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Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice

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American Journal of Physiology - Heart and Circulatory Physiology 2025年第4期328卷 H900-H914页

作者： Du, Liya Rodgers, Jeffrey Gharraee, Nazli Gary, Olivia Shazly, Tarek Eberth, John F. Lessner, Susan M. Biomedical Engineering Program College of Engineering and Computing University of South Carolina Columbia SC United States College of Arts and Sciences University of South Carolina Columbia SC United States Department of Cell Biology and Anatomy School of Medicine University of South Carolina Columbia SC United States Biomedical Engineering Science and Health Systems Drexel University Philadelphia PA United States

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our results show that homeostatic levels of passive circumferential stress and stretch were preserved in KO mice by remodeling adventitial collagen fibers toward a more predominantly circumferential direction with age, rather than by increased fibrosis, in response to hypertension induced by endothelial dysfunction. However, passive aortic stiffness in KO mice was significantly increased owing to geometrical changes, including significant increases in wall thickness and decreases in inner diameter, and by ECM microstructural reorganization, during this maladaptive vascular remodeling. Furthermore, long-term NO deficiency significantly increased smooth muscle cell (SMC) contractility initially, but this effect was attenuated with age. These findings improve our understanding of microstructural and mechanical changes during the maladaptive vascular remodeling process, demonstrating a role for adventitial collagen fiber reorientation in the response to hypertension. © 2025 The Authors.

关键词： endothelial dysfunction microstructure of extracellular matrix passive and active vascular biomechanics vascular remodeling

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BPS2025 - Matrix stiffness drives Piezo1 activity in oral cancer spheroids and secreted extracellular vesicles

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Biophysical Journal 2025年第3期124卷 266a-266a页

作者： Maulee Sheth Supasek Kongsomros Manju Sharma Leyla Esfandiari Biomedical Engineering Program University of Cincinnati Cincinnati OH USA

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TiCu-CMC/PDA coatings with long-term antimicrobial activity and cytocompatibility for surface engineering of implants

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Surface and Coatings Technology 2025年 509卷

作者： Zheng, Xiaosong Jiang, Yehao Zheng, Fazhan Xiang, Long Zhou, Lili Liang, Wenlang Huang, Nan Leng, Yongxiang Akhavan, Behnam Jing, Fengjuan Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Sichuan Chengdu610031 China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu610031 China School of Engineering University of Newcastle CallaghanNSW2308 Australia Precision Medicine Program New Lambton HeightsNSW2305 Australia School of Biomedical Engineering University of Sydney SydneyNSW2006 Australia School of Physics University of Sydney SydneyNSW2006 Australia Sydney Nano Institute University of Sydney SydneyNSW2006 Australia

Long-term antibacterial effects and favourable biocompatibility are crucial to sustaining the long-term application of medical devices such as cardiac implantable devices, orthopedic devices, hernia meshes, and catheters. This study reports the development of sodium carboxymethyl cellulose/polydopamine films on Ti[sbnd]Cu coatings (TiCu-CMC/PDA) with long-term antimicrobial effects and cytocompatibility for surface engineering of implants. The TiCu-CMC/PDA coatings demonstrate sustained antimicrobial efficacy, maintaining bacterial inhibition rates above 99.6 % after aging in simulated body fluid (SBF) at 37 °C for 60 days. This remarkable antibacterial performance is primarily driven by the controlled release of copper ions during aging, complemented by surface copper's contribution to antimicrobial effects. Further, the TiCu-CMC/PDA coatings exhibit high cell viability and proliferation with negligible cytotoxicity, attributed to the regulated copper ion release. However, the endothelial cell viability on TiCu-CMC/PDA coatings decreased with aging due to the formation of copper ion complexes and CuO/Cu(OH)2, as well as increased surface roughness and hydrophilicity over time. The technology offers a simple and controllable approach to fabricating TiCu-CMC/PDA coatings, providing a pathway for the design of long-term antibacterial biomedical devices, including cardiovascular and orthopedic implants. © 2024

关键词： Antibiotics

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Estimating continuous and intermittent feedback models of postural control using the least squares method

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Biological cybernetics 2025年第2-3期119卷 11页

作者： Diego Gonzalez Luis Aureliano Imbiriba Frederico Jandre Biomedical Engineering Program Federal University of Rio de Janeiro Av. Horacio Macedo Rio de Janeiro 21941914 Rio de Janeiro Brazil. Electrical Engineering Department Federal Center for Technological Education Celso Suckow da Fonseca Av. Governador Roberto Silveira Nova Friburgo 28635000 Rio de Janeiro Brazil. School of Physical Education and Sports Federal University of Rio de Janeiro Av. Carlos Chagas Filho Rio de Janeiro 21941599 Rio de Janeiro Brazil. Biomedical Engineering Program Federal University of Rio de Janeiro Av. Horacio Macedo Rio de Janeiro 21941914 Rio de Janeiro Brazil. jandre@peb.ufrj.br.

