检索结果-内蒙古大学图书馆

Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids

引用

Nature medicine 2025年第2期31卷 699页

作者： Mattia Francesco Maria Gerli Giuseppe Calà Max Arran Beesley Beatrice Sina Lucinda Tullie Kylin Yunyan Sun Francesco Panariello Federica Michielin Joseph R Davidson Francesca Maria Russo Brendan C Jones Dani Do Hyang Lee Savvas Savvidis Theodoros Xenakis Ian C Simcock Anna A Straatman-Iwanowska Robert A Hirst Anna L David Christopher O'Callaghan Alessandro Olivo Simon Eaton Stavros P Loukogeorgakis Davide Cacchiarelli Jan Deprest Vivian S W Li Giovanni Giuseppe Giobbe Paolo De Coppi Department of Surgical Biotechnology Division of Surgery and Interventional Science University College London London UK. m.gerli@ucl.ac.uk. Great Ormond Street Institute of Child Health University College London London UK. m.gerli@ucl.ac.uk. Department of Surgical Biotechnology Division of Surgery and Interventional Science University College London London UK. Great Ormond Street Institute of Child Health University College London London UK. Politecnico di Milano Milan Italy. Stem Cell and Cancer Biology Laboratory The Francis Crick Institute London UK. Armenise/Harvard Laboratory of Integrative Genomics Telethon Institute of Genetics and Medicine Pozzuoli Italy. Elizabeth Garrett Anderson Institute for Women's Health University College London London UK. Department of Development and Regeneration Woman and Child and UZ Leuven Clinical Department of Obstetrics and Gynaecology KU Leuven Leuven Belgium. Department of Medical Physics and Biomedical Engineering University College London London UK. Department of Radiology Great Ormond Street Hospital London UK. Department of Respiratory Sciences University of Leicester Leicester UK. Specialist Neonatal and Paediatric Surgery Great Ormond Street Hospital for Children NHS Foundation Trust London UK. Department of Translational Medicine University of Naples Federico II Naples Italy. Genomics and Experimental Medicine Program Scuola Superiore Meridionale Naples Italy. Great Ormond Street Institute of Child Health University College London London UK. p.decoppi@ucl.ac.uk. Department of Development and Regeneration Woman and Child and UZ Leuven Clinical Department of Obstetrics and Gynaecology KU Leuven Leuven Belgium. p.decoppi@ucl.ac.uk. Specialist Neonatal and Paediatric Surgery Great Ormond Street Hospital for Children NHS Foundation Trust London UK. p.decoppi@ucl.ac.uk. Medical and Surgical Department of the Fetus Newborn and Infant Ospedale Pediatrico Bambino Gesù IRCCS Rome Italy. p.decoppi@ucl.ac.uk. NIHR G

来源：评论

学校读者我要写书评

暂无评论

How the Australian Functional Genomics Network (AFGN) contributes to improved patient care

引用

Pathology 2024年 56卷 S21-S22页

作者： Hamish S. Scott Ebony Matotek Tessa Mattiske Robert J. Bryson-Richardson Ian Smyth Jozef Gecz John Christodoulou Nathan Palpant Kelly Smith Coral Warr Bruce Bennetts Paul Thomas Josephine Bowles Massimo Hilliard Gary Hime Livia Hool Leonie Quinn Ernst Wolvetang Robyn Jamieson Gareth Baynam Andrew Sinclair Centre for Cancer Biology University of South Australia and SA Pathology Adelaide SA Australia Department of Genetics and Molecular Pathology SA Pathology Adelaide SA Australia ACRF Cancer Genomics Facility Centre for Cancer Biology University of South Australia and SA Pathology Adelaide SA Australia Adelaide Medical School University of Adelaide Adelaide SA Australia Murdoch Children's Research Institute Melbourne Vic Australia Australian Genomics Murdoch Children's Research Institute Melbourne Vic Australia School of Biological Sciences Monash University Melbourne Vic Australia Department of Anatomy and Developmental Biology Development and Stem Cells Program Monash Biomedicine Discovery Institute Monash University Clayton Vic Australia School of Medicine Robinson Research Institute University of Adelaide Adelaide SA Australia South Australian Health and Medical Research Institute Adelaide SA Australia Discipline of Child and Adolescent Health Sydney Medical School University of Sydney Sydney NSW Australia Victorian Clinical Genetics Services Murdoch Children's Research Institute Melbourne Vic Australia Institute for Molecular Bioscience The University of Queensland Brisbane Qld Australia Department of Anatomy and Physiology The University of Melbourne Parkville Vic Australia School of Agriculture Biomedicine and Environment La Trobe University Bundoora Vic Australia Department of Molecular Genetics The Children's Hospital at Westmead Westmead Australia Specialty of Genomic Medicine Faculty of Medicine and Health The University of Sydney Sydney NSW Australia School of Biomedicine University of Adelaide Adelaide SA Australia Genome Editing Program South Australian Health & Medical Research Institute Adelaide SA Australia South Australian Genome Editing Facility University of Adelaide Adelaide SA Australia School of Biomedical Sciences The University of Queensland Brisbane Qld Australia Clem Jones Centre for Ageing Dementia Re

