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A novel plasma p-tau181 assay as a specific biomarker of tau pathology in Alzheimer’s disease

Translational Neurodegeneration 2024年第1期13卷 457-461页

作者： Kenji Tagai Harutsugu Tatebe Sayo Matsuura Zhang Hong Naomi Kokubo Kiwamu Matsuoka Hironobu Endo Asaka Oyama Kosei Hirata Hitoshi Shinotoh Yuko Kataoka Hideki Matsumoto Masaki Oya Shin Kurose Keisuke Takahata Masanori Ichihashi Manabu Kubota Chie Seki Hitoshi Shimada Yuhei Takado Kazunori Kawamura Ming-Rong Zhang Yoshiyuki Soeda Akihiko Takashima Makoto Higuchi Takahiko Tokuda Advanced Neuroimaging Center Institute for Quantum Medical ScienceNational Institutes for Quantum Science and Technology(QST)4-9-1 AnagawaInage-kuChiba-shiChiba 263-8555Japan Department of Psychiatry The Jikei University of MedicineTokyo 105-8461Japan Department of Oral and Maxillofacial Radiology Tokyo Dental CollegeTokyo 101-0061Japan Department of Psychiatry Keio University School of MedicineTokyo 160-0016Japan Department of Functional Neurology and Neurosurgery Center for Integrated Human Brain ScienceBrain Research InstituteNiigata UniversityNiigata 951-8585Japan Laboratory for Alzheimer’s Disease Department of Life ScienceFaculty of ScienceGakushuin UniversityTokyo 171-8588Japan

Main text Alzheimer’s disease(AD),the most prevalent form of dementia,is characterized by deposits of two abnormal proteins,namely amyloid-β(Aβ)and tau,in the *** is growing evidence for the clinical significance of plasma phosphorylated tau(p-tau)assays in detecting AD pathology[1,2],similar to CSF and positron emission tomography(PET)*** available immunoassays for plasma p-tau detect C-terminally truncated p-tau containing the N-terminus to the mid-domain(N-p-tau)[2].

关键词： tau Alzheimer Aβ

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Reshaping Precipitate Structure and Morphology in an Al-Zn-Mg-Cu Alloy Through Dislocation-Precipitate Interactions

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SSRN 2024年

作者： Yan, Lijuan Sun, Yanrong Zhang, Yongchao Wang, Shuai Tang, Huizhen Li, Lei Ge, Binghui Information Materials and Intelligent Sensing Laboratory of Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Institutes of Physical Science and Information Technology Anhui University Anhui Hefei230601 China Shandong Key Laboratory of Advanced Aluminium Materials and Technology Binzhou Institute of Technology Weiqiao-UCAS Science and Technology Park Shandong Province Binzhou China

This study explored the atomic-scale interactions between dislocations and precipitates and their impact on precipitate structures in an under-aged Al-Zn-Mg-Cu alloy. Results revealed that precipitates not only impeded the motion of dislocations but were also sheared by dislocations during the deformation. Moreover, the sheared precipitates experienced structural collapse and deviated from their original evolutionary path, leading to the formation of ordered but non-periodic topologically close-packed structures as well as a shift in precipitate morphologies. The discoveries provide insights into dislocation-nanosized precipitate interactions and strain-induced structural changes of precipitates, which could inspire strategies to modulate precipitates with tailored microstructures and thereby improved alloy properties. © 2024, The Authors. All rights reserved.

关键词： Precipitation (chemical)

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Effect of melting rate on microsegregation and primary MC carbides in M2 high-speed steel during electroslag remelting

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China Foundry 2021年第3期18卷 163-169页

作者： Fu-xing Yin Ming Su Fa Ji Qing-chao Tian Ya-guan Bai Jian-hang Feng Zhi-xia Xiao School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China Tianjin Key Laboratory of Layered Composite Materials Tianjin 300130China State Key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgySchool of Materials Science and EngineeringShanghai UniversityShanghai 200444China Tianjin Heavy Industries Research and Development Co. Ltd.Tianjin 300457China

Large-size primary MC carbides can significantly reduce the performance of M2 high-speed *** better control the morphology and size of primary MC carbides,the effect of melting rate on microsegregation and primary MC carbides of M2 steel during electroslag remelting was *** the melting rate is decreased from 2 kg·min^(-1) to 0.8 kg·min^(-1),the columnar dendrites are gradually coarsened,and the extent of segregation of Mo and V is alleviated,while the segregation of Cr becomes *** 2 kg·min^(-1),the number of primary MC carbides per unit area with the sizes in the range of 2 μm to 6 μm accounts for about 75% of all MC carbides,while the carbides are mainly concentrated on the size larger than 8 μm at 0.8 kg·min^(-1).Thermodynamic calculations based on the Clyne-Kurz (simplified to C-K) model shows that MC carbide can be precipitated in the final solidification stage and a smaller secondary dendrite arm spacing caused by higher melting rate (2 kg·min^(-1) in this experiment) facilitates the refinement of primary MC carbides.

