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Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1

Cell research 2020年第9期30卷 823页

作者： Jia Yu Bo Qin Ann M Moyer Somaira Nowsheen Xinyi Tu Haidong Dong Judy C Boughey Matthew P Goetz Richard Weinshilboum Zhenkun Lou Liewei Wang Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic Rochester MN 55905 USA. Department of Oncology Mayo Clinic Rochester MN 55905 USA. Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN 55905 USA. Mayo Clinic Graduate School of Biomedical Sciences Mayo Clinic School of Medicine and the Mayo Clinic Medical Scientist Training Program Mayo Clinic Rochester MN 55905 USA. Departments of Urology and Immunology Mayo Clinic Rochester MN 55905 USA. Department of Surgery Mayo Clinic Rochester MN 55905 USA. Department of Oncology Mayo Clinic Rochester MN 55905 USA. Lou.Zhenkun@mayo.edu. Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic Rochester MN 55905 USA. Wang.Liewei@mayo.edu.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Commentaries on Viewpoint: Using V̇o2max as a marker of training status in athletes - can we do better?

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Journal of applied physiology (Bethesda, Md. : 1985) 2022年第1期133卷 148-164页

作者： Pedro L Valenzuela Manuel Mateo-March Xabier Muriel Mikel Zabala Alejandro Lucia David Barranco-Gil Grégoire P Millet Franck Brocherie Johannes Burtscher Martin Burtscher Benjamin J Ryan Rachel A Gioscia-Ryan Stephane Perrey Víctor Rodrigo-Carranza Fernando González-Mohíno José María González-Ravé Jordan Santos-Concejero Benedito S Denadai Camila C Greco Arturo Casado Carl Foster Raffaele Mazzolari Giulia Nicole Baldrighi Elisa Pastorio Davide Malatesta Aurélien Patoz Fabio Borrani Stephen J Ives Justin A DeBlauw Ricardo Dantas de Lucas Fernando Klitzke Borszcz Eduardo Marcel Fernandes Nascimento Luiz Guilherme Antonacci Guglielmo Tiago Turnes Richard T Jaspers Stephan van der Zwaard Romuald Lepers Julien Louis Anderson Meireles Hiago L. R. de Souza Géssyca T de Oliveira Marcelo P dos Santos Rhaí A Arriel Moacir Marocolo B Hunter S Meyler D Muniz-Pumares Renato M Ferreira Abigail S Sogard Stephen J Carter Timothy D Mickleborough Guilherme Pereira Saborosa Raphael Dinalli de Oliveira Freitas Paula Souza Alves dos Santos João Pedro de Souza Ferreira Francisco de Assis Manoel Sandro Fernandes da Silva Christoph Triska Bettina Karsten Dajo Sanders Elliot S Lipksi David J Spindler Matthijs K. C. Hesselink Rodrigo Zacca Márcio Fagundes Goethel David Bruce Pyne Brayden M Wood Peyton E Allen Jaden L Gabelhausen Alexandra M Keller Mast T Lige Alicia S Oumsang Greg L Smart Hunter L Paris Arthur H Dewolf Guillaume Toffoli Borja Martinez-Gonzalez Samuele M Marcora Daniela Terson de Paleville Ricardo J Fernandes Susana M Soares J. Arturo Abraldes Guilherme Matta Arthur Henrique Bossi D G McCarthy W Bostad J Gibala Mary Vagula Grupo de Investigación en Actividad física y Salud (PaHerg) Instituto de Investigación Hospital 12 de Octubre (imas12) Madrid Spain Faculty of Sport Sciences Universidad Europea de Madrid Madrid Spain Sport Science Department. Universidad Miguel Hernández Elche Spain Human Performance and Sports Science Laboratory Faculty of Sport Sciences University of Murcia Murcia Spain Department of Physical Education & Sport Faculty of Sport Sciences University of Granada Granada Spain Institute of Sport Sciences University of Lausanne Lausanne Switzerland Laboratory Sport Expertise and Performance (EA 7370) French Institute of Sport (INSEP) Paris France Department of Sport Science University of Innsbruck Innsbruck Austria Thermal and Mountain Medicine Division US Army Research Institute of Environmental Medicine Natick Massachusetts Department of Anesthesiology University of Michigan Ann Arbor Michigan EuroMov Digital Health in Motion University of Montpellier Montpellier France Sport Training Lab University of Castilla-La Mancha Toledo Spain Facultad de Ciencias de la Vida y de la Naturaleza Universidad Nebrija Madrid Spain Department of Physical Education and Sport University of the Basque Country UPV/EHU Vitoria-Gasteiz Spain Human Performance Laboratory São Paulo State University Rio Claro Brazil Center for Sport Studies Rey Juan Carlos University Madrid Spain University of Wisconsin-La Crosse La Crosse Wisconsin Department of Physical Education and Sport University of the Basque Country (UPV/EHU) Vitoria-Gasteiz Spain Department of Molecular Medicine University of Pavia Pavia Italy Department of Brain and Behavioural Sciences − Medical and Genomic Statistics Unit University of Pavia Pavia Italy Department of Biomedical Sciences for Health University of Milan Milan Italy Institute of Sport Sciences of University of Lausanne (ISSUL) University of Lausanne Lausanne Switzerland Health and Human Physiological Sciences Skidmore College Saratoga Springs New

