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38th International Cosmic Ray Conference, ICRC 2023

作者： Noda, Koji Artero, Manuel Fiasson, Armand Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Baxter, J. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Caroff, S. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heckmann, L. Heller, M. Herrera Llorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lainez, M. Lamanna, G. Lamastra, A. Le Flour, T. Linhoff, M. Longo, F. López-Coto, R. López-Oramas, A. Chiba University 1-33 Yayoi-cho Chiba Japan The University of Tokyo 5-1-5 Kashiwanoha Kashiwa Japan Barcelona Bellaterra08193 Spain Annecy-le-Vieux AnnecyF-74941 Cedex France ILANCE Kashiwanoha Kashiwa5-1-5 Japan Department of Physics Tokai University Japan Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy Max-Planck-Institut für Physik Germany INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain CIEMAT Spain Department of Physics TU Dortmund University Germany INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy Palacky University Olomouc Faculty of Science Czech Republic University of Alcalá UAH Spain Port d’Informació Científica Spain University of Rijeka Department of Physics Croatia Institute for Theoretical Physics and Astrophysics Universität Würzburg Germany Institut für Theoretische Physik Lehrstuhl IV: Plasma-Astroteilchenphysik Ruhr-Universit

A decade has passed since high-energy astrophysical neutrinos have been discovered by IceCube, however the corresponding sources have not been fully identified yet. The reported coincidence of the high-energy IceCube-170922A with the gamma-ray blazar TXS 0506+056 is not enough to claim that blazars are the dominant high-energy neutrino emitters in the Universe. In fact, recently IceCube announced a second correlation with NGC 1068, a nearby Seyfert galaxy, which is significantly different from a gamma-emitting blazars. The hunt for counterparts of the IceCube neutrinos using gamma-ray telescopes started in 2012. Nonetheless, these efforts will continue with the next-generation gamma-ray telescopes, such as the CTA Large Size Telescopes (LSTs) and other telescopes, by means of an improved and revised observation strategy. These new observations will allow us to detect enough sources in order to elucidate the mystery of the neutrino emitters. In this contribution, we introduces the efforts made thus far in the search for gamma-ray counterpart of high-energy IceCube events using the current generation IACTs, focusing on alerts made of multiple neutrinos events, and present an idea to improve in the observational strategies with the CTA LSTs that will become operational in the coming decade. We will discuss how to reduce the bias to gamma-ray emitters in order to search for possible neutrino counterparts. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Neutrons

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Low energy performance boost through a hardware stereoscopic trigger between CTA LST-1 and MAGIC 38

Low energy performance boost through a hardware stereoscopic...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Baxter, J. Barrio, J.A. Bitossi, M. Donini, A. Mazin, D. Paoletti, R. Pérez Aguilera, A. Tejedor Álvarez, L.Á. Abe, H. Abe, K. Abe, S. Abhir, J. Acciari, V.A. Aguasca-Cabot, A. Agudo, I. Alvarez Crespo, N. Aniello, T. Ansoldi, S. Antonelli, L.A. Aramo, C. Arbet-Engels, A. Cornelia, A. Artero, M. Asano, K. Aubert, P. Baack, D. Babić, A. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bednarek, W. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Besenrieder, J. Bhattacharjee, P. Biederbeck, N. Bigongiari, C. Biland, A. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bošnjak, Ž. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Busetto, G. Campoy-Ordaz, A. Cardillo, M. Caroff, S. Carosi, A. Carosi, R. Carrasco, M.S. Carretero-Castrillo, M. Cassol, F. Castro-Tirado, A.J. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chilingarian, A. Chytka, L. Cifuentes, A. Cikota, S. Colombo, E. Contreras, J.L. Cortina, J. Costantini, H. Covino, S. D’Amico, G. Dalchenko, M. D’Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delfino, M. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Del Popolo, A. Depaoli, D. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Fallah Ramazani, V. Fariña, L. Fattorini, A. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Font, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Garczarczyk, M. Gasbarra, C. Gasparrini, D. Gasparyan, S. Gaug, M. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Green, J. Green, D. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid Spain Sezione di Pisa Pisa56127 Italy Osservatorio Astronomico di Roma Italy Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany Università degli Studi di Siena via Roma 56 Siena53100 Italy Department of Physics Tokai University Japan ETH Zürich Switzerland Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Spain Departament de Física Quàntica i Astrofísica Institut de Ciències del Cosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain Italy INFN Sezione di Trieste Università degli Studi di Udine Italy Italy INAF Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy The Barcelona Institute of Science and Technology Spain LAPP Univ. Grenoble Alpes Univ. Savoie Mont Blanc CNRS-IN2P3 Annecy France Department of Physics TU Dortmund University Germany Croatia Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil Faculty of Physics and Applied Informatics University of Lodz Poland CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF Osservatorio Astronomico di Brera Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Departament de Física CERES-IEEC Universitat Autónoma de Barcelona Spain Italy Università di Pisa INFN Pisa Italy Aix Marseille Univ CNRS IN2P3 CPPM France INFN Sezione di Bari Università di Bari Italy INFN Sezione di Torino Italy ICRANet-Armenia at

