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Activatable NIR-II Photothermal Lipid Nanoparticles for Improved Messenger RNA Delivery

Angewandte Chemie 2023年第25期135卷

作者： Dr. Benhao Li Dr. Mengyao Zhao Weiping Lai Dr. Xuanbo Zhang Bowei Yang Prof. Xiaoyuan Chen Prof. Qianqian Ni Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore Nanomedicine Translational Research Program NUS Centre for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore Contribution: Investigation (lead) Writing - original draft (lead) Contribution: Investigation (supporting) Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers and iChem Shanghai Key Laboratory of Molecular Catalysis and Innovative Material Fudan University Shanghai 200433 China Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) Singapore 138673 Singapore Contribution: Funding acquisition (equal) Supervision (equal) Writing - review & editing (equal)

Endosomal escape remains a central issue limiting the high protein expression of mRNA therapeutics. Here, we present second near-infrared (NIR-II) lipid nanoparticles (LNPs) containing pH activatable NIR-II dye conjugated lipid (Cy-lipid) for potentiating mRNA delivery efficiency via a s timulus-responsive p hotothermal-promoted e ndosomal e scape d elivery (SPEED) strategy. In acidic endosomal microenvironment, Cy-lipid is protonated and turns on NIR-II absorption for light-to-heat transduction mediated by 1064 nm laser irradiation. Then, the heat-promoted LNPs morphology change triggers rapid escape of NIR-II LNPs from the endosome, allowing about 3-fold enhancement of enhanced green fluorescent protein (eGFP) encoding mRNA translation capacity compared to the NIR-II light free group. In addition, the bioluminescence intensity induced by delivered luciferase encoding mRNA in the mouse liver region shows positive correlation with incremental radiation dose, indicating the validity of the SPEED strategy.

关键词： Endosomal Escape Lipid Nanoparticle Photothermal Effect Second Near-Infrared Window

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Dynamic compressed sensing for real-Time tomographic reconstruction

arXiv

引用

arXiv 2020年

作者： Schwartz, Jonathan Zheng, Huihuo Hanwell, Marcus Jiang, Yi Hovden, Robert Department of Material Science and Engineering Ann ArborUniversity of Michigan MichiganMI United States Argonne Leadership Computing Facility Argonne National Laboratory LemontIL United States Kitware Inc Clifton ParkNY United States Advanced Photon Source Facility Argonne National Laboratory LemontIL United States Applied Physics Program University of Michigan Ann ArborMI United States

Electron tomography has achieved higher resolution and quality at reduced doses with recent advances in compressed sensing. Compressed sensing (CS) theory exploits the inherent sparse signal structure to effciently reconstruct three-dimensional (3D) volumes at the nanoscale from un-dersampled measurements. However, the process bottlenecks 3D reconstruction with computation times that run from hours to days. Here we demonstrate a framework for dynamic compressed sens-ing that produces a 3D specimen structure that updates in real-Time as new specimen projections are collected. Researchers can begin interpreting 3D specimens as data is collected to facilitate high-throughput and interactive analysis. Using scanning transmission electron microscopy (STEM), we show that dynamic compressed sensing accelerates the convergence speed by 3-fold while also re-ducing its error by 27% for a Au/SrTiO3 nanoparticle specimen. Before a tomography experiment is completed, the 3D tomogram has interpretable structure within 33% of completion and fine details are visible as early as 66%. Upon completion of an experiment, a high-fidelity 3D visualization is produced without further delay. Additionally, reconstruction parameters that tune data delity can be manipulated throughout the computation without rerunning the entire process. Copyright © 2020, The Authors. All rights reserved.

关键词： Compressed sensing

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An effect of humid climate on micro structure and chemical component of natural composite (Boehmeria nivea-Albizia falcata) based wind turbine blade 2

An effect of humid climate on micro structure and chemical c...

引用

2nd International Conference on Energy, Environmental and Information System, ICENIS 2017

作者： Sudarsono, S. Purwanto, P. Sudarsono, Johny W. Department of Mechanical Engineering Institut Sains Dan Teknoogi AKPRIND Yogyakarta Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Diponegoro Indonesia Doctoral Program of Environmental Science School of Postgraduate Studies Universitas Diponogero Semarang Indonesia Depart. of Material and Metallurgy Faculty of Engineering Universitas Indonesia Jakarta Indonesia

In this work, wind turbine blade NACA 4415 is fabricated from natural composite of Boehmeria nivea and Albizia falcate. The composite fabrication method used is hand lay up method. The aim of the work is to investigate an effect of humid climate of coastal area on micro structure and chemical composition of composite material of the blade. The wind turbine is tested at Pantai Baru, Bantul, Yogyakarta for 5.5 months. The micro structure scanning is performed with Scanning Electron Microscope (SEM) and material component is measured with Energy Dispersive X-ray spectrometer (EDS). The samples are tested before and after the use within 5.5 month at the location. The results show that composite material inexperienced interface degradation and insignificant change of micro structure. From EDS test, it is observed that Na filtration reduces C and increases O in composite material after 5.5 months. © 2018 The Authors, published by EDP sciences.