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Cerebral hemodynamics and pseudo-continuous arterial spin labeling considerations in adults with sickle cell anemia

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NMR in Biomedicine 2017年第2期30卷 101002/nbm3681页

作者： Juttukonda, Meher R. Jordan, Lori C. Gindville, Melissa C. Davis, Larry T. Watchmaker, Jennifer M. Pruthi, Sumit Donahue, Manus J. Department of Radiology and Radiological Sciences Vanderbilt University Medical Center NashvilleTN United States Department of Pediatrics Division of Pediatric Neurology Vanderbilt Medical Center NashvilleTN United States Medical Scientist Training Program Vanderbilt University NashvilleTN United States Department of Neurology Vanderbilt University Medical Center NashvilleTN United States Department of Psychiatry Vanderbilt University Medical Center NashvilleTN United States

Sickle cell anemia (SCA) is a genetic disorder resulting in reduced oxygen carrying capacity and elevated stroke risk. Pseudo-continuous arterial spin labeling (pCASL) measures of cerebral blood flow (CBF) may have relevance for stroke risk assessment;however, the effects of elevated flow velocity and reduced bolus arrival time (BAT) on CBF quantification in SCA patients have not been thoroughly characterized, and pCASL model parameters used in healthy adults are often applied to patients with SCA. Here, cervical arterial flow velocities and pCASL labeling efficiencies were computed in adults with SCA (n = 19) and age- and race-matched controls without sickle trait (n = 7) using pCASL in sequence with phase contrast MR angiography (MRA). Controls (n = 7) and a subgroup of patients (n = 8) also underwent multi-post-labeling-delay pCASL for BAT assessment. Mean flow velocities were elevated in SCA adults (velocity = 28.3 ± 4.1 cm/s) compared with controls (velocity = 24.5 ± 3.8 cm/s), and mean pCASL labeling efficiency (α) was reduced in SCA adults (α = 0.72) relative to controls (α = 0.91). In patients, mean whole-brain CBF from phase contrast MRA was 91.8 ± 18.1 ml/100 g/min, while mean pCASL CBF when assuming a constant labeling efficiency of 0.86 was 75.2 ± 17.3 ml/100 g/min (p 1 variation. In conclusion, BAT variation influences pCASL quantification less than elevated cervical arterial velocity and labeling efficiency variation in SCA adults;thus, a lower labeling efficiency (α = 0.72) or subject-specific labeling efficiency should be incorporated for SCA patients. Copyright © 2017 John Wiley & Sons, Ltd.