来源：评论

学校读者我要写书评

暂无评论

MDB-15. CLINICAL CHARACTERISTICS AND OUTCOME OF CHILDHOOD LI-FRAUMENI SYNDROME MEDULLOBLASTOMA PATIENTS

引用

Neuro-Oncology 2023年第SUPPLEMENT_1期25卷 i64–i65页

作者： Anna Kolodziejczak Lea Guerrini-Rousseau Julien Masliah Planchon Martin Mynarek Martin Sill Robert Autry Eric Zhao Steffen Hirsch Christelle Dufour Olivier Ayrault Sebastian Waszak Vijay Ramaswamy Virve Pentikainen Steven Clifford Ed Schwalbe Luca Massimi Matija Snuderl Matthias Karajannis Christine White Shelagh Redmond Loizou Loizos Marcus Jakob Irene Schmid Julia Hauer Claudia Blattmann Maria Filippidou Christian Sutter Torsten Pietsch Stephan Frank Denis Schewe David Malkin Astrid Sehested Tai-Tong Wong Fernando Carceller Sabine Mueller Michael Taylor Uri Tabori Eric Bouffet Marcel Kool Felix Sahm Christian Kratz Dominik Sturm David Jones Stefan Rutkowski Olaf Witt Gaëlle Bougeard Kristian Pajtler Stefan Pfister Franck Bourdeaut Till Milde Hopp Children’s Cancer Center (KiTZ) Heidelberg Germany Department of Children and Adolescents Oncology Gustave Roussy Université Paris-Saclay Villejuif France Somatic Genetics Unit Department of Diagnostic and Theranostic Medicine Institut Curie Paris-Science Lettres University Paris France Pediatric Hematology and Oncology University Medical Center Hamburg-Eppendorf Hamburg Germany Institute of Human Genetics University Hospital Heidelberg Heidelberg Germany Institut Curie PSL Research University CNRS UMR INSERM Orsay France Centre for Molecular Medicine Norway (NCMM) Nordic EMBL Partnership University of Oslo and Oslo University Hospital Oslo Norway Division of Hematology and Oncology Hospital for Sick Children Toronto Canada Division of Hematology-Oncology and Stem Cell Transplantation Children’s Hospital Helsinki University Hospital Helsinki Finland Wolfson Childhood Cancer Research Centre Newcastle University Centre for Cancer Newcastle United Kingdom Pediatric Neurosurgery Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University Medical School Rome Italy Department of Pathology New York University Langone Health New York USA Department of Pediatrics Memorial Sloan Kettering Cancer Center New York USA Hudson Institute of Medical Research Clayton Australia Childhood Cancer Registry Institute of Social and Preventive Medicine University of Bern Bern Switzerland Pediatric Oncology/Hematology/Immunology at the Medical School of the University of Nicosia Nicosia Cyprus Department of Paediatric Haematology Oncology and Stem-Cell Transplantation University Hospital Regensburg Regensburg Germany Paediatric Haematology and Oncology Dr. von Hauner Children’s Hospital Ludwig Maximilians University Munich Munich Germany Department of Pediatrics Technical University Munich Munich Germany Paediatric Haematology Oncology and Immunology Olgahospital Stuttgart Germany Division of Pediatric Hematology-Oncology First Department of Pediatric

Patients with Li-Fraumeni syndrome (LFS) who develop medulloblastoma (MB) have a very poor prognosis. The development of novel therapeutic strategies is challenged by the lack of clinical data for this patient group. We here present clinical and molecular data on a retrospective cohort of pediatric patients with LFS-associated MB.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Hematopoietic stem Cell Transplantation for Mucopolysaccharidoses: Past, Present, and Future

