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Spatially-resolved fluorescence-detected two-dimensional electronic spectroscopy probes varying electronic couplings in photosynthetic bacteria

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arXiv 2018年

作者： Tiwari, Vivek Matutes, Yassel Acosta Gardiner, Alastair T. Cogdell, Richard J. Ogilvie, Jennifer P. Department of Physics University of Michigan Ann ArborMI48109 United States Applied Physics Program University of Michigan Ann ArborMI48109 United States Institute for Molecular Biology University of Glasgow GlasgowG12 8TA United States

We present a variation of two-dimensional electronic spectroscopy that is capable of mapping spatially-varying differences in electronic couplings using a correlated map of excitation and detection frequencies, with sensitivity orders of magnitude better than conventional spatially-averaged electronic spectroscopies. The approach performs fluorescence-detectionbased fully collinear two-dimensional electronic spectroscopy in a microscope, combining femtosecond time-resolution, sub-micron spatial resolution, and the sensitivity of fluorescence detection. We demonstrate the approach on a mixture of photosynthetic bacteria that are known to exhibit variations in electronic structure with growth conditions. Spatial variations in the constitution of mixed bacterial colonies manifests as spatially-varying peak intensities in the measured two-dimensional contour maps, which exhibit well-resolved electronic couplings between excited electronic states of the bacterial proteins. Copyright © 2018, The Authors. All rights reserved.

关键词： Bacteria

Evaluation of kinetic ballooning instability in the near-earth magnetotail

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arXiv 2018年

作者： Khan, Abdullah Zhu, P. Ali, A. CAS Key Laboratory of Geospace Environment Department of Engineering and Applied Physics University of Science and Technology of China Hefei Anhui230026 China Department of Engineering Physics University of Wisconsin-Madison MadisonWI53706 United States National Tokamak Fusion Program Islamabad3329 Pakistan

Ballooning instabilities are widely believed to be a possible triggering mechanism for the onset of substorm and current disruption initiation in the near-Earth magnetotail. Yet the stability of the kinetic ballooning mode (KBM) in a global and realistic magnetotail configuration has not been well examined. In this paper, the growth rate of the KBM is calculated from analytical theory for the two-dimensional Voigt equilibrium within the framework of kinetic magnetohydrodynamic (MHD) model. The growth rate of the KBM is found to be strongly dependent on the field line stiffening factor S, which depends on the trapped electron dynamics, the finite ion gyroradius, and the magnetic drift motion of charged particles. Furthermore, calculations show that the KBM is unstable in a finite intermediate range of equatorial βeq values and the growth rate dependence on βeq is enhanced for larger ρi. The KBM stability is further analyzed in a broad range of ky for different values of ion Larmor radius ρi and gradient ratio ηj ≡ d ln(Tj)/d ln(nj), where Tj is the particle temperature and nj is the particle density. The KBM is found to be unstable for sufficiently high values of ky, where the growth rate first increases to a maximum value and then decreases due to kinetic effects. The ky at the maximum growth rate decreases exponentially with ρi. The current sheet thinning is found to enhance the KBM growth rate and the unstable βeq regime in the near-Earth magnetotail. Copyright © 2018, The Authors. All rights reserved.

关键词： Kinetics

Low-temperature electron-phonon interaction of quantum emitters in hexagonal boron nitride

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arXiv 2019年

作者： Grosso, Gabriele Moon, Hyowon Ciccarino, Christopher J. Flick, Johannes Mendelson, Noah Toth, Milos Aharonovich, Igor Narang, Prineha Englund, Dirk R. Advanced Science Research Center City University of New York Photonics Initiative New YorkNY United States Physics Program Graduate Center City University of New York New YorkNY United States Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology CambridgeMA United States John A. Paulson School of Engineering and Applied Sciences Harvard University CambridgeMA United States School of Mathematical and Physical Sciences University of Technology Sydney UltimoNSW2007 Australia Center for Computational Quantum Physics Flatiron Institute New YorkNY United States

关键词： Electron-phonon interactions

Classification of datasets with imputed missing values: does imputation quality matter?