关键词： Flow velocity

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Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

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Nature Genetics 2025年 1-13页

作者： Strom, Nora I. Gerring, Zachary F. Galimberti, Marco Yu, Dongmei Halvorsen, Matthew W. Abdellaoui, Abdel Rodriguez-Fontenla, Cristina Sealock, Julia M. Bigdeli, Tim Coleman, Jonathan R. Mahjani, Behrang Thorp, Jackson G. Bey, Katharina Burton, Christie L. Luykx, Jurjen J. Zai, Gwyneth Alemany, Silvia Andre, Christine Askland, Kathleen D. Bäckman, Julia Banaj, Nerisa Barlassina, Cristina Nissen, Judith Becker Bienvenu, O. Joseph Black, Donald Bloch, Michael H. Børte, Sigrid Bosch, Rosa Breen, Michael Brennan, Brian P. Brentani, Helena Buxbaum, Joseph D. Bybjerg-Grauholm, Jonas Byrne, Enda M. Cabana-Dominguez, Judit Camarena, Beatriz Camarena, Adrian Cappi, Carolina Carracedo, Angel Casas, Miguel Cavallini, Maria Cristina Ciullo, Valentina Cook, Edwin H. Crosby, Jesse Cullen, Bernadette A. De Schipper, Elles J. Delorme, Richard Djurovic, Srdjan Elias, Jason A. Estivill, Xavier Falkenstein, Martha J. Fundin, Bengt T. Garner, Lauryn Gironda, Christina Goes, Fernando S. Grados, Marco A. Grove, Jakob Guo, Wei Haavik, Jan Hagen, Kristen Harrington, Kelly Havdahl, Alexandra Höffler, Kira D. Hounie, Ana G. Hucks, Donald Hultman, Christina Janecka, Magdalena Jenike, Eric Karlsson, Elinor K. Kelley, Kara Klawohn, Julia Krasnow, Janice E. Krebs, Kristi Lange, Christoph Lanzagorta, Nuria Levey, Daniel Lindblad-Toh, Kerstin Macciardi, Fabio Maher, Brion Mathes, Brittany McArthur, Evonne McGregor, Nathaniel McLaughlin, Nicole C. Meier, Sandra Miguel, Euripedes C. Mulhern, Maureen Nestadt, Paul S. Nurmi, Erika L. O’Connell, Kevin S. Osiecki, Lisa Ousdal, Olga Therese Palviainen, Teemu Pedersen, Nancy L. Piras, Federica Potluri, Sriramya Rabionet, Raquel Ramirez, Alfredo Rauch, Scott Reichenberg, Abraham Riddle, Mark A. Ripke, Stephan Rosário, Maria C. Sampaio, Aline S. Schiele, Miriam A. Skogholt, Anne Heidi Sloofman, Laura G. Smit, Jan Artigas, María Soler Thomas, Laurent F. Tifft, Eric Vallada, Homero van Kirk, Nathanial Veenstra-VanderWeele, Jeremy Vulink, Nienke N. Walker, Christopher P. Wang, Ying Wendland, Jens R. Winsvold Department of Psychology Humboldt-Universität zu Berlin Berlin Germany Department of Psychiatric Phenomics and Genomics (IPPG) Ludwig-Maximilians University Munich Munich Germany Centre for Psychiatry Research Department of Clinical Neuroscience Karolinska Institutet and Stockholm Health Services Region Stockholm Stockholm Sweden Department of Biomedicine Aarhus University Aarhus Denmark University Hospital of Psychiatry and Psychotherapy University of Bern Bern Switzerland Department of Mental Health and Neuroscience Translational Neurogenomics QIMR Berghofer Medical Research Institute Brisbane QLD Australia Department of Population Health and Immunity Healthy Development and Ageing Walter and Eliza Hall Institute of Medical Research Melbourne VIC Australia Department of Psychiatry Human Genetics Yale University New Haven CT United States VA Connecticut Healthcare System West Haven CT United States Department of Center for Genomic Medicine Psychiatric and Neurodevelopmental Genetics Unit Massachusetts General Hospital Boston MA United States Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge MA United States Department of Genetics University of North Carolina at Chapel Hill Chapel Hill NC United States Department of Psychiatry Amsterdam University Medical Centers University of Amsterdam Amsterdam Netherlands Center for Research in Molecular Medicine and Chronic Diseases (CiMUS) Genomics and Bioinformatics University of Santiago de Compostela Santiago de Compostela Spain Grupo de Medicina Xenómica Genetics Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS) Santiago de Compostela Spain Vanderbilt Genetics Institute Vanderbilt University Nashville TN United States Department of Psychiatry and Behavioral Sciences SUNY Downstate Health Sciences University Brooklyn NY United States VA NY Harbor Healthcare System Brooklyn NY United States Social Genetic and Developmental Psychiatry Centre Insti

