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63rd IEEE Conference on Decision and control, CDC 2024

作者： Fang, Xiaozhu Mu, Biqiang Chen, Tianshi The Chinese University of Hong Kong School of Data Science Shenzhen Research Institute of Big Data Shenzhen518172 China Institute of Systems Science Academy of Mathematics and System Science Chinese Academy of Sciences Key Laboratory of Systems and Control of Cas Beijing100190 China

ISBN: (纸本)9798350316339

The identification of continuous-time (CT) systems from discrete-time (DT) input and output signals, i.e., the sampled data, has received considerable attention for half a century. The state-of-the-art methods are parametric methods and thus subject to the typical issues of parametric methods. In the last decade, a major advance in system identification is the so-called kernel-based regularization method (KRM), which is free of the issues of parametric methods. It is interesting to test the potential of KRM on CT system identification. However, very few results have been reported, mainly because the estimators have no closed forms for general CT input signals, except for some very special cases. In this paper, we show for KRM that the estimators have closed forms when the DT input signal has the typical intersample behavior, i.e., zero-order hold or band-limited, and this paves the way for the application of KRM for CT system identification. Numerical Monte Carlo simulations show that the proposed method is more robust than the state-of-the-art methods and more accurate when the sample size is small. © 2024 IEEE.

关键词： Continuous time systems

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A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response

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Neuroscience Bulletin 2024年第3期40卷 310-324页

作者： Man Yuan Sen Jin Gao Tan Siyuan Song Yizong Liu Huadong Wang Yin Shen Eye Center Renmin Hospital of Wuhan UniversityWuhan UniversityWuhan430060China The Brain Cognition and Brain Disease Institute Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNational Medical Products Administration Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhen Key Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhen518055China Jan and Dan Duncan Neurological Research Institute Baylor College of MedicineHouston77030USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Key Laboratory of Magnetic Resonance in Biological SystemsWuhan Center for Magnetic ResonanceInnovation Academy for Precision Measurement Science and TechnologyCASWuhan430071China Frontier Science Center of Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan430071China

Parvalbumin-positive retinal ganglion cells(PV+RGCs)are an essential subset of RGCs found in various ***,their role in transmitting visual information remains ***,we characterized PV+RGCs in the retina and explored the functions of the PV+RGC-mediated visual *** applying multiple viral tracing strategies,we investigated the downstream of PV+RGCs across the whole ***,we found that the PV+RGCs provided direct monosynaptic input to PV+excitatory neurons in the superficial layers of the superior colliculus(SC).Ablation or suppression of SC-projecting PV+RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual ***,using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs,we found that PV+RGCs are predominant glutamatergic ***,our findings indicate the critical role of PV+RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+RGCs to PV+SC neurons that regulates looming visual *** results provide a potential target for intervening and treating diseases related to this circuit,such as schizophrenia and autism.

关键词： Parvalbumin-positive retinal ganglion cell Innate fear Superior colliculus Excitatory-excitatory neuronal connection Looming-evoked defensive response Subcortical pathway

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Global Convergence of Continual Learning on Non-IID Data

arXiv

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arXiv 2025年

作者： Zhu, Fei Liu, Yujing Liu, Wenzhuo Zhang, Zhaoxiang Centre for Artificial Intelligence and Robotics Hong Kong Institute of Science & Innovation CAS Hong Kong Key Laboratory of Systems and Control Academy of Mathematics and Systems Science CAS China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of Automation CAS China School of Artificial Intelligence University of Chinese Academy of Sciences China

Continual learning, which aims to learn multiple tasks sequentially, has gained extensive attention. However, most existing work focuses on empirical studies, and the theoretical aspect remains under-explored. Recently, a few investigations have considered the theory of continual learning only for linear regressions, establishes the results based on the strict independent and identically distributed (i.i.d.) assumption and the persistent excitation on the feature data that may be difficult to verify or guarantee in practice. To overcome this fundamental limitation, in this paper, we provide a general and comprehensive theoretical analysis for continual learning of regression models. By utilizing the stochastic Lyapunov function and martingale estimation techniques, we establish the almost sure convergence results of continual learning under a general data condition for the first time. Additionally, without any excitation condition imposed on the data, the convergence rates for the forgetting and regret metrics are provided. Copyright © 2025, The Authors. All rights reserved.