The next generation facility for gamma-ray ground-based observations is the Cherenkov Telescope Array (CTA) observatory, which comprises three types of imaging atmospheric Cherenkov telescopes (IACTs). The Large-Sized Telescopes (LSTs) of CTA are the largest telescope type with a mirror dish of 23 m diameter. They cover the low energy end of the accessible gamma-ray energies for IACTs, starting from about 20 GeV up to a few TeV. The first LST prototype, known as LST-1, was officially inaugurated at the Observatorio del Roque de Los Muchachos in La Palma (Canary Islands, Spain) in 2018 and has since performed calibration observations of various known gamma-ray sources. Additionally, the site houses the MAGIC telescopes, two 17 m IACTs situated approximately 100 m away from LST-1, which have been performing stereo observations since 2009. Currently, joint observations between LST-1 and MAGIC are being carried on, and the data taken independently by the two IACT systems is analyzed by combining events via software. However, this method increases the energy threshold, as it discards all but the relatively high-energy events triggered by all three telescopes. To address this issue, we have developed a novel hardware stereo trigger system between LST-1 and MAGIC, which is capable of handling events triggered by any-two out of the three telescopes. In this contribution, we will report on the performance estimation of joint LST-1 and MAGIC observations using the hardware trigger. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Cosmology

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Actual Evapotranspiration for Sugarcane Based on Bowen Ratio-Energy Balance and Soil Water Balance Models with Optimized Crop Coefficients.

Research Square

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Research Square 2021年

作者： da Costa Faria Martins, Suelen dos Santos, Marcos Alex Lyra, Gustavo Bastos de Souza, José Leonaldo Lyra, Guilherme Bastos Teodoro, Iêdo Ferreira, Fábio Freitas Ferreira, Ricardo Araújo dos Santos Almeida, Alexsandro Claudio de Souza, Renan Cantalice Graduate Program in Agricultural and Environmental Engineering Department of Agricultural and Environmental Engineering Institute of Technology Federal Rural University of Rio de Janeiro Seropédica Rio de Janeiro23.890-000 Brazil Agricultural Science Center Federal University of Alagoas AL Rio Largo57100-000 Brazil Department of Environmental Sciences Forest Institute Federal Rural University of Rio de Janeiro Seropédica Rio de Janeiro23.890-000 Brazil Department of Natural Sciences Institute of Humanity and Health Fluminense Federal University Rio das Ostras RJ 28895-532 Brazil

