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第11届世界畜产大会(WCAP2013)

作者： Mi Jang Hyun-Jeong Lee Hyeongmin Kim Woori Kwak WonCheoul Park Jae-Yeon Hwang Chang-Kyu Lee Gul Won Jang Mi Na Park Hyeong-Cheol Kim Jin Young Jeong Kang Seok Seo Heebal Kim Seoae Cho Bo-Young Lee C&K Genomics Seoul National University NakSeoungDaeGwanakguSeoulKorea Department of Agricultural Biotechnology and Research Institute for Agriculture and Life ScienceSeoul National UniversitySeoulKorea Department of Animal Science and TechnologyCollege of Life Science and Natural ResourcesSunchon National UniversitySeoulRepublic of Korea C&K GenomicsSeoul National University NakSeoungDaeGwanakguSeoulKorea C&K Genomics Seoul National University NakSeoungDaeGwanakguSeoulKorea Department of Agricultural Biotechnology and Research Institute of Population GenomicsSeoul National UniversitySeoulRepublic of Korea Department of Animal Science and Technology College of Life Science and Natural ResourcesSunchon National UniversitySeoulRepublic of Korea Division of Animal Genomics and BioinformaticsNational Institute of Animal scienceRural Development AdministrationSuwonRepublic of Korea Department of Agricultural Biotechnology and Research Institute of Population GenomicsSeoul National UniversitySeoulRepublic of Korea Interdisciplinary Program in BioinformaticsSeoul National UniversityKorea Division of Animal Genomics and Bioinformatics National Institute of Animal scienceRural Development AdministrationSuwonRepublic of Korea

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Cancer Diagnostics: A Trachea-Inspired Bifurcated Microfilter Capturing Viable Circulating Tumor Cells via Altered Biophysical Properties as Measured by Atomic Force Microscopy (Small 18/2013)

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Small 2013年第18期9卷

作者： Minseok S. Kim Jinhoon Kim Wonho Lee Sang-Joon Cho Jin-Mi Oh June-Young Lee Sanghyun Baek Yeon Jeong Kim Tae Seok Sim Hun Joo Lee Goo-Eun Jung Seung-Il Kim Jong-Myeon Park Jin Ho Oh Ogan Gurel Soo Suk Lee Jeong-Gun Lee POCT In Vitro Diagnostics Group R&D Solution Group Samsung Advanced Institute of Technology (SAIT) San 14 Nongseo-dong Giheung-gu Yongin-si Gyeonggi-do Korea Research and Development Center Park Systems Korea Interdisciplinary Program of Integrated Biotechnology Sogang University Korea Department of Surgery Yonsei University College of Medicine Korea Department of Chemistry and Center for Bioactive Molecular Hybrids Yonsei University Korea MOT Research Center CTO Office Samsung Advanced Institute of Technology Korea and Samsung Advanced Institute of Health Sciences & Technology SungKyunKwan University Korea

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Whole Genome Gene Discovery in the Pathogenic Oomycete Pythium insidiosum by 454 Sequencing Technology

Whole Genome Gene Discovery in the Pathogenic Oomycete Pythi...

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The Annual Oomycete Molecular Genetics Network Meeting(国际卵菌分子遗传学年会)

作者： Theerapong Krajaejun Shoba Ranganathan Rommanee Khositnithikul Tassanee Lerksuthirat Tassanee Lowhnoo Thidarat Rujirawat Wanta Yingyong Prapat Suriyaphol Sittichoke Tangphatsornruang Gagan Garg Department of Pathology Mahidol University Bangkok Department of Chemistry and Biomolecular Sciences Macquarie University Australia Molecular Medicine Program Multidisciplinary Unit Faculty of Science Mahidol University Bangkok Research Center Faculty of Medicine Ramathibodi HospitalMahidol University Bangkok Bioinformatics and Data Management for Research Office for Research and Development Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Genome Sequencing Laboratory National Center for Genetic Engineering and Biotechnology National Science and Technology Development Agency PathumthaniThailand

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Transcriptomic Data Integration Inferring the Dominance of Starch Biosynthesis in Carbon Utilization of Developing Cassava Roots

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Procedia Computer Science 2012年 11卷 96-106页

