检索结果-内蒙古大学图书馆

SSRN 2023年

作者： Li, Jiasheng Cui, Xuesen Tang, Fenghua Fan, Wei Han, Zhen Wu, Zuli Key and Open Laboratory of Remote Sensing Information Technology in Fishing Resource East China Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Shanghai200090 China College of Fisheries and Life Science Shanghai Ocean University Shanghai201306 China College of Marine Sciences Shanghai Ocean University Shanghai201306 China

In order to further analyze the impact of the marine environment factors in the Northwest Pacific Ocean on the distribution of Chub Mackerel (Scomber Japonicus) resources, a spatio-temporal weighted regression model was constructed based on the marine environmental and fishery data of China's light netting production in the high seas of the Northwest Pacific Ocean. Six environmental factors, including sea surface temperature (SST), chlorophyll a concentration (CHL), eddy kinetic energy (EKE), SST gradient intensity (GSST), meridional SST gradient (xGSST) and zonal SST gradient (yGSST) in spring, summer and autumn were used to analyze the impact of the temporal and spatial environmental factors on Chub Mackerel. The results show that the statistically significant variables (p © 2023, The Authors. All rights reserved.

关键词： Fisheries

Electrochemiluminescent/Colorimetric Biosensors for Ultrasensitive Detection of Aβ Based on CDS Quantum Dot-Modulated Hofs-Cu2+-G-C3n4

学校读者我要写书评

暂无评论

SSRN 2025年

作者： Tang, Yingru Xing, Kangli Wan, Jiayu Wang, Xinhao Li, Yinan Li, Fang Yang, Xiaoyan Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOE Qingdao University of Science and Technology Qingdao266042 China College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao266042 China Analytical & Testing Center Qingdao University of Science and Technology Qingdao266042 China

In this work, we presented an electrochemiluminescent (ECL)/colorimetric biosensors for the ultrasensitive detection of β-amyloid peptide (Aβ) based on hydrogen-bonded organic framework (HOFs)-Cu2+-graphitic carbon nitride (g-C3N4) nanocomposites. HOFs-Cu2+-g-C3N4 could be used both as an ECL luminescent substrate and as a nanozyme to catalyze the chromogenic reaction of 3,3′,5,5′-tetramethylbenzidine (TMB). Specifically, in the ECL mode, HOFs-Cu2+-g-C3N4 were first loaded on the surface of the electrode. The target analyte Aβ could simultaneously bind both Cu2+ and the peptide fragment KLVFF, thereby capturing the CdS quantum dots (QDs)-KLVFF on the electrode. The CdS QDs could perform ECL resonance energy transfer with HOFs-Cu2+-g-C3N4, resulting the increase in the ECL intensity. Meanwhile, in the colorimetric mode, the aptamer loaded on the magnetic beads could specifically capture the target Aβ. HOFs-Cu2+-g-C3N4 used as the nanozyme in the TMB-H2O2 chromogenic system could be sequentially bound with Aβ. The sensitive detection of Aβ was achieved by magnetically separating the functionalized magnetic beads. The concentration range of Aβ detected by ECL mode was 0.1 pM ~ 0.1 μM with a detection limit of 0.07 pM, while the concentration range of Aβ detected by colorimetric assay was 0.1 pM ~ 0.1 μM with a detection limit of 0.032 pM. These two different assay modes enhanced the sensitivity and reliability of the detection of Aβ and demonstrated potential applicability in the early diagnosis of Alzheimer's disease. © 2025, The Authors. All rights reserved.

关键词： Forster resonance energy transfer

TR-SNN: a lightweight spiking neural network based on tensor ring decomposition

学校读者我要写书评

暂无评论

Brain-Apparatus Communication: A Journal of Bacomics 2025年第1期4卷

作者： Shifeng Mao Baoxin Yang Hongze Sun Wuque Cai Daqing Guo The Clinical Hospital of Chengdu Brain Science Institute MOE Key Lab for NeuroInformation China-Cuba Belt and Road Joint Laboratory on Neurotechnology and Brain-Apparatus Communication School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China

AimSpiking neural networks (SNNs), inspired by biological neural mechanisms, have demonstrated remarkable capabilities in various intelligent tasks. However, addressing more complex scenarios often requires larger SNN models with a vast number of parameters, leading to challenges in model training and hardware deployment. To mitigate these issues, researchers have developed various lightweight strategies for compressing SNN model parameters, primarily categorized into pruning, quantization, and distillation. Nevertheless, these methods often involve complex training processes and are prone to significant accuracy *** this work, we propose a novel TR-SNN model that achieves parameter compression using tensor ring decomposition. By expressing weight tensors as a sequence of elementary operations acting on other, TR-SNN models significantly reduce parameter *** experiments demonstrate that TR-SNN models achieve competitive performance compared to other state-of-the-art methods, effectively reducing the number of parameters while maintaining ***, our findings highlight the potential of tensor ring decomposition as a promising approach for developing lightweight SNN models.