Evapotranspiration is an important parameter to evaluate soil water deficit and water use efficiency, especially at places with irregularly distributed precipitation. The aim of this study was to assess the daily actual evapotranspiration (ETa) estimated by the Thornthwaite and Mather soil water balance method adapted for crops (ThM) and by the dual Kc approach with the crop coefficients optimized from inversing modeling and by the adjustment procedure suggested in FAO-56. The models comparison and optimization were performed with actual evapotranspiration determined by the Bowen ratio – energy balance method (ETβ) for sugarcane at full canopy closure grown in Alagoas State, Northeastern Brazil. The objective function of the inverse problem was defined in terms of ETβ and ETa estimated by the ThM and dual Kc method by optimizing single crop coefficient (Kc) and the basal coefficient Kcb, respectively. Both optimized Kc and Kcb were lower than the adjusted Kc FAO56, with optimized Kc only 3% less than the Kc obtained experimentally. ETa estimated by ThM and dual Kc models with optimized crop coefficients (Kc = 1.05 or Kcb = 1.00) had similar high precision (r2 > 0.79) and accuracy (dm > 0.93 and RMSE -1), whereas using the coefficients derived from FAO 56 overestimated ETa in both models. © 2021, CC BY.

关键词： Evapotranspiration

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Effect of light Intensity and photoperiod on growth of Chlorella pyrenoidosa and CO2 Biofixation 2

Effect of light Intensity and photoperiod on growth of Chlor...

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2nd International Conference on Energy, environmental and Information System, ICENIS 2017

作者： Gunawan, Teuku Johar Ikhwan, Yusni Restuhadi, Fajar Pato, Usman Post Graduate Program of Environmental Science Universitas Riau Pekanbaru Riau Indonesia Faculty of Agriculture Universitas Riau Pekanbaru Riau Indonesia

Microalgae have been viewed as one of potential solution for CO2 biofixation or CO2 sequestration. However, many factors need to be evaluated to support development of CO2 biofixation. One important environmental factor for the growth of micro algae is related with light requirement. The aim of this study was to evaluate the effect of light intensity and photoperiod on growth of Chlorellapyrenoidosa (***) and CO2 biofixation. Experiments were carried out in 1000 mL semi batch photo bioreactors, purged continuously with air (0.034% CO2). An Experiment of Factorial Design was employed in which the light intensity was evaluated 4 level at 2000, 4000, 6000 and 8000 lux with 3 level of photo period at L/D (light/dark) 8 hours/16 hours;L/D 12 hours/12 hours and L/D 16 hours/8 hours. The result indicated that both light intensity and photo period had significant effect (p2biofixation rate of around 2 times was also observed between highest setting (8000 lux;L/D 16/12 hours) relative to that of lowest setting (2000 lux;L/D 8/12 hours). © 2018 The Authors, published by EDP sciences.

关键词： Carbon dioxide

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Correction: Evaluating the environmental Impacts at the End Point Level of the Biodiesel Production Process from Multiple Feedstocks in Indonesia Through Life Cycle Assessment Methodology

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Waste and Biomass Valorization 2023年第1期15卷 523-523页

作者： Wahyono, Yoyon Hadiyanto, Hadiyanto Gheewala, Shabbir H. Budihardjo, Mochamad Arief Adiansyah, ·Joni Safaat Widayat, Widayat Christwardana, Marcelinus Doctoral Program of Environmental Science School of Postgraduate Studies Diponegoro University Semarang Indonesia Department of Chemical Engineering Faculty of Engineering Diponegoro University Semarang Indonesia Master Program of Energy School of Postgraduate Studies Diponegoro University Semarang Indonesia The Joint Graduate School of Energy and Environment King Mongkut’s University of Technology Thonburi Bangkok Thailand Center of Excellence on Energy Technology and Environment (CEE) Ministry of Higher Education Science Research and Innovation Bangkok Thailand Department of Environmental Engineering Faculty of Engineering Diponegoro University Semarang Indonesia Mining Engineering Department Faculty of Engineering Muhammadiyah University of Mataram Mataram Indonesia Department of Chemistry Faculty of Science and Mathematics Diponegoro University Semarang Indonesia