作者： Wanatsanan Siriwat Saowalak Kalapanulak Malinee Suksangpanomrung Supatcharee Netrphan Asawin Meechai Treenut Saithong Bioinformatics and Systems Biology Program School of Bioresources and Technology and School of Information Technology King Mongkut's University of Technology Thonburi (Bang Khun Thian campus) Bangkok 10150 Thailand School of Bioresources and Technology King Mongkut's University of Technology Thonburi (Bang Khun Thian campus) Bangkok 10150 Thailand Systems Biology and Bioinformatics Research Group Pilot Plant Development and Training Institute King Mongkut's University of Technology Thonburi Bangkok 10150 Thailand National Center for Genetic Engineering and Biotechnology (BIOTEC) Pathumthani 12120 Thailand Department of Chemical Engineering King Mongkut's University of Technology Thonburi Bangkok 10140 Thailand

Carbon metabolism, which is an important process underlying the plant development, has been extensively studied in model plant Arabidopsis, however the understanding in this process for cassava root crop is very little. To enhance our understanding into the process, we studied carbon partitioning during cassava root development at the transcriptional level via transciptomic data integration into the metabolic pathways. The transcriptome data of three different developmental stages of cassava roots—fibrous root (FR), developing storage root (DR), and mature storage root (MR) from Yang et al. [1] —was integrated into the key carbon metabolism pathways reconstructed following the protocol of Rongsirikul et al. [2] . According to the 43 differentially expressed genes (56 proteins IDs) mapped into the pathways, we found that the genes involved in starch biosynthesis are more up-regulated, in contrast to the expression of genes in the cell wall biosynthesis and respiration. The results may imply the significance of starch biosynthesis among the carbon utilization processes in the developing cassava roots. In other words, the carbon source from α-D-glucose-1-phosphate (G1P) might be mostly used for starch biosynthesis rather than cell wall biosynthesis and respiration pathways during cassava root development.

关键词： carbon partitioning carbon metabolism pathway starch biosynthesis cassava root development data integration

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Multiresponse optimization of inoculum conditions for the production of amylases and proteases by aspergillus awamori in solid-state fermentation of babassu cake

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Enzyme research 2011年第1期2011卷 457392页

作者： Castro, Aline Machado de Teixeira, Mariana Martins Pereira Carvalho, Daniele Fernandes Freire, Denise Maria Guimarães Castilho, Leda Dos Reis Biotechnology Division Research and Development Center PETROBRAS Ilha do Fundão 21941-915 Rio de Janeiro RJ Avenide Horácio Macedo 950 Brazil COPPE Chemical Engineering Program Federal University of Rio de Janeiro 21941-972 Rio de Janeiro RJ Brazil Institute of Chemistry Federal University of Rio de Janeiro 21945-970 Rio de Janeiro RJ Brazil

This work aimed at investigating the simultaneous production of amylases and proteases by solid-state fermentation (SSF) of babassu cake using Aspergillus awamori IOC-3914. By means of experimental design techniques and the desirability function, optimum inoculum conditions (C/N ratio of propagation medium, inoculum age, and concentration of inoculum added to SSF medium) for the production of both groups of enzymes were found to be 25.8, 28.4 h, and 9.1 mg g^-1, respectively. Significant influence of both initial C/N ratio and inoculum concentration was observed. Optimum amylolytic activities predicted by this multiresponse analysis were validated by independent experiments, thus indicating the efficacy of this approach. © 2011 Aline Machado de Castro et al.

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A Large Therizinosauroid (Dinosauria: Theropoda) from the Early Cretaceous of Northwestern China

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Acta Geologica Sinica - English Edition 2011年第4期81卷

作者： LI Daqing PENG Cuo YOU Hailu Matthew C. LAMANNA Jerald D. HARRIS Kenneth J. LACOVARA ZHANG Jianping China University of Geosciences School of Earth Sciences and Resources Beijing 100083 P. R. China Fossil Research and Development Center of the Third Geology and Mineral Resources Exploration Academy of Gansu Province Lanzhou Gansu Province 730050 P. R. China Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 P. R. China Section of Vertebrate Paleontology Carnegie Museum of Natural History Pittsburgh Pennsylvania 15213 USA Dixie State College Science Building Utah 84770 USA Paleontology and Geology Program Department of Bioscience and Biotechnology Drexel University Philadelphia Pennsylvania 19104 USA