Biomechanical models of postural control provide valuable insights into the mechanisms underlying balance. Although continuous and intermittent controller structures have been widely applied, their parameter identification from experimental data across diverse populations and sensory conditions remains underexplored. This study employs ankle torque signals and least squares (LS)-based methods to estimate and compare parameters of continuous and intermittent feedback models using sway data from young and older adults during quiet standing under varied sensory conditions. The LS, non-negative LS, and bounded-variable LS methods achieved high mean coefficients of determination ( ) for both models. Passive stiffness in the intermittent models remained consistent across sensory conditions, whereas active parameters varied for both models, reflecting adaptability. Simulations with these estimated models reproduced human sway patterns with reasonable accuracy. Despite some limitations, these techniques may contribute to advancing our understanding of postural control mechanisms.

关键词： Intermittent control Parameter estimation Postural control Postural sway

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Scientometric analysis of evolution in sex-specific MSC therapy for cardiovascular diseases

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Biochimica et Biophysica Acta - Molecular Basis of Disease 2025年第6期1871卷 167878页

作者： Verma, Elika Gupta, Mehak Sierhuis, Riley Dhingra, Sanjiv Institute of Cardiovascular Sciences St. Boniface Hospital Albrechtsen Research Centre Regenerative Medicine Program Department of Physiology and Pathophysiology Rady Faculty of Health Sciences Biomedical Engineering Program University of Manitoba Winnipeg R2H2A6 MB Canada

Background: Mesenchymal stem cell (MSC) therapy for cardiovascular diseases has shown promise;however, sex-specific differences remain understudied. This scientometric analysis provides the first comprehensive overview of sex-specific differences in mesenchymal stem cell (MSC) therapy for cardiovascular diseases, spanning from 1947 to 2024. Methods: We analyzed 61,029 publications using advanced bibliometric tools to identify research hotspots, publication trends, and collaborative networks. Results: A significant shift in research focus has been observed in the field of mesenchymal stem cell (MSC) therapy for cardiovascular diseases, transitioning from broad cardiovascular concepts in the 20th century to specialized sex-specific considerations in the 21st century. Furthermore, in the 21st-century research landscape, the formation of two distinct clusters for “male” and “female” in VOSviewer-generated network visualizations is highly important, emphasizing the growing recognition of sex-specific differences in MSC therapy responses and outcomes. This shift was accompanied by a marked increase in terminology related to sex-specific differences, with keywords like “genetic association” and “body mass index” forming distinct clusters in recent years. Conclusions: This analysis underscores the critical need for sex-specific considerations in MSC therapy for cardiovascular disease. The emergence of distinct male and female clusters in research networks emphasizes the importance of tailoring approaches based on sex differences. Key areas identified for future investigation include the role of epigenetics in mediating sex-specific effects and the potential of sex-matched MSC-derived exosomes. These findings pave the way for more effective and personalized approaches in cardiovascular regenerative medicine, potentially leading to improved outcomes through sex-specific therapeutic strategies. © 2025 The Authors

关键词： Cardiovascular disease Mesenchymal stem cells Scientometric analysis Sex

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Mitochondrial dynamics, biogenesis, mitophagy and oxidative stress in gestational obesity: A review

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Endocrine and Metabolic Science 2025年 17卷

作者： Rodríguez-Córdoba, Karenth Milena Soto, Sofia Agreda Garzón, Jenniffer Alejandra Castellanos Pustovrh-Ramos, Maria Carolina Faculty of Basic Sciences Department of Morphology TEBLAMI Research Group Universidad del Valle Cali 7600 Colombia Faculty of Engineering Biomedical Engineering Program Unidad Central del Valle del Cauca Valle del Cauca Tuluá 763029 Colombia

