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A Novel Technique for the Fabrication of Free-Standing Adhesive Films Using a Polymer Template

MRS Online Proceedings Library 1998年第1期518卷 111-115页

作者： D. J. Hansford L. P. Lee M. Ferrari Biomedical Microdevices Center University of California Berkeley USA Department of Materials Science and Mineral Engineering U.C. Berkeley USA Applied Science and Technology Program U.C. Berkeley USA Department of Civil and Environmental Engineering U.C. Berkeley USA

A technique has been developed that allows the application of free-standing membranes of polymer adhesives used in microfabricated structures. The film is made free-standing by the application of the adhesive to a polymer template, followed by an adhesion step to a microfabricated substrate, and the final release of the film by the removal of the polymer template. It was found that the surface treatment used to treat the Teflon template made it adhere too strongly to the adhesive film for this application. The results show that Gel-Paks make a suitable template for the transference of polymer films over holes of at least micron size.

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In-vivo Fluorescence EEM Collection of Normal and Cancerous Epithelial Tissue in the Hamster Cheek Pouch Model

In-vivo Fluorescence EEM Collection of Normal and Cancerous ...

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biomedical Optical Spectroscopy and Diagnostics, BOSD 1998

作者： Zuluaga, Andrès F. Utzinger, Urs Brookner, Carrie Weiss, Dale Gimenez-Conti, Irma Mitchell, Michele Follen Coghlan, Lezlee Richards-Kortum, Rebecca Biomedical Engineering Program The University of Tenet at Austin AustinTX78712 United States Department of Gynecology The University of Texas M.D. Anderson Cancer Center HoustonTX77030-4095 United States Science Park Animal Research Center The University of Texas M.D. Anderson Cancer Center BastropTX78602 United States

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Contributory presentations/posters

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Journal of Biosciences 1999年第1期24卷 33-198页

