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Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase

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中国药理学报（英文版） 2022年第2期43卷 470-482页

作者： Wen Li Li-ping Liao Ning Song Yan-jun Liu Yi-luan Ding Yuan-yuan Zhang Xiao-ru Zhou Zhong-ya Sun Sen-hao Xiao Hong-bo Wang Jing Lu Nai-xia Zhang Hua-liang Jiang Kai-xian Chen Chuan-peng Liu Jie Zheng Ke-hao Zhao Cheng Luo School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China Center of Immunological Diseases Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Department of Gastroenterology Xinhua HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 201210China Department of Analytical Chemistry Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Life Science and Technology Harbin Institute of TechnologyHarbin 200092China Drug Discovery and Design Center the Center for Chemical BiologyState Key Laboratory of Drug ResearchSha

Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer cell glucose metabolism and plays a crucial role in the activation of various types of immune *** 3-phosphate dehydrogenase(GAPDH)catalyzes the conversion of D-glyceraldehyde 3-phosphate to D-glycerate 1,3-bisphosphate in the 6th critical step in *** exerts metabolic flux control during aerobic glycolysis and therefore is an attractive therapeutic target for cancer and autoimmune ***,GAPDH inhibitors were reported to function through common suicide inactivation by covalent binding to the cysteine catalytic residue of ***,by developing a high-throughput enzymatic screening assay,we discovered that the natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose(PGG)is an inhibitor of GAPDH with Ki=0.5 μ*** blocks GAPDH activity by a reversible and NAD+and Pi competitive mechanism,suggesting that it represents a novel class of GAPDH ***-depth hydrogen deuterium exchange mass spectrometry(HDX-MS)analysis revealed that PGG binds to a region that disrupts NAD+and inorganic phosphate binding,resulting in a distal conformational change at the GAPDH tetramer *** addition,structural modeling analysis indicated that PGG probably reversibly binds to the center pocket of ***,PGG inhibits LPS-stimulated macrophage activation by specific downregulation of GAPDH-dependent glucose consumption and lactate *** summary,PGG represents a novel class of GAPDH inhibitors that probably reversibly binds to the center pocket of *** study sheds new light on factors for designing a more potent and specific inhibitor of GAPDH for future therapeutic applications.

关键词： glyceraldehyde 3-phosphate dehydrogenase 1 2 3 4 6-penta-O-galloyl-β-D-glucopyranose hydrogen deuterium exchange mass spectrometry reversible inhibitor glycolysis

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Safe RL-based Adaptive Cooperative Game Control of Wing Deformation and Flight State Tracking for Morphing Hypersonic Vehicles

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IEEE Transactions on Aerospace and Electronic systems 2025年

作者： Wang, Jun-Wei Wang, Feng Wu, Huai-Ning Liu, Zhou-Yang University of Science and Technology Beijing School of Intelligence Science and Technology Beijing100083 China Beihang University School of Automation Science and Electrical Engineering Beijing100191 China Beihang University Hangzhou International Innovation Institute Hangzhou311115 China National Key Laboratory of Complex System Control and Intelligent Agent Cooperation Beijing100074 China

This study addresses the issue of adaptive cooperative game control (ACGC) design for wing deformation and flight state tracking of morphing hypersonic vehicles (MHVs) with variable wing shapes, input constraints and state constraints. To access a better flight control performance, the wing deformation parameter is extended in this work as an auxiliary control input. An oriented-coordinated-control nonlinear differential equation model is first established to describe the complicated longitudinal flight state tracking error dynamics of the MHV. Then, a control barrier function (CBF) is introduced and incorporated into the value function as a risk penalty term of state security constraint. Based on the differential game (DG) theory, the optimal coordinated control problem for the MHV with input constraints and state constraints is treated as a constrained cooperative DG that is further formulated as a Hamilton-Jacobi-Bellman (HJB) equation with barrier and hyperbolic functions. A safe RL algorithm is proposed to solve the above HJB equation and an online Pareto joint control strategy is achieved thereby. Hereafter the stability analysis of the closed-loop state tracking error system is done by the Lyapunov technique. Meanwhile, both state and input constraints are met during the the parameter learning regulation process. At last, a simulation study is performed to support the proposed safe RL-ACGC algorithm. © 2025 IEEE.