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arXiv 2022年

作者： Shadbahr, Tolou Roberts, Michael Stanczuk, Jan Gilbey, Julian Teare, Philip Dittmer, Sören Thorpe, Matthew Torné, Ramon Viñas Sala, Evis Lió, Pietro Patel, Mishal Rudd, James H.F. Mirtti, Tuomas Rannikko, Antti Sakari Aston, John A.D. Tang, Jing Schönlieb, Carola-Bibiane Selby, Ian Breger, Anna Weir-McCall, Jonathan R. Gkrania-Klotsas, Effrossyni Korhonen, Anna Jefferson, Emily Langs, Georg Yang, Guang Prosch, Helmut Preller, Jacobus Stanczuk, Jan Babar, Judith Sánchez, Lorena Escudero Wassin, Marcel Holzer, Markus Walton, Nicholas Research Program in Systems Oncology Faculty of Medicine University of Helsinki Helsinki Finland Department of Applied Mathematics and Theoretical Physics University of Cambridge Cambridge United Kingdom Data Science & Artificial Intelligence AstraZeneca Cambridge United Kingdom Department of Mathematics University of Manchester Manchester United Kingdom Department of Computer Science and Technology University of Cambridge Cambridge United Kingdom Department of Radiology University of Cambridge Cambridge United Kingdom Clinical Pharmacology & Safety Sciences AstraZeneca Cambridge United Kingdom Department of Medicine University of Cambridge Cambridge United Kingdom Department of Pathology University of Helsinki Helsinki University Hospital Finland iCAN-Digital Precision Cancer Medicine Flagship Helsinki Finland Department of Urology University of Helsinki Helsinki University Hospital Helsinki Finland Department of Pure Mathematics and Mathematical Statistics University of Cambridge Cambridge United Kingdom ZeTeM University of Bremen Bremen Germany Faculty of Mathematics University of Vienna Austria Royal Papworth Hospital Cambridge Royal Papworth Hospital NHS Foundation Trust Cambridge United Kingdom Addenbrooke’s Hospital Cambridge University Hospitals NHS Trust Cambridge United Kingdom Language Technology Laboratory University of Cambridge Cambridge United Kingdom Population Health and Genomics School of Medicine University of Dundee Dundee United Kingdom Department of Biomedical Imaging and Image-guided Therapy Computational Imaging Research Lab Medical University of Vienna Vienna Austria National Heart and Lung Institute Imperial College London London United Kingdom Contextflow GmbH Vienna Austria Institute of Astronomy University of Cambridge Cambridge United Kingdom

Classifying samples in incomplete datasets is a common aim for machine learning practitioners, but is non-trivial. Missing data is found in most real-world datasets and these missing values are typically imputed using established methods, followed by classification of the now complete, imputed, samples. The focus of the machine learning researcher is then to optimise the downstream classification performance. In this study, we highlight that it is imperative to consider the quality of the imputation. We demonstrate how the commonly used measures for assessing quality are flawed and propose a new class of discrepancy scores which focus on how well the method recreates the overall distribution of the data. To conclude, we highlight the compromised interpretability of classifier models trained using poorly imputed data. All code and data used in this paper are also released publicly at [inserted upon publication]. © 2022, CC BY.

关键词： Classification (of information)

Stacking, Strain, & Twist in 2D Materials Quantified by 3D Electron Diffraction

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arXiv 2019年

作者： Sung, Suk Hyun Schnitzer, Noah Brown, Lola Park, Jiwoong Hovden, Robert Department of Materials Science and Engineering University of Michigan Ann ArborMI48109 United States Intel Electronics Kiryat Gat82109 Israel Department of Chemistry University of Chicago ChicagoIL60637 United States Institute for Molecular Engineering University of Chicago ChicagoIL60637 United States James Franck Institute University of Chicago ChicagoIL60637 United States Applied Physics Program University of Michigan Ann ArborMI48109 United States