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An ALMA Glimpse of Dense Molecular Filaments Associated with High-mass Protostellar Systems in the Large Magellanic Cloud

arXiv

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arXiv 2023年

作者： Tokuda, Kazuki Harada, Naoto Tanaka, Kei E.I. Inoue, Tsuyoshi Shimonishi, Takashi Zhang, Yichen Sewilo, Marta Kunitoshi, Yuri Konishi, Ayu Fukui, Yasuo Kawamura, Akiko Onishi, Toshikazu Machida, Masahiro N. Department of Earth and Planetary Sciences Faculty of Science Kyushu University Fukuoka Nishi-ku819-0395 Japan National Astronomical Observatory of Japan National Institutes of Natural Sciences 2-21-1 Osawa Mitaka Tokyo181-8588 Japan Department of Earth and Planetary Sciences Tokyo Institute of Technology Meguro Tokyo152-8551 Japan Department of Physics Konan University Okamoto 8-9-1 Kobe Japan Environmental Science Program Faculty of Science Niigata University Ikarashi-ninocho 8050 Nishi-ku Niigata950-2181 Japan Department of Astronomy University of Virginia CharlottesvilleVA22904-4325 United States RIKEN Cluster for Pioneering Research Saitama Wako351-0198 Japan Exoplanets and Stellar Astrophysics Laboratory NASA Goddard Space Flight Center GreenbeltMD20771 United States Department of Astronomy University of Maryland College ParkMD20742 United States Center for Research and Exploration in Space Science and Technology NASA Goddard Space Flight Center GreenbeltMD20771 United States Department of Physics Graduate School of Science Osaka Metropolitan University 1-1 Gakuen-cho Naka-ku Sakai Osaka599-8531 Japan Department of Physics Nagoya University Furo-cho Chikusa-ku Nagoya464-8601 Japan

Recent millimeter/sub-millimeter facilities have revealed the physical properties of filamentary molecular clouds in relation to high-mass star formation. A uniform survey of the nearest, face-on star-forming galaxy, the Large Magellanic Cloud (LMC), complements the Galactic knowledge. We present ALMA survey data with a spatial resolution of ∼0.1 pc in the 0.87 mm continuum and HCO+(4–3) emission toward 30 protostellar objects with luminosities of 104–105.5 L☉ in the LMC. The spatial distributions of the HCO+(4–3) line and thermal dust emission are well correlated, indicating that the line effectively traces dense, filamentary gas with an H2 volume density of 105 cm−3 and a line mass of ∼103–104 M☉ pc−1. Furthermore, we obtain an increase in the velocity linewidths of filamentary clouds, which follows a power-law dependence on their H2 column densities with an exponent of ∼0.5. This trend is consistent with observations toward filamentary clouds in nearby star-forming regions withiin 1 kpc from us and suggests enhanced internal turbulence within the filaments owing to surrounding gas accretion. Among the 30 sources, we find that 14 are associated with hub-filamentary structures, and these complex structures predominantly appear in protostellar luminosities exceeding ∼5 ×104 L☉. The hub-filament systems tend to appear in the latest stages of their natal cloud evolution, often linked to prominent H ii regions and numerous stellar clusters. Our preliminary statistics suggest that the massive filaments accompanied by hub-type complex features may be a necessary intermediate product in forming extremely luminous high-mass stellar systems capable of ultimately dispersing the parent cloud. © 2023, CC BY.

关键词： Clouds

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Observation of Active Galactic Nuclei with the Large-Sized Telescope prototype of the Cherenkov Telescope Array 38

Observation of Active Galactic Nuclei with the Large-Sized T...