关键词： high-speed steel MC carbide melting rate electroslag remelting microsegregation

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Simultaneous regulation of cations and anions in an electrolyte for high-capacity, high-stability aqueous zinc–vanadium batteries

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escience 2022年第2期2卷 209-218页

作者： Ziqing Wang Miao Zhou Liping Qin Minghui Chen Zixian Chen Shan Guo Liangbing Wang Guozhao Fang Shuquan Liang School of Materials Science and Engineering Central South UniversityChangsha410083PR China College of Biological and Chemical Engineering Guangxi University of Science and TechnologyLiuzhou545006GuangxiPR China Department of Chemistry The University of Texas at AustinAustinTX78712USA School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081PR China Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South UniversityChangsha410083PR China

Safe,inexpensive aqueous zinc-ion batteries(AZIBs)are regarded as promising energy storage ***,they still face issues,including dissolution and collapse of the cathode as well as H_(2)evolution and the growth of Zn dendrites on the Zn ***,we simultaneously regulate the cations and anions in the electrolyte for high-capacity,high-stability aqueous zinc–vanadium(Zn–V)batteries based on a bimetallic cation-doped Na_(0.33)K_(0.1)V_(2)O_(5)·nH_(2)O *** demonstrate that Na^(+) cations suppress cathode dissolution and restrain Zn dendrite growth on the anode via an electrostatic shield *** also illustrate that ClO_(4)^(-) anions participate in energy storage at the cathode and are reduced to Cl^(-),generating a protective layer on the Zn anode surface and providing a stable interface to decrease Zn dendrites and H_(2)evolution during long-term *** Na^(+) and ClO_(4)^(-) are introduced into an aqueous ZnSO_(4) electrolyte,a Zn/Zn symmetric cell shows durable and reversible Zn stripping/plating for 1500 h at a current density of 1 mA cm^(-2) and with an area capacity of 1 mAh cm^(-2).Zn/Na_(0.33)K_(0.1)V_(2)O_(5)·nH_(2)O full batteries exhibit a high capacity of 600 mAh g^(-1)at 0.1 A g^(-1) and long-term cycling performance for 5000 cycles,with a capacity of 200 mAh g^(-1) at 20 Ag^(-1).

关键词： Vanadium-based cathode Electrolyte additives High capacity Interfacial layer Zinc-ion batteries

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Room Temperature Phosphorescence from Intermolecular Hydrogen-Bonded Quinolone Quinoline Carboxylic Acid/Polyacrylamide Material and the Application for Anti-Counterfeiting

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SSRN 2024年

作者： Zhang, Jiamei Zhou, Wei Yang, Li Dou, Mingsong Qu, Wenwen Lu, Shaolin Chen, Xudong Faculty of Science Kunming University of Science and Technology Kunming650500 China Key Laboratory for Polymeric Composite and Functional Materials Ministry of Education Guangdong Engineering Technology Research Center for High-performance Organic and Polymer Photoelectric Functional Films School of Chemistry Sun Yat-sen University Guangzhou510275 China School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory Guangdong Jieyang China

Polymer-based organic room temperature phosphorescence (RTP) materials are of critical importance in organic light-emitting diodes, displays, and anti-counterfeiting applications. Nevertheless, the development of heavy-atom-free materials that exhibit long RTP lifetimes and high quantum yields via a straightforward, cost-effective, and environmentally friendly preparation remains a significant challenge. In this study, we design and construct an environmentally sustainable and highly efficient hydrogen-bonding network (QA/PAM) employing commercially available quinoline carboxylic acid (QA) derivatives and the water-soluble polymer polyacrylamide (PAM) with high hydrogen bond capacity. By increasing the conjugation degree and the number of carboxyl groups in QA, we can effectively enhance the π-π* and n-π* transitions, thereby reducing the energy gap between the S1 and T1 states, resulting in high quantum yields and offering the ability to adjust colors from blue to green and subsequently to yellow-green. Particularly, BQDA/PAM-0.3 wt% system shows an average lifetime of 392.46 ms and QY of 26.93% under 300 nm excitation at 297 K. Anti-counterfeiting patterns and 2D code fabricated by the BQDA/PAM solution by environmentally friendly screen printing can be facilely deciphered by mobile phone, offering potential applications in optical and digital information security for commercial production. © 2024, The Authors. All rights reserved.

