Neuromorphic computing,inspired by the human brain,uses memristor devices for complex *** studies show that self-organizing random nanowires can implement neuromorphic information processing,enabling data *** paper pr...
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Neuromorphic computing,inspired by the human brain,uses memristor devices for complex *** studies show that self-organizing random nanowires can implement neuromorphic information processing,enabling data *** paper presents a model based on these nanowire networks,with an improved conductance variation *** suggest using these networks for temporal information processing via a reservoir computing scheme and propose an efficient data encoding method using voltage *** nanowire network layer generates dynamic behaviors for pulse voltages,allowing time series prediction *** experiment uses a double stochastic nanowire network architecture for processing multiple input signals,outperforming traditional reservoir computing in terms of fewer nodes,enriched dynamics and improved prediction *** results confirm the high accuracy of this architecture on multiple real-time series datasets,making neuromorphic nanowire networks promising for physical implementation of reservoir computing.
Currently, modular multilevel converter-based flexible direct current transmission technology (MMC-HVDC) is the prevalent method for connecting long-distance offshore wind farms (OWF) to large power grid systems. Due ...
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Citrinin(CIT)is one of by-products by Monascus fermentation with known *** dihydro-citrinone,no other metabolites including the possible metabolic pathways have been found in vivo *** this study,we applied ultra-perfo...
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Citrinin(CIT)is one of by-products by Monascus fermentation with known *** dihydro-citrinone,no other metabolites including the possible metabolic pathways have been found in vivo *** this study,we applied ultra-performance liquid chromatography-mass spectrometry(UPLC-MS)to analyze and identify potential CIT metabolites in the human cytochrome 450(P450)subtype *** new metabolites with liver microsomes incubation were first found,namely 3-hydroxy-citrinin(M1),4,5-ene-citrinin(M2),5-hydroxymethyl-citrinin(M3),and 7-hydroxy-citrinin(M4).We also found the distinguished levels of the four metabolites with the incubation of various P450 *** to the results of molecular docking prediction,it showed the metabolic correlation of CYP3A4 with M1,CYP1A2,CYP2C9,and CYP2D6 with M2,M3,and *** maximum level of M1 metabolite was found in the incubation with liver microsome and P450 ***,M1 and M4 metabolites were found in mice’s duodenum,jejunum,ileum,liver,kidney,and hippocampus,but not M2 and *** results indicated the mediation of citrinin metabolism by *** also suggested the concentration differences of metabolites with the incubation of different P450 subtypes.
SGDWSDIGGR(S-10-R)is a kind of antioxidant peptide derived from broken *** the present study,the effects of S-10-R against H_(2)O_(2)-induced cell damage and premature senescence in 2BS cells were *** results indicate...
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SGDWSDIGGR(S-10-R)is a kind of antioxidant peptide derived from broken *** the present study,the effects of S-10-R against H_(2)O_(2)-induced cell damage and premature senescence in 2BS cells were *** results indicated that S-10-R could improve cell viability and mitochondrial membrane potential at least 1.06 and 1.12 folds compared with senescence ***,S-10-R inhibitedβ-galactosidase,and DNA damage alleviates the effect on 2BS senescence cells due to scavenging *** apoptosis rate can be reduced by 80.58%.Furthermore,S-10-R could inhibit PI3K and Akt phosphorylation,downregulate Bax and caspases-3 expression,and inhibit premature senescence through activating PI3K/Akt related intrinsic apoptotic signaling pathways and suppressing JNK/Bcl-2 related mitochondria-dependent *** present study confirmed the feasibility of antioxidants as anti-aging drugs,as well as provided a substantial basis for future application of S-10-R as a functional ingredient against oxidative stress-induced premature aging.
In this paper, the technology of aircraft wing deformation monitoring based on fiber Bragg grating (FBG) sensor is studied. By comparing the limitations of traditional nondestructive monitoring technology,the advantag...
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This article presents a thorough and broad analysis of the passive slot heat path (HP) concept. Six HP shapes are proposed and compared in terms of their combined thermal and electrical performance. Through an extensi...
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Carbon-14(C-14) has been a major contributor to the human radioactive exposure dose,as it is released into the environment from the nuclear industry in larger quantities compared to other *** most abundant nuclide e...
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Carbon-14(C-14) has been a major contributor to the human radioactive exposure dose,as it is released into the environment from the nuclear industry in larger quantities compared to other *** most abundant nuclide enters the biosphere as organically bound C-14(OBC-14),posing a potential threat to public ***,it remains unknown how this relatively low radiotoxic nuclide induces health risks via chemical effects,such as isotope *** establishing a trophic transfer model involving algae(Scenedesmus obliquus),daphnia(Daphnia magna) and zebrafish(Danio rerio),we demonstrate that rapid incorporation and transformation of inorganic C-14 by algae into OB C-14 facilitates the blending of C-14 into the biomolecules of *** find that internalized C-14 is persistently retained in the brain of zebrafish,affecting DNA methylation and causing alterations in *** isotope tracing metabolomics with C-14 exposure further reveals the involvement of C-14 in various critical metabolic pathways,including one-carbon metabolism and nucleotide *** thus characterize the kinetic isotope effects for12C/14C in the key reactions of these metabolic pathways through kinetic experiments and density functional theory computations,showing that the isotopic substitution of carbon in bio chemicals regulates metabolism by disrupting reaction ratios via isotope *** results suggest that inorganic C-14discharged by the nuclear industry can be biotransformed into OBC-14 to impact metabolism via isotope effects,providing new insights into understanding the health risk of C-14,which is traditionally considered as a low radiotoxic nuclide.
At present, sensorless becomes a research hit for its lower cost and smaller size, among the present sensorless methods, Luenberger Observer has outstanding advantages for its dynamic performance, parameter robustness...
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With the explosive growth of mobile data, Mobile Crowd Sensing (MCS) has become a popular paradigm for large-scale data collection. The difficulty of data collection and the gaps in workers’ sensing capabilities are ...
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In this study, a flexible grasping terminal manipulator that uses the pneumatic vacuum principle and granular material as its base is given. Pneumatic device and granular material are wrapped in elastic film by the en...
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