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38th International Cosmic Ray Conference, ICRC 2023

作者： Takeishi, R. Álvarez Crespo, N. Arbet-Engels, A. Baquero Larriva, A. Baxter, J. Biederbeck, N. Caroff, S. Di Marco, G. Fallah Ramazani, V. Green, D. Heckmann, L. Láinez, M. Nickel, L. Nievas Rosillo, M. Pons, E. Priyadarshi, C. Sanchez, D.A. Vázquez Acosta, M. Abe, K. Abe, S. Aguasca-Cabot, A. Agudo, I. Antonelli, L.A. Aramo, C. Arcaro, C. Artero, M. Asano, K. Aubert, P. Baktash, A. Bamba, A. Baquero Larriva, A. Baroncelli, L. Barres de Almeida, U. Barrio, J.A. Batkovic, I. Becerra González, J. Bernardini, E. Bernardos, M.I. Bernete Medrano, J. Berti, A. Bhattacharjee, P. Bigongiari, C. Bissaldi, E. Blanch, O. Bonnoli, G. Bordas, P. Bulgarelli, A. Burelli, I. Burmistrov, L. Buscemi, M. Cardillo, M. Carosi, A. Carrasco, M.S. Cassol, F. Cauz, D. Cerasole, D. Ceribella, G. Chai, Y. Cheng, K. Chiavassa, A. Chikawa, M. Chytka, L. Cifuentes, A. Contreras, J.L. Cortina, J. Costantini, H. Dalchenko, M. Dazzi, F. De Angelis, A. de Bony de Lavergne, M. De Lotto, B. De Lucia, M. de Menezes, R. Del Peral, L. Deleglise, G. Delgado, C. Delgado Mengual, J. della Volpe, D. Dellaiera, M. Di Piano, A. Di Pierro, F. Di Pilato, A. Di Tria, R. Di Venere, L. Díaz, C. Dominik, R.M. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Eisenberger, L. Elsässer, D. Emery, G. Escudero, J. Ferrara, G. Ferrarotto, F. Fiasson, A. Foffano, L. Freixas Coromina, L. Fröse, S. Fukami, S. Fukazawa, Y. Garcia, E. Garcia López, R. Gasbarra, C. Gasparrini, D. Geyer, D. Giesbrecht Paiva, J. Giglietto, N. Giordano, F. Gliwny, P. Godinovic, N. Grau, R. Gunji, S. Günther, P. Hackfeld, J. Hadasch, D. Hahn, A. Hashiyama, K. Hassan, T. Hayashi, K. Heller, M. HerreraLlorente, J. Hirotani, K. Hoffmann, D. Horns, D. Houles, J. Hrabovsky, M. Hrupec, D. Hui, D. Hütten, M. Iarlori, M. Imazawa, R. Inada, T. Inome, Y. Ioka, K. Iori, M. Ishio, K. Jimenez Martinez, I. Jurysek, J. Kagaya, M. Karas, V. Katagiri, H. Kataoka, J. Kerszberg, D. Kobayashi, Y. Kohri, K. Kong, A. Kubo, H. Kushida, J. Lamanna, G. Lamastra, A. Institute for Cosmic Ray Research University of Tokyo Chiba Kashiwa277-8582 Japan Grupo de Electronica Universidad Complutense de Madrid Av. Complutense s/n Madrid28040 Spain Max-Planck-Institut für Physik Föhringer Ring 6 München80805 Germany IPARCOS-UCM Instituto de Física de Partículas y del Cosmos EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain Faculty of Science and Technology Universidad del Azuay Cuenca Ecuador Department of Physics TU Dortmund University Otto-Hahn-Str. 4 Dortmund44227 Germany Univ. Savoie Mont Blanc CNRS Laboratoire d’Annecy de Physique des Particules - IN2P3 Annecy74000 France Instituto de Astrofísica de Canarias Departamento de Astrofísica Universidad de La Laguna Tenerife La Laguna Spain Institut für Theoretische Physik Lehrstuhl IV: Plasma-Astroteilchenphysik Ruhr-Universität Bochum Universitätsstraße 150 Bochum44801 Germany The Barcelona Institute of Science and Technology Campus UAB Bellaterra Barcelona08193 Spain Department of Physics Tokai University Japan Departament de Física Quàntica i Astrofísica Institut de Ciències delCosmos Universitat de Barcelona IEEC-UB Spain Instituto de Astrofísica de Andalucía-CSIC Spain EMFTEL department IPARCOS Universidad Complutense de Madrid Spain INAF - Osservatorio Astronomico di Roma Italy INFN Sezione di Napoli Italy INFN Sezione di Padova Università degli Studi di Padova Italy Universität Hamburg Institut für Experimentalphysik Germany Graduate School of Science University of Tokyo Japan Universidad del Azuay Ecuador INAF - Osservatorio di Astrofisica e Scienza dello spazio di Bologna Italy Centro Brasileiro de Pesquisas Físicas Brazil CIEMAT Spain INFN Sezione di Bari Politecnico di Bari Italy INAF - Osservatorio Astronomico di Brera Italy INFN Sezione di Trieste Università degli Studi di Udine Italy University of Geneva Département de physique nucléaire et corpusculaire Switzerland INFN Sezione di Catania Italy Italy Aix Marseille Uni