Obsessive–compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along with D₁ and D₂ type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa and Tourette syndrome and was negatively associated with inflammatory bowel diseases, educational attainment and body mass index. © The Author(s) 2025.

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Bleeding Risk Using INR/aPTT PreSurgery: Systemtic Review (BRUISR) (BRUISR)

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BLOOD 2017年第Sup1期130卷 4654-4654页

作者： Liontos, Larissa Fralick, Michael Longmore, Avery Hicks, Lisa K. Sholzberg, Michelle Department of Laboratory Medicine and Pathobiology The University of Toronto Toronto Canada Brigham and Women's Hospital and Harvard Medical School Boston MA Clinician Scientist Training Program The University of Toronto Toronto Canada Hematology/Oncology St. Michael's Hospital Toronto Canada St. Michael's Hospital Toronto Canada Hematology/Oncology Clinical Research Group St. Michael's Hospital Toronto Canada Hematology-Oncology Clinical Research Group Division of Hematology St. Michael's Hospital and University of Toronto Toronto Canada St. Michael's Hospital University of Toronto Toronto Canada

Background: Multiple published studies have shown that abnormal coagulation tests, the prothrombin time (PT) and activated partial thromboplastin time (aPTT), are not helpful in predicting peri-operative bleeding. Despite numerous guidelines suggesting against their use, these tests continue to be ordered routinely in many pre-operative or pre-interventional settings. Objective: Our objective was to systematically assess the utility of unselected pre-operative PT and aPTT testing to predict bleeding outcomes. Data sources: We conducted a systematic literature review of MEDLINE, EMBASE and Evidence-based Medicine databases for articles published between 1970 and 2016 that addressed pre-operative and/or pre-interventional coagulation testing that was conducted in unselected fashion (i.e. not directed by the patient's personal/family history). Two independent reviewers (LL and AL) screened 3373 articles and 207 studies were included for full-text review. Study eligibility criteria: The minimum criteria for the 54 articles included in our qualitative analysis were: adult and/or pediatric patients undergoing elective surgery and/or an interventional procedure with pre-operative coagulation test results (PT and/or international normalized ratio (INR) and/or aPTT). Outcomes: The primary outcome was to examine the relationship between pre-operative coagulation results and peri-operative bleeding. As a secondary outcome, we also included studies that reported on the frequency of abnormal tests in routinely screened pre-operative patients as well as studies that described the cost of testing. Results: Of the 54 articles we included in our systematic review, studies were grouped according to procedure type: cardiac surgery (N=13), liver transplant (N=7) and tonsillectomy (N=13), major surgery (as defined in Choosing Wisely Canada, 2016) (N=12), and minor surgery (N=9). Within the combined studies of tonsillectomy and minor surgery categories, a total of 21 studies (after exclu

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Commentaries on Viewpoint: Physiology and fast marathons

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Journal of applied physiology (Bethesda, Md. : 1985) 2020年第4期128卷 1069-1085页

