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THE THEORY Of CONCENTRATED LANGEVIN DISTRIBUTIONS

JOURNAL Of MULTIVARIATE ANALYSIS 1984年第1期14卷 74-82页

作者： WATSON, GS Princeton University USA

The density of the Langevin (or fisher-Von Mises) distribution is proportional to exp κμ ′ x , where x and the modal vector μ are unit vectors in R q . κ (≥0) is called the concentration parameter. The distribution of statistics for testing hypotheses about the modal vectors of m distributions simplify greatly as the concentration parameters tend to infinity. The non-null distributions are obtained for statistics appropriate when κ 1 ,…, κ m are known but tend to infinity, and are unknown but equal to κ which tends to infinity. The three null hypotheses are H 01 : μ = μ 0 ( m =1), H 02 : μ 1 = … = μ m , H 03 : μ i ϵ V , i =1,…, m In each case a sequence of alternatives is taken tending to the null hypothesis.

关键词： 62E15 62f03 Directional data Langevin distribution fisher-von Mises distribution hypothesis tests estimates multivariate Gaussian distribution non-central chi-square distribution non-central f distribution

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CHAOTIC DYNAMICS IN YEAST GLYCOLYSIS UNDER PERIODIC SUBSTRATE INPUT fLUX

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fEBS LETTERS 1984年第2期172卷 235-238页

作者： MARKUS, M KUSCHMITZ, D HESS, B Max-Planck-Institut für Ernährungsphysiologie Rheinlanddamm 201 4600 Dortmund 1 FRG

The numerical analysis for a glycolytic model containing the enzymes phosphofructokinase and pyruvate kinase reveals different types of entrainment, as well as chaotic response under sinusoidal substrate input. Entrainment with response periods 1, 2, 3, 5 and 7-times the input flux period and aperiodic behaviour is verified by measurements of NADH fluorescence in extracts of Saccharomyces cerevisiae in the theoretically predicted range. The stroboscopic transfer function obtained from the aperiodic signal admits period 3, implying chaos according to the Li-Yorke theorem.

关键词： Oscillation Chaos Entrainment Glycolysis Yeast PfK, phosphofructokinase(EC2.7.1.11) PK, pyruvate kinase (EC 2.7.1.40) fBP, fructose 1,6-bisphosphate f6P, fructose 6-phosphate PEP, phosphoeno/pyruvate [K tot ] and [Mg tot ], total concentrations (bound plus unbound) of potassium and magnesium f , NADH fluorescence in arbitrary units ω e , T e , frequency and period of the externally (e) applied flux ω, T , frequency and period of the system response ω 0 . T 0 , frequency and period of the system at constant input flux, i.e., without periodic excitation

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THE ROLE Of PROTHYMOCYTES IN RADIATION-INDUCED LEUKEMOGENESIS IN C57BL/RIJ MICE

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LEUKEMIA RESEARCH 1984年第3期8卷 461-471页

作者： VANBEKKUM, DW BOERSMA, WJA ELIASON, Jf KNAAN, S TNO INST EXPTL GERONTOL POB 5815 2280 HV RIJSWIJK NETHERLANDS TNO INST RADIOBIOL 2280 HV RIJSWIJK NETHERLANDS

following transplantation of bone marrow into recipient mice subjected to irradiation with four weekly fractions of 1.8 Gy, donor progenitor cells were found to compete with host elements for colonization of the thymus. The capacity for thymus repopulation of bone marrow cells from 4 X 1.8 Gy irradiated mice is decreased to a similar low level as that of regenerating bone marrow derived from lethally irradiated mice reconstituted with isogeneic marrow. It was calculated that the prothymocyte content of both types of regenerating marrow was less than 0.1% of that of normal marrow. Long-term cultures of C57BL bone marrow were found to contain the same numbers of prothymocytes per CfU-S as normal bone marrow, in contrast to cultured marrow from (C3H X AKR)f1 mice, that shows a striking decrease of prothymocytes. Normal bone marrow cells and long-term cultured bone marrow cells of C57BL mice were about equally effective on the basis of numbers of CfU-S injected in protecting 4 X 1.8 Gy irradiated syngeneic recipients from developing thymic lymphomas, while regenerating bone marrow was virtually nonprotective. These data are interpreted as supporting the notion that prothymocytes from the bone marrow play a crucial role in the prevention of radiation-induced thymic lymphomas.