Cherenkov Telescope Array (CTA) will be the next generation gamma-ray observatory. It will consist of three different sizes of telescopes, with a collective improvement of about an order of magnitude in sensitivity, compared with the current generation gamma-ray telescopes. LargeSized Telescopes (LSTs) will be the most sensitive at energies from tens of GeV up to a few TeVs, and will be the best suited to observe gamma-ray sources such as Active Galactic Nuclei (AGN). The first Large-Sized Telescope prototype (LST-1), inaugurated in 2018 and currently in commissioning phase, has accumulated more than one thousand hours of data to date. From 2020 to 2022, we have detected various gamma-ray sources, and prominent among them are several well-known AGN, like Mrk 421, Mrk 501, 1ES 1959+650, 1ES 0647+250, PG 1553+113, etc. We report on light curves and energy spectra reconstructed out of these observations down to energies of tens of GeV, which is very close to the energy threshold of LST-1. © Copyright owned by the author(s) under the terms of the Creative Commons.

关键词： Active Galactic Nuclei

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Calycosin Enhances Heat Shock Related-Proteins in H9c2 Cells to Modulate Survival and Apoptosis against Heat Shock

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The American journal of Chinese medicine 2024年第4期52卷 1173-1193页

作者： Pei-Fang Lai Ramasamy Mahendran Bruce Chi-Kang Tsai Cheng-You Lu Chia-Hua Kuo Kuan-Ho Lin Shang-Yeh Lu Yu-Ling Wu Yung-Ming Chang Wei-Wen Kuo Chih-Yang Huang Department of Emergency Medicine Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien 970 Taiwan. Department of Medicine Tzu Chi University Hualien 970 Taiwan. Cardiovascular and Mitochondrial Related Disease Research Center Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien 970 Taiwan. Department of Post-Baccalaureate Medicine College of Medicine National Chung Hsing University Taichung 402 Taiwan. Laboratory of Exercise Biochemistry University of Taipei Taipei 111 Taiwan. Institute of Sports Sciences University of Taipei Taipei 111 Taiwan. School of Physical Education and Sports Science Soochow University Suzhou 215021 China. Department of Kinesiology and Health College of William and Mary Williamsburg VA 23185 USA. Department of Emergency Medicine China Medical University Hospital Taichung 404 Taiwan. College of Medicine China Medical University Taichung 406 Taiwan. Division of Cardiovascular Medicine Department of Internal Medicine China Medical University Hospital Taichung 404 Taiwan. The School of Chinese Medicine for Post-Baccalaureate I-Shou University 840 Kaohsiung Taiwan. Chinese Medicine Department E-DA Hospital Kaohsiung 824 Taiwan. 1PT Biotechnology Co. Ltd. Taichung 433 Taiwan. Department of Biological Science and Technology College of Life Sciences China Medical University Taichung 406 Taiwan. Ph.D. Program for Biotechnology Industry China Medical University Taichung 406 Taiwan. School of Pharmacy China Medical University Taichung 406 Taiwan. Graduate Institute of Biomedical Sciences China Medical University Taichung 406 Taiwan. Department of Medical Laboratory Science and Biotechnology Asia University Taichung 413 Taiwan. Center of General Education Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien 970 Taiwan. Department of Medical Research China Medical University Hospital China Medical University Taichung 404 Taiwan.