作者： Jordan Santos-Concejero Fernando González-Mohíno José María González-Ravé Stephane Perrey Arthur H. Dewolf Brandon A. Yates Anton Ušaj Tadej Debevec José Manuel González-Rayas Ana Lilia Rayas-Gómez José Manuel González-Yáñez Romuald Lepers Paul Stapley Julien Louis Felix Proessl P T Nikolaidis B Knechtle D Muniz-Pumares B Hunter L Bottoms Bastien Bontemps Pedro L. Valenzuela Daniel Boullosa Juan Del Coso Richard C. Blagrove Philip R. Hayes Gregoire P. Millet Davide Malatesta Yuri de Almeida Costa Campos Miller Pereira Guimarães Jeferson Macedo Vianna Sandro Fernandes da Silva Paulo Henrique Silva Marques de Azevedo Hunter L. Paris Margaret A. Leist Mast T. Lige William Malysa Alicia S. Oumsang Erin C. Sinai Rasmus K. Hansen Niels H. Secher Stefanos Volianitis Laura Hottenrott Kuno Hottenrott Thomas Gronwald Jonathon W. Senefeld Ricardo J. Fernandes João Paulo Vilas-Boas Alain Riveros-Rivera Dieter Böning Daniel H. Craighead Shalaya Kipp Rodger Kram Christoph Zinner Billy Sperlich Hans-Christer Holmberg Borja Muniz-Pardos Shaun Sutehall Konstantinos Angeloudis Fergus M. Guppy Andrew Bosch Yannis Pitsiladis David C. Andrade Rodrigo Del Rio Rodrigo Ramirez-Campillo Thiago Ribeiro Lopes Bruno Moreira Silva Stephen J. Ives Peter G. Weyand Cayque Brietzke Paulo Estevão Franco-Alvarenga Tony Meireles dos Santos Flávio Oliveira Pires Gwenael Layec Wouter Hoogkamer Christopher S. Balestrini Curtis S. Goss Mikaela C. Gabler Albaro Escalera Shane A. Bielko Robert F. Chapman Department of Physical Education and Sport University of the Basque Country UPV/EHU Vitoria-Gasteiz Spain University of Castilla-La Mancha Sport Training Lab Toledo Spain Facultad de Lenguas y Educación Universidad Nebrija Madrid Spain EuroMov Digital Health in Motion University of Montpellier IMT Mines Ales Montpellier France Department of Systems Medicine and Center of Space Biomedicine University of Rome Tor Vergata Rome Italy Department of Kinesiology Indiana University-Purdue University of Indianapolis Indianapolis Indiana Indiana Center for Musculoskeletal Health Indiana University School of Medicine Indianapolis Indiana Faculty of Sport University of Ljubljana Ljubljana Slovenia Department of Automation Biocybernetics and Robotics Jozef Stefan Institute Ljubljana Slovenia School of Medicine and Health Sciences Monterrey Institute of Technology and Higher Education Monterrey México Hospital San José de Querétaro Querétaro México INSERM UMR1093-CAPS UFR des Sciences du Sport Université Bourgogne Franche-Comté Dijon France Neural Control of Movement Laboratory School of Medicine Faculty of Science Medicine and Health Illawarra Health and Medical Research Institute University of Wollongong New South Wales Australia Research Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool United Kingdom Neuromuscular Research Laboratory University of Pittsburgh Pittsburgh Pennsylvania School of Health and Caring Sciences University of West Attica Athens Greece Institute of Primary Care University of Zurich Zurich Switzerland Department of Psychology and Sport Sciences School of Life and Medical Sciences University of Hertfordshire Hatfield United Kingdom Unité de recherche Impact de l’Activité Physique sur la Santé (UR IAPS Number 201723207F) University of Toulon Toulon France Department of Systems Biology University of Alcalá Madrid Spain Department of Sport and Health Spanish Agency for Health Protection in Sport (AEPSAD)

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Subnational mapping of HIV incidence and mortality among individuals aged 15–49 years in sub-Saharan Africa, 2000–18: a modelling study

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The Lancet HIV 2021年第6期8卷 e363-e375页