关键词： Radiation leukemogenesis prothymocytes CfU-S , colony-forming unit-spleen EBM , Eagle's Basal Medium f 1 , hybrid mouse H -2, mouse histocompatibility antigens HEPES , H-2 hydroxyyethylpiperazine-N '2-ethane sulphonic acid HVL , half value layer TdT , terminal deoxynucleotidyl transferase

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PRACTICAL METHODS fOR COMPUTING POWER IN TESTING THE MULTIVARIATE GENERAL LINEAR-HYPOTHESIS

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COMPUTATIONAL STATISTICS & DATA ANALYSIS 1984年第2期2卷 143-158页

作者： MULLER, KE PETERSON, BL UNIV N CAROLINA DEPT BIOSTATCHAPEL HILLNC 27514

four test statistics are commonly used in multivariate general linear hypothesis tests such as MANOVA: Roy's largest root, Wilks' Lambda, Hotelling-Lawley trace and Pillai-Bartlett trace. Closed form, finite series expressions do not exist for the distribution functions in either the null or non-null case (except for special cases). In practice, asymptotic approximations, based on f or chi square distributions, are used for the null case. It is not widely known that similarly accurate and general approximations have been published for the non-null case, for all except the largest root [15,38]. In this paper new approximations, based on noncentral f 's, are provided for power for all but the largest root. These generalize existing f approximations for the central case. Much less calculation is needed than for earlier approximations and accuracy appears not to suffer in practice. An upper bound f approximation is provided for the largest root power. Power calculation can be used to help choose a test statistic as well as for experimental design. A particularly convenient method for estimating power, using standard linear models programs [20], is generalized to the multivariate case.

关键词： MANOVA Noncentral distributions Wilks' Lambda Hotelling-Lawley trace Pillai-Bartlett trace f approximations

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CO-ABSOLUTES Of BETA-N/N

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TOPOLOGY AND ITS APPLICATIONS 1984年第1期18卷 1-15页

作者： DOW, A UNIV TORONTO DEPT MATHTORONTO M5S 1A1ONTARIOCANADA

It is shown that “every Parovičenko space is co-absolute with β N\N ” does not imply CH and in turn is not implied by c <2 ω 1 . We also obtain a characterization of the above statement in terms of the non-exis... 详细信息

关键词： 54G05 54D40 54A35 06E99 f -space, β N\N Boolean algebra Novák number. absolute trees

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PRIMARY STRUCTURE Of A REGULATING fACTOR, 15-KDA PROTEIN, Of ATP SYNTHASE IN YEAST MITOCHONDRIA

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fEBS LETTERS 1984年第1期170卷 135-138页

作者： YOSHIDA, Y WAKABAYASHI, S MATSUBARA, H HASHIMOTO, T TAGAWA, K OSAKA UNIV SCH MEDDEPT PHYSIOL CHEMKITA KUOSAKA 530JAPAN OSAKA UNIV FAC SCIDEPT BIOLTOYONAKAOSAKA 560JAPAN

The amino acid sequence of a factor, 15 kDa protein, which facilitates the formation of, and stabilizes the inactivated complex between mitochondrial ATPase and intrinsic inhibitor was established. The factor was found to be composed of 83 amino acid residues and to have an M r of 9450, though the apparent M r was 15 000 when determiend by SDS—polyacrylamide gel electrophoresis. The factor was characterized as a basic protein with 18 basic and 12 acidic amino acid residues. The amino acid sequence of the factor showed significant homology with those of yeast ATPase inhibitor and the 9 kDa protein which acts in concert with the 15 kDa protein in stabilizing the inactivated ATPase complex.