引用

Biology of Blood and Marrow Transplantation 2019年第7期25卷 e226-e246页

作者： Taylor, Madeleine Khan, Shaukat Stapleton, M. Wang, Jianmin Chen, Jing Wynn, Robert Yabe, Hiromasa Chinen, Yasutsugu Boelens, Jaap Jan Mason, Robert W. Kubaski, Francyne Horovitz, Dafne D.G. Barth, Anneliese L. Serafini, M. Bernardo, Maria Ester Kobayashi, Hironori Orii, Kenji E. Suzuki, Yasuyuki Orii, T. Tomatsu, Shunji Department of Biomedical Nemours/Alfred I. duPont Hospital for Children Wilmington DE United States Deparment of Biological Science University of Delaware Newark DE United States Department of Hematology/Oncology Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China Department of Paediatric Haematology and Cell Therapy University of Manchester Manchester United Kingdom Department of Cell Transplantation and Regenerative Medicine Tokai University School of Medicine Isehara Japan Department of Pediatrics Faculty of Medicine University of the Ryukyus Nishihara Japan Stem Cell Transplantation and Cellular Therapies Memorial Sloan Kettering Cancer Center New York New York United States Medical Genetics Service Hospital de ClÃnicas de Porto Alegre (HCPA) Department of Genetics and Molecular Biology-Program Partnership Graduate in Genetics and Molecular Biology (PPGBM) Federal University of Rio Grande do Sul (UFRGS) and National Institute of Populational Medical Genetics Porto Alegre Brazil Medical Genetics Department National Institute of Women Children and Adolescent Health Oswaldo Cruz Foundation Rio de Janeiro Brazil Department of Pediatrics Dulbecco Telethon Institute University of Milano-Bicocca Monza Italy Pediatric Immunohematology and Bone Marrow Transplantation Unit San Raffaele-Telethon Institute for Gene Therapy IRCCS San Raffaele Scientific Institute Milan Italy Department of Pediatrics Shimane University Faculty of Medicine Shimane Japan Department of Pediatrics Graduate School of Medicine Gifu University Gifu Japan Medical Education Development Center Gifu University Gifu Japan Department of Pediatrics Thomas Jefferson University Philadelphia United States

Allogenic hematopoietic stem cell transplantation (HSCT) has proven to be a viable treatment option for a selected group of patients with mucopolysaccharidoses (MPS), including those with MPS types I, II, IVA, VI, and VII. Early diagnosis and timely referral to an expert in MPS are critical, followed by a complete examination and evaluation by a multidisciplinary team, including a transplantation physician. Treatment recommendations for MPS are based on multiple biological, sociological, and financial factors, including type of MPS, clinical severity, prognosis, present clinical signs and symptoms (disease stage), age at onset, rate of progression, family factors and expectations, financial burden, feasibility, availability, risks and benefits of available therapies such as HSCT, enzyme replacement therapy (ERT), surgical interventions, and other supportive care. International collaboration and data review are critical to evaluating the therapeutic efficacy and adverse effects of HSCT for MPS. Collaborative efforts to assess HSCT for MPS have been ongoing since the first attempt at HSCT in a patient with MPS reported in 1981. The accumulation of data since then has made it possible to identify early outcomes (ie, transplantation outcomes) and long-term disease-specific outcomes resulting from HSCT. The recent identification of predictive factors and the development of innovative regimens have significantly improved the outcomes of both engraftment failure and transplantation-related mortality. Assessment of long-term outcomes has considered a variety of factors, including type of MPS, type of graft, age at transplantation, and stage of disease progression, among others. Studies on long-term outcomes are considered a key factor in the use of HSCT in patients with MPS. These studies have shown the effects and limitations of HSCT on improving disease manifestations and quality of life. In this review, we summarize the efficacy, side effects, risks, and cost of HSCT for

关键词： Allogenic hematopoietic stem cell transplantation Enzyme replacement therapy Limitations Mucopolysaccharidoses Outcomes

来源：评论

学校读者我要写书评

暂无评论

Investing in Department Chairs

引用

Change 2018年第2期50卷 58-62页

作者： Gardner, Susan K. Ward, Kelly Susan K. Gardner Ph.D. (susan.k.gardner@maine.edu) is Director of the University of Maine’s Rising Tide Center for Equity and Inclusive Excellence and the Women’s Gender and Sexuality Studies Program along with her role as Professor of Higher Education. Her research focuses on the intersections of individual development and success within higher education cultures and structures. Data for this article emanate from a $3.3 million grant from the National Science Foundation’s ADVANCE program for which she served as Co-PI. Kelly Ward Ph.D. (kaward@wsu.edu) is Vice Provost for Faculty Development and Recognition at Washington State University where she is also Professor of Higher Education having previously served as the chair of the Department of Educational Leadership Sport Studies and Educational/Counseling Psychology . Dr. Ward is interested in faculty issues including integration of teaching research and service work and family concerns for faculty and leaders faculty career development and faculty diversity in STEM.