The field of two-dimensional (2D) materials has expanded to multilayered systems where electronic, optical, and mechanical properties change—often dramatically—with stacking order, thickness, twist, and interlayer spacing [1–5]. For transition metal dichalcogenides (TMDs), bond coordination within a single van der Waals layer changes the out-of-plane symmetry that can cause metal-insulator transitions [1, 6] or emergent quantum behavior [7]. Discerning these structural order parameters is often difficult using real-space measurements, however, we show 2D materials have distinct, conspicuous three-dimensional (3D) structure in reciprocal space described by near infinite oscillating Bragg rods. Combining electron diffraction and specimen tilt we probe Bragg rods in all three dimensions to identify multilayer structure with sub-Angstrom precision across several 2D materials—including TMDs (MoS2, TaSe2, TaS2) and multilayer graphene. We demonstrate quantitative determination of key structural parameters such as surface roughness, inter- & intra-layer spacings, stacking order, and interlayer twist using a rudimentary transmission electron microscope (TEM). We accurately characterize the full interlayer stacking order of multilayer graphene (1-, 2-, 6-, 12-layers) as well the intralayer structure of MoS2 and extract a chalcogen-chalcogen layer spacing of 3.07 ± 0.11 Å. Furthermore, we demonstrate quick identification of multilayer rhombohedral graphene. Copyright © 2019, The Authors. All rights reserved.

关键词： Molybdenum compounds

Search for continuous gravitational waves from 20 accreting millisecond x-ray pulsars in O3 LIGO data

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Physical Review D 2022年第2期105卷 022002-022002页

作者： R. Abbott T. D. Abbott F. Acernese K. Ackley C. Adams N. Adhikari R. X. Adhikari V. B. Adya C. Affeldt D. Agarwal M. Agathos K. Agatsuma N. Aggarwal O. D. Aguiar L. Aiello A. Ain T. Akutsu S. Albanesi A. Allocca P. A. Altin A. Amato C. Anand S. Anand A. Ananyeva S. B. Anderson W. G. Anderson M. Ando T. Andrade N. Andres T. Andrić S. V. Angelova S. Ansoldi J. M. Antelis S. Antier S. Appert Koji Arai Koya Arai Y. Arai S. Araki A. Araya M. C. Araya J. S. Areeda M. Arène N. Aritomi N. Arnaud S. M. Aronson K. G. Arun H. Asada Y. Asali G. Ashton Y. Aso M. Assiduo S. M. Aston P. Astone F. Aubin C. Austin S. Babak F. Badaracco M. K. M. Bader C. Badger S. Bae Y. Bae A. M. Baer S. Bagnasco Y. Bai L. Baiotti J. Baird R. Bajpai M. Ball G. Ballardin S. W. Ballmer A. Balsamo G. Baltus S. Banagiri D. Bankar J. C. Barayoga C. Barbieri B. C. Barish D. Barker P. Barneo F. Barone B. Barr L. Barsotti M. Barsuglia D. Barta J. Bartlett M. A. Barton I. Bartos R. Bassiri A. Basti M. Bawaj J. C. Bayley A. C. Baylor M. Bazzan B. Bécsy V. M. Bedakihale M. Bejger I. Belahcene V. Benedetto D. Beniwal T. F. Bennett J. D. Bentley M. BenYaala F. Bergamin B. K. Berger S. Bernuzzi D. Bersanetti A. Bertolini J. Betzwieser D. Beveridge R. Bhandare U. Bhardwaj D. Bhattacharjee S. Bhaumik I. A. Bilenko G. Billingsley S. Bini R. Birney O. Birnholtz S. Biscans M. Bischi S. Biscoveanu A. Bisht B. Biswas M. Bitossi M.-A. Bizouard J. K. Blackburn C. D. Blair D. G. Blair R. M. Blair F. Bobba N. Bode M. Boer G. Bogaert M. Boldrini L. D. Bonavena F. Bondu E. Bonilla R. Bonnand P. Booker B. A. Boom R. Bork V. Boschi N. Bose S. Bose V. Bossilkov V. Boudart Y. Bouffanais A. Bozzi C. Bradaschia P. R. Brady A. Bramley A. Branch M. Branchesi J. E. Brau M. Breschi T. Briant J. H. Briggs A. Brillet M. Brinkmann P. Brockill A. F. Brooks J. Brooks D. D. Brown S. Brunett G. Bruno R. Bruntz J. Bryant T. Bulik H. J. Bulten A. Buonanno R. Buscicchio D. Buskulic C. Buy R. L. Byer L. Cadonati G. Cagnoli C. Cahillane J. Calderón Bustillo J. D. Callaghan T. A. Callister E. Ca LIGO Laboratory California Institute of Technology Pasadena California 91125 USA Louisiana State University Baton Rouge Louisiana 70803 USA Dipartimento di Farmacia Università di Salerno I-84084 Fisciano Salerno Italy INFN Sezione di Napoli Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy OzGrav School of Physics & Astronomy Monash University Clayton 3800 Victoria Australia LIGO Livingston Observatory Livingston Louisiana 70754 USA University of Wisconsin-Milwaukee Milwaukee Wisconsin 53201 USA OzGrav Australian National University Canberra Australian Capital Territory 0200 Australia Max Planck Institute for Gravitational Physics (Albert Einstein Institute) D-30167 Hannover Germany Leibniz Universität Hannover D-30167 Hannover Germany Inter-University Centre for Astronomy and Astrophysics Pune 411007 India University of Cambridge Cambridge CB2 1TN United Kingdom Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena D-07743 Jena Germany University of Birmingham Birmingham B15 2TT United Kingdom Center for Interdisciplinary Exploration & Research in Astrophysics (CIERA) Northwestern University Evanston Illinois 60208 USA Instituto Nacional de Pesquisas Espaciais 12227-010 São José dos Campos São Paulo Brazil Gravity Exploration Institute Cardiff University Cardiff CF24 3AA United Kingdom INFN Sezione di Pisa I-56127 Pisa Italy Gravitational Wave Science Project National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan Advanced Technology Center National Astronomical Observatory of Japan (NAOJ) Mitaka City Tokyo 181-8588 Japan INFN Sezione di Torino I-10125 Torino Italy Università di Napoli “Federico II” Complesso Universitario di Monte S. Angelo I-80126 Napoli Italy Université de Lyon Université Claude Bernard Lyon 1 CNRS Institut Lumière Matière F-69622 Villeurbanne France Department of Physics The University of Tokyo Bunkyo-ku Tokyo 113-0033 Japan Research Center for the Early Un