作者： N. Manoj V. R. Srinivas A. Surolia M. Vijayan K. Suguna R. Ravishankar R. Schwarzenbacher K. Zeth Diederichs G. M. Kostner A. Gries P. Laggner R. Prassl Madhusudan Pearl Akamine Nguyen-huu Xuong Susan S. Taylor M. Bidva Sagar K. Saikrishnan S. Roy K. Purnapatre P. Handa U. Varshney B. K. Biswal N. Sukumar J. K. Mohana Rao A. Johnson Vasantha Pattabhi S. Sri Krishna Mira Sastri H. S. Savithri M. R. N. Murthy Bindu Pillai Kannan M. V. Hosur Mukesh Kumar Swati Patwardhan K. K. Kannan B. Padmanabhaa S. Sasaki-Sugio M. Nukaga T. Matsuzaki S. Karthikevan S. Sharma A. K. Sharma M. Paramasivam P. Kumar J. A. Khan S. Yadav A. Srinivasan T. P. Singh S. Gourinath Neelima Alam A. Srintvasan Vikas Chandra Punit Kaur Ch. Betzel S. Ghosh A. K. Bera S. Bhattacharya S. Chakraborty A. K. Pal B. P. Mukhopadhyay I. Dey U. Haldar Asok Baneriee Jozef Sevcik Adriana Solovicova K. Sekar M. Sundaralingam N. Genov Dong-cai Liang Tao Jiang Ji-ping Zhang Wen-rui Chang Wolfgang Jahnke Marcel Blommers S. C. Panchal R. V. Hosur Bindu Pillay Puniti Mathur S. Srivatsun Ratan Mani Joshi N. R. Jaganathan V. S. Chauhan H. S. Atreya S. C. Sahu K. V. R. Chary Girjesh Govil Elisabeth Adjadj Éric Quinjou Nadia Izadi-Pruneyre Yves Blouquit Joël Mispelter Bernadette Heyd Guilhem Lerat Philippe Milnard Michel Desmadreil Y. Lin B. D. Nageswara Rao Vidva Raghunathan Mei H. Chau Prashant Pesais Sudha Srivastava Evans Coutinho Anil Saran Leizl F. Sapico Jayson Gesme Herbert Lijima Raymond Paxton Thamarapu Srikrishnan C. R. Grace G. Nagenagowda A. M. Lynn Sudha M. Cowsik Sarata C. Sahu S. Chauhan A. Bhattacharya G. Govil Anil Kumar Maurizio Pellecchia Erik R. P. Zuiderweg Keiichi Kawano Tomoyasu Aizawa Naoki Fujitani Yoichi Hayakawa Atsushi Ohnishi Tadayasu Ohkubo Yasuhiro Kumaki Kunio Hikichi Katsutoshi Nitta V. Rani Parvathy R. M. Kini Takumi Koshiba Yoshihiro Kobashigawa Min Yao Makoto Demura Astushi Nakagawa Isao Tanaka Kunihiro Kuwajima Jens Linge Seán O. Donoghue Michael Nilges G. Chakshusmathi Girish S. Ratnaparkhi P. K. Madhu R. Varadarajan C. Tetreau Molecular Biophysics Unit Indian Institute of Science Bangalore India Austrian Academy of Sciences Institute of Biophysics and X-ray Structure Research Graz Austria Faculty of Biology University of Konstanz Germany Institute of Medical Biochemistry University of Graz Austria Howard Huges Medical Institute Department of Chemistry & Biochemistry University of California La Jolla USA Department of Chemistry & Biochemistry University of California San Diego La Jolla USA Molecular Biophysics Unit India Department of Microbiology &Cell Biology Indian Institute of Science Bangalore India Macromolecular Structure Laboratory NCI - Frederick Cancer Research and Development Center ABL - Basic Research Program Frederick USA Department of Crystallography and Biophysics University of Madras Chennai Biochemistry Department Indian Institute of Science Bangalore India Condensed Matter Physics Division B.A.R.C. Trombay Mumbai Condensed Matter Physics Division Bhabha Atomic Research Centre Trombay Mumbai IMCB The University of Tokyo Tokyo Japan Mitsubishi Chemical Corporation Yokohama Research Center Yokohama Japan Faculty of Pharmaceutical Sciences Chiba University Chiba Japan Department of Biophysics All India Institute of Medical Sciences New Delhi India Department of Biophysics All India Institute of Medical sciences New Delhi India Institüt Physiologische Chemie Hamburg Germany Biophysics Department Bose Institute Calcutta India Slovak Academy of Sciences Institute of Molecular Biology Bratislava Slovakia Indian Institute of Science Bioinformatics Centre Bangalore Departments of Chemistry and Biochemistry Biological Macromolecular Structure Center USA Bulgarian Academy of Sciences Institute of Organic Chemistry Sofia Bulgaria Chinese Academy of Sciences Institute of Biophysics Beijing China Novartis Pharma AG Preclinical Research Basel Switzerland Department of Chemical Sciences Tata Institute of Fundamental Research Mumbai India Solid State Physics Div

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Three-dimensional motion estimation in elastography

Three-dimensional motion estimation in elastography

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IEEE Symposium (IUS) Ultrasonics

作者： E.E. Konofagou F. Kallel J. Ophir Biomedical Engineering Program University of Houston Houston TX USA Ultrasonics Laboratory Department of Radiology University of Texas Medical School Houston TX USA University of Texas Health Science Center at Houston Houston TX US

In elastography we are capable of estimating the two in-plane principal strain components following an applied compression, namely the axial and lateral components, along and perpendicular to the compressor/transducer axis, respectively. However, the motion resulting from the compression is three-dimensional. Therefore, in order fully describe the resulting three-dimensional motion we need to also estimate the third strain, or elevational (out-of-plane) component. In this paper, we describe a method that estimates motion, i.e., displacement and strain, in the elevational direction. In a similar way as in the lateral motion estimation, and by assuming that ultrasonic frames are available in more than one parallel elevational planes, we used methods of interpolation and cross-correlation between elevationally displaced RF echo segments. We were thus able to obtain high resolution elevational displacement and strain estimates. An iterative method corrected for motion in the axial and lateral directions. As a result, together with the corrected axial and lateral strain estimates, we obtained the full 3D normal strain tensor resulting from a uniform compression. Results of this method from three-dimensional finite-element simulations are shown.