The examples of remarks provided at the begining of this article describing their department chairs show two extremes: a department where the chair is highly valued by its faculty and contributes to a positive climate and, conversely, a chair who is seen as a bully and is perceived as a detriment to the work environment. While it is likely that many academic departments fall somewhere in between these two extremes, it is also clear that department chairs play a significant role in the department's work environment and climate. In this perspective piece, the authors describe their efforts in utilizing literature and research to connect to, support, and partner with department chairs to create positive cultures and climates for our faculty. Their hope is that this information can support other leaders in supporting organizational change.

关键词： Investment Department Heads Leadership Styles Organizational Change Partnerships in Education Teacher Administrator Relationship College Administration Staff development School Support Transformational Leadership Deans Middle Management

来源：评论

学校读者我要写书评

暂无评论

Gender-specific effects of a summer research program on stem research self-efficacy 123

Gender-specific effects of a summer research program on STEM...

引用

123rd ASEE Annual Conference and Exposition

作者： Listman, Jennifer B. Kapila, Vikram Program Development and Evaluation Center for K12 STEM Education New York University Polytechnic School of Engineering United States

来源：评论

学校读者我要写书评

暂无评论

引用

BLOOD 2017年第Sup1期130卷 3212-3212页

作者： Al Malki, Monzr M. Song, Joo Y. Yang, Dongyun Cao, Thai Aldoss, Ibrahim Mokhtari, Sally Dadwal, Sanjeet Gendzekhadze, Ketevan Pawlowska, Anna B. Ameri, Maryam Marcucci, Guido Karanes, Chatchada Parker, Pablo Snyder, David S. Senitzer, David Nademanee, Auayporn P. Forman, Stephen J. Nakamura, Ryotaro Pullarkat, Vinod Department of Hematology/HCT City of Hope National Medical Center Duarte CA Department of Pathology City of Hope National Medical Center Duarte CA Department of Information Sciences-BRI City of Hope National Medical Center Duarte CA Department of Clinical Translational Program Development City of Hope National Medical Center Duarte CA Department of Infectious Disease City of Hope National Medical Center Duarte CA Histocompatibility Lab City of Hope National Medical Center Duarte CA Department of Pediatrics City of Hope National Medical Center Duarte CA Division of Hematopoietic Stem Cell and Leukemia Research Gehr Family Center for Leukemia Research Hematologic Malignancies and Stem Cell Transplantation Institute Beckman Research Institute City of Hope Medical Center Duarte CA Division of Hematopoietic Stem Cell and Leukemia Research Gehr Family Center for Leukemia Research Hematologic Malignancies and Stem Cell Transplantation Institute Beckman Research Institute City of Hope National Medical Center Duarte CA

TRIO has been shown to be associate with higher risk of morbidity (infections, venocclusive disease and hepatic dysfunction) and mortality after allogeneic HCT. A high transplant iron score (>25 red cell unit transfused prior to HCT, serum ferritin > 1000 ng/ml and a bone marrow (BM) iron stain of +6) was associated with 50% decrease in survival at one year (Storey J. Hem & Oncol 2009). TRIO in BM macrophages can generate free radicals resulting in oxidant stress thereby altering the hematopoietic microenvironment. This could have adverse effects on hematopoiesis and affect engraftment after HCT. To date, limited data are available on the effect of TRIO on outcomes of UCB HCT. We examined whether TRIO quantified based on serum ferritin (sF) and BM iron score (MIS) impact outcomes of UCB HCT, particularly with regards to engraftment. We reviewed 150 consecutive patients (pts) who underwent UCB HCT between March 2006 and September 2015 at City of Hope. Median age at time of HCT was 33.5 years (yrs) (range: 0-70 years) with 55% male and 23% < 18 yrs of age. sF was available within 30 days before HCT for 65%, and MIS was assessed on the pre-HCT BM biopsy for 40% of pts. HCT indications included bone marrow failure (n=13), hemoglobinopathies (n=2), lymphoma (n=23), acute leukemia (n=104), and chronic leukemia (n=8). Disease risk index (DRI) was high/very-high in 38% and 20% of pts had HCT comorbidity index of more than 2. One cord graft was received for 20% of pts. Median TNC of 4.9X10^7/kg (range: 1.8-26.6) and median CD34 count of 1.8X10^5/kg (range: 0.2-122.4). HLA match status was 4/6, 5/6, 6/6 in 93, 48, and 9 pts. Almost 60% of pts received myeloablative conditioning regimen (MAC) and 80% had calcineurin inhibitor/mycophenolate mofetil for graft versus host disease (GVHD) prophylaxis. With a median follow-up of 48.1 months (range: 5.8- 119.6), 2- and 5-yrs progression free survival (PFS) were 41% and 35.5% while 2- and 5-yrs OS were 47% and 36%, respectively. Cumul