Results are presented of searches for continuous gravitational waves from 20 accreting millisecond x-ray pulsars with accurately measured spin frequencies and orbital parameters, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. The search algorithm uses a hidden Markov model, where the transition probabilities allow the frequency to wander according to an unbiased random walk, while the J-statistic maximum-likelihood matched filter tracks the binary orbital phase. Three narrow subbands are searched for each target, centered on harmonics of the measured spin frequency. The search yields 16 candidates, consistent with a false alarm probability of 30% per subband and target searched. These candidates, along with one candidate from an additional target-of-opportunity search done for SAX J1808.4−3658, which was in outburst during one month of the observing run, cannot be confidently associated with a known noise source. Additional follow-up does not provide convincing evidence that any are a true astrophysical signal. When all candidates are assumed nonastrophysical, upper limits are set on the maximum wave strain detectable at 95% confidence, h095%. The strictest constraint is h095%=4.7×10−26 from IGR J17062−6143. Constraints on the detectable wave strain from each target lead to constraints on neutron star ellipticity and r-mode amplitude, the strictest of which are ε95%=3.1×10−7 and α95%=1.8×10−5 respectively. This analysis is the most comprehensive and sensitive search of continuous gravitational waves from accreting millisecond x-ray pulsars to date.

关键词： Gravitational waves Binary stars Neutron stars & pulsars

Ultrafast asymmetric Rosen-Zener-like coherent phonon responses observed in silicon

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arXiv 2018年

作者： Watanabe, Yohei Hino, Ken-Ichi Maeshima, Nobuya Petek, Hrvoje Hase, Muneaki Doctoral Program in Materials Science Graduate School of Pure and Applied Sciences University of Tsukuba Tsukuba Ibaraki305-8573 Japan Division of Materials Science Faculty of Pure and Applied Sciences University of Tsukuba Tsukuba305-8573 Japan Center for Computational Sciences University of Tsukuba Tsukuba305-8577 Japan Department of Physics and Astronomy Pittsburgh Quantum Institute University of Pittsburgh PittsburghPA15260 United States Division of Applied Physics Faculty of Pure and Applied Sciences University of Tsukuba Tsukuba305-8573 Japan