关键词： Federated learning

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Personalized gait trajectory generation based on anthropometric features using Random Forest

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Journal of Ambient Intelligence and Humanized Computing 2023年第12期14卷 15597-15608页

作者： Ren, Shixin Wang, Weiqun Hou, Zeng-Guang Chen, Badong Liang, Xu Wang, Jiaxing Peng, Liang The State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing100190 China University of Chinese Academy of Sciences Beijing100049 China The CAS Center for Excellence in Brain Science and Intelligence Technology Beijing100190 China Institute of Artificial Intelligence and Robotics Xi’an Jiaotong University Xi’an710049 China

Using lower limb rehabilitation robots (LLRRs) to help stroke patients recover their walking ability is attracting more and more attention presently. Previous studies have shown that gait rehabilitation training with natural gait pattern can improve the therapeutic outputs. However, how to generate the personalized gait trajectory has not been well researched. In this paper, a personalized gait generation method based anthropometric features is proposed. Firstly, gait trajectories are fitted and simplified into Fourier coefficient vectors, which are used to represent gait trajectories. Secondly, fourteen body features are used to generate the personalized gait trajectories and the feature set is further optimized based on the minimal redundancy maximal relevance criterion for easy application on the LLRR. Then, the relationship between the optimized feature set and gait trajectories is modeled by using the RF algorithm. Finally, the performance of the proposed method is demonstrated by several comparison experiments. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

关键词： Trajectories

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A Pilot Study on Coupling Behaviors of Limb Movements and Brain Activation Based on EEG and fNIRS Synchronization Information

A Pilot Study on Coupling Behaviors of Limb Movements and Br...

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2023 IEEE International Conference on Real-Time Computing and Robotics, RCAR 2023

作者： Tang, Xi Li, Qingge Tang, Yao Tian, Lan Zheng, Yue Li, Xiangxin Jiang, Naifu Shang, Peng Li, Guanglin Peng, Liang Fang, Peng Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Cas Key Laboratory of Human-Machine Intelligence-Synergy Systems The Shenzhen Engineering Laboratory of Neural Rehabilitation Technology Shenzhen518055 China University of Chinese Academy of Sciences Shenzhen College of Advanced Technology Shenzhen518055 China Chinese Academy of Sciences State Key Laboratory of Management and Control for Complex Systems Institute of Automation Beijing100190 China

ISBN: (纸本)9798350327182

Motion is one of the basic physiological functions of human beings. However, many brain diseases such as stroke may cause different degrees of motor dysfunctions for patients. As a commonly used rehabilitation method, active and passive exercise training may enhance patients' neuromuscular functions and recover their motor abilities. It is known that limb movements are strongly coupled with brain activation but there is currently insufficient exploration on the coupling behaviors from the perspective of informatics. In this study, the coupling relationship between limb movements and brain activation was preliminarily studied based on three healthy subjects. Electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) signals were synchronously collected during lower limb movements, and time-frequency analysis (TFA) and transfer entropy (TE) analysis were performed to quantitatively study the brain activation behaviors. In the experiments, a desynchronization phenomenon of μ rhythm in EEG was observed during exercise states, and the experimental results demonstrate the activation rule of motor and prefrontal cortexes upon limb movements. Calculations show that there exists a bidirectional flow of information between EEG and cerebral oxygen metabolism signals, but with a difference between different directions. This work may support the rehabilitation for patients with motor dysfunctions with a guidance of quantitative indicators and also benefit the exploration on neuroscience. © 2023 IEEE.