Heat shock proteins (HSPs), which function as chaperones, are activated in response to various environmental stressors. In addition to their role in diverse aspects of protein production, HSPs protect against harmful protein-related stressors. Calycosin exhibits numerous beneficial properties. This study aims to explore the protective effects of calycosin in the heart under heat shock and determine its underlying mechanism. H9c2 cells, western blot, TUNEL staining, flow cytometry, and immunofluorescence staining were used. The time-dependent effects of heat shock analyzed using western blot revealed increased HSP expression for up to 2[Formula: see text]h, followed by protein degradation after 4[Formula: see text]h. Hence, a heat shock damage duration of 4[Formula: see text]h was chosen for subsequent investigations. Calycosin administered post-heat shock demonstrated dose-dependent recovery of cell viability. Under heat shock conditions, calycosin prevented the apoptosis of H9c2 cells by upregulating HSPs, suppressing p-JNK, enhancing Bcl-2 activation, and inhibiting cleaved caspase 3. Calycosin also inhibited Fas/FasL expression and activated cell survival markers (p-PI3K, p-ERK, p-Akt), indicating their cytoprotective properties through PI3K/Akt activation and JNK inhibition. TUNEL staining and flow cytometry confirmed that calycosin reduced apoptosis. Moreover, calycosin reversed the inhibitory effects of quercetin on HSF1 and Hsp70 expression, illustrating its role in enhancing Hsp70 expression through HSF1 activation during heat shock. Immunofluorescence staining demonstrated HSF1 translocation to the nucleus following calycosin treatment, emphasizing its cytoprotective effects. In conclusion, calycosin exhibits pronounced protective effects against heat shock-induced damages by modulating HSP expression and regulating key signaling pathways to promote cell survival in H9c2 cells.

关键词： Astragalus Membranaceus Calycosin Cardiomyocyte Heart Protection Heat Shock Heat Shock-Related Protein

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Study of runway crosswind and tailwind potential for airport sustainability: A study of Soekarno Hatta airport, Cengkareng, Indonesia

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IOP Conference Series: Earth and environmental science 2021年第1期729卷

作者： W Sardjono Zulkarnain H Kusnoputranto TEB Soesilo DN Utama J Sudirwan Information Systems Management Department BINUS Graduate Program - Master of Information Systems Management BINA NUSANTARA University Jakarta Indonesia 11480 Post Graduate Program School of Environmental Science University of Indonesia Jakarta Indonesia Faculty of Public Health University of Infonesia Jakarta Indonesia Computer Science Department BINUS Graduate Program - Master of Computer Science Bina Nusantara University Jakarta Indonesia 11480 School of Information Systems Department BINUS Undergraduate Program Bina Nusantara University Jakarta Indonesia 11480

Airport runway designs must consider wind climatology to reduce the potential for crosswind and tailwind events that can cause accidents and aircraft delays. The large potential of crosswind and tailwind on a runway at the airport is very detrimental to aircraft passengers and airlines. Therefore, it is necessary to know the potential of crosswind and tailwind on the runway of Soekarno Hatta Airport and find the right parameters for the approximate direction and speed of the wind on the airport runway. Analysis was carried out using the direction and wind speed data from the Soekarno Hatta meteorological station in 2007-2017 to determine the potential for crosswind and tailwind on the runway of Soekarno Hatta airport and run a Weather Research and Forecasting (WRF) weather model to determine the parameterization of the right weather model for wind forecast at Soekarno Hatta airport. The highest maximum crosswind component in the 2007-2017 period occurred in August 30.53 knots, while the highest maximum tailwind of 25 knots occurred in January for a 250-degree runway and 24 knots occurred in August for a 070-degree runway. The potential for crosswind and tailwind is different every month. The scheme produces forecasts of wind direction and speed with a strong level of correlation with observations of wind direction and speed from the Soekarno Hatta meteorological station, the correlation value is 0.61. The most significant social impact of plane delays is time loss for passengers. While the economic impact on one of the crosswind events at Soekarno Hatta airport was an economic loss for one airline of US $ 43,392.