We investigate the spectral profiles of time signals attributed to coherent phonon generation in an undoped Si crystal. Here, the retarded longitudinal-optical (LO) phonon Green function relevant to the temporal variance of induced charge density of ionic cores is calculated by employing the polaronic quasiparticle model developed by the authors [Y. Watanabe et al., Phys. Rev. B 95, 014301 (2017);ibid., 96, 125204 (2017)]. The spectral asymmetry is revealed in the frequency domain of the signals under the condition that an LO phonon mode stays almost energetically resonant with a plasmon mode in the early time region;this lasts for approximately 100 fs immediately after the irradiation of an ultrashort pump-laser pulse. It is understood that based on the adiabatic picture in time, this asymmetry is caused by the Rosen-Zener coupling between both modes. The associated experimental results are obtained by measuring time-dependent electro-optic reflectivity signals, and it is proved that these are in harmony with the calculated ones. The spectra become more symmetric, as the photoexcited carrier density further changes from that meeting the above condition to higher and lower sides of carrier densities. Moreover, the effect of optical nutation of carrier density on the CP signals is addressed, and the present results are compared with the asymmetry caused by transient Fano resonance, and the spectral profiles observed in a GaAs crystal in the text. Copyright © 2018, The Authors. All rights reserved.

关键词： Carrier concentration

Combined searches for dark matter in dwarf spheroidal galaxies observed with the MAGIC telescopes, including new data from Coma Berenices and Draco

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arXiv 2021年

作者： Acciari, V.A. Ansoldi, S. Antonelli, L.A. Engels, A. Arbet Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. de Almeida, U. Barres Barrio, J.A. Batković, I. González, J. Becerra Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bökenkamp, H. Bonnoli, G. Bošnjak, Ž. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S.M. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D’Amico, G. D’Elia, V. da Vela, P. Dazzi, F. de Angelis, A. de Lotto, B. Delfino, M. Delgado, J. Mendez, C. Delgado Depaoli, D. Di Pierro, F. Di Venere, L. Espiñeira, E. Do Souto Prester, D. Dominis Donini, A. Dorner, D. Doro, M. Elsaesser, D. Ramazani, V. Fallah Fattorini, A. Fonseca, M.V. Font, L. Fruck, C. Fukami, S. López, R.J. García Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, J.G. Green, D. Hadasch, D. Hahn, A. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hütten, M. Inada, T. Ishio, K. Iwamura, Y. Jiménez, I. Jormanainen, J. Jouvin, L. Karjalainen, M. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Linhoff, L. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. de Oliveira Fraga, B. Machado Maggio, Camilla Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martínez, M. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Miranda, J.M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Neustroev, V. Nigro, C. Nilsson, K. Ninci, D. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. Pavletić, L. Peñil, P. Persic, M. Pihet, M. Moroni, P.G. Prada Prandini, E. Priyadarshi, C. Puljak, I. Rhode, W. Ribó, M. Rico, J. Righi, C. Instituto de Astrofísica de Canarias and Dpto. de Astrofísica Universidad de La Laguna Tenerife La LagunaE-38200 Spain Università di Udine and INFN Trieste UdineI-33100 Italy RomeI-00136 Italy ETH Zürich ZürichCH-8093 Switzerland E-08193 Spain University of Tokyo Chiba Kashiwa277-8582 Japan Technische Universität Dortmund D-44221 Dortmund Germany Zagreb10000 Croatia IPARCOS Institute EMFTEL Department Universidad Complutense de Madrid MadridE-28040 Spain URCA RJ Rio de Janeiro22290-180 Brazil Università di Padova and INFN PadovaI-35131 Italy University of Lodz Faculty of Physics and Applied Informatics Department of Astrophysics Lodz90-236 Poland Università di Siena and INFN Pisa SienaI-53100 Italy ZeuthenD-15738 Germany Max-Planck-Institut für Physik MünchenD-80805 Germany Università di Pisa INFN Pisa PisaI-56126 Italy Universitat de Barcelona ICCUB IEEC-UB BarcelonaE-08028 Spain Armenian MAGIC Group A. Alikhanyan National Science Laboratory Yerevan0036 Armenia Centro de Investigaciones Energéticas Medioambientales y Tecnológicas MadridE-28040 Spain INFN MAGIC Group INFN Sezione di Torino Università degli Studi di Torino TorinoI-10125 Italy INFN MAGIC Group INFN Sezione di Bari Dipartimento Interateneo di Fisica dell’Università e del Politecnico di Bari BariI-70125 Italy Croatian MAGIC Group University of Rijeka Department of Physics Rijeka51000 Croatia Universität Würzburg WürzburgD-97074 Germany Finnish MAGIC Group Finnish Centre for Astronomy with ESO University of Turku TurkuFI-20014 Finland Departament de Física CERES-IEEC Universitat Autònoma de Barcelona BellaterraE-08193 Spain Armenian MAGIC Group ICRANet- Armenia at NAS RA Yerevan0019 Armenia Split21000 Croatia Croatian MAGIC Group Josip Juraj Strossmayer University of Osijek Department of Physics Osijek31000 Croatia Japanese MAGIC Group Department of Physics Kyoto University Kyoto606-8502 Japan Japanese MAGIC Group Department of P