关键词： Hyperbolic functions

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Chemical Speciation Distribution and Thermal Stability of Heavy Metals Along Flue Gas Cleaning systems in a Hazardous Waste Incinerator

SSRN

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SSRN 2022年

作者： Li, Wenhan Ma, Zengyi Deng, Lilin Huang, Qianming Zhai, Zian Huang, Bochen Liu, Ting Wang, Shuang Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu610213 China State Key Laboratory of Clean Energy Utilization Institute for Thermal Power Engineering Zhejiang University Hangzhou310027 China

In this study, chemical speciation distribution and thermal stability of heavy metals (As, Cd, Cr, Cu, Pb, Se, Zn, and Hg) along flue gas cleaning systems were investigated in a hazardous waste incinerator located in Zhejiang, China. The chemical speciation and thermal stability of heavy metals, environmental risk evaluation, and morphological and mineralogical characteristics of incineration residues were assessed before and after heat treatments at different temperatures. The results showed that As and Cr in the raw incineration residues mainly fractionated as the residual form with the proportion of over 48.9% and 74.5%, respectively, whereas most of Se was associated with the oxidizable and residual fraction. The chemical speciation of Cu and Pb in bag filter ashes was related to the chlorine content in the waste, and high chlorine availability favored the formation of acid soluble Cu and Pb. The residual fraction of Hg (over 68.0%) was the most dominant in bag filter ashes, which might exist in the form of HgS. During heat treatments at different temperatures, the vaporization of heavy metals increased with increasing temperature. As, Cr and Se showed high thermal stability due to the fact that As, Cr and Se were involved in the crystallization reaction, and heat treatment would promote the transformation from the mobile fractions into residual fraction. Hg and Cd displayed the worst thermal stability, and high temperature heat treatment would contribute to secondary volatilization from the incineration residues. Cu, Pb and Zn had moderate thermal stability, and heat treatment would cause the volatilization of the mobile fractions or transformation from the mobile fractions into residual fraction. With the increase of heat treatment temperature, the environmental risk of incineration residues displayed a decreasing trend and reached the medium risk level or below after heat treatment at 1200 °C without any additives or pretreatments. © 2022, The Authors. All ri

关键词： Heavy metals

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Using Lock-Free design for Throughput-Optimized Cache Eviction 25

Using Lock-Free Design for Throughput-Optimized Cache Evicti...

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Abstracts of the 2025 ACM SIGMETRICS International Conference on Measurement and Modeling of Computer systems

作者： Chao Dong Fang Wang Hong Jiang Dan Feng Key Laboratory of Information Storage System (Wuhan National Laboratory for Optoelectronics) Engineering Research Center of data storage systems and Technology (School of Computer Science and Technology) Ministry of Education of China Huazhong University of Science and Techonolgy Wuhan Hubei China Department of Computer Science and Engineering University of Texas at Arlington Arlington Texas USA

ISBN: (纸本)9798400715938

This paper presents a practical approach to cache eviction algorithm design, called Mobius, that optimizes the concurrent throughput of caches and reduces cache operation latency by utilizing lock-free data structures, while maintaining high cache hit ratios. Mobius includes two key designs. First, Mobius employs two lock-free FIFO queues to manage cache items, ensuring that all cache operations are executed efficiently in concurrency. Second, Mobius integrates a consecutive detection mechanism that merges multiple modifications during eviction into a single operation, thereby reducing data races. The implementation of Mobius in CacheLib and RocksDB highlights its high concurrency in both synthetic and real-world workloads.