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The impact of sodium-glucose cotransporter-2 inhibitors on outcome of patients with diabetes mellitus and colorectal cancer

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Journal of Gastroenterology and Hepatology (Australia) 2024年第5期39卷 902-907页

作者： Chiang, Cho-Han Chiang, Cho-Hung Hsia, Yuan Ping Jaroenlapnopparat, Aunchalee Horng, Chuan-Sheng Wong, Kit Yee Wang, Shih-Syuan Chang, Yu-Cheng Chen, Brian Shiian Luan, Yu-Ze Wang, Chun-Hao Neilan, Tomas G. Chiang, Cho-Hsien Peng, Cheng-Ming Shiah, Her-Shyong Department of Medicine Mount Auburn Hospital Harvard Medical School Cambridge MA United States Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan Department of Family Medicine Taipei Tzu Chi Hospital Buddhist Tzu Chi Foundation New Taipei City Taiwan Department of Internal Medicine Chung Shan Medical University Hospital Taichung Taiwan Department of Anatomical and Cellular Pathology State Key Laboratory of Translational Oncology Prince of Wales Hospital The Chinese University of Hong Kong SAR Hong Kong Department of Neurology SUNY Downstate Medical Center Brooklyn NY United States Department of Medicine Danbury Hospital Danbury CT United States School of Medicine Chung Shan Medical University Taichung Taiwan Department of Medical Education National Taiwan University Hospital Taipei Taiwan Cardio-Oncology Program Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA United States Cardiovascular Imaging Research Center (CIRC) Division of Cardiology and Department of Radiology Massachusetts General Hospital Boston MA United States Department of Environmental and Occupational Medicine National Taiwan University Hospital Taipei Taiwan London School of Hygiene and Tropical Medicine London United Kingdom Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University Hospital Taichung Taiwan Graduate Institute of Cancer Biology and Drug Discovery College of Medical Science and Technology Taipei Medical University Taipei Taiwan Department of Hematology and Oncology Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei City Taiwan

Background and Aim: Patients with type 2 diabetes mellitus (T2DM) have a higher risk of colorectal cancer (CRC), and those with diagnosed CRC have a poorer prognosis compared with individuals with normal glucose levels. The inhibition of sodium-glucose cotransporter 2 (SGLT2) channels has been associated with a reduction in tumor proliferation in preclinical studies. We aimed to investigate the impact of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on the outcome of T2DM patients with colorectal cancer. Methods: We performed a retrospective cohort study comprising adult patients with T2DM and colorectal adenocarcinoma. SGLT2i recipients were matched to non-SGLT2i recipients in a 1:1 ratio based on age, sex, and cancer stage. The primary outcome was overall survival (OS) and progression-free survival (PFS), and the secondary outcomes were previously reported serious adverse events associated with SGLT2i. Results: We identified 1347 patients with T2DM and colorectal adenocarcinoma, from which 92 patients in the SGLT2i cohort were matched to the non-SGLT2i cohort. Compared to non-SGLT2i recipients, SGLT2i recipients had a higher rate of 5-year OS (86.2% [95% CI: 72.0–93.5] vs 62.3% [95% CI: 50.9–71.8], P = 0.013) and 5-year PFS (76.6% [95% CI: 60.7–86.7] vs 57.0% [95% CI: 46.2–66.4], P = 0.021). In Cox proportional hazard analyses, SGLT2i were associated with a 50–70% reduction in all-cause mortality and disease progression. SGLT2i were not associated with an increased risk of serious adverse events. Conclusion: SGLT2i were associated with a higher rate of survival in T2DM patients with colorectal cancer. © 2024 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

关键词： Colorectal cancer Sodium-glucose cotransporter-2 inhibitors Survival

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