关键词： Electroencephalography

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A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1,BA.2,BA.2.12.1,BA.4,and BA.5

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Signal Transduction and Targeted Therapy 2025年第2期10卷 926-933页

作者： Zhe Chen Leilei Feng Lei Wang Li Zhang Binyang Zheng Hua Fu Fengdi Li Ligai Liu Qi Lv Ran Deng YanLi Xu Yongfeng Hu Jianhua Zheng Chuan Qin Linlin Bao Xiangxi Wang Qi Jin NHC Key Laboratory of Systems Biology of Pathogens State Key Laboratory of Respiratory Health and MultimorbidityNational Institute of Pathogen Biologyand Center for Tuberculosis ResearchChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Vaccine Clinical Evaluation Jiangsu Provincial Center for Disease Prevention and Control172 Jiangsu RoadGulou QuNanjing 210009China Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences(CAMS)and Comparative Medicine CenterPeking Union Medical Collage(PUMC)Key Laboratory of Human Disease Comparative MedicineMinistry of HealthBeijingChina Beijing Ditan Hospital Capital Medical UniversityBeijing 100015PR China Chronic Disease Management Center Beijing Ditan HospitalCapital Medical UniversityBeijing 100015PR China

The global spread of Severe Acute Respiratory Syndrome Coronavirus 2.(SARS-CoV-2)and its variant strains,including Alpha,Beta,Gamma,Delta,and now Omicron,pose a significant *** the constant evolution of the virus,Omicron and its subtypes BA.1,BA.2,BA.3,BA.4,and BA.5 have developed the capacity to evade neutralization induced by previous vaccination or *** evasion highlights the urgency in discovering new monoclonal antibodies(mAbs)with neutralizing activity,especially broadly neutralizing antibodies(bnAbs),to combat the *** the current study,we introduced a fully human neutralizing mAb,CR9,that targets Omicron *** demonstrated the mAb’s effectiveness in inhibiting Omicron replication both in vitro and in *** analysis using cryo-electron microscopy(cryo-EM)revealed that CR9 binds to an epitope formed by RBD residues,providing a molecular understanding of its neutralization *** its potency and specificity,CR9 holds promise as a potential adjunct therapy for treating Omicron *** findings highlight the importance of continuous mAb discovery and characterization in addressing the evolving threat of COVID-19.

关键词： monoclonal antibodies mabs severe acute respiratory syndrome coronavirus Omicron SARS CoV BA broadly neutralizin

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A Preliminary Study on the Functional Coupling between Nerve and Blood Microcirculation for Applications in Rehabilitation Robots

A Preliminary Study on the Functional Coupling between Nerve...

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2023 IEEE International Conference on Robotics and Biomimetics, ROBIO 2023

作者： Li, Qingge Dong, Yuanzhe Zhang, Yuxiang Wang, Xin Jiang, Naifu Huang, Jianping Cui, Han Tian, Lan Zheng, Yue Li, Xiangxin Wang, Lin Li, Guanglin Liang, Wenyuan Peng, Liang Fang, Peng Shenzhen Institute of Advanced Technology Cas Key Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen518055 China University of Chinese Academy of Sciences Shenzhen College of Advanced Technology Shenzhen518055 China National Research Center for Rehabilitation Technical Aids Beijing100176 China Chinese Academy of Sciences State Key Laboratory of Management and Control for Complex Systems Institute of Automation Beijing100190 China

ISBN: (纸本)9798350325706

Rehabilitation robots play an important role in the motor function rehabilitation for stroke survivors with hemiplegia. However, the rehabilitation effect of current robots is still limited partly because a single training of motor function can be strongly affected by the decreased blood supply function of the bedridden patients. This work proposed an approach to study the coupling relationship between the motor and blood supply functions by combining the synchronously recorded EEG and cerebral blood oxygen information, where the cerebrations in different movement paradigms were analyzed from an aspect of "functional coupling". The results show that the information of oxyhemoglobin concentration change (ΔHbO) can effectively indicate the cortex activation, and a stronger blood supply is needed in cortexes to perform body movements. The correlations within motor cortexes are significantly stronger than the ones between motor and prefrontal cortexes, and a higher resistance level of extremity training will cause stronger correlations. Calculation of transfer entropy (TE) shows that there exists a bidirectional information transmission between the electrophysiological and blood supply signals, and more information is transmitted always in the direction from ΔHbO to EEG than in the opposite direction. The information transmission or the coupling relationship can be significantly enhanced by extremity movements, and large TE values are achieved in the Theta, Beta and Gamma frequency bands of EEG that correspond to motor functions. This work has demonstrated the functional coupling between nerve and blood microcirculation, which would provide a technical guidance to improve the rehabilitation effect for current robot systems and have great application potentials. © 2023 IEEE.