关键词： f 1 f 0 —ATPase Stabilizing factor 15 kDa protein 9 kDa protein ATPase inhibitor

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IMMUNOHISTOCHEMICAL ANALYSIS Of THE ONTOGENY Of NEUROPEPTIDE-Y IMMUNOREACTIVE NEURONS IN fETAL-RAT BRAIN

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INTERNATIONAL JOURNAL Of DEVELOPMENTAL NEUROSCIENCE 1984年第4期2卷 387-407页

作者： fOSTER, GA SCHULTZBERG, M Department of Histology Karolinska Institutet Stockholm Sweden.

The development of neuropeptide Y-like immunoreactive structures in the foetal rat brain was investigated by means of the indirect immunohistofluorescence technique. Neuropeptide Y-like immunoreactive cells and fibres first appeared on day 13 of gestation, in the solitary tract nucleus, lateral reticular nucleus and nucleus ambiguus in the medulla oblongata, and in the primordial inferior colliculus and deep mesencephalic nucleus. Thereafter, neuropeptide Y-like immunoreactive cells and fibres increased in number in many areas including the primary olfactory cortex, the frontoparietal, somatosensory cortex, caudate putamen, lateral hypothalamus, ventrolateral thalamus, amygdala and parafascicular nucleus. The maximum number of cells over the age range studied, namely day 12 of gestation to birth day, occurred at around day 21. On the day of birth, accordingly, there were significantly fewer neuropeptide Y-like immunoreactive cell bodies in a number of brain areas, the most striking deficit being in the ventrolateral thalamus. The present study demonstrates the very early appearance of neuropeptide Y-like immunoreactive structures during foetal brain development. The functional role of the peptide during this period remains, however, to be determined.

关键词： Neuropeptide Y Immunohistochemistry Pre-atal ontogeny Brain development Aq cerebral aqueduct aca anterior commissure, anteriorpart acp anterior commissure, posterior part Am amygdaloid complex Amb nucleus ambiguus Arc arcuate hypothalamic nucleus BST bed nucleus of the stria terminalis BSTM bed nucleus of the stria terminalis, medial part C cerebellum cc corpus callosum CG central (periaqueductal) grey CPu caudate putamen (striatum) Cu cuneate nucleus DpMe deep mesencephalic nucleus DR dorsal raphe ec external capsule f fornix fi fimbria of the hippocampus fmi forceps minor of the corpus callosum fr frontal cortex fr fasciculus retroflexus frPaM frontoparietal cortex, motor area frPaSS frontoparietal cortex, somatosensory area fStr fundusstriati GP globuspallidus 1C inferior colliculus ic internal capsule icp inferior cerebellar peduncle IG induseum griseum IO inferior olive LC locus coeruleus LH lateral hypothalamus 11 lateral lemniscus lo lateral olfactory tract LRt lateral reticular nucleus LS lateral septum LV lateral ventricle MD mediodorsal thalamus Me median eminence mlf medial longitudinal fasciculus mt mammillothalamic tract MVe medial vestibular nucleus ON olfactory nerve layer OV olfactory ventricle opt optic tract PA gigantocellular reticular nucleus, pars alpha Pa paraventricular nucleus pc posterior commissure Pf parafascicular thalamic nucleus PGi paragigantocellular reticular nucleus PO primary olfactory cortex PrH prepositus hypoglossal nucleus py pyramidal tract RCh retrochiasmatic area rf rhinal fissure ROb raphe obscurus Rt reticular thalamic nucleus SC superior colliculus SN substantia nigra Sol nucleus of solitary tract sol solitary tract Sp5 nucleus of spinal tract trigeminal nerve sp5 spinal tract trigeminal nerve st stria terminalis ts tectospinal tract VL ventrolateral thalamic nucleus VPL ventroposterior thalamic nucleus, lateral part ZI zona incerta 2n optic nerve 3V 3rd ventricle 4V 4th ventricle 7 facial nucleus 12 hypoglossal nucleus