关键词：

来源：评论

学校读者我要写书评

暂无评论

Breast cancer development and progression:Risk factors,cancer stem cells,signaling pathways,genomics,and molecular pathogenesis

引用

Genes & Diseases 2018年第3期5卷 77-106页

作者： Yixiao Feng Mia Spezia Shifeng Huang Chengfu Yuan Zongyue Zeng Linghuan Zhang Xiaojuan Ji Wei Liu Bo Huang Wenping Luo Bo Liu Yan Lei Scott Du Akhila Vuppalapati Hue H.Luu Rex C.Haydon Tong-Chuan He Guosheng Ren Chongqing Key Laboratory of Molecular Oncology and Epigenetics Departments of General SurgeryClinical Laboratory MedicineOrthopaedic SurgeryPlastic Surgery and Burnand OtolaryngologyHead and Neck SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Biochemistry and Molecular Biology China Three Gorges University School of MedicineYichang 443002China Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory Medicine Chongqing Medical UniversityChongqing 400016China Stem Cell Biology and Therapy Laboratory Ministry of Education Key Laboratory of Child Development and DisordersThe Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Clinical Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences The Affiliated Hospital of StomatologyChongqing Medical UniversityChongqing 401147China Student Inquiry Research Program Illinois Mathematics and Science Academy(IMSA)AuroraIL 60506USA

As the most commonly occurring cancer in women worldwide,breast cancer poses a formidable public health challenge on a global *** cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the *** the risk factors associated with this cancer varies with respect to other cancers,genetic predisposition,most notably mutations in BRCA1 or BRCA2 gene,is an important causative factor for this *** cancers can begin in different areas of the breast,such as the ducts,the lobules,or the tissue in *** the large group of diverse breast carcinomas,there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor *** is important to distinguish between the various subtypes because they have different prognoses and treatment *** there are remarkable parallels between normal development and breast cancer progression at the molecular level,it has been postulated that breast cancer may be derived from mammary cancer stem *** breast development and mammary stem cells are regulated by several signaling pathways,such as estrogen receptors(ERs),HER2,and Wnt/b-catenin signaling pathways,which control stem cell proliferation,cell death,cell differentiation,and cell ***,emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer,especially for triple-negative breast *** review provides a comprehensive survey of the molecular,cellular and genetic aspects of breast cancer.

关键词： BRCA1/2 Breast cancer Cancer stem cells Estrogen receptors HER2 Noncoding RNAs Triple-negative breast cancer Tumor heterogeneity

来源：评论

学校读者我要写书评

暂无评论

A consensus protocol for functional connectivity analysis in the rat brain (vol 26, pg 673, 2023)