关键词： SNN TR decomposition lightweight model neuromorphic CV

Evaluation of suitable reference genes for normalization of quantitative real-time PCR analysis in rice plants under Xanthomonas oryzae ***--infection and melatonin supplementation

学校读者我要写书评

暂无评论

Food Production, Processing and Nutrition 2020年第1期2卷 207-216页

作者： Xian Chen Pedro Laborda Yan Dong Fengquan Liu Institute of Plant Protection Jiangsu Key Laboratory for Food Quality and Safety–State Key Laboratory Cultivation Base of Ministry of Science and TechnologyJiangsu Academy of Agricultural SciencesNanjing 210014PR China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Zhejiang Academy of Agricultural SciencesHangzhou 310021PR China School of Life Sciences Nantong UniversityNantong 226019PR China

Exogenous melatonin(MT)was found to be an interesting tool for enhancing the resistance of rice to ***(Xoo)-caused bacterial blight(BB).However,the accurate comparison of the expression levels across samples was a challenging *** this work,the stability of 10 common used housekeeping genes under Xoo-infection and MT supplementation in rice was analyzed using quantitative real-time PCR(qRT-PCR),and algorithms geNorm,NormFinder and *** results indicated that most reference genes remained stable in Xoo-infected rice plants,while a number of reference genes were affected by MT *** all studied genes,the transcript levels of 18S(18S ribosomal RNA)and UBC(Ubiquitin-conjugating enzyme E2)remained unaltered by Xoo infection,while UBC and UBQ5(Ubiquitin 5)were the most stable genes when examining simultaneous Xoo-infection and MT supplementation,demonstrating that UBC is a suitable reference gene for qRT-PCR data normalization in rice under Xoo-infection and MT supplementation.

关键词： Rice Xanthomonas oryzae pv.oryzae Melatonin qRT-PCR Reference genes

Numerical Study of Falling Droplets in a Vertical Electric Field

学校读者我要写书评

暂无评论

SSRN 2024年

作者： Zhang, Hailong Zhang, Tingting Lu, Yuxin Yang, Qingzhen Xing, Hui Research Center Northwestern Polytechnical University Shaanxi Xi’an710129 China Research & Development Institute Northwestern Polytechnical University in Shenzhen Guangdong Shenzhen518063 China College of Mechanical and Electrical Engineering Shaanxi University of Science and Technology Shaanxi Xi’an710021 China School of Energy and Power Engineering Xi’an Jiaotong University Shaanxi Xi’an710049 China The Key Laboratory of Biomedical Information Engineering Ministry of Education School of Life Science and Technology Xi’an Jiaotong University Shaanxi Xi’an710049 China Xi’an Jiaotong University Shaanxi Xi’an710049 China

It is of fundamental importance to study and understand the behavior of falling droplets. External fields, such as electric and magnetic fields, are considered promising methods for controlling falling droplets, especially at small scales. Although some experimental and theoretical work on falling droplets in an electric field has been conducted, a fully numerical model for electrohydrodynamic falling droplets is still lacking. In this paper, we proposed a phase field numerical model and studied the falling droplets in a vertical electric field. In particular, the influence of the electric field on the velocity and interfacial morphology of the falling droplets was investigated. It was found that the vertical electric field can elongate the droplet in the vertical direction and increase its falling velocity. With a weak or no electric field (the electrical Capillary number CaE © 2024, The Authors. All rights reserved.