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INTERACTION Of LINOLENIC ACID WITH BOUND QUINONE MOLECULES IN PHOTOSYSTEM-II - TIME-RESOLVED OPTICAL AND ELECTRON-SPIN RESONANCE STUDIES

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BIOCHIMICA ET BIOPHYSICA ACTA 1984年第2期767卷 263-271页

作者： GOLBECK, JH WARDEN, JT RENSSELAER POLYTECH INST TROY NY 12181 USA

Time-resolved spectroscopic techniques, including optical flash photolysis and ESR spectroscopy, have been utilized to monitor electron-transport activity in Photosystem II subchloroplast [spinach] particles. In the presence of 100 .mu.M linolenic acid a high initial fluorescence yield (fi) is observed upon steady-state illumination of the dark-adapted sample;flash-induced absorption transients (t > 10 .mu.s) in the region of 820 nm, attributed to P-680+, are first slowed, then abolished;and ESR Signal IIs and Signal IIf (Z+) are not detectable. Upon reversal of linolenic acid inhibition by washing with bovine serum albumin, optical and ESR transients originating from the photooxidation of P-680 are restored. Similarly, the variable component of fluorescence is recovered with an accompanying restoration of Signal IIs and Signal IIf. Linolenic acid apparenty affects 2 inhibition sites in Photosystem II: one located between pheophytin and QA on the reducing side, and the other between electron donor Z and P-680 on the oxidizing side. Since both sites are associated with bound quinone molecules, linolenic acid probably interacts at the level of quinone binding proteins in Photosystem II.

关键词： Photosystem II ESR Linolenic acid Quinone Electron transport (Spinach chloroplast) f i initial fluorescence yield f max maximum fluorescence yield f var variable fluorescence yield Ph pheophytin intermediate electron acceptor Q A primary quinone acceptor Q B secondary quinone acceptor Z secondary electron donor Mes 4-morpholineethanesulfonic acid DCMU 3-(3′,4′-dichlorophenyl)-1,1′-dimethylurea Tricine N -[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine TSf-II Triton Photosystem-II particles

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ON A TEST Of EQUALITY Of 2-PARAMETER EXPONENTIAL-DISTRIBUTIONS

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STATISTICS & PROBABILITY LETTERS 1984年第6期2卷 357-361页

作者： NAGARSENKER, BN NAGARSENKER, PB Air Force Institute of Technology Wright-Patterson AFB OH 45433 USA

In this paper, an asymptotic expansion of the distribution of the statistic for testing the equality of p two-parameter exponential distributions is obtained upto the order n −4 with the second term of the order n −3 where n is the size of the sample drawn from the i th exponential population. The asymptotic expansion can therefore be used to obtain accurate approximations to the critical values of the test statistic even for comparatively small values of n . Also we have shown that f -tables can be used to test the hypothesis when the sample size is moderately large.

关键词： beta distribution two-parameter exponential distributions asymptotic expansion f distributions

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IMMUNOLOGICAL COMPARISONS AMONG ENERGY-TRANSDUCING ADENOSINE TRIPHOSPHATASES fROM HIGHER-PLANTS WITH RESPECT TO THE STRUCTURES Of THEIR SUBUNITS

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fEBS LETTERS 1984年第2期171卷 249-252页

作者： IWASAKI, Y MATSUOKA, M ASAHI, T Laboratory of Biochemistry Faculty of Agriculture Nagoya University Chikusa Nagoya 464 Japan

Anti-sweet potato mitchondrial f 1 -ATPase antibody that recognized the α- and β-subunits of its antigen reacted with β-, but not α-, subunits of f 1 -ATPases from guinea pig liver mitochondria and sweet potato, pea and spinach chloroplasts. The peptide maps and their immunoblots corresponded closely with the antibody of the β-subunits from various sources.

关键词： Mitochondrion Chloroplast f 1 -ATPase Peptide mapping Immunological comparison BSA bovine serum albumin f 1 -ATPase soluble form of energy-transducing adenosine triphosphatase f 1 f 0 -ATPase energy-transducing adenosine triphosphatase

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