引用

NATURE NEUROSCIENCE 2023年第6期26卷 1127-1128页

作者： Grandjean, Joanes Desrosiers-Gregoire, Gabriel Anckaerts, Cynthia Angeles-Valdez, Diego Ayad, Fadi Barriere, David A. Blockx, Ines Bortel, Aleksandra Broadwater, Margaret Cardoso, Beatriz M. Celestine, Marina Chavez-Negrete, Jorge E. Choi, Sangcheon Christiaen, Emma Clavijo, Perrin Colon-Perez, Luis Cramer, Samuel Daniele, Tolomeo Dempsey, Elaine Diao, Yujian Doelemeyer, Arno Dopfel, David Dvorakova, Lenka Falfan-Melgoza, Claudia Fernandes, Francisca F. Fowler, Caitlin F. Fuentes-Ibanez, Antonio Garin, Clement M. Gelderman, Eveline Golden, Carla E. M. Guo, Chao C. G. Henckens, Marloes J. A. G. Hennessy, Lauren A. Herman, Peter Hofwijks, Nita Horien, Corey Ionescu, Tudor M. Jones, Jolyon Kaesser, Johannes Kim, Eugene Lambers, Henriette Lazari, Alberto Lee, Sung-Ho Lillywhite, Amanda Liu, Yikang Liu, Yanyan Y. Lopez-Castro, Alejandra Lopez-Gil, Xavier Ma, Zilu MacNicol, Eilidh Madularu, Dan Mandino, Francesca Marciano, Sabina McAuslan, Matthew J. McCunn, Patrick McIntosh, Alison Meng, Xianzong Meyer-Baese, Lisa Missault, Stephan Moro, Federico Naessens, Daphne M. P. Nava-Gomez, Laura J. Nonaka, Hiroi Ortiz, Juan J. Paasonen, Jaakko Peeters, Lore M. Pereira, Mickael Perez, Pablo D. Pompilus, Marjory Prior, Malcolm Rakhmatullin, Rustam Reimann, Henning M. Reinwald, Jonathan Del Rio, Rodrigo Triana Rivera-Olvera, Alejandro Ruiz-Perez, Daniel Russo, Gabriele Rutten, Tobias J. Ryoke, Rie Sack, Markus Salvan, Piergiorgio Sanganahalli, Basavaraju G. Schroeter, Aileen Seewoo, Bhedita J. Selingue, Erwan Seuwen, Aline Shi, Bowen Sirmpilatze, Nikoloz Smith, Joanna A. B. Smith, Corrie Sobczak, Filip Stenroos, Petteri J. Straathof, Milou Strobelt, Sandra Sumiyoshi, Akira Takahashi, Kengo Torres-Garcia, Maria E. Tudela, Raul van den Berg, Monica van der Marel, Kajo van Hout, Aran T. B. Vertullo, Roberta Vidal, Benjamin Vrooman, Roel M. Wang, Victora X. Wank, Isabel Watson, David J. G. Yin, Ting Zhang, Yongzhi Zurbruegg, Stefan Achard, Sophie Alcauter, Sarael Auer, Dorothee P. Barbier, Emmanuel L. Baudewig, Juergen Beckmann, Chri Donders Institute for Brain Behaviour and Cognition Radboud University Nijmegen The Netherlands Department for Medical Imaging Radboud University Medical Center Nijmegen The Netherlands Cerebral Imaging Centre Douglas Mental Health University Institute Verdun QC Canada Integrated Program in Neuroscience McGill University Montreal QC Canada Bio-imaging Lab University of Antwerp Antwerp Belgium µNEURO Research Centre of Excellence University of Antwerp Antwerp Belgium Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro Mexico Biological and Biomedical Engineering McGill University Montreal QC Canada McConnell Brain Imaging Centre McGill University Montreal QC Canada Montreal Neurological Institute McGill University Montreal QC Canada UMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction Physiologie de la reproduction et des comportements Centre de recherche INRAE de Nouzilly Tours France Department of Neurology and Neurosurgery McGill University Montreal QC Canada Center for Animal MRI University of North Carolina at Chapel Hill Chapel Hill NC USA Department of Neurology University of North Carolina at Chapel Hill Chapel Hill NC USA Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC USA Preclinical MRI Champalimaud Research Champalimaud Centre for the Unknown Lisbon Portugal Laboratoire des Maladies Neurodégénératives Molecular Imaging Research Center (MIRCen) Université Paris-Saclay Commissariat à l’Énergie Atomique et aux Énergies Alternatives (CEA) CNRS Fontenay-aux-Roses France Departamento de Neurobiología Conductual y Cognitiva Instituto de Neurobiología Universidad Nacional Autónoma de México Campus Juriquilla Querétaro México Translational Neuroimaging and Neural Control Group High-Field Magnetic Resonance Max Planck Institute for Biological Cybernetics Tuebingen Germany Graduate Training Centre of Neuroscience International Max

Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

关键词： Databases Neural circuits

来源：评论

学校读者我要写书评

暂无评论

Professional development through situated learning techniques adapted with design-based research 123

Professional development through situated learning technique...

引用

123rd ASEE Annual Conference and Exposition

作者： Moorhead, Matthew Elliott, Colin Hennessy Listman, Jennifer B. Milne, Catherine E. Kapila, Vikram Program Development and Evaluation Center for K12 STEM Education New York University Polytechnic School of Engineering United States United States

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：