Maternal obesity is a major global health problem with serious implications for maternal and fetal well-being. It creates a lipotoxic environment in the placenta, characterised by increased inflammation, oxidative stress and disturbances in mitochondrial dynamics and biogenesis. The aim of this review is to explore the intricate interactions between mitochondrial dynamics, biogenesis and mitophagy in the context of gestational obesity. Adverse mitochondrial adaptations associated with maternal obesity contribute to placental dysfunction, impairing its ability to support healthy fetal development and increasing the risk of metabolic, cardiovascular and neurodegenerative diseases in the offspring. In addition, mitochondrial dysfunction exacerbates oxidative stress, creating a vicious cycle that further impairs cellular processes. The findings highlight the urgent need for targeted interventions to improve mitochondrial function and placental health, ultimately reducing long-term health risks for both mother and child. © 2024 The Author(s)

关键词： Fetal programming Gestational obesity Metabolic diseases Mitochondrial dynamics Oxidative stress Placenta Pregnancy

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Reader Comment Regarding Delta shock index in the emergency department as a predictor of clinical outcomes in traumatic injury

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The American journal of emergency medicine 2025年 92卷 187-188页

作者： Jen-Yu Hsu Kazuhiro Komine Fu-Shan Jaw Chien-Chieh Hsieh Department of Neurology Far Eastern Memorial Hospital New Taipei City Taiwan. Department of Emergency and Critical care Medicine Cheng Hsin General Hospital Taipei City Taiwan. Department of Biomedical Engineering National Taiwan University Taipei City Taiwan. Department of Emergency Medicine Far Eastern Memorial Hospital New Taipei City Taiwan Department of Biomedical Engineering National Taiwan University Taipei City Taiwan International Bachelor Program in Electrical and Communication Engineering Yuan Ze University Taoyuan Taiwan. Electronic address: hsiehchienchieh@***.

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Hybrid statistical and machine-learning approach to hearing-loss identification based on an oversampling technique

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Computers in Biology and Medicine 2025年 185卷 109539-109539页

作者： Wang, Tang-Chuan Sun, Ko-Han Chih, Mingchang Chen, Wei-Chun Department of Otolaryngology-Head and Neck Surgery China Medical University Hsinchu Hospital Zhubei City Hsinchu302056 Taiwan Department of Master Program for Biomedical Engineering College of Biomedical Engineering China Medical University Taichung404328 Taiwan School of Medicine College of Medicine China Medical University Taichung404328 Taiwan Department of Business Administration National Chung Hsing University South District Taichung402202 Taiwan Stainless Steel Business Group Walsin Lihwa Corporation Wuqi District Taichung43541 Taiwan

Background and objectives: Hearing loss is a crucial global health hazard exerting considerable social and physiological effects on spoken language and cognition. Patients affected by this condition may experience social and professional hardships that dominate occupational injuries. Therefore, the identification of the features of recessive hearing loss is important for clinicians to prevent further disease progression. This work aimed to develop a hybrid statistical and machine-learning approach as a decision-support mechanism. We expect the proposed model to help predict hearing-loss disorders and support clinical diagnosis. Methods: A three-phase hybrid approach was proposed to implement classification models. A stepwise method and a random forest (RF) technique were utilized as filters during feature selection. Phase I involved reducing the number of input variables and selecting the most influential features. Phase II included the use of an oversampling technique called synthetic minority oversampling technique (SMOTE) to oversample the minority class and balance the sample size between the target and nontarget classes. Phase III focused on the final model selection based on three supervised classification models, namely, the logistic regression, multilayer perceptron, and support vector machine (SVM), for the target identification and prediction of the case of interest (i.e., hearing loss). Results: The analysis of phase I involved the selection and acquisition of three and seven features through the stepwise technique and RF method, respectively. The SMOTE technique alleviated the imbalanced data issue and improved the predictive capability substantially in phase II and III. Accordingly, in terms of accuracy, precision, recall, and F1 score, our empirical results demonstrated that the proposed hybrid approach involving the SVM method combined with a stepwise technique was competitive against the logistic model featuring all variables. Furthermore, the SVM mo

关键词： Diagnosis

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Fibrotic and emphysematous murine lung mechanics under negative-pressure ventilation

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American Journal of Physiology - Lung Cellular and Molecular Physiology 2025年第3期328卷 L443-L455页

作者： Quiros, K.A.M. Nelson, T.M. Ulu, A. Dominguez, E.C. Nordgren, T.M. Eskandari, M. Department of Mechanical Engineering University of California-Riverside Riverside CA United States Division of Biomedical Sciences Riverside School of Medicine University of California-Riverside Riverside CA United States Environmental Toxicology Graduate Program University of California-Riverside Riverside CA United States BREATHE Center School of Medicine University of California-Riverside Riverside CA United States Department of Environmental and Radiological Health Sciences Colorado State University Fort Collins CO United States Department of Bioengineering University of California-Riverside Riverside CA United States