关键词： Multiphase flow

Understanding by design: Implementing deep learning from protein structure prediction to protein design

学校读者我要写书评

暂无评论

MedComm - Future Medicine

MedComm - Future Medicine 2022年第2期1卷

作者： Gao, Yuanxu Zhan, Jiangshan Yu, Albert C. H. State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology Macao Center for Biomedicine and Innovations Faculty of Medicine Macau University of Science and Technology Macao School of Basic Medical Sciences Peking University Health Science Center Beijing China Hai Kang Life Corporation Ltd. Hong Kong

Compared to the trRosetta, the application of RoseTTAFold achieved a better performance in guiding functional site-constrained protein design and can directly generate 3D coordinates of a given sequence. [...]it confers valuable references for jointly optimizing both sequence and structure. With the iteration of deep learning methods and the addition of arithmetic power, the protein folding problem has been better solved, especially in the structure prediction of single-strand proteins which could be reliably predicted. [...]current methods for candidate sequence generation in protein design often generate tens of millions of candidate sequences, either by natural product screening, structural motif combination, or random sampling, which consume a lot of arithmetic power and make the research and development period longer.

关键词：

Associations of ambient air pollutants with pregnancy outcomes in women undergoing assisted reproductive technology and the mediating role of ovarian reserve: A longitudinal study in eastern China

学校读者我要写书评

暂无评论

science of the Total Environment 2025年 958卷 177919页

作者： Huang, Kai Hu, Meihong Zhang, Zeling Li, Zhenhua Hu, Chengyang Bai, Shun Li, Ruojie Wu, Li-Min Zhang, Xiu-Jun Xu, Bo Center for Reproduction and Genetics The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China 17 Lujiang Road Hefei230001 China The Second Affiliated Hospital of Anhui Medical University 678 Furong Road Hefei230601 China Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University 81 Meishan Road Hefei230032 China Key Laboratory of Population Health Across Life Cycle Anhui Medical University Ministry of Education of the People's Republic of China 81 Meishan Road Hefei230032 China

Existing evidence has explored the relationship between exposure to air pollutants with ovarian reserve in women receiving assisted reproductive technology (ART). However, few studies have followed up on ART pregnancy outcomes and evaluated how ovarian reserve is involved in the association between air pollutant exposure and specific ART outcomes. We aimed to determine whether air pollutants affect ART outcomes by interfering with ovarian reserve through long-term follow-up. A total of 5354 women who underwent ART treatment and completed antral follicle count (AFC) detection at the First Affiliated Hospital of University of science and technology of China between 2018 and 2020 were involved. Exposure concentrations (0.1° × 0.1°) for three aerodynamic diameters of particulate matter (PM1, PM2.5, PM10) and three oxidized pollutants (NO2, SO2, O3) were assigned to each individual according to the latitude and longitude of the participant's residential address. Multivariate linear mixed effects models (LMMs) were performed to estimate the impacts of exposure to air pollutants during the first 6 months of AFC and longer periods on ovarian reserve capacity and ART pregnancy outcomes. Exposure to PM1 (OR: 0.914, 95%CI: 0.845–0.988), PM2.5 (OR: 0.908, 95%CI: 0.850–0.970), PM10 (OR: 0.924, 95%CI: 0.865–0.987), and SO2 (OR: 0.908, 95%CI: 0.843–0.978) was linked with decreased OR for live birth. In addition, with each IQR increase in PM1, PM2.5, PM10, SO2, and NO2, AFC levels decreased by 0.370, 0.395, 0.064, 0.311, and 0.465, respectively. The mediation effect was more pronounced for NO2 and SO2, with AFCs explaining 26.83 % and 9.54 % of their associations with live birth, respectively. Additionally, 6.49 %, 9.16 %, and 6.79 % of live birth failures were ascribed to PM1, PM2.5, and PM10, respectively. Findings of this study suggest that exposure to air pollutants may affect reproductive outcomes in women receiving ART by reducing their ovarian reserve capacity. © 2024 Elsevi

关键词： Obstetrics

Strategic preparations of DPP-IV inhibitory peptides from Val-Pro-Xaa and Ile-Pro-Xaa peptide mixtures

学校读者我要写书评

暂无评论

Strategic preparations of DPP-IV inhibitory peptides from Va...