关键词： Motion estimation Capacitive sensors Decorrelation Iterative methods Tracking Phase estimation Laboratories Radiology biomedical imaging biomedical engineering

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BOOK REVIEW: Scientific and Clinical Applications of Magnetic Carriers, edited by U. Häfeli, W. Schütt, J. Teller, and M. Zborowski

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Annals of biomedical engineering 1998年第5期26卷 904-904页

作者： Chris Batich Biomedical Engineering Program Materials Science and Engineering Department University of Florida Gainesville

PAC98: 8740+w, 8722Pg, 8759Pw, 8754Br, 8715-v, 8780+s

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Error associated with the choice of an aortic cannula in measuring regional cerebral blood flow with microspheres during pulsatile CPB in a neonatal piglet model

Error associated with the choice of an aortic cannula in mea...

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作者： Ündar, Akif Lodge, Andrew J. Daggett, Casey W. Runge, Thomas M. Ungerleider, Ross M. Calhoon, John H. Division of Thoracic Surgery Department of Surgery Univ. of Texas Health Science Center San Antonio TX United States Biomedical Engineering Program College of Engineering University of Texas at Austin Austin TX United States Division of Thoracic Surgery Department of Surgery Duke University Medical Center Durham NC United States Division of Thoracic Surgery Department of Surgery Univ. Texas Hlth. Sci. Ctr. S. A. 7703 Floyd Curl Dr. San Antonio TX 78284-7841 United States

The effectiveness of an infant pulsatile cardiopulmonary by-pass (CPB) system on maintaining regional cerebral blood flow (CBF) using two different types of aortic cannulae in 3 kg piglets has been investigated. The University of Texas Neonatal Pulsatile Pump was used with either a DLP (Group I, n = 6) or an Elecath (Group II, n = 7) 10Fr aortic cannula. In all the subjects, nasopharyngeal temperature was reduced to 18°C, followed by 1 hr of deep hypothermic circulatory arrest (DHCA), then 45 min of rewarming. During cooling and rewarming, alpha-stat blood gas management was used. The radionuclide labeled microsphere technique was used to determine blood flows in the cerebellum, basal ganglia, brainstem, right and left hemispheres, as well as global CBF (ml/100 g/min). When the DLP aortic cannula was used, regional and global CBF appeared to be higher pre- and post DHCA. In both groups regional CBF was significantly decreased following DHCA. Although better pulsatile flow was attained using the DLP cannula and this may have resulted in higher regional CBF, these results must be interpreted in light of the large standard deviations noted when this cannula was chosen for the studies. These results demonstrate the importance of choosing an appropriate aortic cannula for measuring regional CBF with a pulsatile neonate-infant CPB system.

关键词： Blood vessels

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Compositional Imaging with Electron Energy Loss Spectroscopy

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Microscopy and Microanalysis 1995年第3期1卷 93-108页

作者： Leapman, R.D. Biomedical Engineering and Instrumentation Program NCRR National Institutes of Health Bethesda. Maryland 20892 United States Department of Materials Science and Engineering Lehigh University Whitaker Laboratory Gatan Research and Development Pennsylvania 18015-3195 Pleasanton94588 #5 Bethlehem United States