作者： Sartorius, Benn VanderHeide, John D. Yang, Mingyou Goosmann, Erik A. Hon, Julia Haeuser, Emily Cork, Michael A. Perkins, Samantha Jahagirdar, Deepa Schaeffer, Lauren E. Serfes, Audrey L. LeGrand, Kate E. Abbastabar, Hedayat Abebo, Zeleke Hailemariam Abosetugn, Akine Eshete Abu-Gharbieh, Eman Accrombessi, Manfred Mario Kokou Adebayo, Oladimeji M. Adegbosin, Adeyinka Emmanuel Adekanmbi, Victor Adetokunboh, Olatunji O. Adeyinka, Daniel Adedayo Ahinkorah, Bright Opoku Ahmadi, Keivan Ahmed, Muktar Beshir Akalu, Yonas Akinyemi, Oluwaseun Oladapo Akinyemi, Rufus Olusola Aklilu, Addis Akunna, Chisom Joyqueenet Alahdab, Fares Al-Aly, Ziyad Alam, Noore Alamneh, Alehegn Aderaw Alanzi, Turki M. Alemu, Biresaw Wassihun Alhassan, Robert Kaba Ali, Tilahun Alipour, Vahid Amini, Saeed Ancuceanu, Robert Ansari, Fereshteh Anteneh, Zelalem Alamrew Anvari, Davood Anwer, Razique Appiah, Seth Christopher Yaw Arabloo, Jalal Asemahagn, Mulusew A. Asghari Jafarabadi, Mohammad Asmare, Wondwossen Niguse Atnafu, Desta Debalkie Atout, Maha Moh'd Wahbi Atreya, Alok Ausloos, Marcel Awedew, Atalel Fentahun Ayala Quintanilla, Beatriz Paulina Ayanore, Martin Amogre Aynalem, Yared Asmare Ayza, Muluken Altaye Azari, Samad Azene, Zelalem Nigussie Babar, Zaheer-Ud-Din Baig, Atif Amin Balakrishnan, Senthilkumar Banach, Maciej Bärnighausen, Till Winfried Basu, Sanjay Bayati, Mohsen Bedi, Neeraj Bekuma, Tariku Tesfaye Bezabhe, Woldesellassie M. Mequanint Bhagavathula, Akshaya Srikanth Bhardwaj, Pankaj Bhattacharyya, Krittika Bhutta, Zulfiqar A. Bibi, Sadia Bikbov, Boris Birhan, Tsegaye Adane Bitew, Zebenay Workneh Bockarie, Moses John Boloor, Archith Brady, Oliver J. Bragazzi, Nicola Luigi Briko, Andrey Nikolaevich Briko, Nikolay Ivanovich Burugina Nagaraja, Sharath Butt, Zahid A. Cárdenas, Rosario Carvalho, Felix Charan, Jaykaran Chatterjee, Souranshu Chattu, Soosanna Kumary Chattu, Vijay Kumar Chowdhury, Mohiuddin Ahsanul Kabir Chu, Dinh-Toi Cook, Aubrey J. Cormier, Natalie Maria Cowden, Richard G. Culquichicon, Carlos Dagnew, Baye Dahlawi, Saad M.A. D Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford United Kingdom Malaria Atlas Project University of Oxford Oxford United Kingdom The George Institute for Global Health University of Oxford Oxford United Kingdom Department of Health Metrics Sciences School of Medicine University of Washington Seattle WA United States Institute for Health Metrics and Evaluation University of Washington Seattle WA United States Department of Global Health University of Washington Seattle WA United States Department of Medicine University of Washington Seattle WA United States Insights Program Bill and Melinda Gates Foundation Seattle WA United States Global Programs Medical Teams International Seattle WA United States Department of Pediatric Newborn Medicine Brigham and Women's Hospital Boston MA United States Advanced Diagnostic and Interventional Radiology Research Center Tehran University of Medical Sciences Tehran Iran Multiple Sclerosis Research Center Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran Pediatric Chronic Kidney Disease Research Center Tehran University of Medical Sciences Tehran Iran Department of Environmental Health Engineering Tehran University of Medical Sciences Tehran Iran Metabolomics and Genomics Research Center Tehran University of Medical Sciences Tehran Iran Research Center for Immunodeficiencies Tehran University of Medical Sciences Tehran Iran Department of Public Health Arba Minch University Arba Minch Ethiopia Department of Medical Laboratory Sciences Arba Minch University Arba Minch Ethiopia College of Medicine and Health Science Arba Minch University Arba Minch Ethiopia Department of Nursing Arba Minch University Arba Minch Ethiopia Department of Biomedical Sciences Arba Minch University Arba Minch Ethiopia Department of Public Health Debre Berhan University Debre Brehan