关键词： Quantum yield

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Light weight optimization of stratospheric airship envelope based on reliability analysis

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Chinese Journal of Aeronautics 2020年第10期33卷 2670-2678页

作者： Yunce ZHANG Yafei WANG Changguo WANG National Key Laboratory of Science and Technology for National Defence on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150001China Center for Composite Materials Harbin Institute of TechnologyHarbin 150001China

A stratospheric airship is an essential flight vehicle in the aviation *** this paper,optimal design approach of stratospheric airships is developed to optimize envelope shape considering three failure modes and multidisciplinary analysis models,and could also reduce the mass of a stratospheric airship to be deployed at a specific *** on a theoretical analysis,three failure modes of airships including bending wrinkling failure,hoop tearing failure and bending kink failure,are given to describe and illustrate the failure mechanism of stratospheric *** results show that the location,length and size of the local uniform load and the large fineness ratio are easier to lead to bending wrinkling failure and bending kink *** small fineness ratio and the increasing differential pressure are more prone to cause hoop tearing failure for an airship *** failure probability is sensitive to the wind *** an optimization design,the reliability analysis is essential to be carried out based on the safety of the *** solution in this study can provide economical design recommendations.

关键词： Failure modes Mass optimization Optimal design Reliability analysis Stratospheric airship

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Twist Design of Lattice Structure Fabricated by Powder Bed Fusion to Adjust the Energy Absorption Behavior

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SSRN 2023年

作者： Zhang, Leyao Lei, Hongshuai Wang, Fei Wang, Panding Duan, Shengyu Zhao, Zeang Institute of Advanced Structure Technology Beijing Institute of Technology Beijing100081 China Beijing Key Laboratory of Lightweight Multi-functional Composite Materials and Structures Beijing Institute of Technology Beijing100081 China Beijing Electro-Mechanical Engineering Institute Beijing100074 China

Additive manufactured lattice structures offer great potential for impact resistance applications. They exhibit excellent energy absorption characteristics during the elasto-plastic deformation process, providing protection to internal devices. However, the mechanical response of lattice structures undergoes substantial variations during the deformation process, thereby imposing limitations on their energy absorption behavior. This study introduces a novel twist design to modify the energy absorption behavior of rectangular and hollow cylindrical lattice structures. Powder bed fusion was used to fabricate the twisted lattice structures. The study employed a combination of compressive simulations and experimental investigations to systematically explore the impact of the twist angle on the peak crushing force, energy absorption, and crash load efficiency of the structures. Adjusting the twist angle results in a reduction of the peak crushing force and a transition towards a stable loading profile during the deformation process. Moreover, the crash load efficiency is also reduced. The twist design concept presented in this paper provides insight into designing and optimizing lattice structures for energy absorption applications. © 2023, The Authors. All rights reserved.

关键词： Energy absorption

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Layered Metastable Cobalt Oxide with Self-Healing Properties for Enhanced Stability in Oxygen Evolution Reactions

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ACS Applied Energy Materials 2025年第12期8卷 8311-8319页

作者： Diandian Lv Dongdong Gao Penghao Li Jinzeng Guo Ziliang Chen Zhenhui Kang Fan Liao Mingwang Shao Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Soochow University 199 Ren’ai Road Suzhou 215123 Jiangsu China Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Soochow University 199 Ren’ai Road Suzhou 215123 Jiangsu China；Macao Institute of Materials Science and Engineering (MIMSE) MUST-SUDA Joint Research Center for Advanced Functional Materials Macau University of Science and Technology Taipa 999078 Macao SAR China Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Soochow University 199 Ren’ai Road Suzhou 215123 Jiangsu China；Shangqi Photoelectric Co. Ltd. 2998 Taidong Road Suzhou 215100 Jiangsu China

The development of durable oxygen evolution reaction (OER) catalysts is critical for improving energy storage and conversion systems. The challenge of active site deactivation during a prolonged electrochemical operation necessitates innovative solutions. Self-healing mechanisms have emerged as a compelling approach to boost the long-term stability of the OER catalysts. Two-dimensional structure catalysts, which offer vast surface areas, can enhance the mass transfer efficiency and expedite reaction kinetics, thus promoting self-repair processes. Here, we synthesized a layered quasi-nevskite metastable-phase cobalt oxide (LQNMP-Co2O3) using a molten-alkali method and investigated its self-healing behaviors during the OER electrocatalytic process. In a Co2+-containing borate buffer solution (KBi, pH = 14), the overpotential decreased by 9 mV after 5000 cyclic voltammetry cycles. The catalyst demonstrated remarkable stability over 200 h at a current density of 10 mA cm–2, after which it exhibited further overpotential reductions. This study marks the first demonstration of self-healing properties in cubic phase cobalt oxides and underscores the potential of metastable-phase materials in advancing the efficacy of OER catalysts for energy systems.