: Compositional imaging with electron energy loss spectroscopy (EELS) can be performed in both the energy-filtering transmission electron microscope (EFTEM) and in the scanning transmission electron microscope (STEM). Quantitative elemental distributions are obtained from core-edges produced by inner-shell excitations, although more detailed information about chemical bonding and electronic structure is also available from the fine structure associated with valence electron excitations. The fixed-beam EFTEM can provide data from large numbers of pixels very rapidly and offers an advantage for analysis of extended specimen regions containing relatively high atomic concentrations. Acquisition of entire spectra at each pixel in the field-emission STEM (spectrum-imaging technique) provides improved flexibility and accuracy despite the longer recording times. Spectrum-imaging allows post facto data processing with parameters that can be varied after acquisition is completed. In suitably thin specimens, EELS compositional mapping can provide a sensitivity of a few atoms for certain elements. © 1995, Cambridge University Press. All rights reserved.

关键词： compositional mapping electron energy loss spectroscopy microanalysis spectral processing spectrum-imaging STEM transmission electron microscope

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Abstract

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Pflügers Archiv 1996年第6期431卷 R322-R356页

作者： L. J. Andries S. U. Sys A. L. Meulemans J. A. J. Schuurkes B. Vanheel J. Van de Voorde P. De Smet J. Li W. Van Driessche B. Flamion S. Foulon M. Abramow P. Calders W. Eechaute E. Lacroix I. Weyne D. Hoeben C. Burvenich P. Fransen D. Van Bedaf M. Demolder R. Ouedraogo P. Lebrun A. Herchuelz M. -H. Antoine S. Vandenput D. Votion N. Anciaux D. H. Duvivier T. Art P. Lekeux Y. Ghafir M. Geurts E. Hermans J. -M. Maloteaux B. Perrad B. Noel F. Lagache J. L. Bister R. Paquay G. Derycke M. A. Vandermeir S. de Brouwer C. -A. Porret N. Stergiopulos J. -J. Meister M. Verbeke N. Lameire N. M. De Clerck J. De Schuytter J. Tytgato G. Buyse J. Eggermont G. Droogmans B. Nilius P. Daenens S. Salomone O. Feron C. Dessy N. Morel T. Godfraind A. M. Aloisi P. Sacerdote L. Lodi G. Carli C. Carobi G. Garinei U. C. Miniaci P. Scotto M. Sabatino P. Sardo L. Iurato V. La Grutta M. A. Bagni G. Cecchi E. Cecchini F. Colomo P. Garzella R. Bottinelli S. D. H. Harridge M. Canepari C. Reggiani Saltin Reggiani D. Bambagioni G. Fanò G, Menchetti P. Danieli-Betto A. Esposito R. Betto A. Megighian M. Midrio D. Danieli Betto C. Orizio D. Liberati C. Locatelli D. De Grandis A. Veicsteinas D. Angoli D. Delia E. Wanke M. Bramucci A. Miano L. Quassinti E. Maccari O. Murri D. Amici G. Cibelli S. Jüngling S. Schoch H. H. Gerdest G. Thiel I. Demori C. Bottazzi A. Voci E. Fugassa A. Barreca F. Minuto G. Gallo S. Fulle S. Belia G. Menchetti M. Cacchio G. Gastaldi U. Laforenza G. Ferrari G. Rindi M. G. Doni E. Padoin O. Residori M. Cesaro L. Toma A. Rubini F Mutinelli L. Paulesu R. Romagnolie M. Cintorino P. Pippia M. A. Meloni L. Sciola A. Spano M. Cogoli-Greuter A. Cogoli A. Sardini G. M. Mintenig M. A. Valverde F. V. Sepùlveda D. R. Gill S. C. Hyde C. F. Higgins P. A. McNaughton A. Spena M. T. Arcuri S. Bonofiglio R. Chimenti C. Covello T. De Cicco S. Mazzulla G. Martino A. Tottene A. Moretti D. Pietrobon M. C. Baccari F. Calamai G. Staderini E. Cova R. Marelli P. Sommi U. Ventura A. M. Lombardi R. Fabris C. Pagano G. Federspil R. Vettor R. Mancinelli P. To Laboratory of Physiology RUCA University of Antwerp Belgium Dept. of Gastroint. Pharmacol. Janssen Research Foundation Beerse Belgium Department of Physiology and Physipathology University of Gent De Pintelaan 185 Gent Belgium Laboratory of Physiology K. U. Leuven Leuven Belgium Laboratory of Pathophysiology University of Bruxelles (ULB) Brussels Belgium Laboratory of Normal and Pathological Physiology University of Gent Belgium Department of Physiology Biochemistry and Biometrics Faculty of Veterinary Medicine University of Ghent Merelbeke Belgium Laboratory of Physiology University of Antwerp (RUCA) Antwerp Belgium Lab. de Pharmacodynamie et de Thérapeutique Université Libre de Bruxelles Bruxelles Belgique Laboratory for Functional Investigation Faculty of Veterinary Medicine University of Liége Liège Belgium Laboratory for Functional Investigation Faculty of Veterinary Medicine University of Liège Liège Belgium Laboratory of Pharmacology Catholic University of Louvain Brussels Laboratoire de Physiologie Animale FUNDP Namur Laboratory of animal Physiology Facultés universitaires Notre-Dame de la Paix Namur Belgium Biomedical Engineering Laboratory Swiss Federal Institute of Technology Lausanne Switzerland RUCA University of Antwerp Antwerp Belgium Laboratory of Physiology Laboratory of Toxicology University of Leuven Leuven Belgium Laboratoire de Pharmacologie Université Catholique de Louvain Bruxelles Belgium Istituto di Fisiologia Umana Università degli Studi Siena Dipartimento di Farmacologia Università degli Studi di Milano Milano Istituto di Fisiologia Umana Università di Perugia Perugia Dipartimento di Medicina Sperimentale Università di Reggio Calabria Laboratorio di Fisiologia Umana Catanzaro Istituto di Fisiologia umana Palermo Dipartimento di Scienze Fisiologiche Università di Firenze Firenze Dipartimento Biologia Cellulare e Molecolare (sez. Fisiologia e Biofisica) Università di Perugia Perugia Istituto di Fisiologia Umana Univer