关键词： Microstructure

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Magnetic Control of Soft Chiral Phonons in PbTe

arXiv

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arXiv 2021年

作者： Baydin, Andrey Hernandez, Felix G.G. Rodriguez-Vega, Martin Okazaki, Anderson K. Tay, Fuyang Timothy Noe, G. Katayama, Ikufumi Takeda, Jun Nojiri, Hiroyuki Rappl, Paulo H.O. Abramof, Eduardo Fiete, Gregory A. Kono, Junichiro Department of Electrical and Computer Engineering Rice University HoustonTX77005 United States Smalley-Curl Institute Rice University HoustonTX77005 United States Instituto de Física Universidade de São Paulo SP São Paulo05508-090 Brazil Theoretical Division Los Alamos National Laboratory Los AlamosNM87545 United States Laboratório Associado de Sensores e Materiais Instituto Nacional de Pesquisas Espaciais SP São José dos Campos12201-970 Brazil Applied Physics Graduate Program Smalley-Curl Institute Rice University HoustonTX77005 United States Department of Physics Graduate School of Engineering Science Yokohama National University Yokohama240-8501 Japan Institute for Materials Research Tohoku University Sendai980-8577 Japan Department of Physics Northeastern University BostonMA02115 United States Department of Physics Massachusetts Institute of Technology CambridgeMA02139 United States Department of Physics and Astronomy Rice University HoustonTX77005 United States Department of Material Science and NanoEngineering Rice University HoustonTX77005 United States

PbTe crystals have a soft transverse optical phonon mode in the terahertz frequency range, which is known to efficiently decay into heat-carrying acoustic phonons, resulting in anomalously low thermal conductivity. Here, we studied this phonon via polarization-dependent terahertz spectroscopy. We observed softening of this mode with decreasing temperature, indicative of incipient ferroelectricity, which we explain through a model including strong anharmonicity with a quartic displacement term. In magnetic fields up to 25 T, the phonon mode splits into two modes with opposite handedness, exhibiting circular dichroism. Their frequencies display Zeeman splitting together with an overall diamagnetic shift with increasing magnetic field. Using a group-theoretical approach, we demonstrate that these observations are the result of magnetic field-induced morphic changes in the crystal symmetries through the Lorentz force exerted on the lattice ions. Thus, our study reveals a novel process of controlling phonon properties in a soft ionic lattice by a strong magnetic field. Copyright © 2021, The Authors. All rights reserved.

关键词： Magnetic fields

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Nonlinear Supramolecular Polymers for Therapeutic Applications (vol 2, 1800103, 2019)

引用

ADVANCED THERAPEUTICS 2019年第5期2卷

作者： Chen, Wenzhuo Kretzschmann, Annika Tian, Wei Wu, Si MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions Shanxi Key Laboratory of Macromolecular Science and Technology School of Science Northwestern Polytechnical University Xi'an 710072 P. R. China Max Planck Institute for Polymer Research Ackermannweg 10 55128 Mainz Germany Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Soft Matter Chemistry Anhui Key Laboratory of Optoelectronic Science and Technology Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026 China

An elegant combination of supramolecular polymers exhibiting nonlinear topological structures results in a series of brand new, nonlinear supramolecular polymers. Recently, these polymers have attracted increased attention in various fields due to their diverse and advantageous properties. Especially in therapeutic applications, one can take advantage of their unique chemical, physical, and biological properties such as degradability and stimuli-responsiveness. Due to the large number of possible module modifications, such polymers have great potential as platforms in disease treatments. In this review, the structures, properties, and functions of different nonlinear supramolecular polymers are summarized. Current therapeutic applications are presented and the prospective design trends are discussed for promoting the development of nonlinear supramolecular polymers.