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and the progressive nature heightens the calamity of the disease. In existing COPD studies, lung mechanics are often reported under positive-pressure ventilation (PPV) and extrapolations made from these studies pose restrictions as recent works have divulged disparate elastic and energetic results between PPV and more physiological negative-pressure ventilation (NPV) counterparts. This nonequivalence of PPV and NPV must be investigated under diseased states to augment our understanding of disease mechanics. To assess the comparability of diseased pulmonary mechanics in PPV and NPV, we pose a novel study to parse out the currently entangled contributions of ventilation mode and diseased state by analyzing murine PV curves from porcine pancreatic elastase (PPE) and hog dust extract (HDE) induced COPD models under positive and negative pressures. We find that, for PPE-exposed, under NPV, volume, compliance (C, C_start, and C_def), and hysteresis are increased in diseased states and that under PPV, only compliance (C and C_start) is increased. For HDE-exposed, under NPV, volume, compliance (C, C_inf, C_def, and K), and hysteresis are decreased, whereas, under PPV, only volume and static compliance decreased. All significant mechanical variations due to disease were observed solely at higher pressures (40 cmH₂O) under both PPV and NPV. Our nuanced conclusions indicate the detection capabilities of multiple mechanics-based biomarkers are sensitive to the ventilation mode, where NPV exhibits more altered mechanics metrics in PPE-exposed and HDE-exposed groups compared with PPV counterparts, suggesting the resolution of biomarkers when applied under NPV research considerations may offer greater versatility. Copyright © 2025 The Authors.

关键词： biomarkers compliance COPD negative pressure pulmonary mechanics

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Short-Chain Dense Brush Pegylation on Rigid Nanocarriers Overcomes Anti-Peg Antibody Recognition for Immune-Stealth Drug Delivery

SSRN

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SSRN 2025年

作者： Chen, Ting-Yu Chang, Chi-Yuan Wen, Ting-Chun Xu, Li Lin, Yu-Han Peng, Cheng-Liang Yeh, Yi-Qi Chen, Chueh-Hsuan Chuang, Kuo-Hsiang Wu, Si-Han Graduate Institute of Pharmacognosy Taipei Medical University Taipei11031 Taiwan Graduate Institute of Nanomedicine and Medical Engineering Taipei Medical University Taipei11031 Taiwan Department of Isotope Application National Atomic Research Institute Taoyuan Taiwan National Synchrotron Radiation Research Center Hsinchu Science Park Hsinchu30076 Taiwan Research Center for Applied Science Academia Sinica Taiwan PhD Program in Clinical Drug Development of Chinese Herbal Medicine Taipei Medical University Taipei Taiwan International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering Taipei Medical University Taipei11031 Taiwan

The immunogenicity of polyethylene glycol (PEG) remains a critical challenge in nanomedicine, as pre-existing anti-PEG antibodies can compromise therapeutic efficacy through accelerated blood clearance (ABC) and life-threatening hypersensitivity. Here, we address this challenge by engineering the PEG architecture, creating short-chain dense brush PEGylation (PEG500) on rigid mesoporous silica nanoparticles (MSNs). Unlike conventional PEG2000-liposomes, MSN-PEG500 evades antibodies via three synergistic mechanisms: (1) short-chain PEG500 reduces epitope accessibility, (2) high grafting density (4.43 chains/nm2, according to TGA) forms an dense steric shield, and (3) the rigid silica surface prevents PEG burial. ELISA studies demonstrated that, at equivalent nanoparticle concentrations, MSN-PEG500 exhibits a 26-fold reduction in anti-PEG IgG (6.3) binding and a 1000-fold reduction in anti-PEG IgM (AGP3) binding compared to Lipodox (PEG2000), both of which target the PEG backbone. Furthermore, radiolabeled MSN-PEG500 achieved prolonged circulation and 25% tumor accumulation (ID/g) at 24 hours. In strongly immunized mice, doxorubicin-loaded MSN-PEG500 preserved therapeutic efficacy and 100% survival, whereas Lipodox induced fatal hypersensitivity. Mechanistic investigations revealed that complement activation drives PEG2000 immunotoxicity, and pretreatment with the C3 inhibitor compstatin effectively mitigated temperature drops from 10°C to 2°C in immunized hosts. By demonstrating that nanoscale control of polymer conformation dictates immunological fate, this work provides a clinically translatable blueprint for developing immune-evasive nanomedicines. © 2025, The Authors. All rights reserved.

关键词： Silica nanoparticles

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