关键词： cache eviction policy

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Generic approach for integrating ferroelectricity and superconductivity into a single two-dimensional monolayer

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Physical Review B 2025年第9期111卷 094516-094516页

作者： Jianyong Chen Wen-Yi Tong Ping Cui Zhenyu Zhang Institute of Quantum Materials and Physics Henan Academy of Sciences Zhengzhou 450046 China International Center for Quantum Design of Functional Materials (ICQD) Hefei National Research Center for Physical Sciences at Microscale University of Science and Technology of China Hefei Anhui 230026 China Key Laboratory of Polar Materials and Devices (MOE) and Department of Electronics East China Normal University Shanghai 200241 China Hefei National Laboratory University of Science and Technology of China Hefei 230088 China

The coexistence of ferroelectricity and superconductivity is a forefront research topic in condensed matter physics, and achieving this coexistence in a single-phase material is particularly challenging, as the former is typically restricted to insulators while the latter demands metallicity. Here, we show that coexistence of robust ferroelectricity and superconductivity can be realized by properly hole doping a fertile ferroelectric insulator that possesses antibonding states as its highest valence bands. Using a prototypical two-dimensional ferroelectric insulating SnS monolayer as an example, we demonstrate that a moderate level of hole doping (∼0.30 hole per formula unit) not only effectively converts the system into a metal, but counterintuitively also enhances its ferroelectricity rather than weakens or even completely destroys the ferroelectricity as commonly encountered. The underlying physical origin is traced to the shifting of the Fermi level into the occupied antibonding bands, which renders the system metallicity and simultaneously also strengthens the in-plane bonding nature associated with polar displacement. We further show that the resultant ferroelectric metal can harbor superconductivity with a pronounced superconducting transition temperature of ∼7 K, due to the emergence of strong Fermi-surface nesting upon hole doping and softening of the out-of-plane acoustic phonon mode that couples effectively with the itinerant electrons. These findings provide a generic approach for achieving ferroelectric superconductivity with appealing device potentials.

关键词： Ferroelectricity

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Experimental Study on Surface Characteristics and Thermal Conductivity of New Zirconium Alloy with Oxide Layer

SSRN

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SSRN 2022年

作者： Zhong, Lei Chen, Deqi Yu, Hongxing Liu, Haidong Chen, Mingjing Liu, Hanzhou Deng, Jian Ding, Shuhua Wu, Dan Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu610041 China Key Laboratory of Low-grade Energy Utilization Technologies and Systems Chongqing University Ministry of Education Chongqing 400044 China

The surface properties and thermal conductivity of oxide layer formed on the new zirconium alloy due to high temperature steam oxidation are studied in this paper. The thickness of oxide layer, surface wettability and thermal conductivity are measured. The effects of oxidation temperature and time on the wettability and thermal conductivity of zirconium alloy are analyzed. The results show that zirconium on the surface is fully oxidized to ZrO2 , and the difference of surface wettability is caused by different surface morphology. The characteristics of oxide layer surface cracks will affect the surface wettability. At the same oxidation temperature, with increasing time duration, the size and number of oxide layer cracks increase. The change of thermal conductivity is the result of competition among factors such as the development of recrystallization process, the increase of oxide layer thickness and the influence of pores and cracks. © 2022, The Authors. All rights reserved.

关键词： Wetting

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Waveform design for pulse radar based on interrupted coding modulation

Waveform design for pulse radar based on interrupted coding ...

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IET International Radar Conference (IRC 2023)

作者： Xiaobin Liu Qihua Wu Zhaoyu Gu Zhenyu Liu Feng Zhao Shunping Xiao The State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System College of Electronic Science and Technology National University of Defense Technology ChangSha People's Republic of China

ISBN: (数字)9781837240982

Coding modulation is utilized to design radar waveform to obtain complex properties so that the waveform is difficult to be recognized. However, traditional coding modulation brings high sidelobe in target range profile which makes the detection performance decrease. To solve this problem, the interrupted coding modulation is proposed in this paper based on the interrupted transmitting and receiving. The signal model is provided and the low sidelobe property of range profile is discussed. Constant false-alarm rate (CFAR) is utilized to evaluate the detection performance of interrupted coding modulation waveform. Simulations are conducted to verify the low sidelobe property and detection performance of the proposed waveform.