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On-Surface Stereochemical Characterization of a Highly Curved Chiral Nanographene by Noncontact Atomic Force Microscopy and Scanning Tunneling Microscopy

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CCS Chemistry 2023年第12期5卷 2888-2896页

作者： Qigang Zhong Viktor Barat Daniel Csokas Kaifeng Niu Marcin Gorecki Animesh Ghosh Jonas Bjork Daniel Ebeling Lifeng Chi Andre Schirmeisen Mihaiela C.Stuparu Institute of Applied Physics Center for Materials Research(LaMa)Justus-Liebig University Giessen35392 Giessen School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University637371 Singapore Institute of Organic Chemistry Research Center for Natural SciencesH-1117 Budapest Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft MaterialsSoochow University215123 Suzhou Department of Physics Chemistry and BiologyIFMLinkoping University58183 Linkoping Institute of Organic Chemistry Polish Academy of Sciences01-224 Warsaw Macao Institute of Materials Science and Engineering(MIMSE) MUST-SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipa 999078MacaoChina

A highly distorted chiral nanographene structure composed of triple corannulene-fused[5]helicenes is prepared with the help of the Heck reaction and oxidative photocyclization with an overall isolated yield of 28%.The complex three-dimensional(3D)structure of the bowl-helix hybrid nanostructure is studied by a combination of noncontact atomic force microscopy(AFM)and scanning tunneling microscopy(STM)on the Cu(111)surface,density functional theory calculations,AFM/STM simulations,and high-performance liquid chromatography-electronic circular dichroism *** examination reveals a molecular structure in which the three bowl-shaped corannulene bladesd position themselves in a C3-symmetric fashion around a highly twisted triphenylene *** molecule appears to be shaped like a propeller in which the concave side of the bowls face away from the connected[5]helicene *** chirality of the nanostructure is confirmed by the direct visualization of both MMM and PPP enantiomers at the single-molecule level by scanning probe *** results underline that submolecular resolution imaging by AFM/STM is a powerful real-space tool for the stereochemical characterization of 3D curved chiral nanographene structures.

关键词： chirality at surfaces noncontact atomic force microscopy scanning tunnelling microscopy submolecular resolution imaging single-bond resolution curved nanographenes multiple helicenes chiral nanostructures bowl-helix hybrids scanning probe microscopy

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Gradient C f /ZrB 2 -SiC composites integrating low-density, good mechanical properties and heat-resistant

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Journal of Materials science & technology 2026年 242卷 156-165页

作者： Qiang Gao Ping Hu Yuxuan Xia Yuan Cheng Guangdong Zhao Jiaxin Feng Zibin Chen Xinghong Zhang National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Center for Composite Materials and Structures Harbin Institute of Technology Harbin 150080 China Beijing Power Machinery Institute The Third Academy of State-owned Aerospace Giant China Aerospace Science & Industry Corporation (CASIC) Beijing 100074 China School of Chemistry and Materials Science Heilongjiang University Harbin 150080 China

Ultra-high temperature ceramic composites (UHTCCs) with low density and exceptional heat resistance are essential for hypersonic vehicle applications, enabling increased payload capacity and higher Mach numbers. However, developing a fabrication process that enables UHTCCs with both lightweight and superior thermal protection performance is still a challenge. To tackle this problem, in this study, a combinatorial process of vibration-assisted slurry impregnation and polymer infiltration pyrolysis was developed to fabricate gradient lightweight C f /ZrB 2 -SiC composites, consisting of continuous carbon fiber fabric, ZrB 2 -SiC and a carbon aerogels (CAs) layer. The resulting composites exhibit a low density of (0.62–0.96 g cm −3 ) but excellent oxidation and ablation resistance, which can withstand ultrahigh temperatures between 2100 °C and 2500 °C. The porous C f /CAs layer, with a density of 0.38 g cm −3 and specific bending and compressive strengths of 43.47 MPa/(g cm −3 ) and 15.53 MPa/(g cm −3 ), respectively, provides both structural integrity and lightweight properties to the C f /ZrB 2 -SiC composite. Furthermore, the density of the composites can be precisely tailored by adjusting the thickness of the C f /ZrB 2 -SiC layer, allowing for customized fabrication to meet diverse service environment requirements. This flexibility highlights the adaptability of the combined processing techniques. The unique combination of controllable low-density properties and exceptional oxidation and ablation resistance endows gradient lightweight C f /ZrB 2 -SiC composites are promising as lightweight, ultra-high temperature thermal protection systems for hypersonic vehicle applications.

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