Abstract: We herein describe an associated partial postcranial skeleton of a theropod dinosaur discovered in the Lower Cretaceous Xinminpu Group of the Yujingzi Basin, in the Jiuquan area of Gansu Province, northwestern China. Features of its humerus, such as strongly expanded proximal and distal ends, a well developed medial tuberosity, distal condyles expressed on the humeral cranial surface, and a hypertrophied entepicondyle, definitively establish the therizinosauroid affinities of the specimen. It differs from other therizinosauroids in having a shallow, poorly demarcated glenoid fossa with a prominent rounded and striated tumescence on the dorsomedial surface of its scapular portion, and a pubis with a strongly concave cranial margin. It represents a new taxon, Suzhousaurus megatherioides gen. et sp. nov. Cladistic analysis recovers Suzhousaurus as the sister taxon of Nothronychus mckinleyi from the mid-Cretaceous of western North America; together, they are basal members of the Therizinosauroidea, more derived than the Early Cretaceous Falcarius and Beipiaosaurus but less derived than Alxasaurus and the Therizinosauridae. Along with “Nanshiungosaurus” bohlini from possibly coeval beds in the Mazongshan area of northern-most Gansu, Suzhousaurus represents one of the largest-known Early Cretaceous therizinosauroids, demonstrating that this clade attained considerable body size early in its evolutionary history.

关键词： Dinosauria Theropoda Therizinosauroidea Yujingzi Basin Early Cretaceous Jiuquan area Gansu Province China

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Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase

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Journal of Medicinal Chemistry 2009年第9期52卷 2716-2723页

作者： Chen, Chien-Shu Chiou, Chun-Tang Chen, Grace Shiahuy Chen, Sheng-Chia Hu, Chih-Yung Chi, Wei-Kuang Chu, Yi-Ding Hwang, Lih-Hwa Chen, Pei-Jer Chen, Ding-Shinn Liaw, Shwu-Huey Chern, Ji-Wang School of Pharmacy College of Medicine National Taiwan University Taipei Taiwan School of Pharmacy College of Pharmacy China Medical University Taichung Taiwan Division of Herbal Drugs and Natural Products National Research Institute of Chinese Medicine Taipei Taiwan Department of Applied Chemistry Providence University Shalu Taiwan Structural Biology Program Faculty of Life Science National Yang-Ming UniVersity Taipei Taiwan Process Development Division Development Center for Biotechnology Taipei Taiwan Department of Internal Medicine College of Medicine National Taiwan University Taipei Taiwan Department of Life Science College of Life Science National Taiwan University Taipei Taiwan

Hepatitis C virus nonstructural protein 3 (HCV NS3) helicase is believed to be essential for viral replication and has become an attractive target for the development of antiviral drugs. A fluorescence resonant energy transfer helicase assay was established for fast screening of putative inhibitors selected from virtual screening using the program DOCK. Soluble blue HT (1) was first identified as a novel HCV helicase inhibitor. Crystal structure of the NS3 helicase in complex with soluble blue HT shows that the inhibitor bears a significantly higher binding affinity mainly through a 4- sulfonatophenylaminophenyl group, and this is consistent with the activity assay. Subsequently, fragment-based searches were utilized to identify triphenylmethane derivatives for more potent inhibitors. Lead optimization resulted in a 3-bromo-4-hydroxyl substituted derivative 12 with an EC50 value of 2.72 μ M to Ava.5/Huh-7 cells and a lower cytotoxicity to parental Huh-7 cells (CC₅₀) 10.5 μM), and it indeed suppressed HCV replication in the HCV replicon cells. Therefore, these inhibitors with structural novelty may serve as a useful scaffold for the discovery of new HCV NS3 helicase inhibitors. © 2009 American Chemical Society.