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Ser68 phosphoregulation is essential for CENP-A deposition,centromere function and viability in mice

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Science China(Life Sciences) 2022年第9期65卷 1881-1889页

作者： Yuting Liu Kehui Wang Li Huang Jicheng Zhao Xinpeng Chen Qiang Wu Zhouliang Yu Guohong Li National Laboratory of Bio-macromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Disease Control and Prevention of PLA Beijing 100071China College of Life Sciences Hubei Normal UniversityHuangshi 435002China Center for Comparative Biomedicine Key Laboratory of Systems Biomedicine(Ministry of Education)Institute of Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China

Centromere identity is defined by nucleosomes containing CENP-A,a histone H3 *** deposition of CENP-A at centromeres is tightly regulated in a cell-cycle-dependent *** previously reported that the spatiotemporal control of centromeric CENP-A incorporation is mediated by the phosphorylation of CENP-A ***,a recent report argued that Ser68 phosphoregulation is dispensable for accurate CENP-A ***,we report that the substitution of Ser68 of endogenous CENP-A with either Gln68 or Glu68 severely impairs CENP-A deposition and cell *** also find that mice harboring the corresponding mutations are ***,these results indicate that the dynamic phosphorylation of Ser68 ensures cell-cycle-dependent CENP-A deposition and cell viability.

关键词： centromere CENP-A cell cycle mitosis phosphorylation chromosome segregation

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Recent developments of the reconstruction in magnetic particle imaging

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 290-302页

作者： Lin Yin Wei Li Yang Du Kun Wang Zhenyu Liu Hui Hui Jie Tian CAS Key Laboratory of Molecular Imaging the State Key Laboratory of Management and Control for Complex SystemsInstitute of AutomationChinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Molecular Imaging Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Medical Imaging Center the First Affiliated HospitalJinan UniversityGuangdong 510632China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of MedicineBeihang UniversityBeijing 100083China

Magnetic particle imaging(MPI)is an emerging molecular imaging technique with high sensitivity and temporal-spatial *** reconstruction is an important research topic in MPI,which converts an induced voltage signal into the image of superparamagnetic iron oxide particles concentration *** reconstruction primarily involves system matrix-and x-space-based *** this review,we provide a detailed overview of the research status and future research trends of these two *** addition,we review the application of deep learning methods in MPI reconstruction and the current open sources of ***,research opinions on MPI reconstruction are *** hope this review promotes the use of MPI in clinical applications.

关键词： Magnetic particle imaging Image reconstruction System matrix X-space

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A Game Approach for Defending System Security from an Attacker

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IFAC-PapersOnLine 2023年第2期56卷 1710-1715页

作者： Yueyue Xu Xiaoming Hu Zhixin Liu Han Zhang Lin Wang Department of Automation Shanghai Jiao Tong University Shanghai 200240 China KTH Royal Institute of Technology Stockholm 10044 Sweden Key Laboratory of Systems and Control Academy of Mathematics and Systems Science CAS Beijing 100190 China

In this paper, a system security problem is studied based on a two-person non-cooperative dynamic game. Security of the system is regarded in the context of observability. Namely a system is secure if it is not observable. Both the defender and attacker are assumed to have means to modify the dimension of unobservable subspace, which is set as the value function. The strategies and algorithms to minimize or maximize the value function are given respectively. Finally, examples are provided to demonstrate the effectiveness of the proposed algorithms and show some interesting game results, including accumulation mode, loop mode and locked mode.

关键词： Linear systems dynamic game unobservable subspace relative degree V∗ space

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