Background: High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods: In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings: The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique,

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Back Cover, Volume 43, Issue 7

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Human Mutation 2022年第7期43卷

作者： Ariadne R. Lima Barbara M. Ferreira Chaofan Zhang Angad Jolly Haowei Du Janson J. White Moez Dawood Tulio C. Lins Marcela A. Chiabai Ellen van Beusekom Mara S. Cordoba Erica C.C. Caldas Rosa Hulya Kayserili Virginia Kimonis Erica Wu Cecilia Mellado Vineet Aggarwal Antonio Richieri-Costa Décio Brunoni Talyta M. Canó Alexander A. L. Jorge Chong A. Kim Rachel Honjo Débora R. Bertola Raissa M. Dandalo-Girardi Yavuz Bayram Alper Gezdirici Elif Yilmaz-Gulec Evren Gumus Gülay C. Yilmaz Nobuhiko Okamoto Hirofumi Ohashi Zeynep Coban–Akdemir Tadahiro Mitani Shalini N. Jhangiani Donna M. Muzny Neysa A.P. Regattieri Robert Pogue Rinaldo W. Pereira Paulo A. Otto Richard A. Gibbs Bassam R. Ali Hans van Bokhoven Han G. Brunner V. Reid Sutton James R. Lupski Angela M. Vianna-Morgante Claudia M. B. Carvalho Juliana F. Mazzeu Programa de Pós-Graduação em Ciências da Saúde Universidade de Brasília Brasília DF Brasil Programa de Pós-Graduação em Ciências Médicas Universidade de Brasília Brasília DF Brasil Department of Molecular and Human Genetics Baylor College of Medicine Houston Texas USA Medical Scientist Training Program Baylor College of Medicine Houston Texas USA Department of Pediatrics University of Washington Seattle Washington USA Human Genome Sequencing Center Baylor College of Medicine Houston Texas USA Programa de Pós-graduação em Ciências Genômicas e Biotecnologia Universidade Católica de Brasília Brasília DF Brasil Radboud University Nijmegen Medical Centre Nijmegen The Netherlands Faculdade de Medicina Universidade de Brasília Brasília DF Brasil Hospital Universitário de Brasília Brasília Brasil Medical Genetics Department School of Medicine (KUSoM) Koç University Istanbul Turkey Division of Genetics and Genomic Medicine Department of Pediatrics University of California-Irvine Irvine California USA Obstetrics and Gynecology Stanford University Stanford California USA Unidad de Genética División de Pediatría Pontificia Universidad Católica de Chile Santiago Chile Department of Orthopedics Indira Gandhi Medical College Snowdon India Hospital de Reabilitação de Anomalias Craniofaciais Bauru Brasil In memoriam. Universidade Presbiteriana Mackenzie–UPM São Paulo Brasil Núcleo de Genética–SESDF Brasília DF Brasil Laboratório de Endocrinologia Celular e Molecular LIM25 Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de São Paulo Unidade de Endocrinologia Genética São Paulo Brasil Unidade de Genética Instituto da Criança-Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de São Paulo São Paulo Brasil Departamento de Genética e Biologia Evolutiva Instituto de Biociências Universidade de São Paulo São Paulo Brasil Programa de Mestrado Profissional em Aconselhamento Genético e Genômica Humana Instituto de Biociências U

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Standards of Care for the Health of Transgender and Gender Diverse People, Version 8 (vol 23, pg S1, 2022)

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INTERNATIONAL JOURNAL OF TRANSGENDER HEALTH 2022年第Suppl 1期23卷 S259-S261页