Milky Way dwarf spheroidal galaxies (dSphs) are among the best candidates to search for signals of dark matter annihilation with Imaging Atmospheric Cherenkov Telescopes, given their high mass-to-light ratios and the fact that they are free of astrophysical gamma-ray emitting sources. Since 2011, MAGIC has performed a multi-year observation program in search for Weakly Interacting Massive Particles (WIMPs) in dSphs. Results on the observations of Segue 1 and Ursa Major II dSphs have already been published and include some of the most stringent upper limits (ULs) on the velocity-averaged cross-section hσannvi of WIMP annihilation from observations of dSphs. In this work, we report on the analyses of 52.1 h of data of Draco dSph and 49.5 h of Coma Berenices dSph observed with the MAGIC telescopes in 2018 and in 2019 respectively. No hint of a signal has been detected from either of these targets and new constraints on the hσannvi of WIMP candidates have been derived. In order to improve the sensitivity of the search and reduce the effect of the systematic uncertainties due to the J-factor estimates, we have combined the data of all dSphs observed with the MAGIC telescopes. Using 354.3 h of dSphs good quality data, 95 % CL ULs on hσannvi have been obtained for 9 annihilation channels. For most of the channels, these results reach values of the order of 10−24 cm3/s at ∼1 TeV and are the most stringent limits obtained with the MAGIC telescopes so far. Copyright © 2021, The Authors. All rights reserved.

关键词： Galaxies

Author Correction: Disrupting cellular memory to overcome drug resistance

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Nature communications 2024年第1期15卷 4264页

作者： Guillaume Harmange Raúl A Reyes Hueros Dylan L Schaff Benjamin Emert Michael Saint-Antoine Laura C Kim Zijian Niu Shivani Nellore Mitchell E Fane Gretchen M Alicea Ashani T Weeraratna M Celeste Simon Abhyudai Singh Sydney M Shaffer Cellular and Molecular Biology Graduate Group Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Biochemistry and Molecular Biophysics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Bioengineering School of Engineering and Applied Sciences University of Pennsylvania Philadelphia PA USA. Division of Biology and Biological Engineering California Institute of Technology Pasadena CA 91125 USA. Department of Electrical and Computer Engineering University of Delaware Newark DE 19716 USA. Abramson Family Cancer Research Institute Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Chemistry College of the Arts and Sciences University of Pennsylvania Philadelphia PA USA. Department of Physics College of the Arts and Sciences University of Pennsylvania Philadelphia PA USA. Department of Biology College of the Arts and Sciences University of Pennsylvania Philadelphia PA USA. The Wharton School University of Pennsylvania Philadelphia PA USA. Cancer Signaling and Microenvironment Research Program Fox Chase Cancer Center Philadelphia PA USA. Department of Biochemistry and Molecular Biology Johns Hopkins School of Public Health Baltimore MD USA. Sidney Kimmel Cancer Center Johns Hopkins School of Medicine Baltimore MD USA. Department of Cell and Developmental Biology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. Department of Bioengineering School of Engineering and Applied Sciences University of Pennsylvania Philadelphia PA USA. sydshaffer@***. Department of Pathology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA. sydshaffer@***.