2020 AIChE Annual Meeting

作者： Guan, Changge Iwatani, Shun Xing, Xin-Hui Yamamoto, Naoyuki MOE Key Laboratory for Industrial Biocatalysis Department of Chemical Engineering Institute of Biochemical Engineering Tsinghua University Beijing100084 China School of Life Science and Technology Tokyo Institute of Technology Yokohama Kanagawa226-8501 Japan

ISBN: (纸本)9780816911141

Various peptides with inhibitory activity against human dipeptidyl peptidase-IV (hDPP-IV), which degrades glucagon-like peptide 1 (GLP-1) and decreases insulin release, were isolated from synthetic tripeptide mixtures, having sequences Val-Pro-Xaa (VPX) or Ile-Pro-Xaa (IPX). All peptides isolated by reversed-phase high performance liquid chromatography (HPLC) analysis were measured for hDPP-IV inhibitory activity. VPV and VPI prepared from the VPX mixture and IPI isolated from the IPX mixture, showed the highest hDPP-IV inhibitory activity. The dissociation constants for hDPP-IV and IC50 values of the peptides were analyzed to understand the reason for the potent inhibitory activity of these tripeptides. The IC50 and Ki values of VPV, VPI, and IPI were found to be 20.2, 22.2, and 46.7 µM and 10.8, 11.3 and 21.4 M-1, respectively. Further, degradation of the peptides by the proteolytic action of hDPP-IV was analyzed to understand the stability of these peptides. Peptides with lower Ki and IC50 values showed relatively slower degradation when incubated with hDPP-IV. These results suggested that a peptide might have higher hDPP-IV inhibitory activity because of its higher affinity and stronger resistance to hDPP-IV, which is caused by the introduction of a hydrophobic amino acid at the C-terminal end of its VP or IP sequence. © Springer Nature B.V. 2020

关键词： Peptides

Removal of Cationic Dyes by a Novel Carboxylate Sugar Beet Pulp with Maleic Anhydride Assisted by Microwave

学校读者我要写书评

暂无评论

SSRN 2023年

作者： Wang, Ke Gao, Youcheng Jiang, Guili Zhu, Siming College of Food Science and Engineering South China University of Technology Guangzhou510640 China Guangzhou510640 China Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou510641 China College of Life and Geographic Sciences Kashi University Kashi844000 China College of Food Science and Engineering Guangdong Ocean University Yangjiang529500 China

A novel biosorbent (MSBP) was synthesized in this paper by microwave-assisted esterification with maleic anhydride (MA) using sugar beet pulp (SBP) as raw material. Characterization methods such as FTIR, XRD, and TG were used to investigate MSBP's physicochemical properties. Then MSBP was used for the adsorption of methylene blue (MB), and the experimental parameters such as microwave time, microwave power and mixing ratio were optimized. The water retention capacity and antibacterial activity of MSBP were determined. The results showed that the optimum modification conditions were a microwave time of 2 min, microwave power of 1000 W, and a mixing ratio of 15:3 between MA and SBP, under which the cation adsorption capacity of MSBP was 343.35 mg/g. In addition, the esterification reaction allowed MSBP to form a tightly cross-linked structure, resulting in lower water retention capability. At the same time, the modified MSBP also showed antibacterial activity against E. coli and S. aureus. In summary, a simple and efficient monofunctional modification method was used in this study, and a green sugar beet pulp-based biosorbent was successfully prepared. © 2023, The Authors. All rights reserved.

关键词： Adsorption

Computational neuroscience:a frontier of the 21st century

学校读者我要写书评

暂无评论

National science Review 2020年第9期7卷 1418-1422页

作者： Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou Center for Neural Science New York University Center for Neuroscience Key Laboratory of Medical Neurobiology of the Ministry of Health of China School of Medicine Zhejiang University Department of Neuroscience and Department of Mathematics Center for the Neural Basis of Cognition University of Pittsburgh Université Claude Bernard Lyon 1 Inserm Stem Cell and Brain Research Institute U1208 Institute of Neuroscience State Key Laboratory of Neuroscience Chinese Academy of SciencesCAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Center for Brain Science and Brain-Inspired Technology Division of Arts and Sciences and NYU-ECNU Institute of Cognitive Neuroscience NYU Shanghai School of Biomedical Engineering Hainan University Huazhong University of Science and Technology-Suzhou Institute for Brainsmatics Division of Biology and Biological Engineering California Institute of Technology Howard Hughes Medical Institute School of Electronics Engineering and Computer Science IDG/Mc Govern Institute for Brain Research PKU-Tsinghua Center for Life SciencesPeking University College of Computer Science and Technology Zhejiang University Institute of Brain-Intelligence Science and Technology Zhangjiang Lab School of Mathematical Sciences MOE-LSCand Institute of Natural Sciences Shanghai Jiao Tong University

THEORY IN NEUROscience The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors, thoughts,emotions and consciousness. Although comprising only 2%of the total body weigh...

关键词：