关键词： drug delivery nanomedicine polymers supramolecules therapeutics

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Low resistivity and high breakdown current density of 10-nm diameter van der waals tase3nanowires by chemical vapor deposition

arXiv

引用

arXiv 2019年

作者： Empante, Thomas A. Martinez, Aimee Wurch, Michelle Zhu, Yanbing Geremew, Adane K. Yamaguchi, Koichi Isarraraz, Miguel Rumyantsev, Sergey Reed, Evan J. Balandin, Alexander A. Bartels, Ludwig Department of Chemistry and Material Science & Engineering Program University of California - Riverside RiversideCA92521 United States Department of Materials Science and Engineering Stanford University StanfordCA94304 United States Nano-Device Laboratory Department of Electrical and Computer Engineering University of California RiversideCA92521 United States Center for Terahertz Research and Applications Institute of High Pressure Physics Polish Academy of Sciences Warsaw01-142 Poland

Micron-scale single-crystal nanowires of metallic TaSe3, a material that forms -Ta-Se3-TaSe3- stacks separated from one another by a tubular van der Waals (vdW) gap, have been synthesized using chemical vapor deposition (CVD) on a SiO2/Si substrate, in a process compatible with semiconductor industry requirements. Their electrical resistivity was found unaffected by downscaling from the bulk to as little as 7 nm in width and height, in striking contrast to the resistivity of copper for the same dimensions. While the bulk resistivity of TaSe3is substantially higher than that of bulk copper, at the nanometer scale the TaSe3wires become competitive to similar-sized copper ones. Moreover, we find that the vdW TaSe3nanowires sustain current densities in excess of 108A/cm2and feature an electromigration energy barrier twice that of copper. The results highlight the promise of quasi-onedimensional transition metal trichalcogenides for electronic interconnect applications and the potential of van der Waals materials for downscaled electronics. Copyright © 2019, The Authors. All rights reserved.

关键词： Van der Waals forces

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Erratum “15.9% organic tandem solar cell with extended near-infrared absorption” [Appl. Phys. Lett. 116, 153501 (2020)]

引用

Applied Physics Letters 2021年第21期118卷

作者： Xinjing Huang Bangjin Sun Yongxi Li Chao Jiang Dejiu Fan Jian Fan Stephen R. Forrest 1Applied Physics Program University of Michigan Ann Arbor Michigan 48109 USA 2Institute of Functional Nano and Soft Materials Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University Suzhou Jiangsu 215123 China 3Department of Electrical Engineering and Computer Science University of Michigan Ann Arbor Michigan 48109 USA 4Department of Physics and Material Science and Engineering University of Michigan Ann Arbor Michigan 48109 USA

The authors regret that a related article was not cited in the original published article.1 In the first paragraph, the sentence “We introduce a surface treatme

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Cover Feature: Light-Responsive Oligothiophenes Incorporating Photochromic Torsional Switches (Chem. Eur. J. 65/2022)

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Chemistry – A European Journal 2022年第65期28卷

作者： Dr. Augustina Jozeliūnaitė Dr. Aiman Rahmanudin Dr. Saulius Gražulis Emilie Baudat Prof. Kevin Sivula Dr. Daniele Fazzi Prof. Edvinas Orentas Dr. Giuseppe Sforazzini Laboratory of Macromolecular and Organic Materials Institute of Material Science and Engineering Ecole Polytechnique Federale de Lausanne (EPFL) 1015 Lausanne Switzerland Department of Organic Chemistry Faculty of Chemistry and Geosciences Vilnius University Naugarduko 24 LT-0325 Vilnius Lithuania Laboratory for Molecular Engineering of Optoelectronic Nanomaterials Institute of Chemical Sciences and Engineering Ecole Polytechnique Federale de Lausanne (EPFL) 1015 Lausanne Switzerland Vilnius University Institute of Biotechnology Saulėtekio al. 7 LT-10257 Vilnius Lithuania Institute of Chemical Sciences and Engineering Ecole Polytechnique Federale de Lausanne (EPFL) 1015 Lausanne Switzerland Dipartimento di Chimica “Giacomo Ciamician” Università di Bologna Via F. Selmi 2 40126 Bologna Italy Present address: Department of Chemical and Geological Sciences University degli Studi di Cagliari SS 554 bivio per Sestu 09042 Monserrato Cagliari Italy

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Computational modeling of the Ce@C82 metallofullerene isomeric composition

引用

ECS Journal of Solid State science and Technology 2019年第12期8卷 M118-M121页

作者： Slanina, Zdeněk Uhlík, Filip Akasaka, Takeshi Lu, Xing Adamowicz, Ludwik State Key Laboratory of Materials Processing and Die and Mould Technology School of Material Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China Department of Physical and Macromolecular Chemistry Faculty of Science Charles University Praha 2 128 43 Czech Republic Department of Chemistry and Biochemistry University of Arizona Tucson 85721-0041 AZ United States