关键词： Inhibitors Inhibition Reaction products Peptides and proteins Genetics

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Triglycerides constituted of short and medium chain fatty acids and dicarboxylic acids in Momordica charantia, as well as capric acid, inhibit PGE₂ production in RAW264.7 macrophages

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Food Chemistry 2009年第2期117卷 306-311页

作者： Wu, Wen-Huey Lin, Bi-Yu Kuo, Yueh-Hsiung Huang, Ching-jang Graduate Program of Nutrition Department of Human Development and Family Studies National Taiwan Normal University Taipei 106 162 Sec. 1 Hoping E. Rd Taiwan Tsuzuki Institute for Traditional Medicine College of Pharmacy China Medical University Taichung 404 91 Hsueh-Shih Rd Taiwan Agricultural Biotechnology Research Center Academia Sinica Taipei 115 Taiwan Department of Biochemical Science and Technology Institute of Microbiology and Biochemistry National Taiwan University Taipei 106 1 Sec. 4 Roosevelt Rd Taiwan

This study was aimed to identify compounds in bitter gourd (Momordica charantia) ethyl acetate extract (EAE), which inhibit lipopolysaccharide-induced prostaglandin E2 (PGE2) production in RAW264.7 cells. Bitter gourd... 详细信息

This study was aimed to identify compounds in bitter gourd (Momordica charantia) ethyl acetate extract (EAE), which inhibit lipopolysaccharide-induced prostaglandin E₂ (PGE₂) production in RAW264.7 cells. Bitter gourd EAE was partitioned between n-hexane and methanol/H₂O (90/10). The hexane fraction was further separated by repeated silica gel chromatographies, and a reverse phase (RP) C18 chromatography. Fraction RP-10 showed the highest inhibition effect on PGE₂ production (Max inhibition = 96%, IC₅₀ = 2.3 μg/ml) and was identified to be triglycerides constituted of short and medium chain fatty acids by ¹H NMR, IR and H-HCOSY, and dicarboxylic acids by GC/MS. Fatty acids with 3-20 carbons were tested for the inhibitory activity, and capric acid exhibited the highest effect (Max inhibition = 99%, IC₅₀ = 6.5 μM). In conclusion, triglycerides composed of short and medium chain fatty acids and dicarboxylic acids in bitter gourd inhibit PGE₂ production, and capric acid is the most potent inhibitor among the fatty acids. © 2009 Elsevier Ltd. All rights reserved.

关键词： Bitter gourd Capric acid Macrophages Momordica charantia Prostaglandin E2

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Biological treatment of nutrients from municipal wastewater with an aerated constructed wetland

Biological treatment of nutrients from municipal wastewater ...

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The International Conference on Advances in Chemical Technologies for Water and Wastewater Treatment

作者： Dul-Sun KIM Jae-Suk SHIN Sung-Jin KIMAND Dong-Keun LEE Dept.of Chemical Engineering Environmental Biotechnology National Core Research CenterEnvironmental and Regional Development InstituteBK21 Graduate Education Program for Environmental Core TechnologyGRETECKorea Gyeongsang National UniversityKajwa-dong 900JinjuGyeongnam 660-701Republic of Korea

A constructed wetland was designed to remove BOD together with total nitrogen（T-N）from municipal *** designed wetland was composed of the aerobic tank and anaerobic/anoxic one which was connected in series immediately after the aerobic one,and could treat 100 m raw municipal wastewater every *** biological oxidation and nitrification could be obtained at the aerobic *** than 80 % of BOD5 and 30.5 % of T-N was removed at the aerobic tank,and more than 96 % of the organic nitrogen and ammonia nitrogen were nitrified successfully into nitrate nitrogen,which is indicative of the successful biological *** removal of BOD and T-N could be obtained at the anaerobic/anoxic tank of the constructed *** 57 % of the remaining BOD was removed at the anaerobic/anoxic *** than 74 % of the remaining T-N was denitrified,and the average concentration of T-N at the final effluent was 6.9 mg/*** maximum available capacity for nutrient uptake in plants was far less（of the order of 5 %）than the loading rate of nutrients to the constructed wetland.

关键词： Aerated constructed wetland Municipal wastewaters Nutrients Biological nitrification

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Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors

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Protein Science 2008年第2期6卷

作者： Ross C. Hoffman Beverly J. Castner Mary Gerhart Marylou G. Gibson Brian D. Rasmussen Carl J. March James Weatherbee Monica Tsang Alla Gustchina Celine Schalk-Hihi Ludmila Reshetnikova Alexander Wlodawer Immunex Corporation Seattle Washington 98101 Biotechnology Division R&D Systems 614 McKinley Place N.E. Minneapolis Minnesota 55413 Macromolecular Structure Laboratory NCI-Frederick Cancer Research and Development Center ABL-Basic Research Program Frederick Maryland 21702

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