq translational landscape uORFs lncRNAs allele-specific translational efficiency rice Oryza sativa

来源：评论

学校读者我要写书评

暂无评论

Study on magnetorheological polishing processing characteristics of different crystal planes of SiC 4

Study on magnetorheological polishing processing characteris...

引用

Advanced Optical Manufacturing Technologies and Applications 2024, AOMTA 2024 and 4th International Forum of Young Scientists on Advanced Optical Manufacturing, YSAOM 2024

作者： Chen, Yunheng Song, Ci Wang, Bo Qiao, Dongyang Zhang, Wanli Peng, Xing Si, Hailun Long, Jianglin College of Intelligent Science and Technology National University of Defense Technology Hunan Changsha410073 China Hunan Provincial Key Laboratory of Ultra-Precision Machining Technology Hunan Changsha410073 China National Key Laboratory of Equipment State Sensing and Smart Support Hunan Changsha410073 China

ISBN: (数字)9781510683037

ISBN: (纸本)9781510683020

As the third-generation wide band gap semiconductor material, single crystal silicon carbide has high electron saturation mobility and excellent thermal properties. It has broad application prospects in the manufacture of high temperature and radiation resistant high frequency and high-power devices. Magnetorheological polishing of silicon carbide wafers has the characteristics of high efficiency and non-destructive processing, but there is a lack of research on magnetorheological polishing of Si and C surfaces at this stage. Therefore, this paper studies the following aspects. Firstly, through the removal function experiment of multi-parameter comparison, the difference between the residence time of magnetorheological polishing and the removal effect of SiC Si and C surfaces is analyzed, and the efficiency evolution law of magnetorheological polishing of different crystal surfaces is obtained. The influence of different immersion depth of polishing ribbon on the removal efficiency of different crystal faces was explored, and the relationship between polishing depth and material removal rate under different crystal faces was obtained. The results show that with the increase of residence time, the removal efficiency of Si and C surfaces increases, and the growth rate of Si surface is much larger than that of C surface. With the increase of immersion depth, the growth rate of material removal efficiency of C surface is more sensitive than that of Si surface. Therefore, this study explores the technical feasibility of magnetorheological polishing of SiC, and provides a new idea for high-efficiency and high-precision polishing of SiC. © 2024 SPIE.

关键词： Silicon wafers

来源：评论

学校读者我要写书评

暂无评论

Implementation and uniformity calibration of LED array for photodynamic therapy

引用

Journal of Innovative Optical Health sciences 2022年第4期15卷 61-69页

作者： Xu Wang Jiyuan Xiong Xiaoming Hu Qin Li Key Laboratory of Convergence Medical Engineering System and Healthcare Technology Ministry of Industry and Information Technology School of Life Science Beijing Institute of Technology Beijing 100081 P.R.China

Irradiance uniformity is an important parameter for a Photodynamic Therapy(PDT)*** calibration and verification of a LED array light source based on computer vision technology were implemented and carried ***,the correlation coe±cients between the pulse width modulate value and the irradiance were ***,the correction of the actual light center and divergence angle were solved by image processing to reduce errors from each LED ***,uniformity was optimized according to the irradiance formula of the Lambertian *** lowest coe±cients of variation of irradiance were 4.87%in a 5 cm×12 cm area and 3.55%in a 3 cm×10 cm area within the depth range of 8–12 cm when the expected irradiance was 100 mW/cm^(2).This finding indicated that the light source can achieve a more uniform illumination and provide a better therapeutic effect for the PDT of port-wine stains.

关键词： Photodynamic therapy computer vision light source calibration

来源：评论

学校读者我要写书评

暂无评论

Investigation into IgG/IgE binding capacity and gut microbiota of digestion products derived from glycated ovalbumin

引用

Food science and Human Wellness 2024年第6期13卷 3633-3641页

作者： Jihua Mao Yanhong Shao Hui Wang Jun Liu Zongcai Tu National R&D Center for Freshwater Fish Processing College of Life ScienceCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China

Gut microbiota plays an important role in food *** immunoglobulin G(IgG)/immunoglobulin E(IgE)binding capacity and human gut microbiota changes of digestion products derived from glycated ovalbumin(OVA)were *** digestion effectively destroyed the primary structure of glycated OVA,resulting in a significantly higher digestibility than gastric digestion,and more abundant peptides<3 ***,gastric and gastrointestinal digestion products have different fluorescence quenching and red shift of fluorescence peaks,and possess different conformational *** changes resulted in a decrease in 28.7%of the IgE binding capacity of gastrointestinal digestion products beyond that of ***,gastrointestinal digestion products of glycated OVA increased significantly the proportion of Subdoligranulum,Collinsella,and ***,gastrointestinal digestion products of glycated OVA altered human intestinal microbiota,reducing the risk of potential allergy.

关键词： Ovalbumin Glycation Digestion IgG/IgE binding capacity Gut microbiota

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：