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RELATION BETWEEN FLUORESCENCE-SPECTRA OF DILUTE AND TURBID SAMPLES

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APPLIED OPTICS 1994年第3期33卷 414-423页

作者： DURKIN, AJ JAIKUMAR, S RAMANUJAM, N RICHARDSKORTUM, R The authors are with the Biomedical Engineering Program Engineering Science Building The University of Texas at Austin Austin Texas 78712-1084.

We present a method to extend rank-annihilation-factor analysis (RAFA) for the analysis of fluorescence from homogeneous turbid samples. The method is based on a fundamental relationship between the fluorescence of a dilute solution and that of a turbid solution. We have derived this relationship, known as the transfer function, for turbid materials using the two-flux Kubelka-Munk theory. The method is tested with spectroscopic data from optically thin and turbid samples of the media of a human aorta. At 450-nm excitation, agreement between the measured and predicted dilute-solution fluorescence spectra is within 5% at all emission wavelengths;at 340-nm excitation, agreement is within 20% at all wavelengths, with some residual Soret-band absorption. The simulations presented indicate that the transfer function is markedly more sensitive to absorption than to scattering properties.

关键词： FLUORESCENCE SCATTERING TURBID KUBELKA-MUNK THEORY TISSUE

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LIGHT DOSIMETRY - EFFECTS OF DEHYDRATION AND THERMAL-DAMAGE ON THE OPTICAL-PROPERTIES OF THE HUMAN AORTA (VOL 32, PG 477, 1993)

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APPLIED OPTICS 1994年第16期33卷 3571-3571页

作者： CILESIZ, I WELCH, AJ []The authors are with the Biomedical Engineering Program The University of Texas at Austin 639 Engineering Science Building Austin Texas 78712-1084.

No abstract available.

关键词： Optical properties Reflection Scattering Thermal effects Tissue optical properties

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