Relative populations of the IPR (isolated-pentagon-rule) isomers ofCe@C82 under the high-temperature synthetic conditions are computed using the Gibbs energy based on characteristics from the density functional theory calculations (B3LYP/3-21G∼SDD entropy term, B2PLYPD/6-31G*∼SDD energetics). In agreement with observation, Ce@C2v (9)-C82 (major isomer) and Ce@Cs (c;6)-C82 (minor isomer) endohedrals are the most populated species. Their observed ratio is in the computational modeling reached at a temperature of about 1225 K (under a presumption of the same solubility of the isomers). © The Author(s) 2019.

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OPTIMADE, an API for exchanging materials data

arXiv

引用

arXiv 2021年

作者： Andersen, Casper W. Armiento, Rickard Blokhin, Evgeny Conduit, Gareth J. Dwaraknath, Shyam Evans, Matthew L. Fekete, Ádám Gopakumar, Abhijith Gražulis, Saulius Merkys, Andrius Mohamed, Fawzi Oses, Corey Pizzi, Giovanni Rignanese, Gian-Marco Scheidgen, Markus Talirz, Leopold Toher, Cormac Winston, Donald Aversa, Rossella Choudhary, Kamal Colinet, Pauline Curtarolo, Stefano Di Stefano, Davide Draxl, Claudia Er, Suleyman Esters, Marco Fornari, Marco Giantomassi, Matteo Govoni, Marco Hautier, Geoffroy Hegde, Vinay Horton, Matthew K. Huck, Patrick Huhs, Georg Hummelshøj, Jens Kariryaa, Ankit Kozinsky, Boris Kumbhar, Snehal Liu, Mohan Marzari, Nicola Morris, Andrew J. Mostofi, Arash A. Persson, Kristin A. Petretto, Guido Purcell, Thomas Ricci, Francesco Rose, Frisco Scheffler, Matthias Speckhard, Daniel Uhrin, Martin Vaitkus, Antanas Villars, Pierre Waroquiers, David Wolverton, Chris Wu, Michael Yang, Xiaoyu École Polytechnique Fédérale de Lausanne Lausanne1015 Switzerland Materials Design and Informatics Unit Department of Physics Chemistry and Biology Linköping University Sweden Tilde Materials Informatics Straßmannstraße 25 Berlin10249 Germany Materials Platform for Data Science Sepapaja 6 Tallinn15551 Estonia Theory of Condensed Matter Group Cavendish Laboratory 19 J.J. Thomson Avenue CambridgeCB3 0HE United Kingdom Lawrence Berkeley Labs BerkeleyCA United States Chemin des Étoiles 8 Louvain-la-Neuve1348 Belgium Department of Physics King's College London London United Kingdom Department of Materials Science and Engineering Northwestern University EvanstonIL60208 United States Institute of Biotechnology Life Science Center Vilnius University Saulétekio av. 7 VilniusLT-10257 Lithuania Institute of Computer Science Faculty of Mathematics and Informatics Vilnius University Naugarduko g. 24 VilniusLT-03225 Lithuania Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6 Berlin14195 Germany Center for Autonomous Materials Design Duke University DurhamNC27708 United States Department of Mechanical Engineering and Materials Science Duke University DurhamNC27708 United States Humboldt-Universität zu Berlin Institut für Physik and IRIS Adlershof Berlin12489 Germany École Polytechnique Fédérale de Lausanne Sion1951 Switzerland Trieste34136 Italy Hermann-von-Helmholtz-Platz 1 Eggenstein-Leopoldshafen76344 Germany Materials Measurement Laboratory National Institute of Standards and Technology GaithersburgMD20899 United States Ansys 300 Rustat House 62 Clifton Rd CambridgeCB1 7EG United Kingdom De Zaale 20 Eindhoven5612 AJ Netherlands Department of Physics and Science of Advanced Materials Program Central Michigan University Mount PleasantMI48859 United States Argonne National Laboratory LemontIL60439 United States Thayer School of Engineering Dartmouth College HanoverNH03755 United States Los AltosCA940

The Open Databases Integration for materials Design (OPTIMADE) consortium has designed a universal application programming interface (API) to make materials databases accessible and interoperable. We outline the first stable release of the specification, v1.0, which is already supported by many leading databases and several software packages. We illustrate the advantages of the OPTIMADE API through worked examples on each of the public materials databases that support the full API specification. © 2021, CC BY.

关键词： Specifications

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