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Quantifying 3D cell-matrix interactions during mitosis and the effect of anticancer drugs on the interactions

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Nano Research 2021年第11期14卷 4163-4172页

作者： Yongman Liu Jianye Wang Yong Su Xiaohai Xu Hong Liu Kainan Mei Shihai Lan Shubo Zhang Xiaoping Wu Yunxia Cao Qingchuan Zhang Shangquan Wu CAS Key Laboratory of Mechanical Behavior and Design of Material Department of Modern MechanicsCAS Center for Excellence in Complex System MechanicsUniversity of Science and Technology of ChinaHefei230027China Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei230022China Anhui Province Key Laboratory of Reproductive Health and Genetics Anhui Medical UniversityHefei230022China Department of Chemical Physics University of Science and Technology of ChinaHefei230026China

The mechanical force between cells and the extracellular microenvironment is crucial to many physiological processes such as cancer metastasis and stem cell differentiation. Mitosis plays an essential role in all these processes and thus an in-depth understanding of forces during mitosis gains insight into disease diagnosis and disease treatment. Here, we develop a traction force microscope method based on monolayer fluorescent beads for measuring the weak traction force (tens of Pa) of mitotic cells in three dimensions. We quantify traction forces of human ovarian granulosa (KGN) cells exerted on the extracellular matrix throughout the entire cell cycle in three dimensions. Our measurements reveal how forces vary during the cell cycle, especially during cell division. Furthermore, we study the effect of paclitaxel (PTX) and nocodazole (NDZ) on mitotic KGN cells through the measurement of traction forces. Our results show that mitotic cells with high concentrations of PTX exert a larger force than those with high concentrations of NDZ, which proved to be caused by changes in the structure and number of microtubules. These findings reveal the key functions of microtubule in generating traction forces during cell mitosis and explain how dividing cells regulate themselves in response to anti-mitosis drugs. This work provides a powerful tool for investigating cell-matrix interactions during mitosis and may offer a potential way to new therapies for cancer.

关键词： cell division traction force paclitaxel nocodazole

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Capillary Evaporating Film Model for a Screen-Wick Heat Pipe

SSRN

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SSRN 2022年

作者： Ma, Yugao Zhang, Yingnan Yu, Hongxing Huang, Shanfang Deng, Jian Chai, Xiaoming Zeng, Chang Zhang, Zhuohua He, Xiaoqiang Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu610213 China Department of Engineering Physics Tsinghua University Beijing100084 China

Screen-wick heat pipes are efficient passive heat transfer devices. The heat transfer capacity is determined by the capillary pressure, which is related to the film curvature inside the screen wick. A capillary evaporating film model was developed for the screen wick that divided the film into a capillary pressure microlayer region and a macroscopic film. The film surface shape in the capillary pressure microlayer region is mainly influenced by the long-range molecular forces (disjoining pressure) and the surface tension, while the film surface shape in the macroscopic film is affected by the wick geometry. The numerical results show that the present model more accurately predicts the three-dimensional characteristics of the liquid film inside the screen wick than the classical model. The wire opening distance and the wire diameter affect the capillary pressure and the flow path in the wick. As the liquid film recedes into the wick, the capillary force first increases and then decreases. The film dynamics in the wick are related to the liquid height, which automatically adapts to the required evaporation and pressure balance for a given heat load. High operating temperatures can lead to a mismatch between the capillary head and the pressure loss, leading to dry out in the wick. Thus, this work provides a reference for operating alkali-metal wick heat pipes. © 2022, The Authors. All rights reserved.

关键词： Heat pipes

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Perceived vs. Objective Human Performance in Diagnostic Tasks: Under-Confidence or Over-Confidence?

SSRN

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SSRN 2022年

作者： Lyu, Xi Li, Zhizhong Ma, Quan She, Manrong Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China Chengdu610213 China Department of Industrial Engineering Tsinghua University Beijing100084 China

Humans are not very good at assessing their own performance, and usually exhibit over-confidence. Little effort has been done to investigate how and how well diagnosticians perceive their performance of sub-processes of diagnosis, for example information seeking and information integration. This study analyzed the performance data of an experiment of diagnosing an accident in a simulated nuclear power plant. The objective performance was measured by eight indicators and the perceived performance was measured by three indicators. Difference relations and correlations between these indictors were explored. Results showed that on one hand there were systematic deviations between perceived and objective performance, on the other hand the perceptions did have some validity. Perceptions of information seeking manifested under-confidence while perceptions of information integration and the overall diagnosis manifested over-confidence. The authors argue that these two biases were mutually complementary and facilitating rather than contradictory. The findings could be used to help diagnosis-related training, operation and decision making. © 2022, The Authors. All rights reserved.

关键词： Information retrieval

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