作者： Coleman, E. Radix, A. E. Bouman, W. P. Brown, G. R. de Vries, A. L. C. Deutsch, M. B. Ettner, R. Fraser, L. Goodman, M. Green, J. Hancock, A. B. Johnson, T. W. Karasic, D. H. Knudson, G. A. Leibowitz, S. F. Meyer-Bahlburg, H. F. L. Monstrey, S. J. Motmans, J. Nahata, L. Arcelus, J. Institute for Sexual and Gender Health Department of Family Medicine and Community Health University of Minnesota Medical School Minneapolis MN USA Callen-Lorde Community Health Center New York NY USA Department of Medicine NYU Grossman School of Medicine New York NY USA Nottingham Centre for Transgender Health Nottingham UK School of Medicine University of Nottingham Nottingham UK James H. Quillen College of Medicine East Tennessee State University Johnson City TN USA James H. Quillen VAMC Johnson City TN USA Department of Child and Adolescent Psychiatry Amsterdam UMC Location Vrije Universiteit Amsterdam Amsterdam Netherlands Center of Expertise on Gender Dysphoria Amsterdam UMC Location Vrije Universiteit Amsterdam Amsterdam The Netherlands Department of Family & Community Medicine University of California-San Francisco San Francisco CA USA UCSF Gender Affirming Health Program San Francisco CA USA New Health Foundation Worldwide Evanston IL USA Weiss Memorial Hospital Chicago IL USA Independent Practice San Francisco CA USA Emory University Rollins School of Public Health Atlanta GA USA Independent Scholar Vancouver WA USA The George Washington University Washington DC USA Department of Anthropology California State University Chico CA USA University of California San Francisco San Francisco CA USA Independent Practice at *** University of British Columbia Vancouver Canada Vancouver Coastal Health Vancouver Canada Ann & Robert H. Lurie Children's Hospital of Chicago Chicago IL USA New York State Psychiatric Institute New York NY USA Department of Psychiatry Columbia University New York NY USA Ghent University Hospital Gent Belgium Transgender Infopunt Ghent University Hospital Gent Belgium Centre for Research on Culture and Gender Ghent University Gent Belgium Department of Pediatrics The Ohio State University College of Medicine Columbus OH USA Endocrinology and Center for Biobehavioral Health The Abigail Wexner Research

Background: Transgender healthcare is a rapidly evolving interdisciplinary field. In the last decade, there has been an unprecedented increase in the number and visibility of transgender and gender diverse (TGD) people seeking support and gender-affirming medical treatment in parallel with a significant rise in the scientific literature in this area. The World Professional Association for Transgender Health (WPATH) is an international, multidisciplinary, professional association whose mission is to promote evidence-based care, education, research, public policy, and respect in transgender health. One of the main functions of WPATH is to promote the highest standards of health care for TGD people through the Standards of Care (SOC). The SOC was initially developed in 1979 and the last version (SOC-7) was published in 2012. In view of the increasing scientific evidence, WPATH commissioned a new version of the Standards of Care, the SOC-8. Aim: The overall goal of SOC-8 is to provide health care professionals (HCPs) with clinical guidance to assist TGD people in accessing safe and effective pathways to achieving lasting personal comfort with their gendered selves with the aim of optimizing their overall physical health, psychological well-being, and self-fulfillment. Methods: The SOC-8 is based on the best available science and expert professional consensus in transgender health. International professionals and stakeholders were selected to serve on the SOC-8 committee. Recommendation statements were developed based on data derived from independent systematic literature reviews, where available, background reviews and expert opinions. Grading of recommendations was based on the available evidence supporting interventions, a discussion of risks and harms, as well as the feasibility and acceptability within different contexts and country settings. Results: A total of 18 chapters were developed as part of the SOC-8. They contain recommendations for health care professiona

关键词： adolescents assessment children communication education endocrinology eunuch gender diverse health care professional institutional settings intersex mental health nonbinary population postoperative care primary care reproductive health sexual health SOC8 Standards of Care surgery terminology transgender voice

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Human genetic and immunological determinants of critical COVID-19 pneumonia

引用

四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Howard Hughes Medical Institute Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaires Saint-Luc Brussels Belgium Institut de Recherche Expérimentale et Clinique (IREC) Université Catholique de Louvain Brussels Belgium

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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